Jeffrey W Dalley

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychopharmacology 30:525-37. 2005
  2. ncbi request reprint Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine
    Jeffrey W Dalley
    Department of Experimental Psychology and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:1195-206. 2007
  3. pmc Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:2057-66. 2012
  4. pmc Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome
    Daniele Caprioli
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1460-71. 2013
  5. pmc Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction
    Bianca Jupp
    Behavioural and Cognitive Neurosciences Institute and The Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Dis Model Mech 6:302-11. 2013
  6. pmc Divergent effects of D₂/₃ receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats
    M Moreno
    Department of Psychology, University of Almeria, Almeria, Spain
    Psychopharmacology (Berl) 228:19-30. 2013
  7. ncbi request reprint Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 28:771-84. 2004
  8. ncbi request reprint Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Pharmacol Biochem Behav 90:250-60. 2008
  9. ncbi request reprint Modelling human drug abuse and addiction with dedicated small animal positron emission tomography
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Neuropharmacology 56:9-17. 2009
  10. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychopharmacology 30:525-37. 2005
    ..Thus, contingent i.v. amphetamine administration has both short- and long-term consequences, which may be relevant to the complex disturbances that accompany drug addiction...
  2. ncbi request reprint Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine
    Jeffrey W Dalley
    Department of Experimental Psychology and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:1195-206. 2007
    ..The demonstration of residual deficits in rats chronically exposed to MDMA raises some concern about the potential harm caused by this drug in human ecstasy users...
  3. pmc Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:2057-66. 2012
    ....
  4. pmc Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome
    Daniele Caprioli
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1460-71. 2013
    ..A similar baseline-dependent mechanism may account for the therapeutic effects of stimulant drugs in clinical disorders such as ADHD...
  5. pmc Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction
    Bianca Jupp
    Behavioural and Cognitive Neurosciences Institute and The Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Dis Model Mech 6:302-11. 2013
    ..Here, we review the use of rodent models of impulsivity for investigating the mechanisms involved in this trait, and how these mechanisms could contribute to the pathogenesis of addiction...
  6. pmc Divergent effects of D₂/₃ receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats
    M Moreno
    Department of Psychology, University of Almeria, Almeria, Spain
    Psychopharmacology (Berl) 228:19-30. 2013
    ..However, the anatomical locus of D2/3 receptor dysfunction in high impulsive (HI) rats is unknown...
  7. ncbi request reprint Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 28:771-84. 2004
    ....
  8. ncbi request reprint Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Pharmacol Biochem Behav 90:250-60. 2008
    ....
  9. ncbi request reprint Modelling human drug abuse and addiction with dedicated small animal positron emission tomography
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Neuropharmacology 56:9-17. 2009
    ....
  10. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences...
  11. ncbi request reprint Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroin
    Jeffrey W Dalley
    MRC Centre for Behavioural and Clinical Neuroscience, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 182:579-87. 2005
    ..Identifying the long-term neurocognitive sequelae of drug addiction may have important implications for understanding the compulsive, chronically relapsing nature of this brain disorder...
  12. pmc Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens
    Jeffrey W Dalley
    Department of Experimental Psychology, Downing Street, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Proc Natl Acad Sci U S A 102:6189-94. 2005
    ..These findings provide the most direct demonstration to date that D1 and NMDA receptors in the NAc contribute to, and are necessary for, the early consolidation of appetitive Pavlovian learning...
  13. ncbi request reprint Dopamine receptors in the learning, memory and drug reward circuitry
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Semin Cell Dev Biol 20:403-10. 2009
    ....
  14. ncbi request reprint Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task
    Emma S J Robinson
    Department of Experimental Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:2398-406. 2008
    ..Our results suggest that the NAc, but not the PL or IL, is implicated in the mediation of the effects of M100907 and SB242084 on inhibitory response control during baseline 5CSRTT performance...
  15. doi request reprint Serotonin depletion impairs waiting but not stop-signal reaction time in rats: implications for theories of the role of 5-HT in behavioral inhibition
    Dawn M Eagle
    Department of Experimental Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 34:1311-21. 2009
    ..This has significant implications for the treatment of conditions such as attention deficit and hyperactivity disorder, substance abuse, and affective disorders, in which inhibitory and impulse-control deficits are common...
  16. pmc Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists
    Anushka B P Fernando
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 219:341-52. 2012
    ..Drugs that augment catecholamine function (e.g. methylphenidate and the selective noradrenaline reuptake inhibitor atomoxetine) have clinical efficacy in ADHD, but their precise mechanism of action is unclear...
  17. ncbi request reprint Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1331-43. 2004
    ..However, not all measures of impulsivity appear to be uniformly affected by 5-HT depletion, or correlate with each other, supporting the suggestion that impulsivity is not a unitary construct...
  18. pmc Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 35:560-9. 2010
    ..Such divergent roles may have relevance for the etiology and treatment of clinical disorders of behavioral control, including attention-deficit hyperactivity disorder and drug addiction...
  19. pmc Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1963-73. 2013
    ..These findings implicate novel markers underlying the vulnerability of impulsive rats to cocaine addiction that localize to the OFC, infralimbic cortex, and striatum...
  20. ncbi request reprint Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:669-82. 2005
    ..These data suggest a significant role for 5-HT : DA interactions within the NAC in the control of impulsivity, and in the mechanism by which amphetamine decreases impulsive choice...
  21. pmc Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat
    Jean A Milstein
    Department of Experimental Psychology, University of Cambridge Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 190:51-63. 2007
    ..This study employed a novel immunotoxin, anti-dopamine-beta hydroylase (DbetaH)-saporin, to make relatively selective lesions of the noradrenergic projections to the prefrontal cortex (PFC) in rats trained to perform the 5CSRT...
  22. pmc Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats
    Andrea Bari
    Behavioral and Clinical Neuroscience Institute, Cambridge, UK
    Neuropsychopharmacology 35:1290-301. 2010
    ..These results parallel some of the findings in humans on effects of 5-HT manipulations and are relevant to hypotheses of altered response to feedback in depression...
  23. pmc Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task
    Marie Astrid Pezze
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:273-83. 2007
    ..The data are discussed in terms of the different functions of NAC dopamine receptors in the processing of information from its different cortico-limbic inputs...
  24. ncbi request reprint 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 176:376-85. 2004
    ..Mounting evidence suggests that 5-HT(2A) and 5-HT(2C) receptors have opposing effects on behaviour, and that the 5-HT(2C) receptor antagonist SB 242084 produces a pattern of behaviour similar to 5-HT depletion...
  25. ncbi request reprint Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat
    Emma S J Robinson
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1028-37. 2008
    ....
  26. ncbi request reprint Conditioned activity and instrumental reinforcement following long-term oral consumption of cocaine by rats
    Felicity J Miles
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Behav Neurosci 118:1331-9. 2004
    ..By contrast, chronic cocaine preexposure enhanced instrumental responding for both cocaine-sucrose and pure sucrose solutions. These results support the idea that long-term cocaine exposure enhances subsequent reinforcement...
  27. pmc Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
    Barry J Everitt
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3125-35. 2008
    ....
  28. pmc Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex
    Emily R Murphy
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 219:401-10. 2012
    ..However, the mechanism underlying this effect is unclear...
  29. doi request reprint Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex
    Bianca Jupp
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Eur J Neurosci 37:1519-28. 2013
    ..Alterations in binding for D1 receptors in the NAcbC and GABA(A) receptors in the anterior cingulate cortex demonstrate additional markers and putative mechanisms underlying the expression of behavioural impulsivity...
  30. ncbi request reprint Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
    ..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior...
  31. ncbi request reprint Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Cereb Cortex 16:106-14. 2006
    ..These data suggest a double dissociation between serotonergic and dopaminergic modulation of impulsive decision-making within distinct areas of frontal cortex...
  32. ncbi request reprint Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing St, CB2 3EB, UK
    Cereb Cortex 14:922-32. 2004
    ..These findings are consistent with an important modulatory influence of PFC function by BF cholinergic neurons, particularly during increased attentional demand...
  33. ncbi request reprint Selective norepinephrine reuptake inhibition by atomoxetine prevents cue-induced heroin and cocaine seeking
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Biol Psychiatry 69:266-74. 2011
    ..Here, we investigated further the effects of ATO on cue-maintained heroin and cocaine seeking and relapse and compared these effects with those of the anti-impulsivity stimulant drug methylphenidate (MPH)...
  34. ncbi request reprint High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats
    Ruth Dilleen
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 222:89-97. 2012
    ..Although high anxiety is commonly associated with drug addiction, its causal role in this disorder is unclear...
  35. ncbi request reprint Trait-like impulsivity does not predict escalation of heroin self-administration in the rat
    Ruth McNamara
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 212:453-64. 2010
    ....
  36. ncbi request reprint Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 167:304-14. 2003
    ..However, it is not known precisely how serotonin (5-HT) modulates the medial prefrontal cortex (mPFC) to affect cognitive function and behaviour...
  37. ncbi request reprint Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 170:320-31. 2003
    ..Although most behavioural effects of amphetamine are attributed to the dopaminergic system, some recent evidence suggests a role for serotonin in this paradoxical "calming" effect...
  38. ncbi request reprint High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge CB2 3EB, United Kingdom
    Biol Psychiatry 65:851-6. 2009
    ..Relapse is a hallmark feature of cocaine addiction and a main challenge for treatment strategies. Human studies indicate a link between impulsivity and increased susceptibility to relapse...
  39. ncbi request reprint Nucleus accumbens dopamine and learned fear revisited: a review and some new findings
    Liat Levita
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Behav Brain Res 137:115-27. 2002
    ..Hence, rather than discount an involvement of NAcc DA in affective processes, we propose that functionally dissociable sub-regions of the NAcc may contribute to different aspects of Pavlovian aversive learning...
  40. doi request reprint Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride
    Marie A Pezze
    Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 202:307-13. 2009
    ..The prefrontal cortex (PFC) and nucleus accumbens (NAC) are key brain loci considered to mediate many of the cognitive deficits associated with schizophrenia and related disorders...
  41. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
    ..This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction...
  42. pmc Cholinergic modulation of visual attention and working memory: dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamine
    Yogita Chudasama
    Cambridge University, Department of Experimental Psychology, Cambridge CB2 3EB, UK
    Learn Mem 11:78-86. 2004
    ..Together, these findings implicate the nBM cortical cholinergic system in both attentional and mnemonic processing...
  43. ncbi request reprint The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats
    Andrea Bari
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Nat Protoc 3:759-67. 2008
    ....
  44. doi request reprint Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders
    Kanwar Virdee
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    Neurosci Biobehav Rev 36:1188-216. 2012
    ..This article reviews the considerable recent progress in preclinical PET and discusses applications relevant to a number of neurological and neuropsychiatric disorders in humans...
  45. doi request reprint Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging
    Patrick J Riss
    Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Nucl Med 54:299-305. 2013
    ....
  46. ncbi request reprint Double dissociation of serotonergic and dopaminergic mechanisms on attentional performance using a rodent five-choice reaction time task
    Filippo Passetti
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 165:136-45. 2003
    ....
  47. doi request reprint Impulsivity, compulsivity, and top-down cognitive control
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Neuron 69:680-94. 2011
    ..These results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype. Implications of these findings for the etiology, development, and treatment of drug addiction are considered...
  48. ncbi request reprint Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat
    Vasileios Boulougouris
    Behavioural and Clinical Neuroscience Institute BCNI and the Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Behav Brain Res 179:219-28. 2007
    ..This study examines the behavioural effects of selective lesions centred on orbitofrontal, infralimbic and prelimbic cortex on serial spatial reversal learning in the rat...
  49. ncbi request reprint High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress
    Anna C Molander
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 215:721-31. 2011
    ..However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood...
  50. pmc Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling
    Patrick J Riss
    Molecular Imaging Chemistry Laboratory, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 31:2334-42. 2011
    ..Blood input as well as reference tissue models were equally appropriate to describe the radiotracer kinetics. [(18)F]altanserin is suitable for quantification of 5-HT(2A) receptor availability in rats...
  51. ncbi request reprint Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task
    Emily R Murphy
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 179:99-107. 2005
    ....
  52. pmc Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior
    Daniele Caprioli
    Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Electronic address
    Biol Psychiatry 75:115-23. 2014
    ..However, the molecular and cellular substrates of impulsivity are poorly understood. Here, we investigated a specific form of motor impulsivity in rats, namely premature responding, on a five-choice serial reaction time task...
  53. pmc Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking
    Jennifer E Murray
    Department of Psychology, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom INSERM European Associated Laboratory, Poitiers Electronic address
    Biol Psychiatry 76:15-22. 2014
    ..However, whether impulsivity facilitates the transition to dorsolateral striatum (DLS) dopamine-dependent cocaine-seeking habits or whether impulsivity and cocaine-induced intrastriatal shifts are additive processes is unknown...
  54. ncbi request reprint Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropsychopharmacology 26:716-28. 2002
    ..These data indicate that elevated 5-HT release in the prefrontal cortex may underlie deficits in impulse control on this task. Additionally, DA dysfunction in this region may be another, possibly independent, trait marker of impulsivity...
  55. ncbi request reprint Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls
    Daniele Caprioli
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Curr Opin Neurobiol 23:597-606. 2013
    ..This article considers current controversies in this field as well as prospects for elucidating neurotransmitter mechanisms in addiction beyond DA. ..
  56. ncbi request reprint Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administration
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 161:425-33. 2002
    ..Although dopaminergic mechanisms have been implicated in incentive motivational processes, their role in appetitive conditioning remains poorly understood...
  57. ncbi request reprint Brain γ-aminobutyric acid: a neglected role in impulsivity
    Dave J Hayes
    Toronto Western Research Institute, Toronto Western Hospital and Division of Neurosurgery, University of Toronto, Toronto, ON, Canada Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK
    Eur J Neurosci 39:1921-32. 2014
    ..Our analysis reveals several promising leads for future research that may help inform the development of new therapies for disorders of impulse control. ..
  58. ncbi request reprint The orbital prefrontal cortex and drug addiction in laboratory animals and humans
    Barry J Everitt
    Behavioural and Clinical Neuroscience and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1121:576-97. 2007
    ....
  59. ncbi request reprint Disruption of Pavlovian contextual conditioning by excitotoxic lesions of the nucleus accumbens core
    Liat Levita
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Behav Neurosci 116:539-52. 2002
    ..These results suggest that during acquisition, processes independent of the NAcc core mediate contextual conditioned freezing, but that the NAcc is implicated in the retention of this aversive memory...
  60. pmc Multiple extra-synaptic spillover mechanisms regulate prolonged activity in cerebellar Golgi cell-granule cell loops
    Tahl Holtzman
    Department of Physiology, Development and Neuroscience, Downing Street, University of Cambridge CB2 3DY
    J Physiol 589:3837-54. 2011
    ..Thus, granule cells may promote their own prolonged activity via paradoxical feed-forward inhibition of Golgi cells, thereby enabling information processing over long timescales...
  61. pmc Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience
    Kanwar Virdee
    1 Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK 2 Department of Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 39:339-50. 2014
    ..Furthermore, they demonstrate these effects are achieved by different, often opponent, adaptive mechanisms in males and females, with translational implications for sex biases commonly found in midbrain DA-associated disorders. ..
  62. pmc Leptin does not directly affect CNS serotonin neurons to influence appetite
    Daniel D Lam
    Department of Pharmacology, University of Cambridge, UK
    Cell Metab 13:584-91. 2011
    ..Thus, leptin does not directly influence 5-HT neurons and does not meaningfully modulate important appetite-related determinants via 5-HT neuron function...
  63. ncbi request reprint Behavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies
    Bianca Jupp
    Behavioral and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge Downing St, Cambridge CB2 3EB, UK Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    Neuropharmacology 76:487-97. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  64. pmc Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF
    Gráinne C O'Keeffe
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0PY, United Kingdom
    Proc Natl Acad Sci U S A 106:8754-9. 2009
    ..We have therefore demonstrated a unique role for EGF as a mediator of dopamine-induced precursor cell proliferation in the SVZ, which has potential implications for future therapies in PD...
  65. doi request reprint Linking ADHD, impulsivity, and drug abuse: a neuropsychological perspective
    Gonzalo P Urcelay
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Curr Top Behav Neurosci 9:173-97. 2012
    ..This scheme embraces animal learning theory to help explain the heterogeneity of impulse control disorders, which are exemplified by ADHD as a vulnerability disorder for drug addiction...
  66. ncbi request reprint Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat
    David S Tait
    School of Psychology, University of St Andrews, St Mary s College, South Street, St Andrews, Fife KY16 9JP, UK
    Eur J Neurosci 25:3719-24. 2007
    ..The findings are also relevant to recent theorizing about the functions of the coeruleo-cortical noradrenergic system...
  67. ncbi request reprint Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease
    Fiona E O'Keeffe
    Cambridge Center for Brain Repair and Department of Clinical Neurosciences, Forvie Site, Robinsons Way, Cambridge CB2 2PY, UK
    Brain 131:630-41. 2008
    ..This demonstrates that given the correct signals, NSCs can be induced to become dopaminergic neurons that can differentiate into the correct nigrastriatal phenotype required for the treatment of Parkinson's disease...