Jacob Z. Dalgaard

Summary

Affiliation: University of Warwick
Location: Coventry, UK
URL: http://www2.warwick.ac.uk/fac/med/research/csri/dnalab

Publications

  1. ncbi request reprint Protein-coding introns from the 23S rRNA-encoding gene form stable circles in the hyperthermophilic archaeon Pyrobaculum organotrophum
    J Z Dalgaard
    Institute of Biological Chemistry B, Copenhagen University, Denmark
    Gene 121:103-10. 1992
  2. pmc Complex mechanism of site-specific DNA replication termination in fission yeast
    Sandra Codlin
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK
    EMBO J 22:3431-40. 2003
  3. pmc RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching
    Sonya Vengrova
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK
    Genes Dev 18:794-804. 2004
  4. ncbi request reprint Selective gene expression in multigene families from yeast to mammals
    Jacob Z Dalgaard
    Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, UK
    Sci STKE 2004:re17. 2004
  5. pmc Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage
    Elena Sommariva
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 25:2770-84. 2005
  6. ncbi request reprint SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions
    Jordi Torres-Rosell
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 7:412-9. 2005
  7. ncbi request reprint The Schizosaccharomyces pombe imprint--nick or ribonucleotide(s)?
    S Vengrova
    Curr Biol 15:R326-7; author reply R327. 2005
  8. pmc The wild-type Schizosaccharomyces pombe mat1 imprint consists of two ribonucleotides
    Sonya Vengrova
    Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    EMBO Rep 7:59-65. 2006
  9. pmc Schizosaccharomyces pombe switches mating type by the synthesis-dependent strand-annealing mechanism
    Tomoko Yamada-Inagawa
    Marie Curie Research Institute, Surry RH8 0TL, United Kingdom
    Genetics 177:255-65. 2007
  10. pmc Rtf1-mediated eukaryotic site-specific replication termination
    T Eydmann
    Marie Curie Research Institute, The Chart, Oxted RH8 0TL, United Kingdom
    Genetics 180:27-39. 2008

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Protein-coding introns from the 23S rRNA-encoding gene form stable circles in the hyperthermophilic archaeon Pyrobaculum organotrophum
    J Z Dalgaard
    Institute of Biological Chemistry B, Copenhagen University, Denmark
    Gene 121:103-10. 1992
    ..Putative proteins encoded by the introns and covering most of the intron sequence share a decapeptide motif with proteins encoded by another archaeal intron and by group I introns...
  2. pmc Complex mechanism of site-specific DNA replication termination in fission yeast
    Sandra Codlin
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK
    EMBO J 22:3431-40. 2003
    ..Interestingly, RTS1 displays similarities to mammalian rDNA replication barriers...
  3. pmc RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching
    Sonya Vengrova
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK
    Genes Dev 18:794-804. 2004
    ..We propose a model in which a swi1- and swi3-dependent signal during lagging-strand synthesis leads to pausing of leading-strand replication and the introduction of the imprint...
  4. ncbi request reprint Selective gene expression in multigene families from yeast to mammals
    Jacob Z Dalgaard
    Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, UK
    Sci STKE 2004:re17. 2004
    ....
  5. pmc Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage
    Elena Sommariva
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 25:2770-84. 2005
    ..In conclusion, Swi1, Swi3, and Hsk1 act in a novel S-phase checkpoint pathway that contributes to replication fork maintenance and to survival of alkylation damage...
  6. ncbi request reprint SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions
    Jordi Torres-Rosell
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 7:412-9. 2005
    ..These results point towards a role for the Smc5-Smc6 complex in preventing the formation of sister chromatid junctions, thereby ensuring the correct partitioning of chromosomes during anaphase...
  7. ncbi request reprint The Schizosaccharomyces pombe imprint--nick or ribonucleotide(s)?
    S Vengrova
    Curr Biol 15:R326-7; author reply R327. 2005
  8. pmc The wild-type Schizosaccharomyces pombe mat1 imprint consists of two ribonucleotides
    Sonya Vengrova
    Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    EMBO Rep 7:59-65. 2006
    ..Second, using a novel assay based on ligation-mediated PCR, a 3'-terminal ribonucleotide is detected at the hydrolysed imprint. Our observations allow the unification of available data sets characterizing the wild-type imprint...
  9. pmc Schizosaccharomyces pombe switches mating type by the synthesis-dependent strand-annealing mechanism
    Tomoko Yamada-Inagawa
    Marie Curie Research Institute, Surry RH8 0TL, United Kingdom
    Genetics 177:255-65. 2007
    ..We show that in such strains wild-type P-cassette DNA is efficiently generated at mat1 through heteroduplex DNA formation and repair. The present data provide an in vivo genetic test of the proposed molecular recombination mechanism...
  10. pmc Rtf1-mediated eukaryotic site-specific replication termination
    T Eydmann
    Marie Curie Research Institute, The Chart, Oxted RH8 0TL, United Kingdom
    Genetics 180:27-39. 2008
    ..Together our data establish that multiple protein DNA and protein-protein interactions between Rtf1 molecules and both the repeated motifs and the enhancer region of RTS1 are required for site-specific termination at the RTS1 element...
  11. pmc Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart
    Takabumi Inagawa
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Proc Natl Acad Sci U S A 106:7927-32. 2009
    ..Our results are consistent with a model in which Rtf2 stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin...
  12. doi request reprint Random and site-specific replication termination
    Jacob Z Dalgaard
    Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    Methods Mol Biol 521:35-53. 2009
    ..This review gives an overview about what is known about replication termination, with a focus on these natural site-specific replication termination sites...
  13. doi request reprint High-resolution mapping of points of site-specific replication stalling
    Sonya Vengrova
    Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    Methods Mol Biol 521:215-27. 2009
    ..The data obtained using this method allow determining the position of the 3'-end of the nascent strand at a stalled fork with a one-nucleotide resolution...
  14. ncbi request reprint The many facets of the Tim-Tipin protein families' roles in chromosome biology
    Ramsay J McFarlane
    North West Cancer Research Fund Institute, College of Natural Sciences, Bangor University, Bangor, Gwynedd, UK
    Cell Cycle 9:700-5. 2010
    ..Here we report on our current understanding of the many facets of these protein families in maintaining genome stability and replication checkpoint control...
  15. pmc Identification of a novel type of spacer element required for imprinting in fission yeast
    Suha Sayrac
    Clinical Sciences Research Institute, Gibbet Hill Campus, University of Warwick, Coventry, United Kingdom
    PLoS Genet 7:e1001328. 2011
    ..The presented work addresses how differentiated sister chromatids are established during DNA replication through the involvement of replication barriers...
  16. pmc Comparative functional genomics of the fission yeasts
    Nicholas Rhind
    Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Science 332:930-6. 2011
    ..These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade...
  17. ncbi request reprint A mark in the core: silence no more!
    Patrick D Varga-Weisz
    Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, UK
    Mol Cell 9:1154-6. 2002
    ..Dot1p is a new type of methyltransferase that methylates lysine 79 in the histone H3 core only in its nucleosomal context and has a possible role in marking open chromatin regions...
  18. ncbi request reprint RTS1-an eukaryotic terminator of replication
    Sonya Vengrova
    Marie Curie Research Institute, The Chart, Oxted, Surrey RH80TL, UK
    Int J Biochem Cell Biol 34:1031-4. 2002
    ..This is the first replication terminator shown to play a role in cellular differentiation...
  19. pmc A DNA replication-arrest site RTS1 regulates imprinting by determining the direction of replication at mat1 in S. pombe
    J Z Dalgaard
    Marie Curie Research Institute MCRI, The Chart, Oxted, Surrey RH8 0TL, UK
    Genes Dev 15:2060-8. 2001
    ..Such elements could play a more general role during development and differentiation in higher eukaryotes by regulating the direction of DNA replication at key loci...
  20. pmc Prokaryotic introns and inteins: a panoply of form and function
    M Belfort
    Molecular Genetics Program, Wadsworth Center and School of Public Health, State University of New York at Albany 12201 2002, USA
    J Bacteriol 177:3897-903. 1995
  21. ncbi request reprint Purification and characterization of two forms of I-DmoI, a thermophilic site-specific endonuclease encoded by an archaeal intron
    J Z Dalgaard
    Molecular Genetics Program, Wadsworth Center, New York State Department of Health, Albany 12201 0509
    J Biol Chem 269:28885-92. 1994
    ..These results support the view that these phylogenetically diverse enzymes, which function to mobilize the DNA sequences that encode them, share a common ancestry...
  22. ncbi request reprint Mobile introns and inteins: friend or foe?
    J Z Dalgaard
    Trends Genet 10:306-7. 1994
  23. pmc A site-specific endonuclease encoded by a typical archaeal intron
    J Z Dalgaard
    Molecular Genetics Program, Wadsworth Center for Laboratories, New York State Department of Health, Albany 12201 0509
    Proc Natl Acad Sci U S A 90:5414-7. 1993
    ..These observations support the independent evolutionary origin of endonucleases and intron core elements and are consistent with the invasive potential of endonuclease genes...
  24. pmc Intercellular mobility and homing of an archaeal rDNA intron confers a selective advantage over intron- cells of Sulfolobus acidocaldarius
    C Aagaard
    Institute of Molecular Biology, Copenhagen University, Denmark
    Proc Natl Acad Sci U S A 92:12285-9. 1995
    ..By using a double drug-resistant mutant of S. acidocaldarius, it was shown that spreading resulted partly from a selective advantage of intron+ cells and partly from intercellular mobility of the intron and homing...
  25. pmc A novel Ty1-mediated fragmentation method for native and artificial yeast chromosomes reveals that the mouse steel gene is a hotspot for Ty1 integration
    J Z Dalgaard
    Molecular Genetics Program, Wadsworth Center, David Axelrod Institute, Albany, New York, USA
    Genetics 143:673-83. 1996
    ..The accessibility of mammalian transcription units to Ty1 insertion stands in contrast to that of yeast transcription units...
  26. ncbi request reprint Statistical modeling, phylogenetic analysis and structure prediction of a protein splicing domain common to inteins and hedgehog proteins
    J Z Dalgaard
    NCI Frederick Cancer Research and Development Center, ABL Basic Research Program, Frederick, Maryland 21702 1201, USA
    J Comput Biol 4:193-214. 1997
    ..This domain may play a role in formation of surface-associated protein complexes...
  27. pmc Genetic definition of a protein-splicing domain: functional mini-inteins support structure predictions and a model for intein evolution
    V Derbyshire
    New York State Department of Health, School of Public Health, State University of New York at Albany, Albany, NY 12201 2002, USA
    Proc Natl Acad Sci U S A 94:11466-71. 1997
    ....
  28. pmc Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family
    J Z Dalgaard
    NCI Frederick Cancer Research and Development Center, ABL Basic Research Program, PO Box B, Building 549, Room 154, Frederick, MD 21702 1202, USA
    Nucleic Acids Res 25:4626-38. 1997
    ..However, there does appear to have been considerable exchange of endonuclease domains amongst elements of the same type. Such events are suggested to be important for the formation of elements of new specficity...
  29. ncbi request reprint Multiple epigenetic events regulate mating-type switching of fission yeast
    A J Klar
    National Cancer Institute Frederick Cancer Research, Frederick, MD 21702 1201, USA
    Novartis Found Symp 214:87-99; discussion 99-103. 1998
    ..We speculate that the unit of inheritance in the mat2/3 interval is both DNA plus its associated chromatin structure. Such a control is likely to be essential in maintaining particular states of gene expression during development...
  30. ncbi request reprint Crystal structure of the thermostable archaeal intron-encoded endonuclease I-DmoI
    G H Silva
    Wadsworth Center, New York State Department of Health, Albany, NY, 12201 0509, USA
    J Mol Biol 286:1123-36. 1999
    ..This is reversed compared to PI-SceI, where the amino-terminal domain is more similar to carboxy-terminal domain of I-DmoI and to I-CreI, with interesting evolutionary implications...
  31. ncbi request reprint Crystallization and preliminary crystallographic analysis of the archaeal intron-encoded endonuclease I-DmoI
    J Z Dalgaard
    Wadsworth Center, New York State Department of Health, PO Box 509, Albany, NY 12201, USA
    Acta Crystallogr D Biol Crystallogr 54:1435-6. 1998
    ..03, c = 55.56 A, beta = 113.4 degrees, with one molecule per asymmetric unit (Vm = 2.01 A3 Da-1). The crystals diffract to at least 2.3 A resolution. A complete native data set has been measured and structure determination is on-going...
  32. ncbi request reprint Orientation of DNA replication establishes mating-type switching pattern in S. pombe
    J Z Dalgaard
    Gene Regulation and Chromosome Biology Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Nature 400:181-4. 1999
    ..Two-dimensional gel analysis confirmed that mat1 is preferentially replicated by a centromere-distal origin(s). Thus, the DNA replication machinery may confer different developmental potential to sister cells...
  33. ncbi request reprint swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe
    J Z Dalgaard
    DHHS, NCI, Division of Basic Sciences Gene Regulation and Chromosome Biology Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cell 102:745-51. 2000
    ..These results suggest that swi1p and swi3p promote imprinting in novel ways both by pausing replication at mat1 and by terminating replication at RTS1...
  34. ncbi request reprint Does S. pombe exploit the intrinsic asymmetry of DNA synthesis to imprint daughter cells for mating-type switching?
    J Z Dalgaard
    Marie Curie Research Institute, The Chart, Oxted, Surrey, UK RH8 0TL
    Trends Genet 17:153-7. 2001
    ..The discovery raises the possibility that DNA replication might be more generally involved in the establishment of asymmetric cellular differentiation...
  35. doi request reprint Causes and consequences of ribonucleotide incorporation into nuclear DNA
    Jacob Z Dalgaard
    Division of Biomedical Cell Biology, Gibbet Hill Campus, University of Warwick, Coventry, CV4 7AL, UK Electronic address
    Trends Genet 28:592-7. 2012
    ..Indeed, genomic ribonucleotides might have diverse roles affecting genetic stability, DNA damage repair, heterochromatin formation, cellular differentiation, and development...