Research Topics
| Russell C DaleSummaryAffiliation: University College London Country: UK Publications
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Publications
Post-streptococcal autoimmune disorders of the central nervous systemRussell C Dale
Neurosciences Unit, Great Ormond Street Hospital NHS Trust, London, UK
Dev Med Child Neurol 47:785-91. 2005..However, post-streptococcal disorders of the CNS remain a useful model of neuropsychiatric disease, which may improve our understanding of abnormal movements and behaviours in children...- Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunityRussell C Dale
Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, and Department of Neuroinflammation, Institute of Neurology, University College London, UK
Brain 127:21-33. 2004..We believe an EL-like syndrome is still prevalent, and propose that this syndrome may be secondary to autoimmunity against deep grey matter neurons... - Acute disseminated encephalomyelitisRussell C Dale
Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, and the Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
Semin Pediatr Infect Dis 14:90-5. 2003..In view of the treatment differences between ADEM and viral encephalitis, being familiar with ADEM is essential for pediatricians managing acute neurological disorders... - CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?Andrew J Church
Neuroimmunology Unit, Neuroinflammation Department, Institute of Neurology, Room 917, Queen Square, London WC1N 3BG, UK
J Neuroimmunol 136:149-53. 2003..OCB were found in 46% of acute SC, ABGA were in 93% of acute SC and 50% of persistent SC was of IgG(1) and IgG(3) subclass. These findings support an autoantibody pathogenesis... - Striatal encephalitis after varicella zoster infection complicated by TourettismRussell C Dale
Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, United Kingdom
Mov Disord 18:1554-6. 2003..The patient subsequently developed a chronic tic disorder with attention deficit disorder. This case furthers the proposed association between Tourettism and the basal ganglia... - Quantitative demonstration of intrathecal synthesis of high affinity immunoglobulin G in herpes simplex encephalitis using affinity-mediated immunoblottingMiles D Chapman
Department of Neuroimmunology, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neuroimmunol 185:130-5. 2007..Digitisation of the blots enabled further analysis. We showed that the clones of antigen-specific IgG, which were produced intrathecally, were of higher relative affinity than polyclonal antigen-specific IgG... - Childhood opsoclonus myoclonusRussell C Dale
Neurosciences Unit, Institute of Child Health, University College, London, UK
Lancet Neurol 2:270. 2003 - Post-streptococcal autoimmune dystonia with isolated bilateral striatal necrosisRussell C Dale
Neurosciences Unit, Institute of Child Health, London, UK
Dev Med Child Neurol 44:485-9. 2002..Acute IBSN is part of the poststreptococcal autoimmune neuropsychiatric spectrum. An autoimmune aetiology should be considered in this phenotype, as immunomodulatory therapies may reduce morbidity and mortality... - Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS diseaseRussell C Dale
Department of Neuroinflammmation, Institute of Neurology, University College London, and Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, London WC1N 3JJ, UK
J Neuroimmunol 172:187-97. 2006..GAS also expresses glycolytic enzymes on cell surfaces that have 0-49% identity with human NGE, suggesting molecular mimicry and autoimmune cross-reactivity may be the pathogenic mechanism in post-streptococcal CNS disease... - Incidence of anti-brain antibodies in children with obsessive-compulsive disorderRussell C Dale
Department of Child and Adolescent Psychiatry, PO Box 085, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 187:314-9. 2005..CONCLUSIONS: Our findings support the hypothesis that central nervous system autoimmunity may have a role in a significant subgroup of cases of OCD. Further study is required to examine whether the antibodies concerned are pathogenic... - Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodiesMark J Edwards
Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
Mov Disord 19:1190-6. 2004..We suggest that there might be a causal relationship between ABGA and the clinical syndrome in these cases and that ABGA should be considered as a possible etiology for adult-onset tics... - Antibasal ganglia antibodies and PANDASDavide Martino
Mov Disord 20:116-7. 2005 - Antistreptolysin-O titers: implications for adult PANDAS. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionsAndrew J Church
Am J Psychiatry 159:320. 2002 - Dementia-like presentation of striatal hypermetabolic state with antistriatal antibodies responsive to steroidsGabriel C Léger
Neurology Service, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Arch Neurol 61:754-7. 2004..Hypermetabolic lesions of the striatum are rare. They usually involve autoimmunity and are associated with choreatic disorders such as Sydenham chorea, lupus, and the antiphospholipid antibody syndrome... - Post-streptococcal autoimmune psychiatric and movement disorders in childrenRussell C Dale
Br J Psychiatry 181:188-90. 2002 - Parkinsonian features after streptococcal pharyngitisHilla Ben-Pazi
Pediatric Department, Hadassah University Hospital, Ein Kerem, POB 12000, Jerusalem 91120, Israel
J Pediatr 143:267-9. 2003..We suggest that autoimmune antibodies may cause remitting parkinsonian signs subsequent to streptococcal tonsillitis as part of the spectrum of poststreptococcal CNS disease... - Post-streptococcal autoimmune neuropsychiatric disease presenting as paroxysmal dystonic choreoathetosisRussell C Dale
Department of Neurology, Great Ormond Street Hospital NHS Trust and Institute of Child Health, London, United Kingdom
Mov Disord 17:817-20. 2002..We propose that autoantibodies produced in post-streptococcal neuropsychiatric disease cause alteration in neurotransmission, possibly secondary to ion channel binding... - New autoantibody mediated disorders of the central nervous systemBethan Lang
Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Curr Opin Neurol 16:351-7. 2003..This review summarizes the recent findings and assesses the evidence that these conditions are caused by the antibodies, using the criteria established for peripheral nervous system autoimmune diseases... - Antineuronal antibody status and phenotype analysis in Tourette's syndromeDavide Martino
Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 22:1424-9. 2007..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS... - Early relapse risk after a first CNS inflammatory demyelination episode: examining international consensus definitionsRussell C Dale
Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, Australia
Dev Med Child Neurol 49:887-93. 2007..However, it is hoped that these new criteria may improve prognostic specificity and provide uniformity to future paediatric CNS demyelination research... - Contemporary encephalitis lethargica presenting with agitated catatonia, stereotypy, and dystonia-parkinsonismRussell C Dale
Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Mov Disord 22:2281-4. 2007..We believe these cases support the hypothesis that this syndrome is an inflammatory encephalitis that specifically effects dopamine neurotransmission... 
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured proteinKevin C O'Connor
Center for Neurologic Diseases, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 13:211-7. 2007..MOG-specific autoantibodies were identified in a subset of ADEM but only rarely in adult-onset MS cases, indicating that MOG is a more prominent target antigen in ADEM than MS...- Soluble adhesion molecules in acute disseminated encephalomyelitisDavide Martino
Department of Neuroinflammation, Institute of Neurology, University College London, UK
Pediatr Neurol 33:255-8. 2005..Further larger studies are required including serial measurements and cerebrospinal fluid analysis... - Three cases of central nervous system complications associated with Mycoplasma pneumoniaePaul M Candler
Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Pediatr Neurol 31:133-8. 2004..Systematic investigation to discriminate between these two processes will be essential to select appropriate antibiotic and immunomodulatory therapies... - Normal MRI neuroimaging and acute dancing eyes syndromeRussell C Dale
Dev Med Child Neurol 44:356. 2002 - Acute disseminated encephalomyelitis: where does it start and where does it stop?Russell C Dale
Discipline of Paediatrics and Child Health Faculty of Medicine, University of Sydney, Australia
Dev Med Child Neurol 50:326-7. 2008