Russell C Dale

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Autoimmunity and the basal ganglia: new insights into old diseases
    R C Dale
    Neurosciences Unit, Institute of Child Health, London, UK
    QJM 96:183-91. 2003
  2. ncbi request reprint Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitis
    R C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    Neuropediatrics 34:141-5. 2003
  3. ncbi request reprint [Streptococcus pyogenes and the brain: living with the enemy]
    R C Dale
    Neurosciences Unit, Institute of Child Health, University College Londres, Reino Unido
    Rev Neurol 37:92-7. 2003
  4. ncbi request reprint Acute disseminated encephalomyelitis
    Russell C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, and the Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
    Semin Pediatr Infect Dis 14:90-5. 2003
  5. ncbi request reprint Post-streptococcal autoimmune dystonia with isolated bilateral striatal necrosis
    Russell C Dale
    Neurosciences Unit, Institute of Child Health, London, UK
    Dev Med Child Neurol 44:485-9. 2002
  6. ncbi request reprint Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity
    Russell C Dale
    Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, and Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Brain 127:21-33. 2004
  7. ncbi request reprint Striatal encephalitis after varicella zoster infection complicated by Tourettism
    Russell C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, United Kingdom
    Mov Disord 18:1554-6. 2003
  8. pmc Dyskinesias and associated psychiatric disorders following streptococcal infections
    R C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Arch Dis Child 89:604-10. 2004
  9. pmc Acute disseminated encephalomyelitis or multiple sclerosis: can the initial presentation help in establishing a correct diagnosis?
    R C Dale
    Great Ormond Street Hospital NHS Trust and Institute of Child Health, London, UK
    Arch Dis Child 90:636-9. 2005
  10. ncbi request reprint Childhood opsoclonus myoclonus
    Russell C Dale
    Neurosciences Unit, Institute of Child Health, University College, London, UK
    Lancet Neurol 2:270. 2003

Detail Information

Publications42

  1. ncbi request reprint Autoimmunity and the basal ganglia: new insights into old diseases
    R C Dale
    Neurosciences Unit, Institute of Child Health, London, UK
    QJM 96:183-91. 2003
    ....
  2. ncbi request reprint Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitis
    R C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    Neuropediatrics 34:141-5. 2003
    ..05). These results would suggest a role for IL-6 in the pathology of ADEM, and a possible direct link between an increased IL-6 and a proliferation of B lymphocytes with consequent IgG production...
  3. ncbi request reprint [Streptococcus pyogenes and the brain: living with the enemy]
    R C Dale
    Neurosciences Unit, Institute of Child Health, University College Londres, Reino Unido
    Rev Neurol 37:92-7. 2003
    ..This represents a possible model of immunological mimicry and its potential importance with respect to certain idiopathic disorders such as Tourette syndrome and obsessive compulsive disorder...
  4. ncbi request reprint Acute disseminated encephalomyelitis
    Russell C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, and the Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
    Semin Pediatr Infect Dis 14:90-5. 2003
    ..In view of the treatment differences between ADEM and viral encephalitis, being familiar with ADEM is essential for pediatricians managing acute neurological disorders...
  5. ncbi request reprint Post-streptococcal autoimmune dystonia with isolated bilateral striatal necrosis
    Russell C Dale
    Neurosciences Unit, Institute of Child Health, London, UK
    Dev Med Child Neurol 44:485-9. 2002
    ..Acute IBSN is part of the poststreptococcal autoimmune neuropsychiatric spectrum. An autoimmune aetiology should be considered in this phenotype, as immunomodulatory therapies may reduce morbidity and mortality...
  6. ncbi request reprint Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity
    Russell C Dale
    Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, and Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Brain 127:21-33. 2004
    ..We believe an EL-like syndrome is still prevalent, and propose that this syndrome may be secondary to autoimmunity against deep grey matter neurons...
  7. ncbi request reprint Striatal encephalitis after varicella zoster infection complicated by Tourettism
    Russell C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, United Kingdom
    Mov Disord 18:1554-6. 2003
    ..The patient subsequently developed a chronic tic disorder with attention deficit disorder. This case furthers the proposed association between Tourettism and the basal ganglia...
  8. pmc Dyskinesias and associated psychiatric disorders following streptococcal infections
    R C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Arch Dis Child 89:604-10. 2004
    ..Recently, other post-streptococcal movement disorders have been described, including motor tics and dystonia. Associated emotional and behavioural alteration is characteristic...
  9. pmc Acute disseminated encephalomyelitis or multiple sclerosis: can the initial presentation help in establishing a correct diagnosis?
    R C Dale
    Great Ormond Street Hospital NHS Trust and Institute of Child Health, London, UK
    Arch Dis Child 90:636-9. 2005
    ..When there are relapses or progressive disease, the term multiple sclerosis (MS) is used (for full recommended diagnostic criteria for multiple sclerosis refer to McDonald and colleagues)...
  10. ncbi request reprint Childhood opsoclonus myoclonus
    Russell C Dale
    Neurosciences Unit, Institute of Child Health, University College, London, UK
    Lancet Neurol 2:270. 2003
  11. ncbi request reprint Post-streptococcal autoimmune neuropsychiatric disease presenting as paroxysmal dystonic choreoathetosis
    Russell C Dale
    Department of Neurology, Great Ormond Street Hospital NHS Trust and Institute of Child Health, London, United Kingdom
    Mov Disord 17:817-20. 2002
    ..We propose that autoantibodies produced in post-streptococcal neuropsychiatric disease cause alteration in neurotransmission, possibly secondary to ion channel binding...
  12. ncbi request reprint CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?
    Andrew J Church
    Neuroimmunology Unit, Neuroinflammation Department, Institute of Neurology, Room 917, Queen Square, London WC1N 3BG, UK
    J Neuroimmunol 136:149-53. 2003
    ..OCB were found in 46% of acute SC, ABGA were in 93% of acute SC and 50% of persistent SC was of IgG(1) and IgG(3) subclass. These findings support an autoantibody pathogenesis...
  13. ncbi request reprint Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease
    Russell C Dale
    Department of Neuroinflammmation, Institute of Neurology, University College London, and Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, London WC1N 3JJ, UK
    J Neuroimmunol 172:187-97. 2006
    ..GAS also expresses glycolytic enzymes on cell surfaces that have 0-49% identity with human NGE, suggesting molecular mimicry and autoimmune cross-reactivity may be the pathogenic mechanism in post-streptococcal CNS disease...
  14. ncbi request reprint Antineuronal antibody status and phenotype analysis in Tourette's syndrome
    Davide Martino
    Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 22:1424-9. 2007
    ..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS...
  15. ncbi request reprint Post-streptococcal autoimmune disorders of the central nervous system
    Russell C Dale
    Neurosciences Unit, Great Ormond Street Hospital NHS Trust, London, UK
    Dev Med Child Neurol 47:785-91. 2005
    ..However, post-streptococcal disorders of the CNS remain a useful model of neuropsychiatric disease, which may improve our understanding of abnormal movements and behaviours in children...
  16. ncbi request reprint Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies
    Mark J Edwards
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Mov Disord 19:1190-6. 2004
    ..We suggest that there might be a causal relationship between ABGA and the clinical syndrome in these cases and that ABGA should be considered as a possible etiology for adult-onset tics...
  17. ncbi request reprint Quantitative demonstration of intrathecal synthesis of high affinity immunoglobulin G in herpes simplex encephalitis using affinity-mediated immunoblotting
    Miles D Chapman
    Department of Neuroimmunology, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neuroimmunol 185:130-5. 2007
    ..Digitisation of the blots enabled further analysis. We showed that the clones of antigen-specific IgG, which were produced intrathecally, were of higher relative affinity than polyclonal antigen-specific IgG...
  18. ncbi request reprint Soluble adhesion molecules in Gilles de la Tourette's syndrome
    D Martino
    Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 234:79-85. 2005
    ..These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and support the hypothesis of an ongoing immune-mediated process in this condition...
  19. pmc A dystonic syndrome associated with anti-basal ganglia antibodies
    M J Edwards
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 75:914-6. 2004
    ..It is hypothesised that dystonia in adults or adolescents may be part of the clinical spectrum of the post-infectious syndrome associated with ABGA...
  20. ncbi request reprint Soluble adhesion molecules in acute disseminated encephalomyelitis
    Davide Martino
    Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Pediatr Neurol 33:255-8. 2005
    ..Further larger studies are required including serial measurements and cerebrospinal fluid analysis...
  21. pmc Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis
    A J Church
    Neuroinflammation Department, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 74:602-7. 2003
    ..Anti-basal ganglia antibodies (ABGA) are present in most cases of acute Sydenham's chorea, but rarely in controls...
  22. pmc Anti-basal ganglia antibodies: a possible diagnostic utility in idiopathic movement disorders?
    A J Church
    Neuroinflammation Department, Institute of Neurology, Queen Square, London, UK WC1N 3BG
    Arch Dis Child 89:611-4. 2004
    ..The spectrum of post-streptococcal brain disorders includes chorea, tics, and dystonia. The proposed mediators of disease are anti-basal ganglia (neuronal) antibodies (ABGA)...
  23. pmc Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies
    P M Candler
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 77:507-12. 2006
    ..Adult opsoclonus-myoclonus (OM), a disorder of eye movements accompanied by myoclonus affecting the trunk, limbs, or head, is commonly associated with an underlying malignancy or precipitated by viral infection...
  24. ncbi request reprint Anti-basal ganglia antibodies in acute and persistent Sydenham's chorea
    A J Church
    Neuroimmunology Unit, Neuroinflammation Department, Institute of Neurology, Queen Square, London, UK
    Neurology 59:227-31. 2002
    ..To determine the sensitivity and specificity of methods to detect anti-basal ganglia antibodies (ABGA) in Sydenham's chorea (SC)...
  25. ncbi request reprint Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective study
    M J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK
    Neurology 63:156-8. 2004
    ..An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders...
  26. ncbi request reprint Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children
    R C Dale
    Departments of Neurology, Radiology and Histopathology, Great Ormond Street Hospital for Children and Institute of Child Health, University College London, London, UK
    Brain 123:2407-22. 2000
    ..These differences in the presentation of ADEM/MDEM compared with multiple sclerosis may help in the prognosis given to families regarding the possibility of later development of multiple sclerosis...
  27. ncbi request reprint Three cases of central nervous system complications associated with Mycoplasma pneumoniae
    Paul M Candler
    Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Pediatr Neurol 31:133-8. 2004
    ..Systematic investigation to discriminate between these two processes will be essential to select appropriate antibiotic and immunomodulatory therapies...
  28. pmc Tracing Sydenham's chorea: historical documents from a British paediatric hospital
    D Martino
    Department of Neuroinflammation, Institute of Neurology, University College Medical School, London, UK
    Arch Dis Child 90:507-11. 2005
    ....
  29. ncbi request reprint Immune mediated chorea encephalopathy syndrome in childhood
    L M Hartley
    Department of Neurology, Great Ormond Street Hospital for Children NHS Trust, and Institute of Child Health, London, UK
    Dev Med Child Neurol 44:273-7. 2002
    ..All four children made an apparently full recovery within four months of the onset. We suggest that these patients represent an immune-mediated movement disorder and encephalopathy syndrome...
  30. ncbi request reprint Unihemispheric cerebral vasculitis mimicking Rasmussen's encephalitis
    C Derry
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
    Neurology 58:327-8. 2002
  31. pmc Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
    Kevin C O'Connor
    Center for Neurologic Diseases, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 13:211-7. 2007
    ..MOG-specific autoantibodies were identified in a subset of ADEM but only rarely in adult-onset MS cases, indicating that MOG is a more prominent target antigen in ADEM than MS...
  32. ncbi request reprint Early relapse risk after a first CNS inflammatory demyelination episode: examining international consensus definitions
    Russell C Dale
    Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, Australia
    Dev Med Child Neurol 49:887-93. 2007
    ..However, it is hoped that these new criteria may improve prognostic specificity and provide uniformity to future paediatric CNS demyelination research...
  33. ncbi request reprint Incidence of anti-brain antibodies in children with obsessive-compulsive disorder
    Russell C Dale
    Department of Child and Adolescent Psychiatry, PO Box 085, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 187:314-9. 2005
    ..The proposed mediators are anti-basal ganglia antibodies (ABGA)...
  34. ncbi request reprint Antibasal ganglia antibodies and PANDAS
    Davide Martino
    Mov Disord 20:116-7. 2005
  35. ncbi request reprint Dementia-like presentation of striatal hypermetabolic state with antistriatal antibodies responsive to steroids
    Gabriel C Léger
    Neurology Service, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arch Neurol 61:754-7. 2004
    ..Hypermetabolic lesions of the striatum are rare. They usually involve autoimmunity and are associated with choreatic disorders such as Sydenham chorea, lupus, and the antiphospholipid antibody syndrome...
  36. ncbi request reprint Parkinsonian features after streptococcal pharyngitis
    Hilla Ben-Pazi
    Pediatric Department, Hadassah University Hospital, Ein Kerem, POB 12000, Jerusalem 91120, Israel
    J Pediatr 143:267-9. 2003
    ..We suggest that autoimmune antibodies may cause remitting parkinsonian signs subsequent to streptococcal tonsillitis as part of the spectrum of poststreptococcal CNS disease...
  37. ncbi request reprint New autoantibody mediated disorders of the central nervous system
    Bethan Lang
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Curr Opin Neurol 16:351-7. 2003
    ..This review summarizes the recent findings and assesses the evidence that these conditions are caused by the antibodies, using the criteria established for peripheral nervous system autoimmune diseases...
  38. ncbi request reprint Post-streptococcal autoimmune psychiatric and movement disorders in children
    Russell C Dale
    Br J Psychiatry 181:188-90. 2002
  39. ncbi request reprint Antistreptolysin-O titers: implications for adult PANDAS. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections
    Andrew J Church
    Am J Psychiatry 159:320. 2002
  40. ncbi request reprint Normal MRI neuroimaging and acute dancing eyes syndrome
    Russell C Dale
    Dev Med Child Neurol 44:356. 2002
  41. ncbi request reprint Contemporary encephalitis lethargica presenting with agitated catatonia, stereotypy, and dystonia-parkinsonism
    Russell C Dale
    Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    Mov Disord 22:2281-4. 2007
    ..We believe these cases support the hypothesis that this syndrome is an inflammatory encephalitis that specifically effects dopamine neurotransmission...
  42. ncbi request reprint Acute disseminated encephalomyelitis: where does it start and where does it stop?
    Russell C Dale
    Discipline of Paediatrics and Child Health Faculty of Medicine, University of Sydney, Australia
    Dev Med Child Neurol 50:326-7. 2008