Research Topics
| H V CurranSummaryAffiliation: University College London Country: UK Publications
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Publications
Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of lifeH V Curran
Psychopharmacology Research Unit, Clinical Health Psychology, University College London
Psychol Med 33:1223-37. 2003..Withdrawal from BZDs produces some subtle cognitive advantages for older people, yet little in the way of withdrawal symptoms or emergent sleep difficulties. These findings also suggest that, taken long-term, BZDs do not aid sleep...
Quitting ecstasy: an investigation of why people stop taking the drug and their subsequent mental healthSuzanne L Verheyden
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, London, UK
J Psychopharmacol 17:371-8. 2003..The present study shows that some ex-users experience an impairment to mental health that persists for years after they stop using this drug...
Neurocognitive function in current and ex-users of ecstasy in comparison to both matched polydrug-using controls and drug-naïve controlsRosa Hoshi
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK
Psychopharmacology (Berl) 194:371-9. 2007..Attempting to reduce methodological problems, such as concurrent use of other recreational drugs, could lead to a clearer picture of the effects of ecstasy use on cognitive function...
Mood and cognitive effects of +/-3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy'): week-end 'high' followed by mid-week lowH V Curran
Department of Psychology, University College London, UK
Addiction 92:821-31. 1997..Recreational use of +/-3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') is widespread. The present study aimed to examine both the acute and residual effects of this drug on users' mood and cognitive function...
Eating attitudes, weight concerns and beliefs about drug effects in women who use ecstasyH Valerie Curran
Clinical Psychopharmacology Unit, University College London, Gower Street, London WC1E 6BT, UK
J Psychopharmacol 20:425-31. 2006..However, our findings indicated that women are not using ecstasy as a deliberate means of weight control...
Altered response to tryptophan supplementation after long-term abstention from MDMA (ecstasy) is highly correlated with human memory functionH Valerie Curran
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower Street, London, WC1 6BT, UK
Psychopharmacology (Berl) 169:91-103. 2003..This raises the question of whether long lasting effects occur in human beings that persist even after they have stopped using MDMA...
Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis usersH Valerie Curran
Psychopharmacology Laboratories, Clinical Health Psychology, University College London, Gower Street, London WC1 6BT, UK
Psychopharmacology (Berl) 164:61-70. 2002....
Empathy and aggression: two faces of ecstasy? A study of interpretative cognitive bias and mood change in ecstasy usersH Valerie Curran
Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1 6BT, UK
Psychopharmacology (Berl) 173:425-33. 2004....
In and out of the K-hole: a comparison of the acute and residual effects of ketamine in frequent and infrequent ketamine usersH V Curran
Psychopharmacology Research Unit, Sub Department of Clinical Health Psychology, University College London, London, UK
Addiction 96:749-60. 2001..To explore whether such persisting effects reflect chronic effects of ketamine use, the present study compared frequent with infrequent users of ketamine on the night of drug use and again 3 days later...
Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: a dose-response studyH V Curran
Psychopharmacology Research Unit, Clinical Health Psychology, University College London, UK
Psychopharmacology (Berl) 154:153-60. 2001..Objective: The present study aimed to assess the acute effects of methadone in patients admitted to an opiate detoxification programme...
Is MDMA ('Ecstasy') neurotoxic in humans? An overview of evidence and of methodological problems in researchH V Curran
Department of Psychology, University College London, UK
Neuropsychobiology 42:34-41. 2000..These issues are critically discussed within the context of the wide-ranging methodological problems in human research with MDMA...
Cognitive, dissociative and psychotogenic effects of ketamine in recreational users on the night of drug use and 3 days laterH V Curran
Department of Psychology, University College London, UK
Addiction 95:575-90. 2000..The present study aimed to examine both the acute and residual effects of this drug on cognitive function, dissociation and schizotypal symptomatology in recreational users...
Dissociative effects of alcohol on recollective experienceH V Curran
Department of Psychology, University College London, United Kingdom
Conscious Cogn 8:497-509. 1999..That both alcohol and depth of processing produce dissociative effects on recollective experience provides further evidence that remembering and knowing reflect distinct memory systems...
Additional methadone increases craving for heroin: a double-blind, placebo-controlled study of chronic opiate users receiving methadone substitution treatmentH V Curran
Department of Psychology, University College London, UK
Addiction 94:665-74. 1999..To assess the acute-on-chronic effects of methadone on drug craving, mood and cognitive and psychomotor functioning in patients on long-term methadone substitution treatment...
Drug cue induced overshadowing: selective disruption of natural reward processing by cigarette cues amongst abstinent but not satiated smokersT P Freeman
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, London, UK
Psychol Med 42:161-71. 2012..Similarly, blocking, a demonstration that learning depends on prediction error, can be influenced by the salience of the cues employed...
The incidence of unpleasant dreams after sub-anaesthetic ketamineMark Blagrove
Department of Psychology, Swansea University, Swansea, SA2 8PP, UK
Psychopharmacology (Berl) 203:109-20. 2009....
The effects of immediate-release morphine on cognitive functioning in patients receiving chronic opioid therapy in palliative careSunjeev K Kamboj
Clinical Psychopharmacology Unit, Sub-Department of Clinical Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK
Pain 117:388-95. 2005..These impairments may impact negatively on patients' everyday functioning...
Acute effects of opioids on memory functions of healthy men and womenJames Friswell
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower St, London WC1E 6BT, UK
Psychopharmacology (Berl) 198:243-50. 2008..However, both anterograde and retrograde memory impairments have been reported following an acute dose of morphine in palliative care patients (Kamboj et al., Pain 117:388-395, 2005)...
An experimental study of aggressive and neutral interpretative bias in opiate-dependent and opiate-abstinent menJ Clair
Clinical Psychopharmacology Unit, University College London, London, UK
J Psychopharmacol 23:428-35. 2009..Decreased testosterone levels associated with chronic opiate use may underpin this neutral bias...
Journey through the K-hole: phenomenological aspects of ketamine useL Muetzelfeldt
Clinical Psychopharmacology Unit, University College London, Gower Street, London WC1E 6BT, United Kingdom
Drug Alcohol Depend 95:219-29. 2008..Additionally, the dependence on ketamine frequently reported by users may be a cause for concern as its popularity grows and substance misuse services should be made aware of this when clients present in the future...
Acute effects of alcohol on memory: impact of emotional context and serial positionJennie Brown
Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London WC1E6BT, United Kingdom
Neurobiol Learn Mem 93:428-34. 2010..The results suggest that under certain circumstances emotional context or physiological arousal make memories labile and susceptible to disruption through pharmacological manipulation during encoding...
Ecstasy (MDMA) does not have long-term effects on aggressive interpretative bias: a study comparing current and ex-ecstasy users with polydrug and drug-naive controlsRosa Hoshi
Clinical Psychopharmacology Unit, University College London, London, United Kingdom
Exp Clin Psychopharmacol 15:351-8. 2007....
A comparison of the effects of a beta-adrenergic blocker and a benzodiazepine upon the recognition of human facial expressionsAndrea Zangara
Department of Psychology, University College London, Gower Street, London WC1H 6BT, UK
Psychopharmacology (Berl) 163:36-41. 2002..The results may have implications for understanding why 'paradoxical' aggression is sometimes elicited by benzodiazepines and for extending our psychological understanding of the anxiolytic effects of these drugs...
Attentional bias to incentive stimuli in frequent ketamine usersC J A Morgan
Clinical Psychopharmacology Unit, University College London, London, UK
Psychol Med 38:1331-40. 2008..Dependence on ketamine has been reported anecdotally but no systematic study has investigated this phenomenon. We aimed to explore attentional biases to incentive stimuli in different populations of ketamine users...
Global impairment of prospective memory following acute alcoholJulie R Leitz
Clinical Psychopharmacology Unit, Clinical Psychology, University College London, Gower St, London WC1E 6BT, UK
Psychopharmacology (Berl) 205:379-87. 2009..Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future...
Drinking and future thinking: acute effects of alcohol on prospective memory and future simulationTheadora Paraskevaides
Clinical Psychopharmacology Unit, Research Department of Clinical, Health and Educational Psychology, University College London, Gower St, London, WC1E 6BT, UK
Psychopharmacology (Berl) 208:301-8. 2010..in Psychopharmacology 205:379-387, 2009). In healthy, sober individuals, simulating future events at encoding enhances PM performance...
Scopolamine induces impairments in the recognition of human facial expressions of anger and disgustS K Kamboj
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK
Psychopharmacology (Berl) 185:529-35. 2006..However, it is unclear if these impairments are a general property of benzodiazepines and other drugs that produce a similar profile of neurocognitive impairment to benzodiazepines, such as the anticholinergic, scopolamine...
Selective impairment in the recognition of anger induced by diazepamR J Blair
Institute of Cognitive Neuroscience, London, UK
Psychopharmacology (Berl) 147:335-8. 1999..Given this functional specialization of expression processing, it is plausible that these neurocognitive systems may also be dissociable pharmacologically...
Managing constraint: the experience of people with chronic painA Miles
Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK
Soc Sci Med 61:431-41. 2005....
Attitudes to long-term use of benzodiazepine hypnotics by older people in general practice: findings from interviews with service users and providersS Iliffe
Department of Primary Care and Population Sciences, Royal Free and UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
Aging Ment Health 8:242-8. 2004..Both increased patient awareness of the problems of long-term benzodiazepine use and an evidence-based approach to withdrawal efforts in primary care are necessary to reduce the consumption of medication that has little real benefit...
Harms associated with psychoactive substances: findings of the UK National Drug SurveyCelia J A Morgan
Clinical Psychopharmacology Unit, University College London, London, UK
J Psychopharmacol 24:147-53. 2010..They also suggest that the current UK legal classification system is not acting to inform users of the harms of psychoactive substances...
Hyper-priming in cannabis users: a naturalistic study of the effects of cannabis on semantic memory functionCelia J A Morgan
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, Gower St, London, WC1E 6BT, United Kingdom
Psychiatry Res 176:213-8. 2010..The acute increase in automatic semantic priming may be one factor contributing to the psychotomimetic effects of cannabis...
The psychotomimetic states inventory (PSI): measuring psychotic-type experiences from ketamine and cannabisOliver J Mason
Sub Department of Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Schizophr Res 103:138-42. 2008..The Psychotomimetic States Inventory (PSI) has sub-scales of Delusory Thinking, Perceptual Distortions, Cognitive Disorganization, Anhedonia, Mania and Paranoia...
Is persistent ketamine use a valid model of the cognitive and oculomotor deficits in schizophrenia?Celia J A Morgan
Clinical Psychopharmacology Unit, University College London, United Kingdom
Biol Psychiatry 65:1099-102. 2009..In this study, we investigated the effect of persistent recreational ketamine use on tests of episodic and working memory and on oculomotor tasks of smooth pursuit and pro- and antisaccades...
Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controlsCelia J A Morgan
Clinical Psychopharmacology Unit, University College London, London, UK
Addiction 104:77-87. 2009..In this study we aimed to determine how variations in ketamine use and abstention from prior use affect neurocognitive function and psychological wellbeing...
Superstitious conditioning as a model of delusion formation following chronic but not acute ketamine in humansTom P Freeman
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower Street, London, UK
Psychopharmacology (Berl) 206:563-73. 2009..Delusions are theoretically underpinned by increased superstitious conditioning or the erroneous reinforcement of random events...
Acute and chronic effects of ketamine on semantic priming: modeling schizophrenia?Ana Stefanovic
Clinical Psychopharmacology Unit, University College London, London, United Kingdom
J Clin Psychopharmacol 29:124-33. 2009..In summary, acute and chronic ketamine-induced changes partially mirrored the findings on semantic priming in schizophrenia...
Can recreational doses of THC produce significant dopamine release in the human striatum?Paul R A Stokes
Psychiatry Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, UK
Neuroimage 48:186-90. 2009..In animals, Delta9-tetrahydrocannabinol (THC) increases the rate of dopamine neuronal firing and release in the striatum. Thus cannabis use may increase dopamine release in the human striatum leading to vulnerability to psychosis...
Encoding of marginal utility across time in the human brainAlex Pine
Wellcome Trust Centre for Neuroimaging, London, United Kingdom
J Neurosci 29:9575-81. 2009..Our data support an integrative architecture for decision making, revealing the neural representation of distinct subcomponents of value that may contribute to impulsivity and decisiveness...
Decreases in recollective experience following acute alcohol: a dose-response studyJames A Bisby
Clinical Psychopharmacology Unit, University College London, Gower Street, London, UK
Psychopharmacology (Berl) 208:67-74. 2010..Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact...
Acute effects of alcohol on intrusive memory development and viewpoint dependence in spatial memory support a dual representation modelJames A Bisby
Clinical Psychopharmacology Unit, University College London, United Kingdom
Biol Psychiatry 68:280-6. 2010..We tested the model by investigating the effect of alcohol on intrusive memories and, concurrently, on egocentric and allocentric spatial memory...
Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal studyCelia J A Morgan
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, London, UK
Addiction 105:121-33. 2010..In healthy individuals an acute dose of the N-methyl D-aspartate (NMDA) receptor antagonist ketamine induces marked psychosis-like effects and cognitive impairments, but little is known about the long-term effects of the drug...
Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabisCelia J A Morgan
Clinical Psychopharmacology Unit, Research Department of Clinical, Health and Educational Psychology, University College London, London, UK
Neuropsychopharmacology 35:1879-85. 2010..Our findings suggest that CBD has potential as a treatment for cannabis dependence. The acute modulation of the incentive salience of drug cues by CBD may possibly generalize to a treatment for other addictive disorders...
Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabisCelia J A Morgan
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, London, UK
Br J Psychiatry 192:306-7. 2008..This provides evidence of the divergent properties of cannabinoids and has important implications for research into the link between cannabis use and psychosis...
Ketamine impairs response inhibition and is positively reinforcing in healthy volunteers: a dose-response studyCelia J A Morgan
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, Gower St, London, WC1E 6BT, UK
Psychopharmacology (Berl) 172:298-308. 2004..Previous research has found persisting cognitive and psychotogenic effects of ketamine in chronic abusers of this drug 3 days after an acute dose...
Acute, sub-acute and long-term subjective consequences of 'ecstasy' (MDMA) consumption in 430 regular usersSuzanne L Verheyden
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, UK
Hum Psychopharmacol 18:507-17. 2003..In terms of what might persuade users to stop using MDMA, their most prominent concern was the drug's long-term effects on mental health...
Acute effects of ketamine on memory systems and psychotic symptoms in healthy volunteersCelia J A Morgan
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, London, England
Neuropsychopharmacology 29:208-18. 2004..These data suggest that, in humans, ketamine produces a selective pattern of impairments to working, episodic, and procedural memory but not to perceptual priming, attention or aspects of executive functioning...
Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational usersCelia J A Morgan
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower St, London WC1E 6BT, UK
Drug Alcohol Depend 75:301-8. 2004..Previous research has shown gross generalised verbal memory impairments persisting 3 days after ketamine use in chronic users, however episodic memory has not specifically investigated in this population...
Beyond the K-hole: a 3-year longitudinal investigation of the cognitive and subjective effects of ketamine in recreational users who have substantially reduced their use of the drugCelia J A Morgan
Clinical Psychopharmacology Unit, University College London, London, UK
Addiction 99:1450-61. 2004..However, the degree to which these deficits might be reversible upon reduction or cessation of ketamine use was not known...
The acute and sub-acute effects of 'ecstasy' (MDMA) on processing of facial expressions: preliminary findingsRosa Hoshi
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, UK
Drug Alcohol Depend 76:297-304. 2004..It is therefore possible that the recreational drug 'ecstasy' (MDMA), which has marked serotonergic effects, may affect people's ability to recognise human facial expressions portraying fear...
Disruption of sequential priming in organic and pharmacological amnesia: a role for the medial temporal lobes in implicit contextual learningDavid R Shanks
Department of Psychology, University College London, London, UK
Neuropsychopharmacology 31:1768-76. 2006..The results suggest that a function of the hippocampal memory system is to support contextual learning and performance, even when that learning is nondeclarative...
An investigation into the sub-acute effects of ecstasy on aggressive interpretative bias and aggressive mood - are there gender differences?Rosa Hoshi
Clinical Psychopharmacology Unit, University College London, UK
J Psychopharmacol 20:291-301. 2006..Both male and female ecstasy users show a bias toward interpretation of ambiguous material in an aggressive manner when compared to controls 4 days after ecstasy use...
Acute and chronic effects of ketamine upon human memory: a reviewCelia J A Morgan
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK
Psychopharmacology (Berl) 188:408-24. 2006..FUTURE TRENDS: An important aim of future research should be to detail the specificity of ketamine's amnestic effects on both a neuropharmacological and a cognitive level...
Semantic priming after ketamine acutely in healthy volunteers and following chronic self-administration in substance usersCelia J A Morgan
Clinical Psychopharmacology Unit, University College London, London WC1E 6BT, United Kingdom
Biol Psychiatry 59:265-72. 2006..As semantic processing deficits are considered central to cognitive impairments in schizophrenia, this study aimed to characterize semantic impairments following both acute and chronic ketamine...
Neutral and emotional episodic memory: global impairment after lorazepam or scopolamineSunjeev K Kamboj
Clinical Psychopharmacology Unit, Sub Department of Clinical Health Psychology, University College London, London, WC1E 6BT, UK
Psychopharmacology (Berl) 188:482-8. 2006..Benzodiazepines and anticholinergic drugs have repeatedly been shown to impair episodic memory for emotionally neutral material in humans. However, their effect on memory for emotionally laden stimuli has been relatively neglected...
Neurocognitive function and schizophrenia-proneness in individuals dependent on ketamine, on high potency cannabis ('skunk') or on cocaineC J A Morgan
Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, London, U K
Pharmacopsychiatry 45:269-74. 2012..Ketamine, psychostimulants and cannabis have all been associated with psychotic phenomena but no study has directly compared users of these drugs...
Acute cannabis use causes increased psychotomimetic experiences in individuals prone to psychosisO Mason
Clinical Psychopharmacology Unit, University College London, London, UK
Psychol Med 39:951-6. 2009..We hypothesized that highly psychosis-prone individuals would report more marked psychotic experiences under the acute influence of cannabis...
Sub-acute effects of MDMA (+/-3,4-methylenedioxymethamphetamine, "ecstasy") on mood: evidence of gender differencesSuzanne L Verheyden
Psychopharmacology Laboratories, Sub Department of Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, UK
Psychopharmacology (Berl) 161:23-31. 2002..If the same is true in humans, then functions thought to be modulated by 5-HT may differ in MDMA users compared with non-users a few days after the drug is taken...
Attentional bias, inhibitory control and acute stress in current and former opiate addictsNatasha Constantinou
Clinical Psychopharmacology Unit, University College London, United Kingdom
Drug Alcohol Depend 109:220-5. 2010..Although acute stress is known to increase craving, it is not known whether this effect is mediated via changes in attentional bias and inhibitory control...
Enhanced recognition of facial expressions of disgust in opiate users receiving maintenance treatmentLouise Martin
Clinical Psychopharmacology Unit, UCL, London, UK
Addiction 101:1598-605. 2006..Further, opiate maintained individuals' global slowness in processing emotional expressions may reflect the sedative effects of methadone...
Perceptual organization in ketamine users: preliminary evidence of deficits on night of drug use but not 3 days laterPeter J Uhlhaas
Max Planck Institute for Brain Research, Frankfurt, Germany
J Psychopharmacol 21:347-52. 2007..Levels of dissociation were also higher in ketamine users only on the night of drug use. These preliminary data provide some support for the role of NMDA-receptor hypofunctioning in dysfunctional coordination of cognitive activity...
Pharmacological manipulations of arousal and memory for emotional material: effects of a single dose of methylphenidate or lorazepamCatherine M Brignell
School of Psychology, University of Southampton, Southampton, UK
J Psychopharmacol 21:673-83. 2007..The effects of Lorazepam add to a growing literature that benzodiazepines may exert their clinical, anxiolytic effects in part via altering emotionaL cognitive function...
Angry cognitive bias, trait aggression and impulsivity in substance usersAlyson J Bond
National Addiction Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, UK
Psychopharmacology (Berl) 171:331-9. 2004..This may relate to low 5-HT release, and so a 5-HT challenge may increase cognitive bias towards anger differentially in MDMA users and non-users...
Drugs, sweat, and fears: a comparison of the effects of diazepam and methylphenidate on fear conditioningCatherine M Brignell
School of Psychology, University of Southampton, Highfield, Southampton, SO17 1BJ, UK
Psychopharmacology (Berl) 186:504-16. 2006..While both benzodiazepines and stimulant drugs may influence the formation of episodic memories for emotional events, their effects on fear conditioning are less clear...
Psychopharmacology of memoryH Valerie Curran
Psychopharmacology (Berl) 188:393-6. 2006
