Vincent T Cunliffe

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc Eloquent silence: developmental functions of Class I histone deacetylases
    Vincent T Cunliffe
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    Curr Opin Genet Dev 18:404-10. 2008
  2. doi request reprint Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain
    Jonathan D Wood
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2RX, UK
    Hum Mol Genet 18:391-404. 2009
  3. ncbi request reprint Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS
    Vincent T Cunliffe
    Department of Biomedical Science, Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, South Yorks, S10 2TN, UK
    Mech Dev 123:24-30. 2006
  4. pmc Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia
    Richard Butler
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Dis Model Mech 3:743-51. 2010
  5. pmc The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos
    Michael R M Harrison
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    BMC Genomics 12:24. 2011
  6. ncbi request reprint The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo
    Jonathan D Wood
    MRC Centre Development for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, UK
    Hum Mol Genet 15:2763-71. 2006
  7. doi request reprint Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis
    Elewys G Lightman
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Int J Dev Biol 55:597-602. 2011
  8. pmc Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures
    Sarah Baxendale
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Dis Model Mech 5:773-84. 2012
  9. ncbi request reprint Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling
    Vincent T Cunliffe
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Development 131:2983-95. 2004
  10. doi request reprint A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens
    Tomasz K Prajsnar
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield S102TN, UK
    Cell Microbiol 10:2312-25. 2008

Collaborators

Detail Information

Publications15

  1. pmc Eloquent silence: developmental functions of Class I histone deacetylases
    Vincent T Cunliffe
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    Curr Opin Genet Dev 18:404-10. 2008
    ....
  2. doi request reprint Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain
    Jonathan D Wood
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2RX, UK
    Hum Mol Genet 18:391-404. 2009
    ..GenBank accession number for Danio rerio disc1: EU273350...
  3. ncbi request reprint Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS
    Vincent T Cunliffe
    Department of Biomedical Science, Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, South Yorks, S10 2TN, UK
    Mech Dev 123:24-30. 2006
    ....
  4. pmc Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia
    Richard Butler
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Dis Model Mech 3:743-51. 2010
    ..Thus, disruption of microtubule dynamics might underlie neuronal dysfunction in this model, and this system could be used to identify compounds that modulate microtubule dynamics, some of which might have therapeutic potential in HSP...
  5. pmc The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos
    Michael R M Harrison
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    BMC Genomics 12:24. 2011
    ..This co-ordinating function for Hdac1 is evolutionarily conserved in zebrafish and mouse, but the mechanism of action of Hdac1 in the developing CNS is not well-understood...
  6. ncbi request reprint The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo
    Jonathan D Wood
    MRC Centre Development for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, UK
    Hum Mol Genet 15:2763-71. 2006
    ..Taken together with other recent studies, our findings suggest that axon outgrowth defects may be a common feature of childhood SPG3A and SPG4 cases...
  7. doi request reprint Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis
    Elewys G Lightman
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Int J Dev Biol 55:597-602. 2011
    ....
  8. pmc Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures
    Sarah Baxendale
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Dis Model Mech 5:773-84. 2012
    ..Moreover, our results demonstrate that suppression of PTZ-induced fos expression provides a sensitive means of identifying compounds with anticonvulsant activities...
  9. ncbi request reprint Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling
    Vincent T Cunliffe
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Development 131:2983-95. 2004
    ..Thus, in the zebrafish embryo, hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors...
  10. doi request reprint A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens
    Tomasz K Prajsnar
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield S102TN, UK
    Cell Microbiol 10:2312-25. 2008
    ..Zebrafish are a new addition to the tools available for the study of S. aureus pathogenesis, and may provide insights into the interactions of bacterial and host genomes in determining the outcome of infection...
  11. ncbi request reprint Foxn1 is required for tissue assembly and desmosomal cadherin expression in the hair shaft
    Sarah A Johns
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, United Kingdom
    Dev Dyn 232:1062-8. 2005
    ..Our results reveal Foxn1 as an essential regulator of tissue assembly in the growing hair shaft and implicate Dsc2 as a downstream effector of this activity...
  12. doi request reprint Submillimeter-scale surface gradients of immobilized protein ligands
    Robert A Walker
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Langmuir 25:4243-6. 2009
    ..To visualize the gradient of Dll1, we have used the multistep approach of binding with rabbit anti-Dll1 primary antibody and then adding colloidal-gold-conjugated secondary antibody...
  13. ncbi request reprint Memory by modification: the influence of chromatin structure on gene expression during vertebrate development
    Vincent T Cunliffe
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Gene 305:141-50. 2003
    ..Here I review recent discoveries that improve our understanding of the influence of chromatin structure on gene expression and I discuss their relevance to mechanisms of vertebrate development...
  14. ncbi request reprint Identification of putative interaction partners for the Xenopus Polycomb-group protein Xeed
    Christopher Showell
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Gene 291:95-104. 2002
    ....
  15. ncbi request reprint Complete rescue of the nude mutant phenotype by a wild-type Foxn1 transgene
    Vincent T Cunliffe
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mamm Genome 13:245-52. 2002
    ..We conclude that sufficient cis-acting regulatory information resides within this 110-kb transgene to direct reliable and appropriate tissue-specific expression of the Foxn1 gene...