J H Cummings
Affiliation: University of Dundee
- Associations between diet and disease activity in ulcerative colitis patients using a novel method of data analysisElizabeth A Magee
Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK
Nutr J 4:7. 2005..The relapsing nature and varying geographical prevalence of ulcerative colitis (UC) implicates environmental factors such as diet in its aetiology...
- Carbohydrate terminology and classificationJ H Cummings
Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
Eur J Clin Nutr 61:S5-18. 2007..A clearer understanding of what is meant by any particular word used to describe carbohydrate is essential to progress in translating the growing knowledge of the physiological properties of carbohydrate into public health messages...
- Gastrointestinal effects of prebioticsJ H Cummings
Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, UK
Br J Nutr 87:S145-51. 2002..However, prebiotic carbohydrates clearly have significant and distinctive physiological effects in the human large intestine, and on the basis of this it is likely that they will ultimately be shown to be beneficial to health...
- A study of fructo oligosaccharides in the prevention of travellers' diarrhoeaJ H Cummings
Ninewells Hospital and Medical School, Dundee, UK
Aliment Pharmacol Ther 15:1139-45. 2001..Prebiotic carbohydrates selectively stimulate the growth of bifidobacteria and lactobacilli in the human colon. These bacteria form part of the gut's inherent defence against invading pathogens...
- Prebiotic digestion and fermentationJ H Cummings
Dunn Nutrition Unit, Dunn Clinical Nutrition Centre, Cambridge, United Kingdom
Am J Clin Nutr 73:415S-420S. 2001..They are, however, distinctive in their selective effect on the microflora and their propensity to produce flatulence...
- Mucosal bacteria in ulcerative colitisS Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
Br J Nutr 93:S67-72. 2005..Results demonstrated that short-term synbiotic treatment resulted in increased bifidobacterial colonisation of the rectal mucosa and induced significant reductions in the expression of molecules that control inflammation in active UC...
- Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trialE Furrie
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Gut 54:242-9. 2005..Therefore, modulation of bacterial communities on the gut mucosa, through the use of probiotics and prebiotics, may be used to modify the disease state...
- Review article: prebiotics in the gastrointestinal tractS Macfarlane
Dundee University Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
Aliment Pharmacol Ther 24:701-14. 2006..It is therefore expected that prebiotics will improve health in a way similar to probiotics, whilst at the same time being cheaper, and carrying less risk and being easier to incorporate into the diet than probiotics...
- Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowelS J Langlands
Department of Gastroenterology, Addenbrookes Hospital, Cambridge, UK
Gut 53:1610-6. 2004..This study has determined the effect of the prebiotic carbohydrates oligofructose and inulin on the mucosal flora...
- Clinical trial: the microbiological and immunological effects of synbiotic consumption - a randomized double-blind placebo-controlled study in active Crohn's diseaseH Steed
University of Dundee, UK
Aliment Pharmacol Ther 32:872-83. 2010..Consequently, modification of mucosal bacterial communities, and the immune effects they elicit, might be used to modify the disease state...
- Contribution of dietary protein to sulfide production in the large intestine: an in vitro and a controlled feeding study in humansE A Magee
Dunn Clinical Nutrition Centre, Hills Road, Cambridge, United Kingdom
Am J Clin Nutr 72:1488-94. 2000..Sulfide generation in the colon is probably driven by dietary components such as sulfur-containing amino acids (SAAs) and inorganic sulfur (eg, sulfite)...
- Dietary carbohydrates and the colonic microfloraJ H Cummings
Dunn Clinical Nutrition Centre, Cambridge, UK
Curr Opin Clin Nutr Metab Care 1:409-14. 1998..New potential therapeutic avenues using bacteria should soon start to open up. Scientifically we lack an understanding of the mechanisms at work...
- Rapidly available glucose in foods: an in vitro measurement that reflects the glycemic responseK N Englyst
MRC Dunn Clinical Nutrition Centre and the MRC Dunn Nutritional Laboratory, Cambridge, United Kingdom
Am J Clin Nutr 69:448-54. 1999..The simple in vitro measurement of RAG and SAG is of physiologic relevance and could serve as a tool for investigating the importance of the amount, type, and form of dietary carbohydrates for health...
- Intestinal bacteria and ulcerative colitisJ H Cummings
Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Curr Issues Intest Microbiol 4:9-20. 2003..There is scope for more work in this area focussing on the mucosal microflora, its interactions with the gut immune system, its metabolic properties and the potential ways of modifying it...
- Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate immune responseE Furrie
MRC Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Gut 53:91-8. 2004..This would provide an explanation for this chronic inflammatory condition...
- Apolipoprotein E genotype modulates the effect of black tea drinking on blood lipids and blood coagulation factors: a pilot studyA Loktionov
Medical Research Council, Dunn Clinical Nutrition Centre, Cambridge, UK
Br J Nutr 79:133-9. 1998..Dietary intervention may be particularly effective in population groups with certain genetic characteristics...
- Starch intake and colorectal cancer risk: an international comparisonA Cassidy
Medical Research Council, Dunn Clinical Nutrition Centre, Cambridge, UK
Br J Cancer 69:937-42. 1994..Measures of both starch and NSPs need to be included in future epidemiological studies of diet and bowel cancer...
- Studies of a urinary biomarker of dietary inorganic sulphur in subjects on diets containing 1-38 mmol sulphur/day and of the half-life of ingested 34SO4(2-)R Curno
Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
Eur J Clin Nutr 62:1106-15. 2008..Additionally we determined the half-life of ingested (34)SO(4)(2-) from its urinary excretion...
- Identification and quantitation of mucosal and faecal desulfovibrios using real time polymerase chain reactionA Fite
MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, UK
Gut 53:523-9. 2004..These bacteria have previously been linked to ulcerative colitis. Traditional methods of culturing these organisms are slow, and often unreliable, while molecular approaches are either non-quantitative or lack sensitivity...
- Physiological aspects of energy metabolism and gastrointestinal effects of carbohydratesM Elia
Institute of Human Nutrition, University of Southampton, Southampton, UK
Eur J Clin Nutr 61:S40-74. 2007....
- Investigation of the reliability of 24 h urine excretion as a biomarker of isoflavone exposure over time and over a wide range of isoflavone intakesM R Ritchie
Bute Medical School, University of St Andrews, Fife, Scotland
Eur J Clin Nutr 58:1286-9. 2004..To study the variation in genistein + daidzein intake over a 6-month period and test the reliability of 24 h urinary isoflavones as a biomarker of exposure over time...
- FAO/WHO scientific update on carbohydrates in human nutrition: conclusionsJ Mann
Eur J Clin Nutr 61:S132-7. 2007
- The formation of colonic digestible films of amylose and ethylcellulose from aqueous dispersions at temperatures below 37 degrees CC W Leong
School of Pharmacy, University of London, London, UK
Eur J Pharm Biopharm 54:291-7. 2002..The extent of digestion was directly related to the amylose content of the films, ensuring the potential to provide films, which could function as colon specific coatings...