Doris Culpan

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease
    Doris Culpan
    Department of Care of the Elderly, University of Bristol, John James Buildings, Frenchay Hospital, Frenchay, Bristol, BS16 1LE, UK
    Neurosci Lett 350:61-5. 2003
  2. ncbi Neither sequence variation in the IL-10 gene promoter nor presence of IL-10 protein in the cerebral cortex is associated with Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, John James Buildings, Frenchay Hospital, Frenchay, Bristol, BS16 1LE, United Kingdom
    Neurosci Lett 408:141-5. 2006
  3. ncbi Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
    Exp Gerontol 42:538-44. 2007
  4. ncbi TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, John James Buildings, Frenchay Hospital, Bristol, United Kingdom
    Neurobiol Aging 30:1052-60. 2009
  5. ncbi APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease
    Katy A Chalmers
    University of Bristol, Department of Care of the Elderly, Frenchay Hospital, Bristol BS16 1LE, UK
    Neuroreport 15:95-8. 2004
  6. pmc The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro
    Doris Culpan
    Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Building, Frenchay Hospital Bristol, BS16 1LE, United Kingdom
    Int J Mol Epidemiol Genet 2:409-15. 2011
  7. pmc Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro
    Doris Culpan
    Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Buildings, Frenchay Hospital Frenchay, Bristol, BS16 1LE, United Kingdom
    Int J Mol Epidemiol Genet 2:156-62. 2011

Detail Information

Publications7

  1. ncbi Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease
    Doris Culpan
    Department of Care of the Elderly, University of Bristol, John James Buildings, Frenchay Hospital, Frenchay, Bristol, BS16 1LE, UK
    Neurosci Lett 350:61-5. 2003
    ..014, Fisher's exact test) suggesting that the 2-1-2 haplotype may be protective against AD...
  2. ncbi Neither sequence variation in the IL-10 gene promoter nor presence of IL-10 protein in the cerebral cortex is associated with Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, John James Buildings, Frenchay Hospital, Frenchay, Bristol, BS16 1LE, United Kingdom
    Neurosci Lett 408:141-5. 2006
    ..Levels of IL-10 protein and gene expression examined also did not appear to be related to AD. Despite this being a relatively small sample, these data suggest that IL-10 does not play a major role in the development of AD...
  3. ncbi Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
    Exp Gerontol 42:538-44. 2007
    ..Our findings suggest that TNF-RI and -RII promoter gene polymorphisms and variations in protein and gene expression of these receptors are unlikely to play a major role in the development of AD...
  4. ncbi TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, John James Buildings, Frenchay Hospital, Bristol, United Kingdom
    Neurobiol Aging 30:1052-60. 2009
    ..The 3' UTR SNP (rs7852970) GG allele was significantly protective against AD (p=0.030). Our findings suggest that the TRAF-2 pathway is involved AD. The mechanisms are currently unclear and need further examination...
  5. ncbi APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease
    Katy A Chalmers
    University of Bristol, Department of Care of the Elderly, Frenchay Hospital, Bristol BS16 1LE, UK
    Neuroreport 15:95-8. 2004
    ..Here we report that polymorphisms within the APOE promoter, ACE1 and CYP46 gene are not risk factors for AD and are not associated with parenchymal or vascular accumulation of Abeta...
  6. pmc The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro
    Doris Culpan
    Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Building, Frenchay Hospital Bristol, BS16 1LE, United Kingdom
    Int J Mol Epidemiol Genet 2:409-15. 2011
    ..In conclusion, apart from a transient reduction in ECE-2 protein levels, TNF-α had no impact in our in vitro experimental system on transcription or translation of any of our selected mediators of Aβ degradation...
  7. pmc Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitro
    Doris Culpan
    Dementia Research Group, School of Clinical Sciences, University of Bristol, John James Buildings, Frenchay Hospital Frenchay, Bristol, BS16 1LE, United Kingdom
    Int J Mol Epidemiol Genet 2:156-62. 2011
    ..Our brain tissue findings argue against a role for TNF-α in influencing the expression of these miRNAs in AD...