Peter J Cullen


Affiliation: University of Bristol
Country: UK


  1. Strutt H, Langton P, Pearson N, McMillan K, Strutt D, Cullen P. Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions. Curr Biol. 2019;: pubmed publisher
  2. Simonetti B, Cullen P. Endosomal Sorting: Architecture of the Retromer Coat. Curr Biol. 2018;28:R1350-R1352 pubmed publisher
    ..Using cryo-EM, a new study now reveals how, in yeast, this multiprotein complex is assembled on tubular membranes to form a coat complex that orchestrates the process of tubular-based cargo sorting. ..
  3. McGough I, de Groot R, Jellett A, Betist M, Varandas K, Danson C, et al. SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. Nat Commun. 2018;9:3737 pubmed publisher
    ..Together, these findings provide in vitro and in vivo mechanistic details to describe SNX3-retromer-mediated transport during Wnt secretion and the formation of Wnt-morphogenic gradients. ..
  4. Simonetti B, Cullen P. Actin-dependent endosomal receptor recycling. Curr Opin Cell Biol. 2018;56:22-33 pubmed publisher
  5. Cullen P, Steinberg F. To degrade or not to degrade: mechanisms and significance of endocytic recycling. Nat Rev Mol Cell Biol. 2018;19:679-696 pubmed publisher
  6. Danson C, Pearson N, Heesom K, Cullen P. Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin. J Cell Sci. 2018;131: pubmed publisher
    ..Our work paves the way for a more-detailed mechanistic analysis of the role(s) of the SNX-PXB proteins in endosomal biology. ..
  7. McNally K, Cullen P. Endosomal Retrieval of Cargo: Retromer Is Not Alone. Trends Cell Biol. 2018;28:807-822 pubmed publisher
    ..Here, we review endosomal retrieval complexes, with a focus on recently discovered retromer-independent mechanisms. ..
  8. Cullen P. Phosphoinositides and the regulation of tubular-based endosomal sorting. Biochem Soc Trans. 2011;39:839-50 pubmed publisher
  9. McGough I, Steinberg F, Jia D, Barbuti P, McMillan K, Heesom K, et al. Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. Curr Biol. 2014;24:1670-1676 pubmed publisher

More Information


  1. Cullen P, Korswagen H. Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol. 2011;14:29-37 pubmed publisher
    ..Here we discuss how retromer complexes regulate endosomal sorting, and describe how this is generating exciting new insight into the central role played by endosomal sorting in development and homeostasis of normal tissues. ..
  2. Tilley F, Gallon M, Luo C, Danson C, Zhou J, Cullen P. Retromer associates with the cytoplasmic amino-terminus of polycystin-2. J Cell Sci. 2018;131: pubmed publisher
    ..This article has an associated First Person interview with the first author of the paper. ..
  3. McMillan K, Gallon M, Jellett A, Clairfeuille T, Tilley F, McGough I, et al. Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. J Cell Biol. 2016;214:389-99 pubmed publisher
    ..By showing how a retromer mutant leads to altered endosomal sorting of specific PDZ ligand-containing cargo proteins, we reveal a new mechanism for perturbed endosomal cargo sorting in atypical parkinsonism. ..
  4. McGough I, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom K, et al. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. J Cell Sci. 2014;127:4940-53 pubmed publisher
    ..Overall, these data reveal hidden complexities in retromer-mediated sorting and open up new directions in our molecular understanding of this essential sorting complex. ..
  5. McMillan K, Korswagen H, Cullen P. The emerging role of retromer in neuroprotection. Curr Opin Cell Biol. 2017;47:72-82 pubmed publisher
  6. Simonetti B, Danson C, Heesom K, Cullen P. Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. J Cell Biol. 2017;216:3695-3712 pubmed publisher
    ..Therefore, the data presented in this study reappraise retromer's role in CI-MPR transport. ..