S G Cull-Candy

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi TARP-associated AMPA receptors display an increased maximum channel conductance and multiple kinetically distinct open states
    Chris Shelley
    Department of Neuroscience, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 590:5723-38. 2012
  2. ncbi Role of distinct NMDA receptor subtypes at central synapses
    Stuart G Cull-Candy
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Sci STKE 2004:re16. 2004
  3. ncbi Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond
    Stuart Cull-Candy
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Curr Opin Neurobiol 16:288-97. 2006
  4. ncbi NMDA receptor subunits: diversity, development and disease
    S Cull-Candy
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:327-35. 2001
  5. ncbi NMDA receptor diversity in the cerebellum: identification of subunits contributing to functional receptors
    S G Cull-Candy
    Department of Pharmacology, University College London, UK
    Neuropharmacology 37:1369-80. 1998
  6. ncbi Identification of a native low-conductance NMDA channel with reduced sensitivity to Mg2+ in rat central neurones
    A Momiyama
    Department of Pharmacology, University College London, UK
    J Physiol 494:479-92. 1996
  7. ncbi Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors
    David Soto
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 10:1260-7. 2007
  8. ncbi Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs
    Laurence Cathala
    1] Department of Pharmacology, University College London, UK
    Nat Neurosci 8:1310-8. 2005
  9. ncbi Deactivation and desensitization of non-NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells
    R A Silver
    Department of Pharmacology, University College London, UK
    J Physiol 493:167-73. 1996
  10. ncbi Locus of frequency-dependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses
    R A Silver
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 510:881-902. 1998

Collaborators

Detail Information

Publications22

  1. ncbi TARP-associated AMPA receptors display an increased maximum channel conductance and multiple kinetically distinct open states
    Chris Shelley
    Department of Neuroscience, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 590:5723-38. 2012
    ..We have explored how these data place novel constraints on possible kinetic models of TARP-associated AMPARs that may be used to define AMPAR-mediated synaptic transmission...
  2. ncbi Role of distinct NMDA receptor subtypes at central synapses
    Stuart G Cull-Candy
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Sci STKE 2004:re16. 2004
    ....
  3. ncbi Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond
    Stuart Cull-Candy
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Curr Opin Neurobiol 16:288-97. 2006
    ..The dynamic regulation of these receptors is important for normal synaptic function and in disease states...
  4. ncbi NMDA receptor subunits: diversity, development and disease
    S Cull-Candy
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:327-35. 2001
    ..Recent studies are beginning to address the functional significance of NMDAR diversity under normal and pathological conditions...
  5. ncbi NMDA receptor diversity in the cerebellum: identification of subunits contributing to functional receptors
    S G Cull-Candy
    Department of Pharmacology, University College London, UK
    Neuropharmacology 37:1369-80. 1998
    ....
  6. ncbi Identification of a native low-conductance NMDA channel with reduced sensitivity to Mg2+ in rat central neurones
    A Momiyama
    Department of Pharmacology, University College London, UK
    J Physiol 494:479-92. 1996
    ....
  7. ncbi Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors
    David Soto
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 10:1260-7. 2007
    ....
  8. ncbi Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs
    Laurence Cathala
    1] Department of Pharmacology, University College London, UK
    Nat Neurosci 8:1310-8. 2005
    ..Our findings raise the possibility that structural alterations could be a general mechanism underlying the change in the time course of AMPAR-mediated synaptic transmission...
  9. ncbi Deactivation and desensitization of non-NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells
    R A Silver
    Department of Pharmacology, University College London, UK
    J Physiol 493:167-73. 1996
    ..The slow phase of transmitter removal could account for the time course of the slow component of the spontaneous EPSC (tau EPSCslow = 8 ms at 23 degrees C)...
  10. ncbi Locus of frequency-dependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses
    R A Silver
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 510:881-902. 1998
    ....
  11. ncbi Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites
    R A Silver
    Department of Pharmacology, University College London, UK
    J Physiol 494:231-50. 1996
    ..We conclude that the level of postsynaptic receptor occupancy can depend on the probability of transmitter release at individual multi-site synapses...
  12. ncbi Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
    S G Brickley
    Department of Pharmacology, University College London, London WC1E 6BT, UK
    Nature 409:88-92. 2001
    ....
  13. ncbi CNQX increases GABA-mediated synaptic transmission in the cerebellum by an AMPA/kainate receptor-independent mechanism
    S G Brickley
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Neuropharmacology 41:730-6. 2001
    ..These results demonstrate that the novel excitatory action of CNQX, unrelated to blockade of ionotropic glutamate receptors, is not restricted to the hippocampus and can be observed with structurally related compounds...
  14. ncbi NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites
    Stephen G Brickley
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:4958-66. 2003
    ..The presence of the NR2D subunit within an assembly may therefore result in its restriction to extrasynaptic sites...
  15. ncbi Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses
    Siqiong June Liu
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 8:768-75. 2005
    ..This dynamic regulation of AMPARs provides a feedback mechanism for controlling Ca2+ permeability of synaptic receptors...
  16. ncbi Activity-dependent change in AMPA receptor properties in cerebellar stellate cells
    Siqiong June Liu
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:3881-9. 2002
    ..The activity-induced expression of GluR2-containing receptors significantly reduced the Ca(2+) permeability of AMPARs in stellate cells but did not slow the decay time course of synaptic currents...
  17. ncbi Activity-dependent recruitment of extrasynaptic NMDA receptor activation at an AMPA receptor-only synapse
    Beverley A Clark
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:4428-36. 2002
    ..We suggest that such a spatial separation of receptor types may provide a mechanism for rapid changes in EPSC properties, depending on the amount of synaptic activity...
  18. ncbi Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum
    I D Coombs
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuroscience 162:656-65. 2009
    ..Here we discuss some of these recent findings in relation to the main TARPs and the AMPAR subunits identified in cerebellar neurons and glia...
  19. ncbi The density of AMPA receptors activated by a transmitter quantum at the climbing fibre-Purkinje cell synapse in immature rats
    Akiko Momiyama
    Department of Pharmacology, University College London, UK
    J Physiol 549:75-92. 2003
    ....
  20. ncbi Acetylcholine receptor channels and their block by clonidine in cultured bovine chromaffin cells
    S G Cull-Candy
    Department of Pharmacology, University College, London
    J Physiol 402:255-78. 1988
    ..Burst length distributions could be described by two exponential components with fast and slow time constants of tau f = 0.69 +/- 0.17 and tau s = 9.51 +/- 0.84 ms.(ABSTRACT TRUNCATED AT 400 WORDS)..
  21. ncbi Climbing-fibre activation of NMDA receptors in Purkinje cells of adult mice
    Massimiliano Renzi
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 585:91-101. 2007
    ..Furthermore, we show that NMDA receptor-mediated EPSCs can be evoked by climbing fibre stimulation, and appear to be mediated mainly by NR2A-containing receptors...
  22. ncbi Influence of agonist concentration on AMPA and kainate channels in CA1 pyramidal cells in rat hippocampal slices
    Christine Gebhardt
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 573:371-94. 2006
    ..We consider the implications of these findings for the change in EPSC properties during long-term potentiation (LTP)...