Ana Cuenda

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 380:19-30. 2004
  2. ncbi p38 MAP-kinases pathway regulation, function and role in human diseases
    Ana Cuenda
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochim Biophys Acta 1773:1358-75. 2007
  3. ncbi p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
    EMBO J 24:1134-45. 2005
  4. ncbi BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo
    Yvonne Kuma
    Medical Research Council Protein Phosphorylation Unit, University of Dundee, Scotland, UK
    J Biol Chem 280:19472-9. 2005
  5. ncbi The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
    Claire E Eyers
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 389:127-35. 2005
  6. ncbi CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, United Kingdom
    Cell Signal 18:1897-905. 2006
  7. ncbi Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly
    Carmen Feijoo
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 118:397-408. 2005
  8. ncbi A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs
    Helen McNeill
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 384:391-400. 2004
  9. ncbi Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta
    Yvonne Kuma
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 379:133-9. 2004
  10. ncbi p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response
    Xiaomei Qi
    Department of Pharmacology and Toxicology, Zablocki Department of Veterans Affairs Medical Center, Wisconsin 53226, USA
    J Biol Chem 282:31398-408. 2007

Collaborators

Detail Information

Publications11

  1. ncbi Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 380:19-30. 2004
    ....
  2. ncbi p38 MAP-kinases pathway regulation, function and role in human diseases
    Ana Cuenda
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochim Biophys Acta 1773:1358-75. 2007
    ..Here we focus on these emergent roles of p38MAPKs and their implication in different pathologies...
  3. ncbi p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
    EMBO J 24:1134-45. 2005
    ..This is likely to regulate the integrity of intercellular-junctional complexes, and cell shape and volume in response to osmotic stress...
  4. ncbi BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo
    Yvonne Kuma
    Medical Research Council Protein Phosphorylation Unit, University of Dundee, Scotland, UK
    J Biol Chem 280:19472-9. 2005
    ....
  5. ncbi The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
    Claire E Eyers
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 389:127-35. 2005
    ..Osmotic shock or anisomycin triggered the dissociation of CapZIP from CapZ in Jurkat cells, suggesting that phosphorylation of CapZIP may regulate the ability of CapZ to remodel actin filament assembly in vivo...
  6. ncbi CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, United Kingdom
    Cell Signal 18:1897-905. 2006
    ..These results demonstrate a general and essential role of the PAK-p38alpha MAPK-MAPKAP-K2-HSP27 signalling pathway in mediating the effects of chemotactic stimuli on cell migration...
  7. ncbi Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly
    Carmen Feijoo
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 118:397-408. 2005
    ..These findings suggest a role for Tau in the adaptative response of neurons to stress and indicate that SAPK4/p38delta and/or SAPK3/p38delta may contribute to the hyperphosphorylation of Tau in the human tauopathies...
  8. ncbi A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs
    Helen McNeill
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 384:391-400. 2004
    ..We suggest that SAKS1 may be an adaptor that directs VCP to polyubiquitinated proteins, and PNGase to misfolded glycoproteins, facilitating their destruction by the proteasome...
  9. ncbi Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta
    Yvonne Kuma
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 379:133-9. 2004
    ..These results suggest that SAPK2b/p38b may be a priming kinase that allows glycogen synthase kinase 3 to phosphorylate Ser640 and thereby inhibit glycogen synthase activity...
  10. ncbi p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response
    Xiaomei Qi
    Department of Pharmacology and Toxicology, Zablocki Department of Veterans Affairs Medical Center, Wisconsin 53226, USA
    J Biol Chem 282:31398-408. 2007
    ..These results suggest that p38alpha may, upon phosphorylation, act as a gatekeeper of the p38 MAPK family to yield a coordinative biological response through disrupting its antagonistic p38gamma family protein...
  11. ncbi Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A
    Alfonso Mora
    Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, Universidad de Extremadura, Avenida Universidad s n, 10071 Caceres, Spain
    Cell Signal 14:557-62. 2002
    ..Since lithium inhibits in vivo the observed protein phosphatase-2A (PP2A) activation induced by ceramide, we hypothesise that the neuroprotective action of lithium may be due to the inhibition of the PP2A activation by apoptotic stimuli...