H S Cuckle

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Down syndrome screening in the first and/or second trimester: model predicted performance using meta-analysis parameters
    Howard Cuckle
    University of Leeds, Leeds, UK
    Semin Perinatol 29:252-7. 2005
  2. ncbi request reprint Suboptimal Down syndrome screening test interpretation
    H Cuckle
    Leeds Screening Centre, University of Leeds Leeds LS7 3JB, UK
    Ultrasound Obstet Gynecol 27:6-8. 2006
  3. doi request reprint Nuchal translucency screening in triplets: Down syndrome risk calculation taking account of between-fetus correlations
    Howard Cuckle
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA
    Prenat Diagn 32:214-9. 2012
  4. ncbi request reprint Age-standardisation when target setting and auditing performance of Down syndrome screening programmes
    Howard Cuckle
    Reproductive Epidemiology, University of Leeds, UK
    Prenat Diagn 24:851-6. 2004
  5. doi request reprint Screening for pre-eclampsia--lessons from aneuploidy screening
    H S Cuckle
    Department of Obsterics and Gynecology, Columbia University Medical Center, 622 W 168th Street, PH1666, New York, NY 10032, USA
    Placenta 32:S42-8. 2011
  6. ncbi request reprint Biochemical screening for Down syndrome
    H Cuckle
    Reproductive Epidemiology, Centre for Reproduction, Growth and Development, School of Medicine, University of Leeds, 26 Clarendon Road, LS2 9NZ, Leeds, UK
    Eur J Obstet Gynecol Reprod Biol 92:97-101. 2000
  7. ncbi request reprint Maternal urine hyperglycosylated hCG in pregnancies with Down syndrome
    H S Cuckle
    Centre for Reproduction, Growth and Development, University of Leeds, U K
    Prenat Diagn 19:918-20. 1999
  8. ncbi request reprint Collaborative study of maternal urine beta -core human chorionic gonadotrophin screening for Down syndrome
    H S Cuckle
    Reproductive Epidemiology, Centre for Reproduction, Growth and Development, University of Leeds, U K
    Prenat Diagn 19:911-7. 1999
  9. ncbi request reprint Maternal serum activin A and follistatin levels in pregnancies with Down syndrome
    H S Cuckle
    Centre for Reproduction, Growth and Development, University of Leeds, UK
    Prenat Diagn 19:513-6. 1999
  10. ncbi request reprint Appropriate biochemical parameters in first-trimester screening for Down syndrome
    H S Cuckle
    Centre for Reproduction, Growth and Development, School of Medicine, University of Leeds, UK
    Prenat Diagn 19:505-12. 1999

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Down syndrome screening in the first and/or second trimester: model predicted performance using meta-analysis parameters
    Howard Cuckle
    University of Leeds, Leeds, UK
    Semin Perinatol 29:252-7. 2005
    ..To predict the screening performance for 17 policies currently in use or being considered for the near future...
  2. ncbi request reprint Suboptimal Down syndrome screening test interpretation
    H Cuckle
    Leeds Screening Centre, University of Leeds Leeds LS7 3JB, UK
    Ultrasound Obstet Gynecol 27:6-8. 2006
  3. doi request reprint Nuchal translucency screening in triplets: Down syndrome risk calculation taking account of between-fetus correlations
    Howard Cuckle
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA
    Prenat Diagn 32:214-9. 2012
    ..To describe a method for calculating fetus-specific Down syndrome risk in triplets, allowing for nuchal translucency (NT) correlation between fetuses...
  4. ncbi request reprint Age-standardisation when target setting and auditing performance of Down syndrome screening programmes
    Howard Cuckle
    Reproductive Epidemiology, University of Leeds, UK
    Prenat Diagn 24:851-6. 2004
    ..To describe and illustrate a method of setting Down syndrome screening targets and auditing performance that allows for differences in the maternal age distribution...
  5. doi request reprint Screening for pre-eclampsia--lessons from aneuploidy screening
    H S Cuckle
    Department of Obsterics and Gynecology, Columbia University Medical Center, 622 W 168th Street, PH1666, New York, NY 10032, USA
    Placenta 32:S42-8. 2011
    ..Antenatal screening for aneuploidy is an established routine clinical practice worldwide. The same statistical methodology, developed and refined over three decades, might be adapted to screening for pre-eclampsia...
  6. ncbi request reprint Biochemical screening for Down syndrome
    H Cuckle
    Reproductive Epidemiology, Centre for Reproduction, Growth and Development, School of Medicine, University of Leeds, 26 Clarendon Road, LS2 9NZ, Leeds, UK
    Eur J Obstet Gynecol Reprod Biol 92:97-101. 2000
    ..Abnormal marker levels are also associated with a variety of adverse outcomes of pregnancy. High quality information and decision aids are needed to minimise anxiety among screenees...
  7. ncbi request reprint Maternal urine hyperglycosylated hCG in pregnancies with Down syndrome
    H S Cuckle
    Centre for Reproduction, Growth and Development, University of Leeds, U K
    Prenat Diagn 19:918-20. 1999
    ..34 multiples of the normal median (MoM). The H-hCG elevation in affected pregnancies was more marked at 14 weeks' gestation or later: a median of 4.64 MoM and allowing for creatinine bias 4.46 MoM...
  8. ncbi request reprint Collaborative study of maternal urine beta -core human chorionic gonadotrophin screening for Down syndrome
    H S Cuckle
    Reproductive Epidemiology, Centre for Reproduction, Growth and Development, University of Leeds, U K
    Prenat Diagn 19:911-7. 1999
    ..But the considerable variability in results between studies means that further research is needed before a reliable conclusion can be drawn...
  9. ncbi request reprint Maternal serum activin A and follistatin levels in pregnancies with Down syndrome
    H S Cuckle
    Centre for Reproduction, Growth and Development, University of Leeds, UK
    Prenat Diagn 19:513-6. 1999
    ..However, the extent of overlap was too great to be of value in screening. There was a small decrease in follistatin levels among cases but it did not reach statistical significance...
  10. ncbi request reprint Appropriate biochemical parameters in first-trimester screening for Down syndrome
    H S Cuckle
    Centre for Reproduction, Growth and Development, School of Medicine, University of Leeds, UK
    Prenat Diagn 19:505-12. 1999
    ..1 per cent. Routine ultrasound nuchal translucency measurement in addition to serum testing will increase the rates to 86.4 per cent, 87.2 per cent, 87.9 per cent and 88.3 per cent, respectively...
  11. ncbi request reprint The effect of smoking in pregnancy on maternal serum inhibin A levels
    E L Ferriman
    Department of Feto Maternal Medicine, Leeds General Infirmary, UK
    Prenat Diagn 19:372-4. 1999
    ..The increase was highly statistically significant (p<0.0001, Wilcoxon rank sum test, two-tail). On the basis of these results we conclude that if inhibin A is used as a marker, adjustment for maternal smoking status may be necessary...
  12. ncbi request reprint Effect of maternal age curve on the predicted detection rate in maternal serum screening for Down syndrome
    H S Cuckle
    Centre for Reproduction, Growth and Development, School of Medicine, University of Leeds, U K
    Prenat Diagn 18:1127-30. 1998
    ..1-6.5 per cent for inhibin A. This analysis shows that the model inaccuracy caused by the maternal age curve is not small but is unlikely to be large enough to influence Down syndrome screening policy decisions...
  13. ncbi request reprint Down syndrome screening marker levels in women with a previous aneuploidy pregnancy
    Howard S Cuckle
    Reproductive Epidemiology, University of Leeds, Leeds, UK
    Prenat Diagn 25:47-50. 2005
    ..In Down syndrome screening programmes, women with a previous affected pregnancy are assumed to have the same marker distribution as those without a family history. This assumption needs to be tested...
  14. ncbi request reprint Nomograms to help inform women considering Down's syndrome screening
    H S Cuckle
    Centre for Reproduction, Growth and Development, Research School of Medicine, Leeds, UK
    Eur J Obstet Gynecol Reprod Biol 69:69-72. 1996
    ..To derive graphical information for use in counselling women considering whether or not to have maternal serum screening for Down's syndrome...
  15. ncbi request reprint Compromise ultrasound dating policy in maternal serum screening for Down syndrome
    R R Rahim
    Reproductive Epidemiology, University of Leeds, Leeds, UK
    Prenat Diagn 22:1181-4. 2002
    ..06-0.6% and 0.0-0.3%, respectively. We conclude that if routine ultrasound is not financially and practically feasible, the compromise policy yields a clinically important improvement in screening performance compared to menstrual dating...
  16. doi request reprint Decisions about testing and termination of pregnancy for different fetal conditions: a qualitative study of European White and Pakistani mothers of affected children
    Shenaz Ahmed
    Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
    J Genet Couns 17:560-72. 2008
    ..The findings also challenge stereotypes about cultural differences in attitudes about termination of pregnancy...
  17. ncbi request reprint Attitudes to prenatal testing and termination of pregnancy for fetal abnormality: a comparison of white and Pakistani women in the UK
    Jenny Hewison
    Professor of the Psychology of Healthcare, Institute of Health Sciences and Public Health Research, University of Leeds School of Medicine, 15 Hyde Terrace, Leeds LS2 9LT, UK
    Prenat Diagn 27:419-30. 2007
    ....
  18. doi request reprint Contingent screening for Down syndrome--results from the FaSTER trial
    Howard S Cuckle
    Columbia University, New York, USA
    Prenat Diagn 28:89-94. 2008
    ..Comparison of contingent, step-wise and integrated screening policies...
  19. ncbi request reprint Aneuploidy screening: what test should I use?
    Richard L Berkowitz
    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 10128, USA
    Obstet Gynecol 107:715-8. 2006
    ..In this commentary we will define and discuss both the advantages and disadvantages of using integrated, stepwise, sequential or contingency screening for risk assessment of fetal aneuploidy...
  20. ncbi request reprint Psychosocial aspects of genetic screening of pregnant women and newborns: a systematic review
    J M Green
    Mother and Infant Research Unit, University of Leeds, UK
    Health Technol Assess 8:iii, ix-x, 1-109. 2004
    ....
  21. ncbi request reprint Serum müllerian-inhibiting substance in Down's syndrome pregnancies
    David B Seifer
    Maimonides Medical Center, Brooklyn, New York, NY, USA
    Hum Reprod 22:1017-20. 2007
    ..To examine whether maternal serum levels of müllerian-inhibiting substance (MIS) differ in Down's syndrome and unaffected pregnancies...
  22. ncbi request reprint First- and second-trimester screening: detection of aneuploidies other than Down syndrome
    Fionnuala M Breathnach
    Royal College of Surgeons in Ireland
    Obstet Gynecol 110:651-7. 2007
    ..To evaluate the performance of first- and second-trimester screening methods for the detection of aneuploidies other than Down syndrome...
  23. pmc First-trimester maternal serum PP13 in the risk assessment for preeclampsia
    Roberto Romero
    Department of Health and Human Services, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 199:122.e1-122.e11. 2008
    ..The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia...
  24. doi request reprint Prediction of patient-specific risk for fetal loss using maternal characteristics and first- and second-trimester maternal serum Down syndrome markers
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado at Denver Health Sciences Center, Aurora, CO, USA
    Am J Obstet Gynecol 199:290.e1-6. 2008
    ..To develop and evaluate a method of estimating patient-specific risk for fetal loss by combining maternal characteristics with serum markers...
  25. ncbi request reprint Screening for chromosomal anomalies in the first trimester: does repeat maternal serum screening improve detection rates?
    Kevin Spencer
    Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
    Prenat Diagn 22:903-6. 2002
    ..To evaluate whether repeat sampling and testing of free beta-hCG and PAPP-A during this period would result in an improved detection rate...
  26. ncbi request reprint Assessment of risk for the development of pre-eclampsia by maternal characteristics and uterine artery Doppler
    Aris T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    BJOG 112:703-9. 2005
    ..To develop a method for the estimation of patient-specific risk for the development of pre-eclampsia by combining maternal history and uterine artery Doppler...