Research Topics
| Sebastian J CrutchSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Contrasting patterns of comprehension for superordinate, basic-level, and subordinate names in semantic dementia and aphasic stroke patientsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
Cogn Neuropsychol 25:582-600. 2008....- Different patterns of spoken and written word comprehension deficit in aphasic stroke patientsSebastian J Crutch
Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Cogn Neuropsychol 28:414-34. 2011..These ideas are discussed in the context of existing "distributed-only", "distributed-plus-convergence", or "distributed-plus-hub" models of conceptual knowledge... - Posterior cortical atrophySebastian J Crutch
Dementia Research Centre, Institute of Neurology, University College London, London, UK
Lancet Neurol 11:170-8. 2012..Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies... - The differential dependence of abstract and concrete words upon associative and similarity-based information: Complementary semantic interference and facilitation effectsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
Cogn Neuropsychol 27:46-71. 2010.... - Semantic priming in deep-phonological dyslexia: contrasting effects of association and similarity upon abstract and concrete word readingSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
Cogn Neuropsychol 24:583-602. 2007..The findings are considered in the context of competing theories of the abstract/concrete distinction... - The Influence of refractoriness upon comprehension of non-verbal auditory stimuliSebastian J Crutch
Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College London, London, UK
Neurocase 14:494-507. 2008..The implications of the results are discussed with reference to our current understanding of the mechanisms of refractoriness... - The different representational frameworks underpinning abstract and concrete knowledge: evidence from odd-one-out judgementsSebastian J Crutch
Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College London, London, UK
Q J Exp Psychol (Hove) 62:1377-88, 1388-90. 2009..The data provide converging evidence for the different representational frameworks hypothesis and suggest that claims based on information from previous neuropsychological investigations can be generalized to normal cognition... - Contrasting graded effects of semantic similarity and association across the concreteness spectrumSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, London, UK
Q J Exp Psychol (Hove) 64:1388-408. 2011..It also develops the proposal by providing data that are consistent with a graded and not binary or ungraded model of the relationship between concreteness and these two forms of semantic relationship... - Spatially coded semantic information about geographical termsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
Neuropsychologia 48:2120-9. 2010..g. England, London, Surrey, Thames). These results suggest that the comprehension of spoken and written geographical terms is directly influenced by their real-world location... 
The quantitative assessment of apraxic deficits in Alzheimer's diseaseSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
Cortex 43:976-86. 2007....
Accent processing in dementiaJulia C Hailstone
Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Neuropsychologia 50:2233-44. 2012....- The language profile of posterior cortical atrophySebastian J Crutch
Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 84:460-6. 2013..Characterising and quantifying the aphasia associated with PCA is important for clarifying diagnostic and selection criteria for clinical and research studies... - Auditory object cognition in dementiaJohanna C Goll
Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London WC1N 3BG, United Kingdom
Neuropsychologia 49:2755-65. 2011..The findings provide evidence for separable stages of auditory object analysis and separable profiles of impaired auditory object cognition in different dementia syndromes... - Basic visual function and cortical thickness patterns in posterior cortical atrophyManja Lehmann
Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
Cereb Cortex 21:2122-32. 2011..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation... - Progressive logopenic/phonological aphasia: erosion of the language networkJonathan D Rohrer
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
Neuroimage 49:984-93. 2010.... - A novel technique for the quantitative assessment of apraxic deficits: application to individuals with mild cognitive impairmentSebastian J Crutch
Department of Neurodegeneration, Institute of Neurology, Dementia Research Centre, University College, London, UK
J Neuropsychol 1:237-57. 2007..Consequently, this work contributes to the growing literature questioning the clinical usefulness of the concept of MCI and the appropriateness of current diagnostic criteria for distinguishing this condition from mild AD... - Impairments of auditory scene analysis in Alzheimer's diseaseJohanna C Goll
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
Brain 135:190-200. 2012..This work suggests a basis for understanding a class of clinical symptoms in Alzheimer's disease and for delineating cognitive mechanisms that mediate auditory scene analysis both in health and in neurodegenerative disease... - Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's diseaseManja Lehmann
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
Neurobiol Aging 32:1466-76. 2011..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD... - Visualizing the emergence of posterior cortical atrophyJonathan Kennedy
Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Neurocase 18:248-57. 2012..Based on the clinical, neuropsychological and neuroimaging features, a diagnosis of PCA was made. The present case represents a unique opportunity to study and visualize the evolution of PCA from the very earliest symptomatic stages... - The different frameworks underlying abstract and concrete knowledge: evidence from a bilingual patient with a semantic refractory access dysphasiaSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
Neurocase 12:151-63. 2006..We also demonstrate an equivalent refractory deficit of comprehension in both English and Arabic. In addition, we provide the first documented evidence of a category-specific refractory deficit of knowledge for abstract words... - Nonverbal sound processing in semantic dementia: a functional MRI studyJohanna C Goll
Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
Neuroimage 61:170-80. 2012..The breakdown of these mechanisms constitutes a network-level functional signature of this neurodegenerative disease... - The semantic organisation of mass nouns: evidence from semantic refractory access dysphasiaSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
Cortex 43:1057-67. 2007..Furthermore, it is demonstrated that common mass or count noun status did not lead to an enhancement of the refractory effects of semantic similarity... - The variability of country map knowledge in normal and aphasic subjects: evidence from two new category-specific screening testsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, UK
J Neuropsychol 1:171-87. 2007..The surprising variability of map knowledge observed in the standardization sample is considered in the light of one previous report and one newly presented case (IRQ) of apparent selective impairment of country map naming skills... - Global gray matter changes in posterior cortical atrophy: a serial imaging studyManja Lehmann
Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
Alzheimers Dement 8:502-12. 2012..However, differential longitudinal atrophy patterns are not well understood... - Partial knowledge of abstract words in patients with cortical degenerative conditionsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, 8 11 Queen Square, London, United Kingdom
Neuropsychology 20:482-9. 2006..It constitutes a normal phenomenon that is exacerbated in the context of neurodegenerative disease... - Voice processing in dementia: a neuropsychological and neuroanatomical analysisJulia C Hailstone
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Brain 134:2535-47. 2011..The right anterior temporal lobe is likely to have a critical role in the recognition of voices and other modalities of person knowledge... - A within-modality test of semantic knowledge: The Size/Weight Attribute TestElizabeth K Warrington
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, England
Neuropsychology 21:803-11. 2007..However, no significant effects of category were found in either patient group. The Size/Weight Attribute Test has the potential to assess modality-specific deficits of semantic knowledge... - Genetic influences on atrophy patterns in familial Alzheimer's Disease: a comparison of APP and PSEN1 mutationsRachael I Scahill
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
J Alzheimers Dis 35:199-212. 2013..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs... - Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thicknessGerard R Ridgway
Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
Neurology 79:80-4. 2012.... - Taxonomic and thematic organisation of proper name conceptual knowledgeSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, London, UK
Behav Neurol 24:265-76. 2011..It is suggested that moderate proper name knowledge is primarily organised by taxonomy whereas extensive experience results in a more detailed knowledge base in which theme is a powerful organising principle... - Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word readingSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
Cogn Neuropsychol 24:843-66. 2007..In particular, we suggest that crowding constitutes one specific form of early-visual-processing deficit, which impairs the reading process... - Word form access dyslexia: understanding the basis of visual reading errorsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
Q J Exp Psychol (Hove) 60:57-78. 2007.... - Selective category and modality effects in deep dyslexiaElizabeth K Warrington
Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College, London, UK
Neurocase 13:144-53. 2007..This pattern of performance is interpreted as evidence for a degree of autonomy for the semantic processing of written words... - Progranulin-associated primary progressive aphasia: a distinct phenotype?Jonathan D Rohrer
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, UK
Neuropsychologia 48:288-97. 2010.... - Non-verbal sound processing in the primary progressive aphasiasJohanna C Goll
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Brain 133:272-85. 2010.... - Spatial coding of semantic information: knowledge of country and city names depends on their geographical proximitySebastian J Crutch
Dementia Research Group, The National Hospital for Neurology and Neurosurgery, University College, 8-11 Queen Square, London WC1N 3BG, UK
Brain 126:1821-9. 2003..It is argued that information about geographical proximity cannot be encoded in purely verbal or visual terms. Consequently, we propose the existence of a separate module of spatially encoded information within conceptual knowledge... - The relationship between visual crowding and letter confusability: towards an understanding of dyslexia in posterior cortical atrophySebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
Cogn Neuropsychol 26:471-98. 2009.... - The role of polarity in antonym and synonym conceptual knowledge: evidence from stroke aphasia and multidimensional ratings of abstract wordsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
Neuropsychologia 50:2636-44. 2012.... - Qualitatively different semantic representations for abstract and concrete words: further evidence from the semantic reading errors of deep dyslexic patientsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, UK
Neurocase 12:91-7. 2006.... - Progressive associative phonagnosia: a neuropsychological analysisJulia C Hailstone
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
Neuropsychologia 48:1104-14. 2010..The findings have implications for current cognitive models of voice recognition... - Central auditory disorders: toward a neuropsychology of auditory objectsJohanna C Goll
Dementia Research Centre, Institute of Neurology, London, UK
Curr Opin Neurol 23:617-27. 2010..Here we review current evidence concerning the phenomenology, mechanisms and brain substrates of auditory agnosias and related disorders of auditory object processing... - Abstract and concrete concepts have structurally different representational frameworksSebastian J Crutch
Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College, London, UK
Brain 128:615-27. 2005..Our results challenge the generality of many existing models of human conceptual knowledge, which derive their structure from experimental findings in the concrete domain alone... - Abnormal visual phenomena in posterior cortical atrophySebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
Neurocase 17:160-77. 2011..This study contributes to the growing characterisation of PCA whose atypical early visual symptoms are often heterogeneous and frequently under-recognised... - The semantic organisation of proper nouns: the case of people and brand namesSebastian J Crutch
Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College, 8-11 Queen Square, WC1N 3BG, London, UK
Neuropsychologia 42:584-96. 2004..We also interpret our data as providing the strongest empirical support to date for the semantic module of cognitive models of person recognition... - The cognitive organization of music knowledge: a clinical analysisRohani Omar
Dementia Research Centre, Institute of Neurology, University College, and Department of Clinical Neuroscience, Hammersmith Hospital Campus, London, UK
Brain 133:1200-13. 2010..Within the domain of music knowledge, dissociable cognitive mechanisms process knowledge derived from physical sources and the knowledge of abstract musical entities... - Preservation of propositional speech in a pure anomic: the importance of an abstract vocabularySebastian J Crutch
Department of Clinical Neurology, Dementia Research Group, Institute of Neurology, University College, London, UK
Neurocase 9:465-81. 2003..However, we also propose the existence of a feedback circuit which guides sentence construction by providing information regarding lexical availability... - Computation of tactile object properties requires the integrity of praxic skillsSebastian J Crutch
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, Box 16, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
Neuropsychologia 43:1792-800. 2005..Macro-geometrical tactile analysis depends on intact programming of exploratory hand movements, while the role of such movements in micro-geometrical analysis is less clear... - Preserved calculation skills in a case of semantic dementiaSebastian J Crutch
Department of Clinical Neurology, Institute of Neurology, London, UK
Cortex 38:389-99. 2002..More remarkably, BET is able to harness her intact calculation skills to number problem solving tasks. Our report provides further evidence that high-level non-verbal reasoning may persist in the absence of any viable language skills... - Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's diseaseNatalie S Ryan
Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
Brain 136:1399-414. 2013..It may be owing to their dense connectivity that imaging changes are seen first in the thalamus and striatum, which then progress to involve other regions in a vulnerable neuronal network... - Apolipoprotein e genotype modifies the phenotype of Alzheimer diseaseJonathan M Schott
Arch Neurol 63:155-6. 2006