Sebastian J Crutch

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Contrasting patterns of comprehension for superordinate, basic-level, and subordinate names in semantic dementia and aphasic stroke patients
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Cogn Neuropsychol 25:582-600. 2008
  2. doi request reprint Different patterns of spoken and written word comprehension deficit in aphasic stroke patients
    Sebastian J Crutch
    Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Cogn Neuropsychol 28:414-34. 2011
  3. pmc Posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Lancet Neurol 11:170-8. 2012
  4. doi request reprint Semantic priming in deep-phonological dyslexia: contrasting effects of association and similarity upon abstract and concrete word reading
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
    Cogn Neuropsychol 24:583-602. 2007
  5. doi request reprint The Influence of refractoriness upon comprehension of non-verbal auditory stimuli
    Sebastian J Crutch
    Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Neurocase 14:494-507. 2008
  6. doi request reprint The different representational frameworks underpinning abstract and concrete knowledge: evidence from odd-one-out judgements
    Sebastian J Crutch
    Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Q J Exp Psychol (Hove) 62:1377-88, 1388-90. 2009
  7. doi request reprint Spatially coded semantic information about geographical terms
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
    Neuropsychologia 48:2120-9. 2010
  8. doi request reprint The differential dependence of abstract and concrete words upon associative and similarity-based information: Complementary semantic interference and facilitation effects
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Cogn Neuropsychol 27:46-71. 2010
  9. doi request reprint Contrasting graded effects of semantic similarity and association across the concreteness spectrum
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, London, UK
    Q J Exp Psychol (Hove) 64:1388-408. 2011
  10. ncbi request reprint The quantitative assessment of apraxic deficits in Alzheimer's disease
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
    Cortex 43:976-86. 2007

Detail Information

Publications54

  1. doi request reprint Contrasting patterns of comprehension for superordinate, basic-level, and subordinate names in semantic dementia and aphasic stroke patients
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Cogn Neuropsychol 25:582-600. 2008
    ....
  2. doi request reprint Different patterns of spoken and written word comprehension deficit in aphasic stroke patients
    Sebastian J Crutch
    Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Cogn Neuropsychol 28:414-34. 2011
    ..These ideas are discussed in the context of existing "distributed-only", "distributed-plus-convergence", or "distributed-plus-hub" models of conceptual knowledge...
  3. pmc Posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Lancet Neurol 11:170-8. 2012
    ..Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies...
  4. doi request reprint Semantic priming in deep-phonological dyslexia: contrasting effects of association and similarity upon abstract and concrete word reading
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
    Cogn Neuropsychol 24:583-602. 2007
    ..The findings are considered in the context of competing theories of the abstract/concrete distinction...
  5. doi request reprint The Influence of refractoriness upon comprehension of non-verbal auditory stimuli
    Sebastian J Crutch
    Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Neurocase 14:494-507. 2008
    ..The implications of the results are discussed with reference to our current understanding of the mechanisms of refractoriness...
  6. doi request reprint The different representational frameworks underpinning abstract and concrete knowledge: evidence from odd-one-out judgements
    Sebastian J Crutch
    Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Q J Exp Psychol (Hove) 62:1377-88, 1388-90. 2009
    ..The data provide converging evidence for the different representational frameworks hypothesis and suggest that claims based on information from previous neuropsychological investigations can be generalized to normal cognition...
  7. doi request reprint Spatially coded semantic information about geographical terms
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
    Neuropsychologia 48:2120-9. 2010
    ..g. England, London, Surrey, Thames). These results suggest that the comprehension of spoken and written geographical terms is directly influenced by their real-world location...
  8. doi request reprint The differential dependence of abstract and concrete words upon associative and similarity-based information: Complementary semantic interference and facilitation effects
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Cogn Neuropsychol 27:46-71. 2010
    ....
  9. doi request reprint Contrasting graded effects of semantic similarity and association across the concreteness spectrum
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, London, UK
    Q J Exp Psychol (Hove) 64:1388-408. 2011
    ..It also develops the proposal by providing data that are consistent with a graded and not binary or ungraded model of the relationship between concreteness and these two forms of semantic relationship...
  10. ncbi request reprint The quantitative assessment of apraxic deficits in Alzheimer's disease
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
    Cortex 43:976-86. 2007
    ....
  11. pmc Accent processing in dementia
    Julia C Hailstone
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuropsychologia 50:2233-44. 2012
    ....
  12. doi request reprint The language profile of posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 84:460-6. 2013
    ..Characterising and quantifying the aphasia associated with PCA is important for clarifying diagnostic and selection criteria for clinical and research studies...
  13. pmc Auditory object cognition in dementia
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London WC1N 3BG, United Kingdom
    Neuropsychologia 49:2755-65. 2011
    ..The findings provide evidence for separable stages of auditory object analysis and separable profiles of impaired auditory object cognition in different dementia syndromes...
  14. pmc Progressive logopenic/phonological aphasia: erosion of the language network
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    Neuroimage 49:984-93. 2010
    ....
  15. doi request reprint Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
    ..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation...
  16. ncbi request reprint A novel technique for the quantitative assessment of apraxic deficits: application to individuals with mild cognitive impairment
    Sebastian J Crutch
    Department of Neurodegeneration, Institute of Neurology, Dementia Research Centre, University College, London, UK
    J Neuropsychol 1:237-57. 2007
    ..Consequently, this work contributes to the growing literature questioning the clinical usefulness of the concept of MCI and the appropriateness of current diagnostic criteria for distinguishing this condition from mild AD...
  17. doi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  18. pmc Impairments of auditory scene analysis in Alzheimer's disease
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Brain 135:190-200. 2012
    ..This work suggests a basis for understanding a class of clinical symptoms in Alzheimer's disease and for delineating cognitive mechanisms that mediate auditory scene analysis both in health and in neurodegenerative disease...
  19. doi request reprint Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
    ..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD...
  20. doi request reprint Shining a light on posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimers Dement 9:463-5. 2013
    ....
  21. doi request reprint Visualizing the emergence of posterior cortical atrophy
    Jonathan Kennedy
    Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neurocase 18:248-57. 2012
    ..Based on the clinical, neuropsychological and neuroimaging features, a diagnosis of PCA was made. The present case represents a unique opportunity to study and visualize the evolution of PCA from the very earliest symptomatic stages...
  22. ncbi request reprint The different frameworks underlying abstract and concrete knowledge: evidence from a bilingual patient with a semantic refractory access dysphasia
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
    Neurocase 12:151-63. 2006
    ..We also demonstrate an equivalent refractory deficit of comprehension in both English and Arabic. In addition, we provide the first documented evidence of a category-specific refractory deficit of knowledge for abstract words...
  23. pmc Nonverbal sound processing in semantic dementia: a functional MRI study
    Johanna C Goll
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 61:170-80. 2012
    ..The breakdown of these mechanisms constitutes a network-level functional signature of this neurodegenerative disease...
  24. ncbi request reprint The variability of country map knowledge in normal and aphasic subjects: evidence from two new category-specific screening tests
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, UK
    J Neuropsychol 1:171-87. 2007
    ..The surprising variability of map knowledge observed in the standardization sample is considered in the light of one previous report and one newly presented case (IRQ) of apparent selective impairment of country map naming skills...
  25. ncbi request reprint The semantic organisation of mass nouns: evidence from semantic refractory access dysphasia
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, London, UK
    Cortex 43:1057-67. 2007
    ..Furthermore, it is demonstrated that common mass or count noun status did not lead to an enhancement of the refractory effects of semantic similarity...
  26. doi request reprint Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
    ..However, differential longitudinal atrophy patterns are not well understood...
  27. ncbi request reprint Partial knowledge of abstract words in patients with cortical degenerative conditions
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, 8 11 Queen Square, London, United Kingdom
    Neuropsychology 20:482-9. 2006
    ..It constitutes a normal phenomenon that is exacerbated in the context of neurodegenerative disease...
  28. pmc Voice processing in dementia: a neuropsychological and neuroanatomical analysis
    Julia C Hailstone
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 134:2535-47. 2011
    ..The right anterior temporal lobe is likely to have a critical role in the recognition of voices and other modalities of person knowledge...
  29. ncbi request reprint A within-modality test of semantic knowledge: The Size/Weight Attribute Test
    Elizabeth K Warrington
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, England
    Neuropsychology 21:803-11. 2007
    ..However, no significant effects of category were found in either patient group. The Size/Weight Attribute Test has the potential to assess modality-specific deficits of semantic knowledge...
  30. pmc Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness
    Gerard R Ridgway
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurology 79:80-4. 2012
    ....
  31. doi request reprint Taxonomic and thematic organisation of proper name conceptual knowledge
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, London, UK
    Behav Neurol 24:265-76. 2011
    ..It is suggested that moderate proper name knowledge is primarily organised by taxonomy whereas extensive experience results in a more detailed knowledge base in which theme is a powerful organising principle...
  32. ncbi request reprint Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word reading
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Cogn Neuropsychol 24:843-66. 2007
    ..In particular, we suggest that crowding constitutes one specific form of early-visual-processing deficit, which impairs the reading process...
  33. doi request reprint The relationship between visual crowding and letter confusability: towards an understanding of dyslexia in posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Cogn Neuropsychol 26:471-98. 2009
    ....
  34. pmc Non-verbal sound processing in the primary progressive aphasias
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 133:272-85. 2010
    ....
  35. ncbi request reprint Spatial coding of semantic information: knowledge of country and city names depends on their geographical proximity
    Sebastian J Crutch
    Dementia Research Group, The National Hospital for Neurology and Neurosurgery, University College, 8 11 Queen Square, London WC1N 3BG, UK
    Brain 126:1821-9. 2003
    ..It is argued that information about geographical proximity cannot be encoded in purely verbal or visual terms. Consequently, we propose the existence of a separate module of spatially encoded information within conceptual knowledge...
  36. ncbi request reprint Selective category and modality effects in deep dyslexia
    Elizabeth K Warrington
    Department of Neurodegeneration, Dementia Research Centre, Institute of Neurology, University College, London, UK
    Neurocase 13:144-53. 2007
    ..This pattern of performance is interpreted as evidence for a degree of autonomy for the semantic processing of written words...
  37. pmc Progranulin-associated primary progressive aphasia: a distinct phenotype?
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, UK
    Neuropsychologia 48:288-97. 2010
    ....
  38. ncbi request reprint Word form access dyslexia: understanding the basis of visual reading errors
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Q J Exp Psychol (Hove) 60:57-78. 2007
    ....
  39. pmc Mentalising music in frontotemporal dementia
    Laura E Downey
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Cortex 49:1844-55. 2013
    ....
  40. doi request reprint The role of polarity in antonym and synonym conceptual knowledge: evidence from stroke aphasia and multidimensional ratings of abstract words
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
    Neuropsychologia 50:2636-44. 2012
    ....
  41. ncbi request reprint Qualitatively different semantic representations for abstract and concrete words: further evidence from the semantic reading errors of deep dyslexic patients
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, UK
    Neurocase 12:91-7. 2006
    ....
  42. pmc Central auditory disorders: toward a neuropsychology of auditory objects
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, London, UK
    Curr Opin Neurol 23:617-27. 2010
    ..Here we review current evidence concerning the phenomenology, mechanisms and brain substrates of auditory agnosias and related disorders of auditory object processing...
  43. pmc Progressive associative phonagnosia: a neuropsychological analysis
    Julia C Hailstone
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Neuropsychologia 48:1104-14. 2010
    ..The findings have implications for current cognitive models of voice recognition...
  44. ncbi request reprint Abstract and concrete concepts have structurally different representational frameworks
    Sebastian J Crutch
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College, London, UK
    Brain 128:615-27. 2005
    ..Our results challenge the generality of many existing models of human conceptual knowledge, which derive their structure from experimental findings in the concrete domain alone...
  45. doi request reprint Abnormal visual phenomena in posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK
    Neurocase 17:160-77. 2011
    ..This study contributes to the growing characterisation of PCA whose atypical early visual symptoms are often heterogeneous and frequently under-recognised...
  46. ncbi request reprint The semantic organisation of proper nouns: the case of people and brand names
    Sebastian J Crutch
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College, 8 11 Queen Square, WC1N 3BG, London, UK
    Neuropsychologia 42:584-96. 2004
    ..We also interpret our data as providing the strongest empirical support to date for the semantic module of cognitive models of person recognition...
  47. pmc The cognitive organization of music knowledge: a clinical analysis
    Rohani Omar
    Dementia Research Centre, Institute of Neurology, University College, and Department of Clinical Neuroscience, Hammersmith Hospital Campus, London, UK
    Brain 133:1200-13. 2010
    ..Within the domain of music knowledge, dissociable cognitive mechanisms process knowledge derived from physical sources and the knowledge of abstract musical entities...
  48. ncbi request reprint Preservation of propositional speech in a pure anomic: the importance of an abstract vocabulary
    Sebastian J Crutch
    Department of Clinical Neurology, Dementia Research Group, Institute of Neurology, University College, London, UK
    Neurocase 9:465-81. 2003
    ..However, we also propose the existence of a feedback circuit which guides sentence construction by providing information regarding lexical availability...
  49. ncbi request reprint Computation of tactile object properties requires the integrity of praxic skills
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College, Box 16, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 43:1792-800. 2005
    ..Macro-geometrical tactile analysis depends on intact programming of exploratory hand movements, while the role of such movements in micro-geometrical analysis is less clear...
  50. pmc Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
    Brain 136:1399-414. 2013
    ..It may be owing to their dense connectivity that imaging changes are seen first in the thalamus and striatum, which then progress to involve other regions in a vulnerable neuronal network...
  51. ncbi request reprint Preserved calculation skills in a case of semantic dementia
    Sebastian J Crutch
    Department of Clinical Neurology, Institute of Neurology, London, UK
    Cortex 38:389-99. 2002
    ..More remarkably, BET is able to harness her intact calculation skills to number problem solving tasks. Our report provides further evidence that high-level non-verbal reasoning may persist in the absence of any viable language skills...
  52. doi request reprint Intact reading in patients with profound early visual dysfunction
    Keir X X Yong
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, University College London, UK Electronic address
    Cortex 49:2294-306. 2013
    ..The current data emphasise the need for much clearer evidence of causality when attempting to draw connections between specific aspects of visual processing and different types of acquired peripheral dyslexia. ..
  53. pmc Abstract conceptual feature ratings: the role of emotion, magnitude, and other cognitive domains in the organization of abstract conceptual knowledge
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London London, UK Stroke Unit, Northwick Park Hospital Harrow, London, UK
    Front Hum Neurosci 7:186. 2013
    ....
  54. ncbi request reprint Apolipoprotein e genotype modifies the phenotype of Alzheimer disease
    Jonathan M Schott
    Arch Neurol 63:155-6. 2006