J Helen Cross

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Differential diagnosis of epileptic seizures in infancy including the neonatal period
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Semin Fetal Neonatal Med 18:192-5. 2013
  2. ncbi request reprint Fever and fever-related epilepsies
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London and Young Epilepsy, Lingfield, United Kingdom
    Epilepsia 53:3-8. 2012
  3. ncbi request reprint Safety and tolerability of zonisamide in paediatric patients with epilepsy
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, and Young Epilepsy, Lingfield, UK Electronic address
    Eur J Paediatr Neurol 18:747-58. 2014
  4. ncbi request reprint Neurological features of epilepsy, ataxia, sensorineural deafness, tubulopathy syndrome
    J Helen Cross
    Neurosciences Unit, Great Ormond Street Hospital for Children NHS Trust and UCL Institute of Child Health, London, UK
    Dev Med Child Neurol 55:846-56. 2013
  5. ncbi request reprint New research with diets and epilepsy
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, and Young Epilepsy, Lingfield, UK
    J Child Neurol 28:970-4. 2013
  6. ncbi request reprint Advancing the management of childhood epilepsies
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London
    Eur J Paediatr Neurol 17:334-47. 2013
  7. ncbi request reprint The epileptic encephalopathies
    J Helen Cross
    Neurosciences Unit, UCL Institute of Child Health, Great Ormond Street Hospital, London and the Young Epilepsy, Lingfield, UK Electronic address
    Handb Clin Neurol 111:619-26. 2013
  8. ncbi request reprint Seizure outcome after extratemporal epilepsy surgery in childhood
    Luigi D'Argenzio
    Neurosciences Unit, University College London Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    Dev Med Child Neurol 54:995-1000. 2012
  9. ncbi request reprint A population-based study of newly diagnosed epilepsy in infants
    Christin M Eltze
    Paediatric Neurology Department, Great Ormond Street Hospital for Children, London, United Kingdom
    Epilepsia 54:437-45. 2013
  10. ncbi request reprint Influence of motor functional magnetic resonance imaging on the surgical management of children and adolescents with symptomatic focal epilepsy
    Xavier De Tiège
    Neurosciences Unit, University College London Institute of Child Health, London, United Kingdom
    Neurosurgery 64:856-64; discussion 864. 2009

Detail Information

Publications48

  1. ncbi request reprint Differential diagnosis of epileptic seizures in infancy including the neonatal period
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Semin Fetal Neonatal Med 18:192-5. 2013
    ..Here are highlighted the key clinical features that distinguish some of these disorders, their management and prognosis. ..
  2. ncbi request reprint Fever and fever-related epilepsies
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London and Young Epilepsy, Lingfield, United Kingdom
    Epilepsia 53:3-8. 2012
    ..This review examines the existing knowledge on febrile seizures and the various clinical phenotypes to which they are linked...
  3. ncbi request reprint Safety and tolerability of zonisamide in paediatric patients with epilepsy
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, and Young Epilepsy, Lingfield, UK Electronic address
    Eur J Paediatr Neurol 18:747-58. 2014
    ..Zonisamide has recently been approved in Europe for the adjunctive treatment of partial seizures (with or without secondary generalisation) in adolescents and children aged ≥6 years...
  4. ncbi request reprint Neurological features of epilepsy, ataxia, sensorineural deafness, tubulopathy syndrome
    J Helen Cross
    Neurosciences Unit, Great Ormond Street Hospital for Children NHS Trust and UCL Institute of Child Health, London, UK
    Dev Med Child Neurol 55:846-56. 2013
    ..Here, we provide a detailed characterization of the clinical features of the syndrome to aid patient management with respect to diagnosis, prognostic counselling, and identification of best treatment modalities...
  5. ncbi request reprint New research with diets and epilepsy
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, and Young Epilepsy, Lingfield, UK
    J Child Neurol 28:970-4. 2013
    ..We also have a clearer idea in utilization, type of diet to use, and in whom. Questions however remain and further work is required, not least in recognizing likely candidates and in simplifying administration. ..
  6. ncbi request reprint Advancing the management of childhood epilepsies
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London
    Eur J Paediatr Neurol 17:334-47. 2013
    ..Although in early stages of development, cell-based approaches (e.g., focal targeting of adenosine augmentation) and gene therapy may also provide new treatment choices in the future...
  7. ncbi request reprint The epileptic encephalopathies
    J Helen Cross
    Neurosciences Unit, UCL Institute of Child Health, Great Ormond Street Hospital, London and the Young Epilepsy, Lingfield, UK Electronic address
    Handb Clin Neurol 111:619-26. 2013
    ..However, avoidance of treatment that may lead to deterioration of seizure control may be equally important...
  8. ncbi request reprint Seizure outcome after extratemporal epilepsy surgery in childhood
    Luigi D'Argenzio
    Neurosciences Unit, University College London Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    Dev Med Child Neurol 54:995-1000. 2012
    ..The aim of the study was to describe seizure outcome following surgery for focal extratemporal epilepsy and identify factors associated with prolonged postsurgical freedom from seizures...
  9. ncbi request reprint A population-based study of newly diagnosed epilepsy in infants
    Christin M Eltze
    Paediatric Neurology Department, Great Ormond Street Hospital for Children, London, United Kingdom
    Epilepsia 54:437-45. 2013
    ....
  10. ncbi request reprint Influence of motor functional magnetic resonance imaging on the surgical management of children and adolescents with symptomatic focal epilepsy
    Xavier De Tiège
    Neurosciences Unit, University College London Institute of Child Health, London, United Kingdom
    Neurosurgery 64:856-64; discussion 864. 2009
    ..To determine the clinical value of motor functional magnetic resonance imaging (fMRI) in the presurgical evaluation of a large group of children and adolescents with epilepsy caused by lesions close to the central sulcus...
  11. ncbi request reprint Early-onset symptomatic focal epilepsy: a dilemma in the timing of surgery
    Neely Desai
    Great Ormond Street Hospital for Children NHS Trust and UCL Institute of Child Health, London, England
    Epileptic Disord 10:356-61. 2008
    ..5 years, which located the ictal onset zone deep within the lesion. This enabled a right inferior parietal lobe resection to be performed. Four years post-surgery he remains seizure-free and has shown progress in development...
  12. ncbi request reprint A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy
    Elizabeth G Neal
    UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Epilepsia 50:1109-17. 2009
    ..To conduct the first randomized trial on classical and medium-chain triglyceride (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months...
  13. ncbi request reprint Focal cortical dysplasia type II: biological features and clinical perspectives
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK
    Lancet Neurol 8:830-43. 2009
    ....
  14. ncbi request reprint EEG-fMRI in children with pharmacoresistant focal epilepsy
    Xavier De Tiège
    Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom
    Epilepsia 48:385-9. 2007
    ..To evaluate the usefulness of EEG-combined functional magnetic resonance imaging (EEG-fMRI) to localize epileptogenic sources...
  15. ncbi request reprint Memory in paediatric temporal lobe epilepsy: effects of lesion type and side
    Francesca Cormack
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, Guilford Street, London, UK
    Epilepsy Res 98:255-9. 2012
    ..Semantic memory was impaired in both HS groups, and also in the left DNT group. These results suggest a role for type, and to a lesser extent, side of pathology in the memory profile of children with TLE...
  16. ncbi request reprint The development of intellectual abilities in pediatric temporal lobe epilepsy
    Francesca Cormack
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, UK
    Epilepsia 48:201-4. 2007
    ..The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE)...
  17. ncbi request reprint Psychopathology in children before and after surgery for extratemporal lobe epilepsy
    M Chiara Colonnelli
    Neuroscience Department, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Dev Med Child Neurol 54:521-6. 2012
    ..To establish the rates and types of psychiatric disorder in children before and after surgery for extratemporal epilepsy. Relationships between psychiatric morbidity and demographic/clinical variables were examined...
  18. ncbi request reprint Cognitive outcome after extratemporal epilepsy surgery in childhood
    Luigi D'Argenzio
    Neuroscience Department, UCL Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, United Kingdom
    Epilepsia 52:1966-72. 2011
    ..The present study aims to describe the cognitive profile of children with medically refractory extratemporal epilepsies who undergo focal surgery and to identify determinants for preoperative and postoperative cognitive level...
  19. ncbi request reprint Temporal lobe surgery in childhood and neuroanatomical predictors of long-term declarative memory outcome
    Caroline Skirrow
    1 Cognitive Neuroscience and Neuropsychiatry Section, Developmental Neurosciences Programme, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK 2 Great Ormond Street Hospital NHS Trust, Great Ormond Street, WC1N 3JH, UK
    Brain 138:80-93. 2015
    ..Careful tailoring of resections for children undergoing epilepsy surgery may enhance long-term memory outcome. ..
  20. ncbi request reprint Is streamlined evaluation of children for epilepsy surgery possible?
    Shekhar G Patil
    The National Centre for Young People with Epilepsy, Lingfield, United Kingdom
    Epilepsia 49:1340-7. 2008
    ..However, the contributions of each investigation to surgical decision making has not been systematically assessed...
  21. ncbi request reprint The surgical treatment of Landau-Kleffner syndrome
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children and National Centre for Young People with Epilepsy, London, United Kingdom
    Epilepsia 50:63-7. 2009
    ..Surgical series in the literature are few and outcome from surgery variable...
  22. pmc Migrating partial seizures of infancy: expansion of the electroclinical, radiological and pathological disease spectrum
    Amy McTague
    Neurosciences Unit, UCL Institute of Child Health, London, UK
    Brain 136:1578-91. 2013
    ..Comparative genomic hybridization array, SCN1A testing and genetic testing for other currently known early infantile epileptic encephalopathy genes (including PLCB1 and SLC25A22) was non-informative for the rest of the cohort...
  23. ncbi request reprint The effects of epilepsy surgery on emotions, behavior, and psychosocial impairment in children and adolescents with drug-resistant epilepsy: a prospective study
    Siobhan Hannan
    Great Ormond Street Hospital for Sick Children, London, UK
    Epilepsy Behav 15:318-24. 2009
    ..Our findings suggest that emotional and behavioral symptoms in children undergoing epilepsy surgery may improve following surgery, with reduction in their functional impact, and that these improvements are maintained in the long term...
  24. ncbi request reprint Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery
    J Helen Cross
    Institute of Child Health, The Wolfson Centre, London, UK
    Epilepsia 47:952-9. 2006
    ..The panel also outlined areas of agreement and disagreement on which future research and consensus meetings should focus attention to generate practice guidelines and criteria for pediatric epilepsy surgery centers...
  25. ncbi request reprint Myoclonic epilepsy in a child with 17q22-q23.1 deletion
    Antonietta Coppola
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK
    Am J Med Genet A 161:2036-9. 2013
    ..We describe a clinical phenotype of epilepsy characterized by myoclonic atonic and absence seizures in a 6-year-old boy carrying a de novo 17q22q23 deletion detected by oligonucleotide array comparative genomic hybridization (aCGH)...
  26. ncbi request reprint Neurodevelopmental effects of anti-epileptic drugs
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children and National Centre for Young People with Epilepsy, The Wolfson Centre, London, UK
    Epilepsy Res 88:1-10. 2010
    ..Ongoing evaluation is required to ensure the best clinical practice in each individual...
  27. pmc Mesial temporal lobe epilepsy: How do we improve surgical outcome?
    Maria Thom
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, London, UK
    Ann Neurol 68:424-34. 2010
    ..That recognition may lead to identifying the appropriate subgroups that will require different diagnostic and surgical approaches to improve surgical outcomes...
  28. ncbi request reprint Pathological tau tangles localize to focal cortical dysplasia in older patients
    Arjune Sen
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Epilepsia 48:1447-54. 2007
    ..We therefore hypothesized that the developmentally abnormal cortex of FCD might be more susceptible to tau-mediated neurodegeneration than adjacent histologically normal cortex...
  29. pmc Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances
    Sophia Varadkar
    Epilepsy Unit, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Institute of Child Health, London, UK Electronic address
    Lancet Neurol 13:195-205. 2014
    ..Immunomodulatory treatments seem to slow rather than halt disease progression in Rasmussen's encephalitis, without changing the eventual outcome. ..
  30. ncbi request reprint mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis
    Shireena A Yasin
    Neural Development Unit, Birth Defects Research Centre, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Acta Neuropathol 126:207-18. 2013
    ....
  31. ncbi request reprint Evolution of the EEG in children with Rasmussen's syndrome
    Francesca Longaretti
    Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom
    Epilepsia 53:1539-45. 2012
    ..This study reviewed electroencephalography (EEG) in the two conditions for early indicators of either pathology...
  32. ncbi request reprint Treatment of epileptic encephalopathies
    Amy McTague
    Neurosciences Unit, UCL Institute of Child Health, 4 5 Long Yard, London, WC1N 3LU, UK
    CNS Drugs 27:175-84. 2013
    ..Finally, it is vital that the identification and treatment of developmental, behavioural and psychiatric co-morbidities are not neglected and that a rational, holistic approach is taken to the management of epileptic encephalopathies...
  33. ncbi request reprint Ketogenic dietary therapies for adults with epilepsy: feasibility and classification of response
    Natasha E Schoeler
    NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK Neurosciences Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, 4 5 Long Yard, London, UK Electronic address
    Epilepsy Behav 37:77-81. 2014
    ..Other aspects besides seizure frequency may be relevant when classifying response in adults, and appropriate ways to quantify these factors should be considered for use in future studies...
  34. pmc Are we failing to provide adequate rescue medication to children at risk of prolonged convulsive seizures in schools?
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital NHS Foundation Trust, London, UK
    Arch Dis Child 98:777-80. 2013
    ..This paper explores the issues that arise from the discussion of administering rescue medication to children who experience prolonged convulsive seizures in mainstream schools in the UK...
  35. ncbi request reprint Role of fMRI in the decision-making process: epilepsy surgery for children
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom
    J Magn Reson Imaging 23:933-40. 2006
    ..In our experience, fMRI has significantly contributed to the decision-making process, and improved the counseling and management of young people with intractable epilepsy...
  36. ncbi request reprint When is epileptic encephalopathy nonconvulsive status epilepticus?
    J Helen Cross
    Neurosciences Unit, UCL Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, London, United Kingdom
    Epilepsia 48:42-3. 2007
  37. ncbi request reprint Hippocampal sclerosis in children with lesional epilepsy is influenced by age at seizure onset
    Catherine J Riney
    Neuroscience Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Epilepsia 47:159-66. 2006
    ....
  38. ncbi request reprint The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial
    Elizabeth G Neal
    Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, University College London, London, UK
    Lancet Neurol 7:500-6. 2008
    ..The ketogenic diet has been widely and successfully used to treat children with drug-resistant epilepsy since the 1920s. The aim of this study was to test the efficacy of the ketogenic diet in a randomised controlled trial...
  39. ncbi request reprint Elevated VGKC-complex antibodies in a boy with fever-induced refractory epileptic encephalopathy in school-age children (FIRES)
    Marjorie A Illingworth
    Department of Neurology, Great Ormond Street Hospital, London
    Dev Med Child Neurol 53:1053-7. 2011
    ....
  40. ncbi request reprint The ketogenic diet--update on recent clinical trials
    J Helen Cross
    UCL Institute of Child Health, London, UK
    Epilepsia 49:6-10. 2008
    ..A recently published randomized controlled trial has shown that the benefit of the KD is equivalent to any of the new anticonvulsant medications, emphasizing the need for more resources to ensure greater diet availability...
  41. ncbi request reprint The ketogenic and related diets in adolescents and adults--a review
    Natasha E Payne
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom
    Epilepsia 52:1941-8. 2011
    ..A better understanding of the mechanisms underlying the effects of the KD might allow the same treatment effects to be achieved using novel, better-tolerated, nondietary approaches...
  42. ncbi request reprint Statistical process control (SPC)--a simple objective method for monitoring seizure frequency and evaluating effectiveness of drug interventions in refractory childhood epilepsy
    Suresh Pujar
    National Centre for Young People with Epilepsy, Lingfield, Surrey, UK
    Epilepsy Res 91:205-13. 2010
    ..We therefore evaluated the utility of Statistical Process Control (SPC) charts as a simple objective clinical tool to demonstrate variability in seizure frequency and to assess the efficacy of drug interventions...
  43. ncbi request reprint Transition in lesional focal epilepsy, and following epilepsy surgery
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London and Young Epilepsy, Lingfield, United Kingdom
    Epilepsia 55:34-6. 2014
    ..The value of continuing antiepileptic drug (AED) treatment after successful surgery remains unclear, and the adjustment to a life without seizures may be challenging. ..
  44. ncbi request reprint The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells
    Sean David Hughes
    Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, UK Chemical Pathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    J Neurochem 129:426-33. 2014
    ..Evidence that C10 on its own can modulate mitochondrial number raises the possibility that a simplified and less stringent C10-based diet could be developed. ..
  45. ncbi request reprint Neurocutaneous syndromes and epilepsy-issues in diagnosis and management
    J Helen Cross
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, London, U K
    Epilepsia 46:17-23. 2005
    ..Neurofibromatosis is the second most common of the disorders but the prevalence of epilepsy in this population is relatively low; in addition, a greater proportion may be easier to treat with medication...
  46. pmc Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations
    Detlef Bockenhauer
    Great Ormond Street Hospital University College London, London, United Kingdom
    N Engl J Med 360:1960-70. 2009
    ..We investigated the genetic basis of this autosomal recessive disease, which we call the EAST syndrome (the presence of epilepsy, ataxia, sensorineural deafness, and tubulopathy)...
  47. ncbi request reprint Dietary therapies--an old idea with a new lease of life
    J Helen Cross
    UCL Institute of Child Health, Great Ormond Street Hospital, London and National Centre for Young people with Epilepsy, Lingfield, UK
    Seizure 19:671-4. 2010
    ..There continues to be a constant struggle with the demand for the resources required, and therefore availability and apparent management choice is limited...
  48. ncbi request reprint Dietary treatments: the road from Phoenix to Edinburgh
    J Helen Cross
    Neurosciences Unit, UCL Institute of Child Health, Great Ormond Street Hospital for Children and National Centre for Young People with Epilepsy, 4 5 Long Yard, London WC1 N 3LU, United Kingdom
    Epilepsy Res 100:203-4. 2012
    ..It is also now quite clear that it may have benefit in wider areas of neurology beyond epilepsy, specifically in metabolic disorders where glucose cannot be used as a primary energy source...