Tessa Crompton

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Sonic hedgehog signalling in T-cell development and activation
    Tessa Crompton
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nat Rev Immunol 7:726-35. 2007
  2. ncbi request reprint Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
    Susan V Outram
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    Blood 113:2217-28. 2009
  3. pmc Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development
    Ekati Drakopoulou
    Immunobiology Unit, UCL Institute of Child Health, London, UK
    Cell Cycle 9:4144-52. 2010
  4. pmc Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London, UK
    Eur J Immunol 42:489-99. 2012
  5. pmc Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog
    Ching In Lau
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford St, London, United Kingdom
    Blood 119:4741-51. 2012
  6. doi request reprint The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms
    Ariadne L Hager-Theodorides
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    J Immunol 183:3023-32. 2009
  7. pmc Tissue-derived hedgehog proteins modulate Th differentiation and disease
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    J Immunol 190:2641-9. 2013
  8. ncbi request reprint KLF13 influences multiple stages of both B and T cell development
    Susan V Outram
    Immunobiology Unit, Institute of Child Health, University College, London, United Kingdom
    Cell Cycle 7:2047-55. 2008
  9. pmc T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London, UK
    J Invest Dermatol 133:1221-30. 2013
  10. ncbi request reprint A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity
    Nicola J Rowbotham
    Immunobiology Unit, UCL Institute of Child Health, London, UK
    Cell Cycle 6:2138-42. 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Sonic hedgehog signalling in T-cell development and activation
    Tessa Crompton
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nat Rev Immunol 7:726-35. 2007
    ..We also review the influence of hedgehog signalling in peripheral T-cell activation...
  2. ncbi request reprint Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
    Susan V Outram
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    Blood 113:2217-28. 2009
    ..Analysis of Ihh conditional knockout and heterozygote adult mice showed that Ihh also influences thymocyte number in the adult...
  3. pmc Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development
    Ekati Drakopoulou
    Immunobiology Unit, UCL Institute of Child Health, London, UK
    Cell Cycle 9:4144-52. 2010
    ..In addition, introduction of a Class I-restricted transgenic TCR into the adult Gli1-deficient and embryonic Gli2-deficient thymus showed that both Gli1 and Gli2 influence its selection to the CD8 lineage...
  4. pmc Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London, UK
    Eur J Immunol 42:489-99. 2012
    ..These data together suggest that Hh signalling may play a role in influencing the later stages of thymocyte development...
  5. pmc Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog
    Ching In Lau
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford St, London, United Kingdom
    Blood 119:4741-51. 2012
    ..During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with WT...
  6. doi request reprint The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms
    Ariadne L Hager-Theodorides
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    J Immunol 183:3023-32. 2009
    ..Overall our data indicate that Gli3 expressed in the thymus stroma regulates negative selection and TCR signal strength via Hh-dependent and -independent mechanisms, with implications for autoimmunity...
  7. pmc Tissue-derived hedgehog proteins modulate Th differentiation and disease
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    J Immunol 190:2641-9. 2013
    ..Our data present an unexpected and novel role for tissue-derived morphogens in the regulation of fluid immune responses, with implications for allergy and tumor responses, suggesting new uses for anti-Hh therapeutics...
  8. ncbi request reprint KLF13 influences multiple stages of both B and T cell development
    Susan V Outram
    Immunobiology Unit, Institute of Child Health, University College, London, United Kingdom
    Cell Cycle 7:2047-55. 2008
    ..Thus KLF13 is involved at multiple different checkpoints in development that require signalling through the TCR, pre-BCR or mature BCR...
  9. pmc T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London, UK
    J Invest Dermatol 133:1221-30. 2013
    ..Our data raise interesting questions about the mechanisms underlying tissue-specific tolerance to skin antigens...
  10. ncbi request reprint A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity
    Nicola J Rowbotham
    Immunobiology Unit, UCL Institute of Child Health, London, UK
    Cell Cycle 6:2138-42. 2007
    ..Modulation of TCR signal strength by Hh pathway activation has importance for immunity as the presence or absence of Hh in the environment in which a T cell is activated would shape the immune response...
  11. pmc Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus
    Ariadne L Hager-Theodorides
    Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London, UK
    Eur J Immunol 37:487-500. 2007
    ..Our data demonstrate in vivo differentiation from DN3 to DN4 cell in the absence of TCRbeta/gammadelta expression in the foetal thymus, and after hydrocortisone treatment of adult mice...
  12. ncbi request reprint Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus
    Juan J Muñoz
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    J Immunol 169:177-84. 2002
    ....
  13. ncbi request reprint Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation
    Ariadne L Hager-Theodorides
    Department of Biological Sciences, Imperial College of Science Technology and Medicine, London SW7 2AZ, UK
    J Immunol 169:5496-504. 2002
    ..Our study suggests that the BMP2/4 pathway may function in thymic homeostasis by regulating T cell lineage commitment and differentiation...
  14. ncbi request reprint Reduced thymocyte development in sonic hedgehog knockout embryos
    Divya K Shah
    Department of Biological Sciences, Imperial College London, London, United Kingdom
    J Immunol 172:2296-306. 2004
    ....
  15. pmc The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes
    Ariadne L Hager-Theodorides
    Division of Cell and Molecular Biology, Faculty of Life Sciences, Imperial College London, Sir Alexander Fleming Bldg, South Kensington Campus, London SW7 2AZ, United Kingdom
    Blood 106:1296-304. 2005
    ..The effect of Gli3 was dose dependent, suggesting its direct involvement in the transcriptional regulation of genes controlling T-cell differentiation during fetal development...
  16. doi request reprint Splenomegaly and modified erythropoiesis in KLF13-/- mice
    Adele R Gordon
    Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, United Kingdom
    J Biol Chem 283:11897-904. 2008
    ..A higher proportion of the Ter119(med)CD71(hi) cells were proliferating, indicating that the mice were under a degree of erythropoietic stress. These data indicate that KLF13 is involved in the normal control of erythropoiesis...
  17. pmc Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation
    Nicola J Rowbotham
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Blood 109:3757-66. 2007
    ..In peripheral T cells, Gli2DeltaN(2) expression attenuated T-cell activation and proliferation, by a mechanism upstream of ERK phosphorylation...
  18. ncbi request reprint Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells
    Cruz Gutiérrez-Frías
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    J Immunol 173:5046-53. 2004
    ..Therefore, Shh may function as a maintenance factor for intrathymic CD34+ precursor cells...
  19. ncbi request reprint Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation
    Nicola J Rowbotham
    Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom
    Cell Cycle 7:904-8. 2008
    ..Thus, as negative regulators of TCR-dependent events, Hh proteins provide an environmental influence on T-cell fate...
  20. pmc Expression of hedgehog proteins in the human thymus
    Rosa Sacedon
    Department of Cell Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
    J Histochem Cytochem 51:1557-66. 2003
    ....
  21. ncbi request reprint The role of morphogens in T-cell development
    Alberto Varas
    Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Trends Immunol 24:197-206. 2003
    ....
  22. pmc Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development
    Susan V Outram
    Department of Biology, Imperial College of Science, Technology and Medicine, Imperial College Road, London SW7 2AZ, UK
    Immunology 105:391-8. 2002
    ..Thus we report a novel activity of DGKalpha in survival of thymocytes immediately after entry into the DP stage in development...