Research Topics
Genomes and GenesSpecies | Tessa CromptonSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Sonic hedgehog signalling in T-cell development and activationTessa Crompton
Immunobiology Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Nat Rev Immunol 7:726-35. 2007..We also review the influence of hedgehog signalling in peripheral T-cell activation...
Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiationSusan V Outram
Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
Blood 113:2217-28. 2009..Analysis of Ihh conditional knockout and heterozygote adult mice showed that Ihh also influences thymocyte number in the adult...
Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte developmentEkati Drakopoulou
Immunobiology Unit, UCL Institute of Child Health, London, UK
Cell Cycle 9:4144-52. 2010..In addition, introduction of a Class I-restricted transgenic TCR into the adult Gli1-deficient and embryonic Gli2-deficient thymus showed that both Gli1 and Gli2 influence its selection to the CD8 lineage...- Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyteAnna L Furmanski
Immunobiology Unit, Institute of Child Health, University College London, London, UK
Eur J Immunol 42:489-99. 2012..These data together suggest that Hh signalling may play a role in influencing the later stages of thymocyte development... - Regulation of murine normal and stress-induced erythropoiesis by Desert HedgehogChing In Lau
Immunobiology Unit, University College London Institute of Child Health, 30 Guilford St, London, United Kingdom
Blood 119:4741-51. 2012..During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with WT... - The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanismsAriadne L Hager-Theodorides
Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
J Immunol 183:3023-32. 2009..Overall our data indicate that Gli3 expressed in the thymus stroma regulates negative selection and TCR signal strength via Hh-dependent and -independent mechanisms, with implications for autoimmunity... - KLF13 influences multiple stages of both B and T cell developmentSusan V Outram
Immunobiology Unit, Institute of Child Health, University College, London, United Kingdom
Cell Cycle 7:2047-55. 2008..Thus KLF13 is involved at multiple different checkpoints in development that require signalling through the TCR, pre-BCR or mature BCR... - A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunityNicola J Rowbotham
Immunobiology Unit, UCL Institute of Child Health, London, UK
Cell Cycle 6:2138-42. 2007..Modulation of TCR signal strength by Hh pathway activation has importance for immunity as the presence or absence of Hh in the environment in which a T cell is activated would shape the immune response... - Reduced thymocyte development in sonic hedgehog knockout embryosDivya K Shah
Department of Biological Sciences, Imperial College London, London, United Kingdom
J Immunol 172:2296-306. 2004.... - Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymusJuan J Muñoz
Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
J Immunol 169:177-84. 2002.... - Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiationAriadne L Hager-Theodorides
Department of Biological Sciences, Imperial College of Science Technology and Medicine, London SW7 2AZ, UK
J Immunol 169:5496-504. 2002..Our study suggests that the BMP2/4 pathway may function in thymic homeostasis by regulating T cell lineage commitment and differentiation... - Splenomegaly and modified erythropoiesis in KLF13-/- miceAdele R Gordon
Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, United Kingdom
J Biol Chem 283:11897-904. 2008..A higher proportion of the Ter119(med)CD71(hi) cells were proliferating, indicating that the mice were under a degree of erythropoietic stress. These data indicate that KLF13 is involved in the normal control of erythropoiesis... - Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymusAriadne L Hager-Theodorides
Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London, UK
Eur J Immunol 37:487-500. 2007..Our data demonstrate in vivo differentiation from DN3 to DN4 cell in the absence of TCRbeta/gammadelta expression in the foetal thymus, and after hydrocortisone treatment of adult mice... - Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activationNicola J Rowbotham
Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
Blood 109:3757-66. 2007..In peripheral T cells, Gli2DeltaN(2) expression attenuated T-cell activation and proliferation, by a mechanism upstream of ERK phosphorylation... - The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytesAriadne L Hager-Theodorides
Division of Cell and Molecular Biology, Faculty of Life Sciences, Imperial College London, Sir Alexander Fleming Bldg, South Kensington Campus, London SW7 2AZ, United Kingdom
Blood 106:1296-304. 2005..The effect of Gli3 was dose dependent, suggesting its direct involvement in the transcriptional regulation of genes controlling T-cell differentiation during fetal development... - Expression of hedgehog proteins in the human thymusRosa Sacedon
Department of Cell Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
J Histochem Cytochem 51:1557-66. 2003.... - Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferationNicola J Rowbotham
Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom
Cell Cycle 7:904-8. 2008..Thus, as negative regulators of TCR-dependent events, Hh proteins provide an environmental influence on T-cell fate... - The role of morphogens in T-cell developmentAlberto Varas
Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
Trends Immunol 24:197-206. 2003.... - Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cellsCruz Gutiérrez-Frías
Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
J Immunol 173:5046-53. 2004..Therefore, Shh may function as a maintenance factor for intrathymic CD34+ precursor cells... - Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte developmentSusan V Outram
Department of Biology, Imperial College of Science, Technology and Medicine, Imperial College Road, London SW7 2AZ, UK
Immunology 105:391-8. 2002..Thus we report a novel activity of DGKalpha in survival of thymocytes immediately after entry into the DP stage in development...