I P Crocker

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, UK
    J Pathol 206:476-85. 2005
  2. pmc Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester M13 0JH
    Br J Pharmacol 144:772-80. 2005
  3. ncbi request reprint Altered cell kinetics in cultured placental villous explants in pregnancies complicated by pre-eclampsia and intrauterine growth restriction
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, Manchester, M13 OJH, UK
    J Pathol 204:11-8. 2004
  4. ncbi request reprint The influence of oxygen and tumor necrosis factor-alpha on the cellular kinetics of term placental villous explants in culture
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    J Histochem Cytochem 52:749-57. 2004
  5. ncbi request reprint Syncytiotrophoblast degradation and the pathophysiology of the malaria-infected placenta
    I P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester M13 0JH, UK
    Placenta 25:273-82. 2004
  6. pmc Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, UK
    Am J Pathol 162:637-43. 2003
  7. ncbi request reprint Utero-placental haemodynamics in the pathogenesis of pre-eclampsia
    E S Hutchinson
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 30:634-41. 2009
  8. doi request reprint Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia
    W B Dunn
    Manchester Centre for Integrative Systems Biology, University of Manchester, M1 7DN, UK
    Placenta 30:974-80. 2009
  9. ncbi request reprint Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast
    A E P Heazell
    University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 29:175-86. 2008
  10. doi request reprint A placental protective role for trophoblast-derived TNF-related apoptosis-inducing ligand (TRAIL)
    X Bai
    Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, St Mary s Hospital, Manchester, UK
    Placenta 30:855-60. 2009

Collaborators

Detail Information

Publications28

  1. ncbi request reprint The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, UK
    J Pathol 206:476-85. 2005
    ..Adequate vascular transformation may therefore rely on a balance between vascular receptivity, oxygen partial pressure, and exposure to inflammatory mediators...
  2. pmc Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester M13 0JH
    Br J Pharmacol 144:772-80. 2005
    ..5. These results suggest that PARP activity plays a pathogenic role in the development of endothelial dysfunction in pre-eclampsia and promotes PARP inhibition as a potential therapy in this condition...
  3. ncbi request reprint Altered cell kinetics in cultured placental villous explants in pregnancies complicated by pre-eclampsia and intrauterine growth restriction
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, Manchester, M13 OJH, UK
    J Pathol 204:11-8. 2004
    ..In addition, the increased susceptibility of villous components to cell death, in the absence of stimulated proliferation, may provide a powerful mechanism for aberrant or adaptive placental cell turnover in utero...
  4. ncbi request reprint The influence of oxygen and tumor necrosis factor-alpha on the cellular kinetics of term placental villous explants in culture
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    J Histochem Cytochem 52:749-57. 2004
    ..These outcomes may reflect previous morphological changes in compromised pregnancies and confirm a possible role for oxygen and TNFalpha in aberrant trophoblast turnover...
  5. ncbi request reprint Syncytiotrophoblast degradation and the pathophysiology of the malaria-infected placenta
    I P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester M13 0JH, UK
    Placenta 25:273-82. 2004
    ..Syncytial destruction could have serious implications; impairing fetal growth and in some rare cases, providing a previously unrecognized pathway to congenital infection...
  6. pmc Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, UK
    Am J Pathol 162:637-43. 2003
    ..This is the first description of enhanced apoptosis in isolated villous trophoblasts in PE and IUGR. These intrinsic differences may represent an important factor in the pathophysiology of these conditions...
  7. ncbi request reprint Utero-placental haemodynamics in the pathogenesis of pre-eclampsia
    E S Hutchinson
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 30:634-41. 2009
    ..This therefore offers a putative link between utero-placental maladaptations in pregnancy and the vascular endothelial complications of pre-eclampsia...
  8. doi request reprint Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia
    W B Dunn
    Manchester Centre for Integrative Systems Biology, University of Manchester, M1 7DN, UK
    Placenta 30:974-80. 2009
    ..Three areas of metabolism were highlighted for systems biology investigation; glutamate and glutamine, tryptophan metabolism and leukotriene or prostaglandin metabolism...
  9. ncbi request reprint Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast
    A E P Heazell
    University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 29:175-86. 2008
    ..The potential role of the p53-pathway in the control of cell turnover in villous trophoblast and the regulation of p53 by altered O(2) tension merits further investigation...
  10. doi request reprint A placental protective role for trophoblast-derived TNF-related apoptosis-inducing ligand (TRAIL)
    X Bai
    Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, St Mary s Hospital, Manchester, UK
    Placenta 30:855-60. 2009
    ..These findings highlight a mechanism by which TRAIL and DR5 serve to protective trophoblasts in normal development, but may be activated in conditions of excessive TNFalpha...
  11. doi request reprint Review: Endothelial progenitor cells in pregnancy and obstetric pathologies
    I P Crocker
    Faculty of Medical and Human Sciences, University of Manchester, Maternal and Fetal Health Research Centre, Institute of Human Development, Manchester, UK
    Placenta 34:S62-7. 2013
    ..This review summarizes our understanding of these cells in pregnancy, paying particular attention to their physiological role in placental development and the uterus, alongside their involvement in related obstetric pathologies...
  12. ncbi request reprint E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia
    L M Brown
    Division of Human Development, St Mary s Hospital, School of Medicine, University of Manchester, Hathersage Road, Manchester, M13 OJH, UK
    Histochem Cell Biol 124:499-506. 2005
    ....
  13. ncbi request reprint Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species
    A E P Heazell
    Maternal and Fetal Health Research Centre, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 28:S33-40. 2007
    ....
  14. doi request reprint Endothelial progenitor cells: their potential in the placental vasculature and related complications
    P I Sipos
    Maternal and Fetal Health Research Group, The University of Manchester, Research Floor, St Mary s Hospital, Oxford Road, Manchester, M13 9WL, UK
    Placenta 31:1-10. 2010
    ..An overview is given as to role of EPC's in the pathophysiology of different disease states and the possible therapeutic and diagnostic applications expected from EPC-related research in obstetrics...
  15. pmc Magnetic resonance imaging relaxation time measurements of the placenta at 1.5 T
    C Wright
    Maternal and Fetal Health Research Centre, University of Manchester, M13 9WL, UK
    Placenta 32:1010-5. 2011
    ..We report on the first phase of testing this hypothesis, in a study of women in normal pregnancy...
  16. ncbi request reprint Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers
    A E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, Research Floor, St Mary s Hospital, Manchester, M13 0JH, UK
    Placenta 29:691-8. 2008
    ..Metabolomics could be used to identify changes in conditions associated with placental pathology...
  17. doi request reprint Oxygen and the liberation of placental factors responsible for vascular compromise
    Nicola J Robinson
    Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, The University of Manchester, St Mary s Hospital, Manchester, UK
    Lab Invest 88:293-305. 2008
    ..These potentially pathogenic factors are now being characterized...
  18. doi request reprint Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies
    A E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, Manchester M13 0JH, UK
    Placenta 29:772-83. 2008
    ..This review describes current knowledge regarding the expression and function of these regulators in villous trophoblast, both in normal and complicated pregnancies...
  19. ncbi request reprint Does altered oxygenation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells?
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
    Reprod Biomed Online 18:111-9. 2009
    ..In addition, these data support a role for p53 in mediating altered trophoblast cell turnover in response to oxidative stress...
  20. ncbi request reprint Vasoactive and permeability effects of vascular endothelial growth factor-165 in the term in vitro dually perfused human placental lobule
    P Brownbill
    University Research Floor, St Mary s Hospital, Hathersage Road, Manchester, United Kingdom
    Endocrinology 148:4734-44. 2007
    ..However, nitric oxide could explain only 50% of the vasodilatory effect. Finally, we measured the permeability of the perfused placenta to inert hydrophilic tracers and found no difference in the presence and absence of VEGF...
  21. ncbi request reprint The mitotic manipulation of cytotrophoblast differentiation in vitro
    I P Crocker
    Maternal and Fetal Health Research Centre, Division of Human Reproduction, University of Manchester, St Mary s Hospital Whitworth Park, Hathersage Road, Manchester M13 0JH, UK
    Placenta 28:408-11. 2007
    ..This approach provides a mechanism for encouraging syncytiotrophoblast formation and may hold benefits for conditions where syncytiotrophoblast cover is attenuated...
  22. ncbi request reprint Characterization of small arteries isolated from the human placental chorionic plate
    M Wareing
    Maternal and Fetal Health Research Centre, University of Manchester, Academic Unit of Obstetrics and Gynaecology and Reproductive Health Care, St Mary s Hospital, Whitworth Park, Manchester, M13 0JH, UK
    Placenta 23:400-9. 2002
    ..Relaxations were only achieved with endothelial-independent agonists (sodium nitroprusside and papaverine)...
  23. ncbi request reprint Epidermal growth factor rescues trophoblast apoptosis induced by reactive oxygen species
    Sarah J Moll
    Division of Human Development, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 12:1611-22. 2007
    ..This study shows that apoptosis may be induced in villous trophoblast following exposure to ROS, and demonstrates the anti-apoptotic effect of EGF in trophoblast, the maintenance of which is essential for normal pregnancy...
  24. doi request reprint A gel-free quantitative proteomics analysis of factors released from hypoxic-conditioned placentae
    Richard T Blankley
    Maternal and Fetal Health Research Group, St Mary s Hospital, Manchester, UK
    Reprod Sci 17:247-57. 2010
    ..Identifying these changes resulting from hypoxic conditioning is hypothesis generating and may provide new mechanistic insights into preeclampsia...
  25. ncbi request reprint A potential role for free fatty acids in the pathogenesis of preeclampsia
    Nicola J Robinson
    Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, The University of Manchester, St Mary s Hospital, Manchester, UK
    J Hypertens 27:1293-302. 2009
    ....
  26. ncbi request reprint Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions
    Sandra V Ashton
    Biochemistry and Immunology Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Arterioscler Thromb Vasc Biol 25:102-8. 2005
    ..The mechanism by which trophoblasts induce this key process is unknown. This study gives the first insights into the potential mechanisms involved...
  27. ncbi request reprint Myometrial and placental artery reactivity alone cannot explain reduced placental perfusion in pre-eclampsia and intrauterine growth restriction
    Stephen S Ong
    The MRC Development Group, School of Human Development, University of Nottingham, Maternity Unit, City Hospital, UK
    BJOG 110:909-15. 2003
    ..2) To confirm that myometrial arteries from women with pre-eclampsia and intrauterine growth restriction exhibit an attenuated endothelium-dependent vasodilatory response...
  28. ncbi request reprint Functional characteristics of chorionic plate placental arteries from normal pregnant women and women with pre-eclampsia
    Stephen S Ong
    The MRC Development Group, School of Human Development, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK
    Hypertens Pregnancy 21:175-83. 2002
    ..In particular, we wished to test the hypothesis that these arteries respond differently to an endothelium-dependent vasodilator, to the presence of nitric oxide, and to the presence of cyclic monophosphate nucleotides...