M Craxton

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Genomic analysis of synaptotagmin genes
    M Craxton
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Genomics 77:43-9. 2001
  2. pmc Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family
    Colin Rickman
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Biochem J 378:681-6. 2004
  3. pmc Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans
    Molly Craxton
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    BMC Genomics 8:259. 2007
  4. pmc Synaptotagmin gene content of the sequenced genomes
    Molly Craxton
    BMC Genomics 5:43. 2004
  5. ncbi Alternative splicing of synaptotagmins involving transmembrane exon skipping
    M Craxton
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    FEBS Lett 460:417-22. 1999
  6. ncbi Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location
    M Craxton
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genomics 42:165-9. 1997
  7. ncbi SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
    S Mertens
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 383:273-6. 1996
  8. pmc Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 16:3563-71. 1997
  9. ncbi Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain
    M Craxton
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 361:196-200. 1995
  10. ncbi Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genomics 41:501-2. 1997

Collaborators

Detail Information

Publications15

  1. ncbi Genomic analysis of synaptotagmin genes
    M Craxton
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Genomics 77:43-9. 2001
    ..Comparison of the genomic structures of the Syt genes makes clear the different phylogenies of the different subgroups. Knowledge of the genomic structures will aid the systematic investigation of alternative splicing in Syt genes...
  2. pmc Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family
    Colin Rickman
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Biochem J 378:681-6. 2004
    ..Our present study suggests that many Syt isoforms can function in membrane trafficking to interact with the target SNARE heterodimer on the pathway to calcium-triggered membrane fusion...
  3. pmc Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans
    Molly Craxton
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    BMC Genomics 8:259. 2007
    ..Understanding the evolutionary relationships among these genes will help to realize the full implications of functional studies and lead to improved genome annotation...
  4. pmc Synaptotagmin gene content of the sequenced genomes
    Molly Craxton
    BMC Genomics 5:43. 2004
    ..The current rapid increase in the number of sequenced genomes from different branches of the tree of life, together with the public deposition of evolutionarily diverse transcript sequences make such studies worthwhile...
  5. ncbi Alternative splicing of synaptotagmins involving transmembrane exon skipping
    M Craxton
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    FEBS Lett 460:417-22. 1999
    ..Although the expression of most synaptotagmins predominates in neural tissue, we find that by contrast, synaptotagmin 6 is more abundant in thymus...
  6. ncbi Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location
    M Craxton
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genomics 42:165-9. 1997
    ..4 by PCR analysis of somatic cell hybrid DNA and by DNA hybridization to arrayed cosmids of the chromosome 19 metric physical map. This provides the first report of linked synaptotagmin genes...
  7. ncbi SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
    S Mertens
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 383:273-6. 1996
    ..Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle...
  8. pmc Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 16:3563-71. 1997
    ..Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 203580 and SB 202190. Our results suggest that cellular functions previously attributed to SAPK1 and/or SAPK2 may be mediated by SAPK3 or SAPK4...
  9. ncbi Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain
    M Craxton
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 361:196-200. 1995
    ..It is expressed at high levels in rat brain, but not in spinal cord or a number of peripheral non-neuronal tissues...
  10. ncbi Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genomics 41:501-2. 1997
  11. ncbi Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotype
    J A Ellis
    Department of Pathology, University of Cambridge, Cambridge CB2 2QQ, UK
    J Cell Sci 111:781-92. 1998
    ..This data suggests that for emerin to function normally it must be correctly localized, retained at the nuclear membrane and phosphorylated by cell cycle-mediated events...
  12. ncbi Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate
    Colin Rickman
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 279:12574-9. 2004
    ..Our results shed new light on the functional importance of the conserved polybasic synaptotagmin motif, suggesting that synaptotagmin interacts with the t-SNARE dimer to up-regulate the probability of SNARE-mediated membrane fusion...
  13. pmc A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology
    Molly Craxton
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK
    BMC Genomics 11:37. 2010
    ..The aim of compiling this open access collection of synaptotagmin and synaptotagmin-like sequences, is that its use may lead to greater understanding of the biological function of these proteins in an evolutionary context...
  14. ncbi Tau gene (MAPT) sequence variation among primates
    Max Holzer
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Gene 341:313-22. 2004
    ..Sequencing of Saitohin revealed an intact open reading frame in chimpanzee and gorilla, but not in gibbon or macaque...
  15. ncbi Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterization
    Hirotaka Yoshida
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Biochemistry 45:2599-607. 2006
    ..Filament assembly of synucleins was directly proportional to their degree of hydrophobicity and their tendency to form beta-sheet structure, and correlated inversely with their net charge...