Research Topics
Genomes and Genes
| M CraxtonSummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Genomic analysis of synaptotagmin genesM Craxton
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
Genomics 77:43-9. 2001..Comparison of the genomic structures of the Syt genes makes clear the different phylogenies of the different subgroups. Knowledge of the genomic structures will aid the systematic investigation of alternative splicing in Syt genes...
Comparative analysis of tandem C2 domains from the mammalian synaptotagmin familyColin Rickman
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Biochem J 378:681-6. 2004..Our present study suggests that many Syt isoforms can function in membrane trafficking to interact with the target SNARE heterodimer on the pathway to calcium-triggered membrane fusion...
Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoansMolly Craxton
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
BMC Genomics 8:259. 2007..Understanding the evolutionary relationships among these genes will help to realize the full implications of functional studies and lead to improved genome annotation...- Synaptotagmin gene content of the sequenced genomesMolly Craxton
BMC Genomics 5:43. 2004..The current rapid increase in the number of sequenced genomes from different branches of the tree of life, together with the public deposition of evolutionarily diverse transcript sequences make such studies worthwhile... - Alternative splicing of synaptotagmins involving transmembrane exon skippingM Craxton
Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, UK
FEBS Lett 460:417-22. 1999..Although the expression of most synaptotagmins predominates in neural tissue, we find that by contrast, synaptotagmin 6 is more abundant in thymus... - Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal locationM Craxton
Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
Genomics 42:165-9. 1997..4 by PCR analysis of somatic cell hybrid DNA and by DNA hybridization to arrayed cosmids of the chromosome 19 metric physical map. This provides the first report of linked synaptotagmin genes... - SAP kinase-3, a new member of the family of mammalian stress-activated protein kinasesS Mertens
MRC Laboratory of Molecular Biology, Cambridge, UK
FEBS Lett 383:273-6. 1996..Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle... - Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinasesM Goedert
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO J 16:3563-71. 1997..Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 203580 and SB 202190. Our results suggest that cellular functions previously attributed to SAPK1 and/or SAPK2 may be mediated by SAPK3 or SAPK4... - Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brainM Craxton
MRC Laboratory of Molecular Biology, Cambridge, UK
FEBS Lett 361:196-200. 1995..It is expressed at high levels in rat brain, but not in spinal cord or a number of peripheral non-neuronal tissues... - Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridizationM Goedert
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Genomics 41:501-2. 1997 - Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotypeJ A Ellis
Department of Pathology, University of Cambridge, Cambridge CB2 2QQ, UK
J Cell Sci 111:781-92. 1998..This data suggests that for emerin to function normally it must be correctly localized, retained at the nuclear membrane and phosphorylated by cell cycle-mediated events... - Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphateColin Rickman
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
J Biol Chem 279:12574-9. 2004..Our results shed new light on the functional importance of the conserved polybasic synaptotagmin motif, suggesting that synaptotagmin interacts with the t-SNARE dimer to up-regulate the probability of SNARE-mediated membrane fusion... - A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biologyMolly Craxton
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK
BMC Genomics 11:37. 2010..The aim of compiling this open access collection of synaptotagmin and synaptotagmin-like sequences, is that its use may lead to greater understanding of the biological function of these proteins in an evolutionary context... - Tau gene (MAPT) sequence variation among primatesMax Holzer
MRC Laboratory of Molecular Biology, Cambridge, UK
Gene 341:313-22. 2004..Sequencing of Saitohin revealed an intact open reading frame in chimpanzee and gorilla, but not in gibbon or macaque... - Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterizationHirotaka Yoshida
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Biochemistry 45:2599-607. 2006..Filament assembly of synucleins was directly proportional to their degree of hydrophobicity and their tendency to form beta-sheet structure, and correlated inversely with their net charge...