R J Cox

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins
    R J Cox
    School of Chemistry, University of Bristol, UK
    FEBS Lett 405:267-72. 1997
  2. ncbi Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): a novel class of antimicrobial compounds
    R J Cox
    University of Bristol, School of Chemistry, UK
    Bioorg Med Chem Lett 8:945-50. 1998
  3. ncbi Design and utility of oligonucleotide gene probes for fungal polyketide synthases
    T P Nicholson
    School of Chemistry, University of Bristol, Cantock s Close, UK
    Chem Biol 8:157-78. 2001

Collaborators

  • T P Nicholson
  • M Dawson
  • T J Simpson
  • B A Rudd
  • C M Lazarus

Detail Information

Publications3

  1. ncbi Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins
    R J Cox
    School of Chemistry, University of Bristol, UK
    FEBS Lett 405:267-72. 1997
    ..Co-expression of act and gris ACPs with ACPS in E. coli led to high levels of production of active holo-ACPs and ACPS. We have also made the significant observation that ACPS is able to transfer acylated CoA moieties to act apo-ACP...
  2. ncbi Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): a novel class of antimicrobial compounds
    R J Cox
    University of Bristol, School of Chemistry, UK
    Bioorg Med Chem Lett 8:945-50. 1998
    ..These compounds were tested in vitro as inhibitors of DAP-AT from E. coli and in vivo as antibiotics. The hydrazino-dipeptides showed potent slow binding slow binding inhibition of DAP-AT as well as antimicrobial activity...
  3. ncbi Design and utility of oligonucleotide gene probes for fungal polyketide synthases
    T P Nicholson
    School of Chemistry, University of Bristol, Cantock s Close, UK
    Chem Biol 8:157-78. 2001
    ..Genomic fragments amplified using these specific primer sequences can be used in blotting experiments and have high potential as aids for the eventual cloning of new fungal PKS gene clusters...