Genomes and Genes
Affiliation: University of Sheffield
- The autoimmune regulator gene (AIRE) is strongly associated with vitiligoR Tazi-Ahnini
Division of Genomic Medicine, University of Sheffield, Sheffield S10 2RX, UK
Br J Dermatol 159:591-6. 2008..3. We have previously detected an association between alopecia areata and single nucleotide polymorphisms (SNPs) in the AIRE gene...
- Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areataR Tazi-Ahnini
Dermato Immunogenetics Group, Biomedical Genetics Project, Division of Genomic Medicine, D Floor Medical School, Royal Hallamshire Hospital, University of Sheffield, Sheffield, S10 2RX, UK
Hum Genet 112:400-3. 2003..02 (1.64, 9.88), P=0.0014]. These results support previous findings showing that different HLA susceptibility alleles are associated with mild and severe AA...
- Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalisR Tazi-Ahnini
Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
Tissue Antigens 60:489-95. 2002..Moreover, our results could provide a rational explanation of the unusually high frequency of AA in APECED patients, supporting the concept of AA as an autoimmune disease...
- Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interactionR Tazi-Ahnini
Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
Eur J Immunogenet 29:25-30. 2002..38 (2.64, 15.42), P = 0.0002]. Our results suggest that these polymorphisms within IL1RN and IL1L1 themselves or a gene in linkage disequilibrium with IL1RN and IL1L1 predispose to the more severe forms of alopecia areata...
- Association analysis of IL1A and IL1B variants in alopecia areataR Tazi-Ahnini
Biomedical Genetics Project, Division of Genomic Medicine and Department of Dermatology, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
Heredity (Edinb) 87:215-9. 2001..This was due mainly to the contribution from mild cases of alopecia areata [OR 1.48 (0.96, 2.29)], suggesting that IL-1 alpha may have a particular role in the pathogenesis of this subgroup...
- Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome regionR Tazi-Ahnini
Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, UK
Hum Genet 106:639-45. 2000..34, 95% CI 1.24-4.43, P = 0.0072), providing new evidence of genetic heterogeneity in AA. Our demonstration of genetic association between the MX1 gene and disease supports the hypothesis that this is a new candidate gene in AA...
- Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitisM J Carter
The Gastroenterology and Liver Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
Genes Immun 5:8-15. 2004..2-3.1) (P=0.018). The IL-1RN*2 is associated with reduced levels of IL-1ra protein and IL-1RN mRNA in the colonic mucosa, providing a biologically plausible explanation for the observed association of the allele with the disease...
- Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature reviewS P Balasubramanian
Academic Surgical Oncology Unit, University of Sheffield, Sheffield, UK
BMC Cancer 6:188. 2006..The aim of this study was to evaluate any role of specific SNPs in the interleukin genes IL1A, IL1B, IL1RN, IL4R, IL6 and IL10 in predisposition to breast cancer susceptibility and severity...
- Evidence of a pharmacogenomic response to interleukin-l receptor antagonist in rheumatoid arthritisN J Camp
Division of Genomic Medicine, University of Sheffield, UK
Genes Immun 6:467-71. 2005..6 x 10(-5)). No associations with IL-1 genotypes were found in patients receiving placebo. Thus, a significant pharmacogenomic effect was found in the treatment of RA patients with recombinant IL-1ra...
- Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritisA Cox
Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, UK
Hum Mol Genet 8:1707-13. 1999..The data provide preliminary evidence for linkage of genes of the IL-1 cluster to RA and suggest a possible role for this region in severe erosive disease...
- An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markersA Cox
Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, United Kingdom
Am J Hum Genet 62:1180-8. 1998..Using this method, we found that there was a reasonable correlation between disequilibrium and physical distance in the region (r=-.540, P=.001, one-tailed). We also identified a common, eight-locus haplotype of the IL-1 gene cluster...
- Identification of novel single nucleotide polymorphisms within the NOTCH4 gene and determination of association with MHC allelesR Tazi-Ahnini
Division of Genomic Medicine, The University of Sheffield, Royal Hallamshire Hospital, UK
Eur J Immunogenet 30:101-5. 2003..65, 0.66 and 0.66, respectively. Linkage disequilibrium was detected both between these markers and with MHC alleles. These findings can be used in the fine mapping of disease susceptibility alleles within the MHC...
- The interleukin 1 receptor antagonist gene allele 2 as a predictor of pouchitis following colectomy and IPAA in ulcerative colitisM J Carter
The Gastroenterology and Liver Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, England, UK
Gastroenterology 121:805-11. 2001..The aim of this study was to assess the allele as a predictor of both the indication for colectomy and the occurrence of pouchitis after ileal pouch-anal anastomosis formation...
- Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitusA I Blakemore
Department of Medicine, University of Sheffield, UK
Hum Genet 97:369-74. 1996..If the DNA polymorphism is associated with altered gene function, new therapeutic interventions may be possible...
- Analysis of the association between diabetic nephropathy and polymorphisms in the aldose reductase gene in Type 1 and Type 2 diabetes mellitusM Neamat-Allah
Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, UK
Diabet Med 18:906-14. 2001..To investigate the association between polymorphisms of the aldose reductase gene and diabetic nephropathy in both Type 1 and Type 2 diabetes mellitus, and to carry out a meta-analysis of published results...
- Candidate gene polymorphisms in solid cancersS P Balasubramanian
Academic Unit of Surgical Oncology, K Floor, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
Eur J Surg Oncol 30:593-601. 2004..In this article, we illustrate the types of genetic variation and the complexities involved in their study and discuss their potential in predicting both the occurrence and outcomes of solid cancers...
- The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosisT S Johnson
Sheffield Kidney Institute, Northern General Hospital NHS Trust, Sheffield S5 7AU, United Kingdom
J Clin Invest 99:2950-60. 1997....
- The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mappingM Dale
Department of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, United Kingdom
Genomics 47:325-6. 1998
- Heterozygote excess is repeatedly observed in females at the BRCA2 locus N372HM D Teare
J Med Genet 41:523-8. 2004
- Association of HLA-DM polymorphism with the production of antiphospholipid antibodiesM L Sanchez
Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, SE1 7EH, UK
Ann Rheum Dis 63:1645-8. 2004....
- Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13H G Nothwang
University Children s Hospital, Freiburg University, Germany
Genomics 41:370-8. 1997..FISH analysis localized PAC clones containing the IL-1 gene cluster to 2q12-q13. The data provide the basis for further characterization of the IL-1 gene cluster and for the construction of a sequence-ready PAC contig of this region...
- The rap and hor proteins of Erwinia, Serratia and Yersinia: a novel subgroup in a growing superfamily of proteins regulating diverse physiological processes in bacterial pathogensN R Thomson
Department of Biochemistry, University of Cambridge, UK
Mol Microbiol 26:531-44. 1997..We have shown that these new homologues of SlyA form a highly conserved subgroup of a growing superfamily of bacterial regulatory proteins controlling diverse physiological processes in human, animal and plant pathogens...
- Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancerL Fallowfield
Sussex Psychosocial Oncology Group, Cancer Research UK, Brighton and Sussex Medical School, University of Sussex, Sussex, UK
Ann Oncol 17:205-10. 2006..Endocrine therapies for advanced breast cancer include tablets and intramuscular injections. When treatments have similar efficacy and tolerability profiles, addressing preferences about routes of administration is important...
- Quantitative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopyK H Weed
Ophthalmology Department, Ninewells Hospital and Medical School, Dundee, Scotland, UK
Eye (Lond) 21:614-23. 2007..To establish and quantify the in vivo confocal microscopic features of moderate to advanced keratoconus...
- Randomized, double-blind, placebo-controlled trial of autologous blood therapy for atopic dermatitisM H Pittler
Department of Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter EX2 4NT, UK
Br J Dermatol 148:307-13. 2003..The improvement in observer-rated skin condition suggested by this study needs confirmation in larger trials...