P J Cowen

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Serotonin, dieting, and bulimia nervosa
    P J Cowen
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Adv Exp Med Biol 467:101-4. 1999
  2. ncbi request reprint Effects of alpha-lactalbumin on emotional processing in healthy women
    Helen Scrutton
    University Department of Psychiatry, Warneford Hospital, Oxford UK
    J Psychopharmacol 21:519-24. 2007
  3. doi request reprint The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression
    Philip Cowen
    Warneford Hospital, Oxford, UK
    J Psychopharmacol 27:575-83. 2013
  4. doi request reprint Cardiovascular and metabolic risk profile in young people at familial risk of depression
    Zola N Mannie
    Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 203:18-23. 2013
  5. pmc A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression
    Zola N Mannie
    Psychopharmacology Research Unit, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Biol Psychiatry 67:471-7. 2010
  6. ncbi request reprint Increase in concentration of waking salivary cortisol in recovered patients with depression
    Zubin Bhagwagar
    University Department of Psyhiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 160:1890-1. 2003
  7. doi request reprint Serotonin and depression: pathophysiological mechanism or marketing myth?
    Philip J Cowen
    Neurosciences Building, Warneford Hospital, Old Road, Headington, Oxford OX3 7JX, UK
    Trends Pharmacol Sci 29:433-6. 2008
  8. doi request reprint NK1 receptor antagonism and emotional processing in healthy volunteers
    P Chandra
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 24:481-7. 2010
  9. pmc Direct effects of diazepam on emotional processing in healthy volunteers
    S E Murphy
    University Department of Psychiatry, Warneford Hospital, Warneford Lane, Oxford, UK
    Psychopharmacology (Berl) 199:503-13. 2008
  10. ncbi request reprint The effects of a branched chain amino acid mixture supplemented with tryptophan on biochemical indices of neurotransmitter function and decision-making
    A Scarna
    University Department of Psychiatry, Warneford Hospital, Oxford, OX37JX, UK
    Psychopharmacology (Berl) 179:761-8. 2005

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Serotonin, dieting, and bulimia nervosa
    P J Cowen
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Adv Exp Med Biol 467:101-4. 1999
    ..Taken together the data suggest that dieting-induced decreases in TRP availability may trigger the development of bulimia nervosa is susceptible individuals...
  2. ncbi request reprint Effects of alpha-lactalbumin on emotional processing in healthy women
    Helen Scrutton
    University Department of Psychiatry, Warneford Hospital, Oxford UK
    J Psychopharmacol 21:519-24. 2007
    ..Further studies in subjects more vulnerable to stress are needed to assess the potential therapeutic effects of alpha-lactalbumin in clinical populations...
  3. doi request reprint The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression
    Philip Cowen
    Warneford Hospital, Oxford, UK
    J Psychopharmacol 27:575-83. 2013
    ..Nevertheless, our understanding of the effects of SSRIs and other conventional antidepressant therapy on cognitive function in healthy humans and depressed patients remains limited...
  4. doi request reprint Cardiovascular and metabolic risk profile in young people at familial risk of depression
    Zola N Mannie
    Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 203:18-23. 2013
    ..Depression is associated with increased risk of several general medical conditions, including diabetes and cardiovascular disease. The nature of the association is complex and may involve bidirectional causation or a common pathophysiology...
  5. pmc A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression
    Zola N Mannie
    Psychopharmacology Research Unit, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Biol Psychiatry 67:471-7. 2010
    ..These abnormalities apparently persist into clinical remission, raising the possibility that they might be trait markers indicating vulnerability to depression...
  6. ncbi request reprint Increase in concentration of waking salivary cortisol in recovered patients with depression
    Zubin Bhagwagar
    University Department of Psyhiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 160:1890-1. 2003
    ..An increase in salivary cortisol levels after waking provides a simple, dynamic measure of HPA axis activity. The authors measured this increase in recovered depressed patients and in a healthy comparison group...
  7. doi request reprint Serotonin and depression: pathophysiological mechanism or marketing myth?
    Philip J Cowen
    Neurosciences Building, Warneford Hospital, Old Road, Headington, Oxford OX3 7JX, UK
    Trends Pharmacol Sci 29:433-6. 2008
    ..Clarification of the mechanism of this effect will enable an understanding of how impaired 5-HT activity contributes to the subjective experience of depression...
  8. doi request reprint NK1 receptor antagonism and emotional processing in healthy volunteers
    P Chandra
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 24:481-7. 2010
    ..Human models of emotional processing may provide a useful means of assessing the likely therapeutic potential of new treatments for depression...
  9. pmc Direct effects of diazepam on emotional processing in healthy volunteers
    S E Murphy
    University Department of Psychiatry, Warneford Hospital, Warneford Lane, Oxford, UK
    Psychopharmacology (Berl) 199:503-13. 2008
    ....
  10. ncbi request reprint The effects of a branched chain amino acid mixture supplemented with tryptophan on biochemical indices of neurotransmitter function and decision-making
    A Scarna
    University Department of Psychiatry, Warneford Hospital, Oxford, OX37JX, UK
    Psychopharmacology (Berl) 179:761-8. 2005
    ..However, the BCAA mixture also lowers the ratio of tryptophan (TRP) to BCAA which could impair brain serotonin function...
  11. doi request reprint Increased neural response to fear in patients recovered from depression: a 3T functional magnetic resonance imaging study
    R Norbury
    Psychopharmacology Research Unit, University of Oxford, Department of Psychiatry, Oxford, UK
    Psychol Med 40:425-32. 2010
    ..Whether these changes persist in unmedicated recovered patients is unclear...
  12. ncbi request reprint Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat
    M Franklin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 14:360-3. 2000
    ..Hyperforin may contribute to the facilitatory effect of LI 160 on DA function, but hypericin does not...
  13. pmc Short-term SSRI treatment normalises amygdala hyperactivity in depressed patients
    B R Godlewska
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychol Med 42:2609-17. 2012
    ..However, it is not clear if these effects occur before, or as a consequence of, changes in clinical state...
  14. ncbi request reprint Tyrosine depletion attenuates dopamine function in healthy volunteers
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychopharmacology (Berl) 154:105-11. 2001
    ..Such information could establish tyrosine depletion as an effective probe of dopamine function in healthy volunteers and would also have relevance for future therapeutic applications of this manipulation...
  15. ncbi request reprint Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man
    M Franklin
    University of Oxford Department of Psychiatry, Warneford Hospital, UK
    Pharmacopsychiatry 34:S29-37. 2001
    ..The data also suggests that hyperforin may be more important than hypericin for effecting these changes following acute treatment. Further studies investigating both acute and sub-chronic effects of these compounds are necessary...
  16. ncbi request reprint Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness
    S F McTavish
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 179:356-60. 2001
    ..In rats, amino acid mixtures lacking tyrosine and its precursor phenylalanine decrease the release of dopamine produced by the psychostimulant drug amphetamine. Amphetamine has been proposed as a model for clinical mania...
  17. ncbi request reprint The effect of a nutritional source of tryptophan on dieting-induced changes in brain 5-HT function
    M J Attenburrow
    University Department of Psychiatry, Warneford Hospital, Oxford
    Psychol Med 33:1381-6. 2003
    ..The aim of the study was to assess whether increased TRP intake during dieting would prevent the changes in TRP availability and 5-HT neuroendocrine function...
  18. ncbi request reprint A single dose of citalopram increases fear recognition in healthy subjects
    M Browning
    Department of Psychiatry, Oxford University, Warneford Hospital, Oxford, UK
    J Psychopharmacol 21:684-90. 2007
    ..Our data also suggests that some of the positive biases in emotional processing produced by SSRI treatment might be detectable at the beginning of treatment...
  19. doi request reprint Dissociable effects of acute antidepressant drug administration on subjective and emotional processing measures in healthy volunteers
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Psychopharmacology (Berl) 199:495-502. 2008
    ..The aim of the present study was to confirm and extend this finding by studying the effects of a single dose of the selective serotonin and noradrenaline re-uptake inhibitor, duloxetine...
  20. ncbi request reprint Acute administration of nutritionally sourced tryptophan increases fear recognition
    M J Attenburrow
    University Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
    Psychopharmacology (Berl) 169:104-7. 2003
    ....
  21. ncbi request reprint The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study
    R Norbury
    Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, UK
    Mol Psychiatry 13:1011-20. 2008
    ..Such adaptations in the neural processing of emotional information support the hypothesis that antidepressants have early effects on emotional processing in a manner which would be expected to reverse negative biases in depression...
  22. ncbi request reprint Low-dose citalopram as a 5-HT neuroendocrine probe
    M J Attenburrow
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychopharmacology (Berl) 155:323-6. 2001
    ..Citalopram infusions were well-tolerated. CONCLUSIONS: Low-dose citalopram has potential utility as a neuroendocrine challenge test. The endocrine responses to citalopram are probably not mediated predominantly by 5-HT2A/2C receptors...
  23. pmc Lack of effect of citalopram on magnetic resonance spectroscopy measures of glutamate and glutamine in frontal cortex of healthy volunteers
    M J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    J Psychopharmacol 24:1217-21. 2010
    ..This supports the potential for MRS in assessing neuroanatomically specific serotonin-glutamate interactions in the human brain...
  24. pmc Using an experimental medicine model to understand the antidepressant potential of the N-Methyl-D-aspartic acid (NMDA) receptor antagonist memantine
    A Pringle
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Psychopharmacol 26:1417-23. 2012
    ..However, the overall profile of effects is more limited than that which might be expected in response to a conventional antidepressant...
  25. doi request reprint Negative ion treatment increases positive emotional processing in seasonal affective disorder
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychol Med 42:1605-12. 2012
    ..High-density negative ion (HDNI) treatment is an environmental manipulation that has efficacy in randomized clinical trials in seasonal affective disorder (SAD)...
  26. ncbi request reprint Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat
    M Franklin
    University Department of Psychiatry, Warneford Hospital, Headington, Oxford
    Pharmacopsychiatry 34:147-9. 2001
    ..The PRL response to DOI was significantly increased in the first week of the diet but returned to normal in the second. The results suggest that a low TRP diet produce a transient up-regulation of brain 5-HT2A receptors...
  27. ncbi request reprint Effect of a long-term low tryptophan diet on the prolactin responses to the 5-HT1A and 5-HT2C agonists, 8-OH-DPAT and mCPP in the male rat
    M Franklin
    University of Oxford, Department of Psychiatry Psychopharmacology Unit, Warneford Hospital, UK
    J Psychopharmacol 13:58-63. 1999
    ..The small or transient changes brought about by long-term TRP depletion on post-synaptic 5-HT1A receptors, suggests that these receptors may be less susceptible to 5-HT depleting effects than the 5-HT2C subtype...
  28. ncbi request reprint Administration of the beta-adrenoceptor blocker propranolol impairs the processing of facial expressions of sadness
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Psychopharmacology (Berl) 154:383-9. 2001
    ..The amygdala has also been associated with the processing of facial expressions of emotion, particularly those of fear and sadness. However, the role of noradrenaline in the latter process is unknown...
  29. doi request reprint Early effects of mirtazapine on emotional processing
    D Arnone
    Department of Psychiatry, Oxford University, Warneford Hospital, Oxford, OX3 7JD, UK
    Psychopharmacology (Berl) 203:685-91. 2009
    ..The aim of the present study was to test whether, like monoamine re-uptake inhibitors, mirtazapine would also produce positive biases in emotional processing...
  30. ncbi request reprint Decreased sensitivity of 5-HT(1D) receptors in melancholic depression
    R Whale
    University Department of Psychiatry, Oxford
    Br J Psychiatry 178:454-7. 2001
    ..The reduction in 5-HT(1D) receptor sensitivity following SSRI treatment is probably an adaptive response to increased levels of synaptic 5-HT...
  31. ncbi request reprint Tryptophan depletion decreases the recognition of fear in female volunteers
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
    Psychopharmacology (Berl) 167:411-7. 2003
    ..The processing of other fear-relevant cues, such as facial expressions, has also been associated with amygdala function, but an effect of serotonin depletion on these processes has not been assessed...
  32. ncbi request reprint Does metergoline selectively attenuate 5-HT mediated prolactin release?
    P M Ellis
    MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK
    Psychopharmacology (Berl) 105:129-31. 1991
    ..The findings suggest that in humans blockade of a prolactin response by a conventional oral dose of metergoline cannot be taken as evidence of involvement of 5-HT-mediated mechanisms...
  33. ncbi request reprint Contrasting effects of citalopram and reboxetine on waking salivary cortisol
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, OX3 7JX, Oxford, UK
    Psychopharmacology (Berl) 167:112-4. 2003
    ..The effects of repeated antidepressant administration have been less studied, but the ability of such treatment to modulate HPA axis activity may be relevant to therapeutic effects...
  34. ncbi request reprint Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome
    C M Vassallo
    University Department of Psychiatry, Warneford Hospital, Oxford
    Psychol Med 31:585-91. 2001
    ..This suggests that the increased PRL response to fenfluramine in CFS is due to elevated activity of pre-synaptic 5-HT neurones. This change is unlikely to be due to increased peripheral availability of tryptophan...
  35. ncbi request reprint Attenuation of some subjective effects of amphetamine following tyrosine depletion
    S F McTavish
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 13:144-7. 1999
    ..These findings are consistent with animal experimental studies indicating that tyrosine depletion attenuates the release of dopamine produced by amphetamine but not the release of noradrenaline...
  36. doi request reprint A cognitive neuropsychological model of antidepressant drug action
    A Pringle
    Department of Psychiatry, University of Oxford, Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, United Kingdom
    Prog Neuropsychopharmacol Biol Psychiatry 35:1586-92. 2011
    ..Experimental medicine models developed under this premise have the potential to screen for new treatments, to predict individual treatment response and to consider the effects of pharmacological vs psychological treatments...
  37. doi request reprint Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy
    M Taylor
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 22:473-6. 2008
    ..Further studies are needed to find out if similar effects occur in anterior brain regions and whether they reflect changes in glutamate or glutamine or both...
  38. ncbi request reprint Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, OX3 7JX, Oxford, UK
    J Affect Disord 72:249-55. 2002
    ..We therefore assessed the effect of a single dose of hydrocortisone on 5-HT-mediated growth hormone (GH) release in healthy volunteers and euthymic subjects recovered from at least two episodes of major depression...
  39. ncbi request reprint Effect of lofepramine on 5-HT function and sleep
    J R Herdman
    MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK
    J Affect Disord 29:63-72. 1993
    ..However, lofepramine does not appear to alter the sensitivity of 5-HT1A receptors...
  40. ncbi request reprint Acute reboxetine administration increases plasma and salivary cortisol
    S A Hill
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 17:273-5. 2003
    ..However, placebo-controlled, within-subject designs are likely to yield a more valid measure of noradrenaline-mediated cortisol release...
  41. ncbi request reprint Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder
    P W Burnet
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychiatr Genet 9:101-4. 1999
    ..We conclude that allelic variation does not account for the involvement of the 5-HT2C receptor in these eating disorders...
  42. ncbi request reprint Acute SSRI administration affects the processing of social cues in healthy volunteers
    C J Harmer
    University Department of Psychiatry, Warneord Hospital, Oxford, UK
    Neuropsychopharmacology 28:148-52. 2003
    ..This effect may represent an early acute effect of SSRIs on social and emotional processing that is relevant to their therapeutic actions...
  43. doi request reprint Memory impairment in young women at increased risk of depression: influence of cortisol and 5-HTT genotype
    Z N Mannie
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychol Med 39:757-62. 2009
    ....
  44. doi request reprint The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis
    S E Murphy
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Mol Psychiatry 18:512-20. 2013
    ....
  45. ncbi request reprint Effect of venlafaxine on pineal melatonin and noradrenaline in the male rat
    M Franklin
    University of Oxford Department of Psychiatry, Warneford Hospital, UK
    J Psychopharmacol 12:371-4. 1998
    ..These data are consistent with in vitro data suggesting that VEN increases NA neurotransmission at higher doses and that repeated treatment can desensitize pinealocyte beta-adrenoceptors...
  46. ncbi request reprint The effect of Li 1370, extract of Ginkgo biloba, on REM sleep in humans
    B J Murray
    Department of Psychiatry, Warneford Hospital, Oxford, UK
    Pharmacopsychiatry 34:155-7. 2001
    ..No significant differences in sleep parameters (including REM sleep measures) were detected; however sleep efficiency measures and subjective sleep quality reports showed that Li 1370 was well tolerated...
  47. ncbi request reprint Metergoline abolishes the prolactin response to buspirone
    C A Gregory
    MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK
    Psychopharmacology (Berl) 100:283-4. 1990
    ..While these findings are consistent with a role for 5-HT receptors in the stimulatory effect of buspirone on plasma prolactin, a dopaminergic mechanism cannot be excluded by the present data...
  48. ncbi request reprint Changes in plasma prolactin during SSRI treatment: evidence for a delayed increase in 5-HT neurotransmission
    P J Cowen
    University Department of Psychiatry, Littlemore Hospital, Oxford, UK
    J Psychopharmacol 11:345-8. 1997
    ....
  49. ncbi request reprint Acute citalopram administration produces correlated increases in plasma and salivary cortisol
    Z Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Psychopharmacology (Berl) 163:118-20. 2002
    ..Intravenous administration of the selective serotonin (5-HT) re-uptake inhibitor, citalopram, increases plasma cortisol. This would be expected to produce a parallel increase in salivary cortisol concentration...
  50. ncbi request reprint Effects of a branched-chain amino acid drink in mania
    A Scarna
    University of Oxford, Warneford Hospital, UK
    Br J Psychiatry 182:210-3. 2003
    ..Administration of a complex tyrosine-free amino acid drink acutely decreases manic symptoms. Although a nutrient-based approach to illness management is attractive, complex amino acid drinks are too unpalatable for repeated administration...
  51. doi request reprint Antidepressant treatment and emotional processing: can we dissociate the roles of serotonin and noradrenaline?
    A Pringle
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Psychopharmacol 27:719-31. 2013
    ..The data reviewed here also suggest that noradrenergic-based treatments may have earlier effects on emotional memory that those which affect serotonin. ..
  52. ncbi request reprint Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. Functional magnetic resonance imaging study
    K A Smith
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Br J Psychiatry 181:411-5. 2002
    ..Subjects recovered from depression have a substantial risk for recurrence of depression, suggesting persistent abnormalities in brain activity...
  53. doi request reprint Effect of interferon-α on cortical glutamate in patients with hepatitis C: a proton magnetic resonance spectroscopy study
    M J Taylor
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychol Med 44:789-95. 2014
    ..The present study used magnetic resonance spectroscopy (MRS) to measure glutamate and its major metabolite glutamine in patients with hepatitis C who received treatment with pegylated IFN-α and ribavirin...
  54. ncbi request reprint Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats
    S F McTavish
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Eur J Pharmacol 424:115-9. 2001
    ..c.), or the 5-hydroxytryptamine releasing agent, p-chloroamphetamine (2 mg/kg s.c.) was not altered. These findings provide behavioural evidence that tyrosine-free amino acid mixtures reduce presynaptic dopamine function in the brain...
  55. ncbi request reprint Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635
    Z Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Mol Psychiatry 9:386-92. 2004
    ..Lowered 5-HT(1A) receptor binding availability could represent a trait abnormality that confers vulnerability to recurrent major depression...
  56. ncbi request reprint Chromium treatment decreases the sensitivity of 5-HT2A receptors
    M J Attenburrow
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Psychopharmacology (Berl) 159:432-6. 2002
    ..Recent case series suggest that chromium picolinate in doses of 400 microg daily may have antidepressant properties, perhaps through increasing the peripheral availability of tryptophan for brain serotonin (5-HT) synthesis...
  57. ncbi request reprint Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635
    Zubin Bhagwagar
    Clinical Sciences Centre Medical Research Council, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Biol Psychiatry 54:890-5. 2003
    ..We tested this hypothesis by studying the effect of acute administration of hydrocortisone on 5-HT(1A) receptor binding potential (BP) in subjects recovered from depression...
  58. ncbi request reprint Single dose antidepressant administration modulates the neural processing of self-referent personality trait words
    Kamilla Miskowiak
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, UK
    Neuroimage 37:904-11. 2007
    ..These results support the hypothesis that antidepressants have early effects on the neural processing of emotional material which may be important in their therapeutic actions...
  59. doi request reprint Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression
    Zola N Mannie
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Br J Psychiatry 192:356-61. 2008
    ..We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation...
  60. ncbi request reprint State and trait abnormalities in serotonin function in major depression
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 180:24-8. 2002
    ..Neuroendocrine studies of brain serotonin (5-HT) function in depression generally show evidence of impaired 5-HT function but it is disputed whether or not this impairment resolves with clinical recovery...
  61. ncbi request reprint Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients
    Ann L Sharpley
    University Department of Psychiatry, Warneford Hospital, Oxford, Oxfordshire, UK
    J Clin Psychiatry 64:192-6. 2003
    ..This study aimed to assess whether risperidone produced typical antidepressant-like effects in the polysomnogram of healthy subjects and in depressed patients unresponsive to antidepressant medication...
  62. ncbi request reprint Toward a neuropsychological theory of antidepressant drug action: increase in positive emotional bias after potentiation of norepinephrine activity
    Catherine J Harmer
    Department of Psychiatry, Oxford University, Warneford Hospital, Oxford OX3 7JX, USA
    Am J Psychiatry 160:990-2. 2003
    ..Cognitive theories suggest that biases in information processing lead depressed patients to make unrealistically negative judgments about themselves and the world...
  63. ncbi request reprint Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?
    Eugenii A Rabiner
    PET Psychiatry, Translational Medicine and Technologies, GlaxoSmithKline, Cambridge, UK
    Neuropsychopharmacology 29:1688-98. 2004
    ..Speculatively, the degree of preferential occupancy may serve as a surrogate marker for depression, or the pharmacological effects of antidepressants...
  64. ncbi request reprint Human 5-HT transporter availability predicts amygdala reactivity in vivo
    Rebecca A Rhodes
    Psychiatry Group, Medical Research Council Clinical Sciences Centre, London W12 0NN, United Kingdom
    J Neurosci 27:9233-7. 2007
    ..Our novel in vivo data highlight the central importance of the serotonergic system in the responsiveness of the human amygdala during emotional processing...
  65. ncbi request reprint Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 161:368-70. 2004
    ..The authors used magnetic resonance spectroscopy (MRS) to assess the effect of acute administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on cortical levels of gamma-aminobutyric acid (GABA)...
  66. ncbi request reprint A dose-finding study on the effects of branch chain amino acids on surrogate markers of brain dopamine function
    Harm J Gijsman
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Psychopharmacology (Berl) 160:192-7. 2002
    ..The amino acid mixture we tested previously is unpalatable, whereas mixtures containing only branch chain amino acids can be made more palatable. However, the effects of such mixtures on dopamine function in humans have not been studied...
  67. ncbi request reprint Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford
    Am J Psychiatry 161:166-8. 2004
    ....
  68. ncbi request reprint Predictors of mood response to acute tryptophan depletion. A reanalysis
    Linda Booij
    Department of Psychology, University, Leiden, The Netherlands
    Neuropsychopharmacology 27:852-61. 2002
    ..Whether the effects of ATD represent a reversal of the action of SSRI antidepressants or individual vulnerability probably depends upon the timing of the procedure in the course of remission of a depressive episode...
  69. ncbi request reprint Comparison of the effects of citalopram and escitalopram on 5-Ht-mediated neuroendocrine responses
    Haitham S Nadeem
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuropsychopharmacology 29:1699-703. 2004
    ..Plasma and salivary cortisol responses after citalopram but not escitalopram correlated significantly. The present study does not support an enhanced effect of escitalopram on 5-HT-mediated neuroendocrine responses...
  70. ncbi request reprint Emotional bias and waking salivary cortisol in relatives of patients with major depression
    Marisa Le Masurier
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychol Med 37:403-10. 2007
    ..We also measured waking salivary cortisol, as the regulation of the hypothalamo-pituitary-adrenal (HPA) axis is thought to be impaired in depressive disorder...
  71. ncbi request reprint Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907
    Rainer Hinz
    Hammersmith Imanet Ltd, London, UK
    J Cereb Blood Flow Metab 27:161-72. 2007
    ..This study confirmed the use of an arterial input kinetic model for the quantification of 5-HT(2A) receptor binding with [(11)C]MDL 100,907 and the use of the cerebellum as a reference region for the free and nonspecific binding...
  72. ncbi request reprint Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers
    Susannah E Murphy
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Psychopharmacology (Berl) 187:121-30. 2006
    ..However, evidence of its efficacy as the primary treatment for depression is limited, and the direct action of TRP on the symptoms of depression and anxiety has not been well-characterised...
  73. ncbi request reprint Lack of effect of chromium supplementation on mental state and body weight in people with schizophrenia
    Rena A Hockney
    J Clin Psychopharmacol 26:544-5. 2006
  74. ncbi request reprint Antidepressant drug treatment modifies the neural processing of nonconscious threat cues
    Catherine J Harmer
    Department of Experimental Psychology, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 59:816-20. 2006
    ..Emotional disorders such as depression and anxiety have been associated with hyperactivity of the amygdala, but it is unknown whether antidepressant treatment directly affects amygdala responses to emotionally significant information...
  75. ncbi request reprint Increased salivary cortisol after waking in depression
    Zubin Bhagwagar
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK
    Psychopharmacology (Berl) 182:54-7. 2005
    ..Cortisol hypersecretion is regarded as important in the pathophysiology of major depression. However, recent studies in community-based samples have been inconclusive...
  76. ncbi request reprint Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1256-63. 2004
    ..The present study therefore assessed the actions of repeated antidepressant administration on perception and memory for positive and negative emotional information in healthy volunteers...
  77. ncbi request reprint Increased waking salivary cortisol levels in young people at familial risk of depression
    Zola N Mannie
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
    Am J Psychiatry 164:617-21. 2007
    ..The present study sought to answer this question by measuring waking salivary cortisol levels in young people at familial risk of depression but with no personal history of mood disorder...
  78. ncbi request reprint Olanzapine increases slow wave sleep and sleep continuity in SSRI-resistant depressed patients
    Ann L Sharpley
    University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom
    J Clin Psychiatry 66:450-4. 2005
    ..The aim of the present study was to determine if the addition of olanzapine to SSRI treatment in depressed patients produced similar effects on sleep...
  79. ncbi request reprint Short-term antidepressant treatment and facial processing. Functional magnetic resonance imaging study
    Ray Norbury
    University of Oxford Centre for Clinical Magnetic Resonance Research, MRS Unit, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Br J Psychiatry 190:531-2. 2007
    ..Our results show that reboxetine modulates the neural substrates of emotional processing, highlighting a mechanism by which drug treatment could normalise negative bias in depression and anxiety...
  80. ncbi request reprint Impaired emotional categorisation in young people at increased familial risk of depression
    Zola N Mannie
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Neuropsychologia 45:2975-80. 2007
    ..However, impairment in emotional categorization could identify a high-risk phenotype and may indicate that people at genetic risk of depression have difficulty in using "mood as information"...
  81. ncbi request reprint Efficacy, safety and tolerability of duloxetine 60 mg once daily in major depression
    Philip J Cowen
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Curr Med Res Opin 21:345-56. 2005
    ..Duloxetine is a dual reuptake inhibitor of 5-HT and NA that has recently been licensed in the USA for the treatment of MDD...
  82. ncbi request reprint Lack of effect of tyrosine depletion on mood in recovered depressed women
    Sarah F B McTavish
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuropsychopharmacology 30:786-91. 2005
    ..However ratings of depression were unaffected, suggesting that disruption of dopaminergic function by this manipulation does not induce a lowering of mood in individuals vulnerable to depression...
  83. ncbi request reprint 5HT(3) antagonism abolishes the emotion potentiated startle effect in humans
    Catherine J Harmer
    Department of Experimental Psychology, University of Oxford, and University Department of Psychiatry, Warneford Hospital, Oxford, OX1 3UD, UK
    Psychopharmacology (Berl) 186:18-24. 2006
    ..The serotonergic system has been implicated in emotional processing in animals and humans. Although the contribution of different receptor subtypes has been hypothesised, there have been few direct tests of this in human subjects...
  84. ncbi request reprint Effect of branch chain amino acids supplemented with tryptophan on tyrosine availability and plasma prolactin
    Antonina Scarna
    Psychopharmacology (Berl) 159:222-3. 2002
  85. ncbi request reprint Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects
    Zubin Bhagwagar
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 61:806-12. 2007
    ..The aim of this study was to use MRS to determine whether changes in GABA and Glu levels were present in patients with mood disorders who had recovered and were no longer taking medication...
  86. ncbi request reprint Methamphetamine activates reward circuitry in drug naïve human subjects
    Birgit A Vollm
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropsychopharmacology 29:1715-22. 2004
    ..Our data also support recent hypotheses suggesting a central role for the orbitofrontal cortex in drug reinforcement and the development of addiction...
  87. doi request reprint Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls
    Rainer Hinz
    Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 28:1478-90. 2008
    ..The SERT occupancy for six target regions with moderate to high binding was 60% derived from BP(ND) and 69% derived from BP(P)...
  88. ncbi request reprint Effects of acute tyrosine depletion on subjective craving and selective processing of smoking-related cues in abstinent cigarette smokers
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    J Psychopharmacol 21:805-14. 2007
    ....
  89. ncbi request reprint Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study
    Andrew J Montgomery
    Imperial College, School of Medicine, University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 160:1887-9. 2003
    ..Extracellular dopamine concentrations were estimated through measurement of [(11)C]raclopride binding with positron emission tomography after dietary manipulation of the dopamine precursors tyrosine and phenylalanine...