Ian G Cowell

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Self-association of chromo domain peptides
    I G Cowell
    Department of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Biochim Biophys Acta 1337:198-206. 1997
  2. pmc Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin
    Ian G Cowell
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Nucleus 2:61-71. 2011
  3. pmc gammaH2AX foci form preferentially in euchromatin after ionising-radiation
    Ian G Cowell
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 2:e1057. 2007
  4. ncbi request reprint Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated
    Ian G Cowell
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    Biochem Pharmacol 71:13-20. 2005
  5. ncbi request reprint Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
    Yan Zhao
    Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Cancer Res 66:5354-62. 2006
  6. ncbi request reprint The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1
    Kayleigh A Smith
    Institute for Cellular and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer 53:117-28. 2014
  7. pmc MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA
    Ka Cheong Lee
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Biol Open 1:863-73. 2012
  8. ncbi request reprint Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure
    Chrysoula Leontiou
    The Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Mol Pharmacol 71:1006-14. 2007
  9. doi request reprint An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay
    Ian G Cowell
    Institute for Cell and Molecular Biosciences, Medical School, Catherine Cookson Building, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Mutagenesis 26:253-60. 2011
  10. pmc Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity
    Ian G Cowell
    Institute for Cellular and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 109:8989-94. 2012

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Self-association of chromo domain peptides
    I G Cowell
    Department of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Biochim Biophys Acta 1337:198-206. 1997
    ....
  2. pmc Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin
    Ian G Cowell
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Nucleus 2:61-71. 2011
    ..We suggest that this redistribution of topoIIβ converts this isoform of topoII to a effective relevant target for topoisomerase poisons...
  3. pmc gammaH2AX foci form preferentially in euchromatin after ionising-radiation
    Ian G Cowell
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 2:e1057. 2007
    ..However, we observed an apparently uneven distribution of gammaH2AX foci following X-irradiation with regions of the nucleus devoid of foci...
  4. ncbi request reprint Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated
    Ian G Cowell
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    Biochem Pharmacol 71:13-20. 2005
    ..However, simultaneous treatment with both compounds dramatically reduced gammaH2AX focus intensity, consistent with the reported role of ATM and DNA-PK in IR induced phosphorylation of H2AX...
  5. ncbi request reprint Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
    Yan Zhao
    Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Cancer Res 66:5354-62. 2006
    ..In conclusion, NU7441 shows sufficient proof of principle through in vitro and in vivo chemosensitization and radiosensitization to justify further development of DNA-PK inhibitors for clinical use...
  6. ncbi request reprint The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1
    Kayleigh A Smith
    Institute for Cellular and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer 53:117-28. 2014
    ..Specifically, we identified a TOP2B-dependent increase in the number of nuclei displaying juxtaposed RUNX1 and RUNX1T1 loci following etoposide treatment...
  7. pmc MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA
    Ka Cheong Lee
    Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Biol Open 1:863-73. 2012
    ..In K562 cells inhibition of MRE11, PARP or replication increased topoisomerase IIα and β complex levels formed in the absence of an anti-topoisomerase II drug...
  8. ncbi request reprint Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure
    Chrysoula Leontiou
    The Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Mol Pharmacol 71:1006-14. 2007
    ..Here, we compare the drug resistance profile of all nine mutations and report the biochemical characterization of three, betaG550R, betaY606C, and betaD661N...
  9. doi request reprint An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay
    Ian G Cowell
    Institute for Cell and Molecular Biosciences, Medical School, Catherine Cookson Building, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Mutagenesis 26:253-60. 2011
    ..Here, we give a perspective of the TARDIS assay including a comparison with other methods for quantifying topoisomerase-DNA covalent complexes and provide technical details required to set up and perform the assay...
  10. pmc Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity
    Ian G Cowell
    Institute for Cellular and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 109:8989-94. 2012
    ....
  11. pmc Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents
    Ian G Cowell
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH, UK
    Int J Environ Res Public Health 9:2075-91. 2012
    ....
  12. ncbi request reprint DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia
    Elaine Willmore
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Cancer Res 14:3984-92. 2008
    ..We hypothesized that inhibiting DNA-PK would sensitize CLL cells to drug-induced DNA damage and that this approach could increase the therapeutic index of agents used to treat CLL...
  13. ncbi request reprint Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53
    I G Cowell
    School of Biochemistry and Genetics, University of Newcastle, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Exp Cell Res 255:86-94. 2000
    ..Furthermore, we show that the regulatory C-terminal basic region of p53 (residues 364-393) is necessary and sufficient for interaction with DNA topo II...
  14. ncbi request reprint Nuclear distribution of human DNA topoisomerase IIbeta: a nuclear targeting signal resides in the 116-residue C-terminal tail
    I G Cowell
    The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Exp Cell Res 243:232-40. 1998
    ..Further analysis revealed that the nuclear localization determinant lies within the 116-residue C-terminal tail of human topoisomerase IIbeta...
  15. pmc NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform
    Eriko Toyoda
    International Graduate School of Arts and Sciences, Yokohama City University, 22 2 Seto, Kanazawa Ku, Yokohama, Japan
    J Biol Chem 283:23711-20. 2008
    ..We also suggest that a series of human knock-out cell lines are useful in assessing DNA damage and repair induced by potential topoisomerase-targeting agents...
  16. ncbi request reprint The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure
    Thomas Scholzen
    Division of Molecular Immunology, Research Center Borstel, D 23845 Borstel, Germany
    J Pathol 196:135-44. 2002
    ..Taken together, the data presented in this study suggest a role for pKi-67 in the control of higher-order chromatin structure...
  17. ncbi request reprint Loss of heterochromatin protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death
    Ilaria Filesi
    Department of Neuroscience, University of Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Cell Sci 115:1803-13. 2002
    ....
  18. ncbi request reprint Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals
    Ian G Cowell
    Division of Gene Expression and Development, The Roslin Institute Edinburgh, Midlothian, UK
    Chromosoma 111:22-36. 2002
    ..Finally, we provide evidence that Me9H3 is neither necessary nor sufficient for localisation of heterochromatin protein 1 (HP1) to chromosomal DNA...
  19. ncbi request reprint E4BP4/NFIL3, a PAR-related bZIP factor with many roles
    Ian G Cowell
    Department of Gene Expression and Development, The Roslin Institute Edinburgh, Roslin, Midlothian Scotland EH25 9PS
    Bioessays 24:1023-9. 2002
    ..This article will cover the unfolding role/s of and regulation of E4BP4, E4BP4-like proteins and PAR factors in species as diverse as mouse and C. elegans...