Research Topics
Genomes and GenesSpecies | Jenny A CourtSummaryAffiliation: University of Newcastle Country: UK Publications
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Publications
Differential nicotinic acetylcholine receptor subunit expression in the human hippocampusA J Graham
Joint MRC University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
J Chem Neuroanat 25:97-113. 2003..Immunoreactivity to all subunits was noted in association with blood vessels. These results indicate the involvement of multiple nAChR subtypes in the modulation of both neuronal and non-neuronal functions in the human hippocampus...- Neurotransmitter abnormalities in vascular dementiaJenny A Court
Joint MRC Newcastle University Centre Development in Clinical Brain Ageing, Newcastle General Hospital, Newcastle upon Tyne, UK
Int Psychogeriatr 15:81-7. 2003..These data suggest neurotransmitter systems as a potential therapeutic target in vascular dementia... - Attenuation of Abeta deposition in the entorhinal cortex of normal elderly individuals associated with tobacco smokingJ A Court
MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
Neuropathol Appl Neurobiol 31:522-35. 2005..Development of nicotinic drugs to protect against beta-amyloidosis as one of the principal pathological hallmarks of brain ageing and Alzheimer's disease is indicated... - Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medicationJ A Court
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
Neuroscience 98:79-87. 2000..Further study is warranted to explore which nicotinic receptor subunits and which neuronal compartments are involved in the changes in [3H]nicotine binding reported, to aid development of potential nicotinic receptor therapy... - Nicotinic receptors in human brain: topography and pathologyJ A Court
Joint MRC Newcastle University, Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
J Chem Neuroanat 20:281-98. 2000.... - Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodiesJ A Court
Joint MRC University of Newcastle Centre Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Pharmacol Biochem Behav 70:571-9. 2001..001). Loss of cortical alpha 7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia... - Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatumMelissa Ray
Institute for Ageing and Health, University of Newcastle upon Tyne, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Neurosci Lett 372:220-5. 2004.... - Selective changes in nicotinic acetylcholine receptor subtypes related to tobacco smoking: an immunohistochemical studyT Teaktong
MRC Building, Centre Development in Clinical Brain Ageing, Newcastle General Hospital, Newcastle upon Tyne, UK
Neuropathol Appl Neurobiol 30:243-54. 2004.... - Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expressionC Martin-Ruiz
Joint MRC-Newcastle University Centre Development for Clinical Brain Aging, MRC Building, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
Neurosci Lett 335:134-8. 2002..The results point to a possible abnormality of striatal nicotinic receptor assembly in PD and DLB... - Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellumA Graham
Joint MRC University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
Neuroscience 113:493-507. 2002..Further investigations are warranted to evaluate the participation of nicotinic acetylcholine receptors in cerebellar pathology associated with both developmental and age-related disorders... - Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease casesR E Goodchild
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK
Eur J Neurosci 11:449-56. 1999..These data suggest that H3-receptors are present upon striatonigral projection neurons of the direct and indirect movement pathways thus providing histaminergic control over the activity of both these circuits... - Neuronal nicotinic acetylcholine receptor subunits in autism: an immunohistochemical investigation in the thalamusM A Ray
Institute for Ageing and Health, University of Newcastle upon Tyne, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
Neurobiol Dis 19:366-77. 2005..This suggested loss of neuronal alpha7 in autism is not caused by loss of GABAergic neurons. These findings indicate nicotinic abnormalities that occur in the thalamus in autism which may contribute to sensory or attentional deficits... - Cholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [(125)I]alpha-conotoxinMII in the striatum and thalamusI J Bohr
Institute for Ageing and Health, Newcastle General Hospital, Centre Development in Clinical Brain Ageing, MRC Building, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Exp Neurol 191:292-300. 2005..In DLB + EPF and PD patients, there was decreased binding in the ventral lateral nucleus. This study demonstrates alterations of alpha6 and/or alpha3 nAChRs binding in DLB and PD, which are likely to relate to extra-pyramidal symptoms... - Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distributionM A Piggott
MRC Neurochemical Pathology Unit, Department of Neuropathology, Old Age Psychiatry, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
Brain 122:1449-68. 1999..The distinct changes in the rostrocaudal pattern of expression of dopaminergic parameters are relevant to the interpretation of the in vivo imaging and diagnosis of DLB... - Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrainE K Perry
Centre Development in Clinical Brain Ageing, Newcastle General Hospital, Newcastle upon Tyne, UK
Am J Psychiatry 158:1058-66. 2001..Measures of cholinergic transmitter activity were investigated in patients with autism because of reported neuropathological abnormalities in cholinergic nuclei in the basal forebrain... - Molecular analysis of nicotinic receptor expression in autismC M Martin-Ruiz
Joint MRC University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, Department of Neuropathology, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
Brain Res Mol Brain Res 123:81-90. 2004..The findings point to dendritic and/or synaptic nicotinic receptor abnormalities that may relate to disruptions in cerebral circuitry development... - Nicotinic receptor subtypes in human brain related to aging and dementiaE K Perry
Joint MRC-Newcastle University Centre Development in Clinical Brain Ageing, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
Alcohol 24:63-8. 2001..Correlations exist between some of these receptor abnormalities and clinical and pathological features of the diseases. Targeting such receptors is a current therapeutic objective... - Human brain nicotinic receptors, their distribution and participation in neuropsychiatric disordersA J Graham
Joint MRC-University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Curr Drug Targets CNS Neurol Disord 1:387-97. 2002..It is possible that the development of nAChR subtype specific drugs may lead to advances in therapy for both age-related and psychiatric disorders... - Physiological and biochemical studies on the cerebellar cortex of the murine mutants "jolting" and "motor end-plate disease"J B Harris
Muscular Dystrophy Group Research Laboratories, Newcastle General Hospital, UK
J Neurol Sci 110:186-94. 1992..It is suggested that an abnormality in the behaviour of a Ca2+ channel is the most likely origin for the deficit in these mutant mice...