S E Coupland

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Intraocular collision tumour: case report and literature review
    Sarah E Coupland
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 5th Floor Duncan Building, Daulby Street, Liverpool, L69 3GA, UK
    Graefes Arch Clin Exp Ophthalmol 251:1383-8. 2013
  2. pmc Molecular pathology of uveal melanoma
    S E Coupland
    Pathology, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
    Eye (Lond) 27:230-42. 2013
  3. pmc Molecular pathology of lymphoma
    S E Coupland
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
    Eye (Lond) 27:180-9. 2013
  4. ncbi request reprint The tale and molecular trail of a disseminated ocular adnexal malt lymphoma
    Sarah E Coupland
    Department of Pathology, University of Liverpool, Liverpool, UK
    Graefes Arch Clin Exp Ophthalmol 245:1055-9. 2007
  5. doi request reprint Understanding intraocular lymphomas
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK
    Clin Experiment Ophthalmol 36:564-78. 2008
  6. doi request reprint Proteomics of uveal melanomas suggests HSP-27 as a possible surrogate marker of chromosome 3 loss
    Sarah E Coupland
    Department of Pathology, School of Cancer Studies, University of Liverpool, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 51:12-20. 2010
  7. ncbi request reprint A TNM-based clinical staging system of ocular adnexal lymphomas
    Sarah E Coupland
    Department of Pathology, School of Cancer Studies, University of Liverpool, Duncan Bldg, Daulby St, Liverpool L69 3GA, England
    Arch Pathol Lab Med 133:1262-7. 2009
  8. pmc Pathophysiology of retinal lymphoma
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, England
    Ocul Immunol Inflamm 17:227-37. 2009
  9. doi request reprint The challenge of the microenvironment in B-cell lymphomas
    Sarah E Coupland
    Department of Pathology, University of Liverpool, Liverpool, UK
    Histopathology 58:69-80. 2011
  10. doi request reprint The pathologist's perspective on vitreous opacities
    S E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Royal Liverpool Hospital, Liverpool, UK
    Eye (Lond) 22:1318-29. 2008

Detail Information

Publications44

  1. doi request reprint Intraocular collision tumour: case report and literature review
    Sarah E Coupland
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 5th Floor Duncan Building, Daulby Street, Liverpool, L69 3GA, UK
    Graefes Arch Clin Exp Ophthalmol 251:1383-8. 2013
    ..Whilst quite common in the skin, the gastrointestional tract, and the ovaries, intraocular collision tumours are exceedingly rare. We describe an exceptional case of a combined uveal melanoma and intraocular plasmacytoma...
  2. pmc Molecular pathology of uveal melanoma
    S E Coupland
    Pathology, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
    Eye (Lond) 27:230-42. 2013
    ..The identification of abnormal signalling pathways, genes and proteins in UM opens the way for target-based therapies, improving prospects for conserving vision and prolonging life...
  3. pmc Molecular pathology of lymphoma
    S E Coupland
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
    Eye (Lond) 27:180-9. 2013
    ....
  4. ncbi request reprint The tale and molecular trail of a disseminated ocular adnexal malt lymphoma
    Sarah E Coupland
    Department of Pathology, University of Liverpool, Liverpool, UK
    Graefes Arch Clin Exp Ophthalmol 245:1055-9. 2007
    ....
  5. doi request reprint Understanding intraocular lymphomas
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK
    Clin Experiment Ophthalmol 36:564-78. 2008
    ..It would be preferable to refer to the various forms of intraocular lymphoma according to whether they are retinal, choroidal, ciliary or iridal and whether they are primary or secondary in these locations...
  6. doi request reprint Proteomics of uveal melanomas suggests HSP-27 as a possible surrogate marker of chromosome 3 loss
    Sarah E Coupland
    Department of Pathology, School of Cancer Studies, University of Liverpool, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 51:12-20. 2010
    ..To compare the proteomic profiles of primary uveal melanomas, with and without loss of chromosome 3...
  7. ncbi request reprint A TNM-based clinical staging system of ocular adnexal lymphomas
    Sarah E Coupland
    Department of Pathology, School of Cancer Studies, University of Liverpool, Duncan Bldg, Daulby St, Liverpool L69 3GA, England
    Arch Pathol Lab Med 133:1262-7. 2009
    ..The Ann Arbor system has several shortcomings, particularly when staging extranodal non- Hodgkin lymphomas, such as OAL, which show different dissemination patterns from nodal lymphomas...
  8. pmc Pathophysiology of retinal lymphoma
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, England
    Ocul Immunol Inflamm 17:227-37. 2009
    ..Further investigations, such as gene expression profiling, are required to identify oncogenic pathways potentially involved in retinal lymphoma development, and to identify new prognostic/therapeutic markers for this tumor...
  9. doi request reprint The challenge of the microenvironment in B-cell lymphomas
    Sarah E Coupland
    Department of Pathology, University of Liverpool, Liverpool, UK
    Histopathology 58:69-80. 2011
    ..As such, the microenvironment of B-cell lymphomas represents a challenge to the development of therapeutic agents, requiring re-direction and inclusion of these non-neoplastic supportive cells into future treatment strategies...
  10. doi request reprint The pathologist's perspective on vitreous opacities
    S E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Royal Liverpool Hospital, Liverpool, UK
    Eye (Lond) 22:1318-29. 2008
    ..An aetiological classification of vitreous opacities is also proposed...
  11. doi request reprint Analysis of intraocular biopsies
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK
    Dev Ophthalmol 49:96-116. 2012
    ..The current molecular genetic techniques for uveal melanoma prognostication are summarized, and how their data can be used for instigation of individualized management plans for patients discussed...
  12. ncbi request reprint Lymphomas involving the eye and the ocular adnexa
    Sarah E Coupland
    Department of Pathology, Royal Liverpool Hospital, Liverpool, England, UK
    Curr Opin Ophthalmol 17:523-31. 2006
    ..To describe recent advances in the understanding of the pathogenesis of the most common malignant lymphomas that occur as primary and secondary tumors in ocular tissues...
  13. pmc Differences in uveal melanomas between men and women from the British Isles
    B E Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 26:292-9. 2012
    ..The purpose of this study is to compare uveal melanomas (UMs) in men and women...
  14. doi request reprint Translating uveal melanoma cytogenetics into clinical care
    Bertil Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, England
    Arch Ophthalmol 127:423-9. 2009
    ..To report our experience in translating uveal melanoma cytogenetics to routine clinical practice...
  15. doi request reprint Clinical mapping of conjunctival melanomas
    B Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, UK
    Br J Ophthalmol 92:1545-9. 2008
    ..To develop a system for clinically mapping conjunctival melanomas, taking into account the tumour's stage of development, location and extent...
  16. pmc Conjunctival melanoma and melanocytic intra-epithelial neoplasia
    N Kenawy
    St Paul s Eye Unit, Liverpool Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 27:142-52. 2013
    ..Such improved prognostication would not only be more relevant to individual patients, but would also provide greater opportunities for basic science research...
  17. ncbi request reprint The Liverpool uveal melanoma liver metastases pathway: Outcome following liver resection
    D Gomez
    North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Liverpool, UK
    J Surg Oncol 109:542-7. 2014
    ..To determine the outcome of patients that underwent liver resection for metastases from uveal melanoma...
  18. ncbi request reprint Multiplex ligation-dependent probe amplification of uveal melanoma: correlation with metastatic death
    Bertil Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 50:3048-55. 2009
    ..To evaluate multiplex ligation-dependent probe amplification (MLPA) of uveal melanoma as a predictive tool for metastatic death...
  19. doi request reprint Routes of extraocular extension of uveal melanoma: risk factors and influence on survival probability
    Sarah E Coupland
    Department of Pathology, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Ophthalmology 115:1778-85. 2008
    ..To correlate extraocular spread with other survival predictors and with metastatic death and determine whether there was any relationship between the size of the extraocular tumor and survival...
  20. doi request reprint A reappraisal of the significance of largest basal diameter of posterior uveal melanoma
    B Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 23:2152-60; quiz 2161-2. 2009
    ..To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality...
  21. doi request reprint Genetic heterogeneity in uveal melanoma assessed by multiplex ligation-dependent probe amplification
    Justyna Dopierala
    Department of Pathology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Invest Ophthalmol Vis Sci 51:4898-905. 2010
    ..To determine intratumor genetic heterogeneity in uveal melanoma (UM) by multiplex ligation-dependent probe amplification (MLPA) in formalin-fixed, paraffin-embedded (FFPE) tumor tissues...
  22. doi request reprint Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma
    Sarah L Lake
    Pathology Department, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Invest Ophthalmol Vis Sci 51:4884-91. 2010
    ..To detect deletions and loss of heterozygosity of chromosome 3 in a rare subset of fatal, disomy 3 uveal melanoma (UM), undetectable by fluorescence in situ hybridization (FISH)...
  23. doi request reprint Artificial neural networks estimating survival probability after treatment of choroidal melanoma
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 115:1598-607. 2008
    ..e., any uveal melanoma involving choroid) and to demonstrate the value of entering age, sex, clinical stage, cytogenetic type, and histologic grade into the predictive model...
  24. ncbi request reprint Cytogenetics of uveal melanoma: a 7-year clinical experience
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 114:1925-31. 2007
    ..Since 1999, we have offered cytogenetic analysis to patients treated by local resection or enucleation. This study correlated our cytogenetic results with clinical and histologic predictors and disease-specific mortality...
  25. doi request reprint An audit of conjunctival melanoma treatment in Liverpool
    B Damato
    St Paul s Eye Unit, Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 23:801-9. 2009
    ..To evaluate treatment of conjunctival melanomas at the Ocular Oncology Service in Liverpool...
  26. doi request reprint Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Clin Experiment Ophthalmol 36:786-95. 2008
    ....
  27. ncbi request reprint Ocular adnexal lymphomas: five case presentations and a review of the literature
    Sarah E Coupland
    Department of Pathology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
    Surv Ophthalmol 47:470-90. 2002
    ....
  28. ncbi request reprint Extranodal marginal zone B-cell lymphoma of the lacrimal gland associated with crystal-storing histiocytosis
    Sarah E Coupland
    Department of Pathology, University Hospital Benjamin Franklin, Freie Universitat, Hindenburgdamm 30, D 12200 Berlin, Germany
    Ophthalmology 109:105-10. 2002
    ..This article reports the clinical, histopathologic, and molecular biologic findings of CSH in association with an extranodal marginal zone lymphoma (EMZL) of the lacrimal gland...
  29. ncbi request reprint Prognostic value of cell-cycle markers in ocular adnexal lymphoma: an assessment of 230 cases
    Sarah E Coupland
    Department of Pathology, University Hospital Benjamin Franklin of the Free University, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 242:130-45. 2004
    ..To determine the prognostic value of cell-cycle associated markers in ocular adnexal lymphoma (OAL)...
  30. ncbi request reprint Primary intraocular lymphoma of T-cell type: report of a case and review of the literature
    Sarah E Coupland
    Department of Pathology, Charite Medical Faculty Berlin, Campus Benjamin Franklin, Germany
    Graefes Arch Clin Exp Ophthalmol 243:189-97. 2005
    ..The aim of the current paper is to report the clinical, histopathological and molecular biological findings of a PIOL of T-cell type...
  31. ncbi request reprint Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial
    Kristoph Jahnke
    Department of Haematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 244:663-9. 2006
    ..The prognosis of intraocular lymphoma (IOL) is poor, and the optimal treatment has yet to be defined. This study assesses the clinical characteristics and outcome of patients with IOL diagnosed and treated in the new millennium...
  32. ncbi request reprint Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome
    Sarah E Coupland
    Department of Pathology, University Hospital Benjamin Franklin, Free University, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 241:860-70. 2003
    ....
  33. ncbi request reprint Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features
    Sarah E Coupland
    Department of Pathology, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, 12200, Germany
    Graefes Arch Clin Exp Ophthalmol 242:901-13. 2004
    ..PIOL remains one of the most difficult diagnoses to establish, particularly due to its ability to mimic other diseases in the eye and to the limited material which is often available for examination...
  34. ncbi request reprint Extranodal marginal zone B cell lymphomas of the uvea: an analysis of 13 cases
    Sarah E Coupland
    Department of Pathology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
    J Pathol 197:333-40. 2002
    ..Aberrant immune profiles of plasma cell-related antigens may be of help in the establishment of malignancy in uveal lymphoproliferative lesions, particularly where interpretation of light chain expression and/or PCR results is difficult...
  35. ncbi request reprint Diagnosis of a primary uveal extranodal marginal zone B-cell lymphoma by chorioretinal biopsy: case report
    Sarah E Coupland
    Department of Pathology, Charite University Hospital, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 243:482-6. 2005
    ..To report the clinical, histopathological and molecular biological findings of a primary extranodal marginal zone B-cell lymphoma (EMZL) of the uvea...
  36. ncbi request reprint Histological and immunohistochemical characterisation of conjunctival graft vs host disease following haematopoietic stem cell transplantation
    Claudia Auw-Haedrich
    Eye Hospital, Albert Ludwigs University, Killianstrasse 5, 79106 Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1001-7. 2007
    ..We additionally propose an adaptive histological classification for cnGvHD analogous to Lerner's GvHD skin classification for predicting patient survival...
  37. ncbi request reprint Molecular analysis of immunoglobulin genes in primary intraocular lymphoma
    Sarah E Coupland
    Department of Pathology, Charite University Hospital Berlin, Campus Benjamin Franklin, Germany
    Invest Ophthalmol Vis Sci 46:3507-14. 2005
    ..To analyze somatic hypermutations in clonally rearranged IgH chain variable (V) genes of primary intraocular lymphoma (PIOL), to identify the differentiation stage of B-PIOL cells...
  38. ncbi request reprint Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma
    Kristoph Jahnke
    Blood 106:384-5. 2005
  39. ncbi request reprint Assessment of HOPE fixation in vitrectomy specimens in patients with chronic bilateral uveitis (masquerade syndrome)
    Sarah E Coupland
    Department of Pathology and Haematopathology Reference Centre, Charite Medical Faculty Berlin, Campus Benjamin Franklin, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 243:847-52. 2005
    ....
  40. ncbi request reprint HHV-8-associated T-cell lymphoma in a lymph node with concurrent peritoneal effusion in an HIV-positive man
    Sarah E Coupland
    Department of Pathology, Charite University Medicine, Campus Benjamin Franklin, Berlin, Germany
    Am J Surg Pathol 29:647-52. 2005
    ..The following case provides another example of a lymph node-based "solid" PEL, demonstrating the variety within the spectrum of HHV-8-associated lymphoma...
  41. ncbi request reprint Treatment of primary intraocular lymphoma with oral trofosfamide: report of two cases and review of the literature
    Kristoph Jahnke
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 242:771-6. 2004
    ..The prognosis of primary intraocular lymphoma (PIOL) is poor. Due to frequent ocular and/or CNS relapses, the optimal treatment for PIOL has not yet been defined. This is the first report of PIOL treatment with trofosfamide...
  42. ncbi request reprint Low-grade primary central nervous system lymphoma in immunocompetent patients
    Kristoph Jahnke
    Department of Haematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, D 12200 Berlin, Germany
    Br J Haematol 128:616-24. 2005
    ..Low-grade PCNSL may differ from classical high-grade PCNSL in its clinical features and radiological morphology. The clinical course may be variable and frequently more indolent than in classical PCNSL...
  43. ncbi request reprint Long distance polymerase chain reaction of ascites lymphoma cells aids diagnosis establishment of abdominal Burkitt's lymphoma and Burkitt-like lymphoma
    Kristoph Jahnke
    Department of Hematology, Oncolgy and Transfusion Medicine, Charite Universitatsmedizin Berlin, Germany
    Leuk Lymphoma 46:83-6. 2005
    ..Long distance PCR analysis of ascites lymphoma cells for the detection of the BL-typical c-myc rearrangement offers a convenient and rapid possibility of diagnosis verification in atypical or borderline cases of BL...
  44. ncbi request reprint Expression of immunoglobulin transcription factors in primary intraocular lymphoma and primary central nervous system lymphoma
    Sarah E Coupland
    Department of Pathology, Charite University Medicine, Campus Benjamin Franklin, Berlin, Germany
    Invest Ophthalmol Vis Sci 46:3957-64. 2005
    ..PIOL is a rare non-Hodgkin lymphoma, considered a subtype of PCNSL. Both are usually diffuse, large B-cell lymphoma (DLBCL), rarely manifest outside the CNS, and carry a poor prognosis...