Seonaidh C Cotton
Affiliation: University of Aberdeen
- Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)Nishat Siddiqi
Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
J Transl Med 11:116. 2013..This is a phase II, randomised, placebo-controlled, double-blinded and multicentre trial...
- A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery--the FOCCUS studyBrian H Cuthbertson
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D132, Toronto, ON M4N 3M5, Canada
Crit Care 15:R296. 2011..Fluid strategies may impact on patient outcomes in major elective surgery. We aimed to study the effectiveness and cost-effectiveness of pre-operative fluid loading in high-risk surgical patients undergoing major elective surgery...
- After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trialSeonaidh Cotton
Institute of Applied Health Sciences, University of Aberdeen, Scotland, UK
Br J Gen Pract 61:e333-9. 2011..Although it is recognised that some women experience pain or bleeding during a cervical cytology test, few studies have quantified physical after-effects of these tests...
- Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial designSeonaidh C Cotton
Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
Contemp Clin Trials 27:449-71. 2006..This paper describes the design of the trial, and discusses the rationale underlying aspects of the design and the challenges faced in designing and implementing the trial...
- Lifestyle and socio-demographic factors associated with high-risk HPV infection in UK womenS C Cotton
Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland
Br J Cancer 97:133-9. 2007..In stratified analyses, current smear status and age remained associated with hrHPV infection. Data of this type are relevant to the debate on human papillomavirus (HPV) testing in screening and development of HPV vaccination programmes...
- Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intakeLinda Sharp
Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
Br J Nutr 99:379-89. 2008..Investigation of particular folate vitamers (for example, tetrahydrofolate, 5,10-methylenetetrahydrofolate) may help clarify carcinogenesis pathways...
- N-acetyltransferase polymorphisms and colorectal cancer: a HuGE reviewN Brockton
Department of Medicine and Therapeutics, University of Aberdeen, Scotland, United Kingdom
Am J Epidemiol 151:846-61. 2000....
- CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE reviewL Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
Am J Epidemiol 160:729-40. 2004..Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases...
- Postcolposcopy Management of Women With Histologically Proven CIN 1: Results From TOMBOLAMahalakshmi Gurumurthy
1Gynaecological Oncology, University Hospital of Llandough, Wales and 2University of Aberdeen, Aberdeen, United Kingdom 3National Cancer Registry Ireland, Cork, Ireland 4Aberdeen Royal Infirmary, Aberdeen, United Kingdom 5Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada and 6Warwick Medical School, Coventry, United Kingdom
J Low Genit Tract Dis 18:203-9. 2014....
- Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial of Management of Borderline and Other Low-grade Abnormal Smears) trialN M Gray
Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen, UK
Qual Life Res 14:1553-62. 2005..The POSM will enable comparison of the alternative management policies for low-grade cervical smears in terms of the benefits (or otherwise) perceived by the women managed by these policies...
- Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE reviewL F Masson
Epidemiology Group, Department of Public Health, University of Aberdeen, Aberdeen, Scotland
Am J Epidemiol 161:901-15. 2005....
- Psychological effects of a low-grade abnormal cervical smear test result: anxiety and associated factorsN M Gray
Department of General Practice and Primary Care, Foresterhill Health Centre, University of Aberdeen and Grampian University Hospitals, Aberdeen, UK
Br J Cancer 94:1253-62. 2006....
- Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)L Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Cancer Lett 181:65-71. 2002..Patterns in risk with regard to genotype and folate combinations are broadly similar those reported for colorectal neoplasia. The roles of MTHFR and folate in breast cancer aetiology are likely to be complex...
- Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of ScotlandJulian Little
Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
Int J Cancer 119:2155-64. 2006..There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other...
- Enclosing a pen with a postal questionnaire can significantly increase the response rateLinda Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
J Clin Epidemiol 59:747-54. 2006..It is important to maximize response rates to postal questionnaires. We compared the impact of three low-cost interventions on response rates...
- Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE reviewS C Cotton
Department of Medicine and Therapeutics, Faculty of Medicine and Medical Sciences, University of Aberdeen, Scotland
Am J Epidemiol 151:7-32. 2000..These finding require confirmation. Methods for determining GSTM1 and GSTT1 genotype are well established. Population testing is not currently justified...
- United Kingdom cervical cancer screening and the costs of time and travelClaire Woolley
University of Nottingham, UK
Int J Technol Assess Health Care 23:232-9. 2007....
- Refining the management of low-grade cervical abnormalities in the UK National Health Service and defining the potential for human papillomavirus testing: a commentary on emerging evidenceElaine Bentley
University of Nottingham Medical School at Derby, Derby City General Hospital, UK
J Low Genit Tract Dis 10:26-38. 2006