Michael J Cork

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi request reprint Association analysis of IL1A and IL1B variants in alopecia areata
    R Tazi-Ahnini
    Biomedical Genetics Project, Division of Genomic Medicine and Department of Dermatology, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Heredity (Edinb) 87:215-9. 2001
  2. ncbi request reprint Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis
    R Tazi-Ahnini
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Tissue Antigens 60:489-95. 2002
  3. ncbi request reprint Severe pruritus in a patient with urticaria pigmentosa treated with topical 5% urea and 3% polidocanol cream
    Jonathan Bowling
    J Dermatolog Treat 14:190-1. 2003
  4. doi request reprint Patch testing is a useful investigation in children with eczema
    Manar Moustafa
    Department of Paediatric Dermatology, Sheffield Children s NHS Foundation Trust, Western Bank, Sheffield S10 2TH, UK
    Contact Dermatitis 65:208-12. 2011
  5. pmc Effect on skin hydration of using baby wipes to clean the napkin area of newborn babies: assessor-blinded randomised controlled equivalence trial
    Tina Lavender
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    BMC Pediatr 12:59. 2012
  6. pmc Improved emollient use reduces atopic eczema symptoms and is cost neutral in infants: before-and-after evaluation of a multifaceted educational support programme
    James M Mason
    School of Medicine, Pharmacy and Health, Durham University, Durham, UK
    BMC Dermatol 13:7. 2013
  7. pmc Infant skin-cleansing product versus water: a pilot randomized, assessor-blinded controlled trial
    Tina Lavender
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    BMC Pediatr 11:35. 2011
  8. ncbi request reprint New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions
    Michael J Cork
    Pediatric Dermatology Clinic, Children s Hospital, Sheffield S10 2RX, UK
    J Allergy Clin Immunol 118:3-21; quiz 22-3. 2006
  9. ncbi request reprint Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse
    M J Cork
    Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield S10 2TH, UK
    Br J Dermatol 149:582-9. 2003
  10. doi request reprint Epidermal barrier dysfunction in atopic dermatitis
    Michael J Cork
    The Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield, UK
    J Invest Dermatol 129:1892-908. 2009

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Association analysis of IL1A and IL1B variants in alopecia areata
    R Tazi-Ahnini
    Biomedical Genetics Project, Division of Genomic Medicine and Department of Dermatology, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Heredity (Edinb) 87:215-9. 2001
    ..This was due mainly to the contribution from mild cases of alopecia areata [OR 1.48 (0.96, 2.29)], suggesting that IL-1 alpha may have a particular role in the pathogenesis of this subgroup...
  2. ncbi request reprint Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis
    R Tazi-Ahnini
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Tissue Antigens 60:489-95. 2002
    ..Moreover, our results could provide a rational explanation of the unusually high frequency of AA in APECED patients, supporting the concept of AA as an autoimmune disease...
  3. ncbi request reprint Severe pruritus in a patient with urticaria pigmentosa treated with topical 5% urea and 3% polidocanol cream
    Jonathan Bowling
    J Dermatolog Treat 14:190-1. 2003
  4. doi request reprint Patch testing is a useful investigation in children with eczema
    Manar Moustafa
    Department of Paediatric Dermatology, Sheffield Children s NHS Foundation Trust, Western Bank, Sheffield S10 2TH, UK
    Contact Dermatitis 65:208-12. 2011
    ..However, recently, allergic contact dermatitis has started to attract more interest as a cause of or contributor to eczema in children, and patch testing has been gaining in recognition as a useful diagnostic tool in this group...
  5. pmc Effect on skin hydration of using baby wipes to clean the napkin area of newborn babies: assessor-blinded randomised controlled equivalence trial
    Tina Lavender
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    BMC Pediatr 12:59. 2012
    ....
  6. pmc Improved emollient use reduces atopic eczema symptoms and is cost neutral in infants: before-and-after evaluation of a multifaceted educational support programme
    James M Mason
    School of Medicine, Pharmacy and Health, Durham University, Durham, UK
    BMC Dermatol 13:7. 2013
    ..Support and information about appropriate care may often be inadequate for patients and carers in the community...
  7. pmc Infant skin-cleansing product versus water: a pilot randomized, assessor-blinded controlled trial
    Tina Lavender
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    BMC Pediatr 11:35. 2011
    ..The aims were to produce baseline data which would inform decisions for the main trial design (i.e. population, primary outcome, sample size calculation) and to optimize the robustness of trial processes within the study setting...
  8. ncbi request reprint New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions
    Michael J Cork
    Pediatric Dermatology Clinic, Children s Hospital, Sheffield S10 2RX, UK
    J Allergy Clin Immunol 118:3-21; quiz 22-3. 2006
    ..One or more of these factors in combination might lead to a defective barrier, thereby increasing the risk of allergen penetration and succeeding inflammatory reaction, thus contributing to exacerbations of this disease...
  9. ncbi request reprint Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse
    M J Cork
    Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield S10 2TH, UK
    Br J Dermatol 149:582-9. 2003
    ..There has been little work assessing compliance/concordance with complex treatment regimens for atopic eczema. Asthma schools led by specialist nurses have been shown to improve knowledge, use of therapies and clinical outcome...
  10. doi request reprint Epidermal barrier dysfunction in atopic dermatitis
    Michael J Cork
    The Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield, UK
    J Invest Dermatol 129:1892-908. 2009
    ..Our understanding of gene-environment interactions should lead to a better use of some topical products, avoidance of others, and the increased use and development of products that can repair the skin barrier...
  11. doi request reprint HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction
    Yiannis Vasilopoulos
    The Medical School, University of Sheffield, Sheffield, UK
    J Hum Genet 56:423-7. 2011
    ....
  12. doi request reprint Genetic analysis of autoimmune regulator haplotypes in alopecia areata
    D A Wengraf
    School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Tissue Antigens 71:206-12. 2008
    ..84 x 10(-7), 11.40 (3.53-36.9) and P = 3.94 x 10(-4), 2.13 (1.39-3.24) respectively]. The AIRE risk haplotypes identified in this study potentially account for a major component of the genetic risk of developing alopecia areata...
  13. ncbi request reprint Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis
    Y Vasilopoulos
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital Medical School, Beech Hill Road, Sheffield, UK
    J Invest Dermatol 123:62-6. 2004
    ..31; p=0.0007]. The AACC insertion in the SCCE gene may result in a change to SCCE activity within the skin barrier. These findings suggest that SCCE could have an important role in the development of atopic dermatitis...
  14. ncbi request reprint Predisposition to sensitive skin and atopic eczema
    Michael J Cork
    Division of Genomic Medicine, University of Sheffield Medical School
    Community Pract 78:440-2. 2005
    ..The skin may become red and dry after repeated application of these products. New insights into the skin barrier can help us improve treatment of the skin and prevent problems associated with atopic eczema and sensitive skin..
  15. doi request reprint The autoimmune regulator gene (AIRE) is strongly associated with vitiligo
    R Tazi-Ahnini
    Division of Genomic Medicine, University of Sheffield, Sheffield S10 2RX, UK
    Br J Dermatol 159:591-6. 2008
    ..3. We have previously detected an association between alopecia areata and single nucleotide polymorphisms (SNPs) in the AIRE gene...
  16. ncbi request reprint Analysis of a microsatellite polymorphism of the cytotoxic T-lymphocyte antigen-4 gene in patients with vitiligo
    E H Kemp
    Section of Medicine, Division of Clinical Sciences Northern General Hospital, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, U K
    Br J Dermatol 140:73-8. 1999
    ..These results indicate that there is no association between the 106-bp allele and vitiligo, at least when the disorder occurs in the absence of an autoimmune disease...
  17. ncbi request reprint The development of a preference-based measure of health in children with atopic dermatitis
    K J Stevens
    Division of Genomic Medicine University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
    Br J Dermatol 153:372-7. 2005
    ..These measures are also usually developed for adults and may not capture the domains pertinent to children...
  18. ncbi request reprint Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region
    R Tazi-Ahnini
    Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, UK
    Hum Genet 106:639-45. 2000
    ..34, 95% CI 1.24-4.43, P = 0.0072), providing new evidence of genetic heterogeneity in AA. Our demonstration of genetic association between the MX1 gene and disease supports the hypothesis that this is a new candidate gene in AA...
  19. ncbi request reprint Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction
    R Tazi-Ahnini
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Eur J Immunogenet 29:25-30. 2002
    ..38 (2.64, 15.42), P = 0.0002]. Our results suggest that these polymorphisms within IL1RN and IL1L1 themselves or a gene in linkage disequilibrium with IL1RN and IL1L1 predispose to the more severe forms of alopecia areata...
  20. ncbi request reprint Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata
    R Tazi-Ahnini
    Dermato Immunogenetics Group, Biomedical Genetics Project, Division of Genomic Medicine, D Floor Medical School, Royal Hallamshire Hospital, University of Sheffield, Sheffield, S10 2RX, UK
    Hum Genet 112:400-3. 2003
    ..02 (1.64, 9.88), P=0.0014]. These results support previous findings showing that different HLA susceptibility alleles are associated with mild and severe AA...
  21. doi request reprint Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5
    Yiannis Vasilopoulos
    School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Eur J Hum Genet 16:1002-9. 2008
    ..22, P=0.0004, 95% CI= 1.42, 3.49). These results represent a major step towards the dissection of genetic factors involved in the pathogenesis of psoriasis...
  22. ncbi request reprint A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis
    Y Vasilopoulos
    The division of Genomic Medicine, University of Sheffield, Sheffield, UK
    Allergy 62:514-9. 2007
    ....
  23. doi request reprint Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care
    Simon G Danby
    Academic Unit of Dermatology Research, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield Medical School, Sheffield, UK
    Pediatr Dermatol 30:42-50. 2013
    ..These findings challenge the unfounded belief that all natural oils are beneficial for the skin and highlight the need for further research...
  24. ncbi request reprint The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata
    E Helen Kemp
    Division of Clinical Sciences North, University of Sheffield, Sheffield, S5 7AU, UK
    Hum Immunol 67:535-9. 2006
    ..05). These results suggest that the non-synonymous C1858T substitution in the PTPN22 gene may have an influence on the severity of alopecia areata and provide further evidence for autoimmunity as an aetiological factor in this disorder...
  25. ncbi request reprint Genome-wide studies of psoriasis susceptibility loci: a review
    Gurdeep S Sagoo
    Biomedical Genetics Project, Division of Genomic Medicine, D Floor Medical School, Royal Hallamshire Hospital, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    J Dermatol Sci 35:171-9. 2004
    ..This approach could provide a much more powerful technique to study the genetics of a complex disease such as psoriasis...
  26. ncbi request reprint Adverse effects of topical glucocorticosteroids
    Ulrich R Hengge
    Department of Dermatology, Heinrich Heine University Duesseldorf, Germany
    J Am Acad Dermatol 54:1-15; quiz 16-8. 2006
    ..The authors provide an updated review of local and systemic adverse effects upon administration of topical corticosteroids, including the latest FDA report on the safety of such steroids in children...
  27. ncbi request reprint Single-point haplotype scores telomeric to human leukocyte antigen-C give a high susceptibility major histocompatibility complex haplotype for psoriasis in a Caucasian population
    Nick Lench
    Oxagen Limited, Abingdon, Oxon, UK
    J Invest Dermatol 124:545-52. 2005
    ..53; p=0.0051). Our results give scores as high as the highest single-point scores suggesting that it is unlikely to be able to discriminate the origin of the association on this analysis on strength of association...
  28. doi request reprint An update on the safety and tolerability of pimecrolimus cream 1%: evidence from clinical trials and post-marketing surveillance
    Richard G B Langley
    Division of Dermatology, Department of Medicine, Dalhousie University, and Queen Elizabeth II Health Science Centre, Halifax, NS, Canada
    Dermatology 215:27-44. 2007
    ..While cases of malignancy have been reported in patients who have used pimecrolimus cream 1%, there is no clinical evidence to establish that treatment with pimecrolimus cream 1% increases the risk of malignancy...
  29. ncbi request reprint Interleukin-1: a key inflammatory mediator in psoriasis?
    John B Mee
    St John s Institute of Dermatology, King s College London, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Cytokine 33:72-8. 2006
    ..Taken together, these data suggest that IL-1 is likely to be an important mediator in the initiation and maintenance of psoriatic plaques and may represent an attractive therapeutic target...