Research Topics
Species | Andrew CoppSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Differential effects of early hippocampal pathology on episodic and semantic memoryF Vargha-Khadem
Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK
Science 277:376-80. 1997..The findings provide support for the view that the episodic and semantic components of cognitive memory are partly dissociable, with only the episodic component being fully dependent on the hippocampus...
Neural basis of an inherited speech and language disorderF Vargha-Khadem
Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, Wolfson Centre, Mecklenbourgh Square, London WC1N 2AP, United Kingdom
Proc Natl Acad Sci U S A 95:12695-700. 1998....
FOXP2 and the neuroanatomy of speech and languageFaraneh Vargha-Khadem
Institute of Child Health, University College London and Great Ormond Street Hospital for Children, 30 Guilford Street, London WC1N 1EH, UK
Nat Rev Neurosci 6:131-8. 2005....
Quantification of the shape of fiber tractsP G Batchelor
Centre for Medical Image Computing, Medical Physics, University College London, London, United Kingdom
Magn Reson Med 55:894-903. 2006..The potential for these techniques to be used in neuroscience research and clinical applications is demonstrated...
The role of the medial temporal lobe in autistic spectrum disordersC H Salmond
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, UK
Eur J Neurosci 22:764-72. 2005..The structural imaging data highlight abnormalities in several brain regions previously implicated in ASD, including the medial temporal lobes...
Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI studyF Liegeois
Developmental Cognitive Neuroscience Unit, Institute of Child Health, UCL, 4th Floor, 30 Guilford Street, London WC1N 1EH, UK
Brain 127:1229-36. 2004..In conclusion, it is difficult to infer intra- versus inter-hemispheric language reorganization on the basis of clinical observations in the presence of early pathology to the left hemisphere...
Magnetic resonance imaging findings within 5 days of status epilepticus in childhoodRod C Scott
Great Ormond Street Hospital for Children NHS Trust, Institute of Child Health, University College London, London, UK
Brain 125:1951-9. 2002..A systematic longitudinal study is required to characterize the evolution of these abnormalities and to determine whether any patient develops MTS...
Limitations and requirements of diffusion tensor fiber tracking: an assessment using simulationsJ D Tournier
Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
Magn Reson Med 47:701-8. 2002..The results derived from real data show similar trends and thus support the findings of the simulations. These simulations may therefore help to determine which structures can be tracked for a given image quality...
Quantification of perfusion using bolus tracking magnetic resonance imaging in stroke: assumptions, limitations, and potential implications for clinical useF Calamante
Radiology and Physics Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children National Health Service Trust, London, UK
Stroke 33:1146-51. 2002..The purpose of this article is to discuss some of the issues involved and the potential implications for absolute cerebral blood flow measurements in clinical use...
Endophenotypes of FOXP2: dysfunction within the human articulatory networkF Liegeois
Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Eur J Paediatr Neurol 15:283-8. 2011..We suggest that nonword repetition is the optimal endophenotype for FOXP2 disruption in humans because this task recruits brain regions involved in the imitation and vocal learning of novel sequences of speech sounds...
MR perfusion imaging in Moyamoya Syndrome: potential implications for clinical evaluation of occlusive cerebrovascular diseaseF Calamante
Radiology and Physics Units, Institute of Child Health, University College London, UK
Stroke 32:2810-6. 2001..This study investigates the scope and limitations of perfusion MRI in the clinical evaluation of such patients...
Quantitative magnetic resonance characterization of mesial temporal sclerosis in childhoodR C Scott
Neurosciences Unit, Institute of Child Health, University College London, UK
Neurology 56:1659-65. 2001..To investigate whether quantitative MR techniques can be used to distinguish between mesial temporal sclerosis in patients with a history of prolonged febrile convulsion and in patients without such a history...
Correction for eddy current induced Bo shifts in diffusion-weighted echo-planar imagingF Calamante
Radiology and Physics Unit, Institute of Child Health, University College London Medical School, England
Magn Reson Med 41:95-102. 1999..The method uses a non-phase-encoded reference scan to correct the phase of each echo in the echo train, and can provide ADC maps that are free of misregistration artifacts, without the need for off-line postprocessing...
Diffusion and perfusion magnetic resonance imaging in childhood strokeD G Gadian
Radiology and Physics Unit, Institute of Child Health, University College London Medical School, UK
J Child Neurol 15:279-83. 2000..These magnetic resonance methods therefore should play an important role in investigation of children with stroke and could be of particular value in studies of at-risk populations of children such as those with sickle cell disease...
Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decompositionF Calamante
Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
Magn Reson Med 44:466-73. 2000..While the error introduced by the delay can be corrected by using the information of the arrival time of the bolus, the correction for the dispersion is less straightforward and requires a model for the vasculature...
Perfusion magnetic resonance abnormalities in patients with sickle cell diseaseF J Kirkham
Neurosciences Unit, Institute of Child Health, University College London, United Kingdom
Ann Neurol 49:477-85. 2001..Perfusion abnormalities are associated with neurological symptoms in patients with SCD, whether or not MRI, MR angiography, and TCD are abnormal. It is likely that this technique will guide management in individual patients...
The precision of anatomical normalization in the medial temporal lobe using spatial basis functionsC H Salmond
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, 30 Guilford Street, London WCIN 1EM, United Kingdom
Neuroimage 17:507-12. 2002..quot; The implications of our results, for users of voxel-based morphometry, are discussed...
MRI analysis of an inherited speech and language disorder: structural brain abnormalitiesK E Watkins
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, London, UK
Brain 125:465-78. 2002..These results thus provide further evidence of a relationship between the abnormal development of this nucleus and the impairments in oromotor control and articulation reported in the KE family...
A direct test for lateralization of language activation using fMRI: comparison with invasive assessments in children with epilepsyF Liegeois
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 2AP, United Kingdom
Neuroimage 17:1861-7. 2002..It is suggested that the direct method could be used in future fMRI studies to establish hemispheric lateralization for cognitive functions...
Distributional assumptions in voxel-based morphometryC H Salmond
Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, United Kingdom
Neuroimage 17:1027-30. 2002..This is despite the fact that conventional group comparisons appear to be robust, remaining valid even with no smoothing. The implications of the results for researchers using voxel-based morphometry are discussed...
A rigorous framework for diffusion tensor calculusP G Batchelor
Imaging Sciences Division, 5th Floor Thomas Guy House, King s College London, London Southern 9RT, UK
Magn Reson Med 53:221-5. 2005..From this distance a method for computing tensor means, a new measure of anisotropy, and a method for tensor interpolation are derived. The method is illustrated using simulated and in vivo data...
Anisotropic noise propagation in diffusion tensor MRI sampling schemesP G Batchelor
Imaging Sciences Division, King's College, Guy's Campus, London, UK
Magn Reson Med 49:1143-51. 2003..The recommended choice of directions for a DT-MRI experiment is therefore the icosahedral set of directions with the highest number of directions achievable in the available time...
