Matthew A Cooper

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Optical biosensors: where next and how soon?
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    Drug Discov Today 11:1061-7. 2006
  2. ncbi request reprint Surface plasmon resonance analysis at a supported lipid monolayer
    M A Cooper
    Department of Chemistry, Cambridge Centre for Molecular Recognition, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochim Biophys Acta 1373:101-11. 1998
  3. ncbi request reprint Direct and sensitive detection of a human virus by rupture event scanning
    M A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
    Nat Biotechnol 19:833-7. 2001
  4. ncbi request reprint Non-optical screening platforms: the next wave in label-free screening?
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    Drug Discov Today 11:1068-74. 2006
  5. ncbi request reprint Advances in membrane receptor screening and analysis
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Recognit 17:286-315. 2004
  6. ncbi request reprint Biosensor profiling of molecular interactions in pharmacology
    Matthew A Cooper
    Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    Curr Opin Pharmacol 3:557-62. 2003
  7. ncbi request reprint Label-free screening of bio-molecular interactions
    Matthew A Cooper
    Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, CB2 1EW, Cambridge, UK
    Anal Bioanal Chem 377:834-42. 2003
  8. ncbi request reprint Optical biosensors in drug discovery
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Nat Rev Drug Discov 1:515-28. 2002
  9. ncbi request reprint A vesicle capture sensor chip for kinetic analysis of interactions with membrane-bound receptors
    M A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Anal Biochem 277:196-205. 2000
  10. pmc A high sensitivity assay for the inflammatory marker C-Reactive protein employing acoustic biosensing
    Jeffrey D McBride
    Akubio Ltd, 181 Cambridge Science Park, Cambridge, CB4 0GJ, UK
    J Nanobiotechnology 6:5. 2008

Collaborators

  • Xin Li
  • D H Williams
  • Chris Abell
  • Tom L Blundell
  • Wilhelm T S Huck
  • Stacey Efstathiou
  • Jonathan M Blackburn
  • Sylvain Ladame
  • Dejian Zhou
  • Julien E Gautrot
  • Sergey A Piletsky
  • Ling Huang
  • Darren J Hart
  • Madeleine Ramstedt
  • T Inoue
  • Yildiz Uludag
  • Benjamin Godber
  • A G Smith
  • F von Delft
  • Matthew Batchelor
  • Jelena Trmcic-Cvitas
  • Jeffrey D McBride
  • Kevin S J Thompson
  • Marian Rehak
  • Mark Frogley
  • Alexander Sleptsov
  • A Ciulli
  • O Kerbarh
  • Marie de Lumley
  • U Genschel
  • C M C Lobley
  • James A Schouten
  • F N Dultsev
  • D Matak-Vinkovic
  • M H Todd
  • M Fiorini
  • Trevor Rayment
  • V Dhanaraj
  • Erol Hasan
  • Heather Coleman
  • Anthony P F Turner
  • A Albert
  • E M M Bulloch
  • F Rebeille
  • R J Payne
  • Klaus Wiehler
  • T Sahr
  • Sven Kelling
  • Christopher Whalen
  • Stefan Symeonides
  • Stephen J Mason
  • M E Webb
  • M L Kilkenny
  • H Whitney
  • E Chakauya
  • K L Tuck
  • F Schmitzberger
  • L M Birch
  • H H Ottenhof
  • Shankar Balasubramanian
  • R McKendry
  • A Lewendon
  • J L Ashurst
  • S A Saldanha
  • V P Ostanin
  • M T Fiorini
  • R N Miguel
  • D Klenerman
  • R E Speight
  • M Vinkovic
  • T Rayment
  • C A Powell
  • R Pulido
  • B L Sibanda
  • G Khan
  • M K Ramjee
  • M Witty
  • P R Alefounder
  • A R Battersby
  • A D Miller
  • M Lander
  • A R Pitt
  • G J Hart
  • D Bardy
  • L C Packman

Detail Information

Publications38

  1. ncbi request reprint Optical biosensors: where next and how soon?
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    Drug Discov Today 11:1061-7. 2006
    ..However, optical label-free platforms have not yet made a major impact in the drug discovery technology markets; are often viewed as having poor throughput, limited application; and are difficult to learn and use effectively...
  2. ncbi request reprint Surface plasmon resonance analysis at a supported lipid monolayer
    M A Cooper
    Department of Chemistry, Cambridge Centre for Molecular Recognition, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochim Biophys Acta 1373:101-11. 1998
    ..Conditions for the formation of lipid monolayers have been optimised with respect to lipid type, chemical and buffer compatibility, ligand stability and reproducibility...
  3. ncbi request reprint Direct and sensitive detection of a human virus by rupture event scanning
    M A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
    Nat Biotechnol 19:833-7. 2001
    ..We term this process rupture event scanning (REVS). The method is quantitative over at least six orders of magnitude, and its sensitivity approaches detection of a single virus particle...
  4. ncbi request reprint Non-optical screening platforms: the next wave in label-free screening?
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    Drug Discov Today 11:1068-74. 2006
    ..This article highlights key advances in commercial label-free analysis platforms, which complement more traditional optical system and which also allow novel assay formats for the analysis of previously intractable targets...
  5. ncbi request reprint Advances in membrane receptor screening and analysis
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Recognit 17:286-315. 2004
    ..To aid the experimenter, a brief synopsis of the techniques commonly employed to purify and reconstitute membranes and membrane receptors is included...
  6. ncbi request reprint Biosensor profiling of molecular interactions in pharmacology
    Matthew A Cooper
    Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    Curr Opin Pharmacol 3:557-62. 2003
    ..In addition, novel biosensor applications are being developed for the predictive profiling of key pharmacokinetic parameters of a molecule (adsorption, distribution, metabolism, excretion and toxicity)...
  7. ncbi request reprint Label-free screening of bio-molecular interactions
    Matthew A Cooper
    Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, CB2 1EW, Cambridge, UK
    Anal Bioanal Chem 377:834-42. 2003
    ....
  8. ncbi request reprint Optical biosensors in drug discovery
    Matthew A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Nat Rev Drug Discov 1:515-28. 2002
    ..This article reviews important advances in optical-biosensor instrumentation and applications, and also highlights some exciting developments, such as highly multiplexed optical-biosensor arrays...
  9. ncbi request reprint A vesicle capture sensor chip for kinetic analysis of interactions with membrane-bound receptors
    M A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Anal Biochem 277:196-205. 2000
    ..No binding of the bacterial endotoxin Cry1A(c) to captured vesicles containing its cell surface receptor could be demonstrated...
  10. pmc A high sensitivity assay for the inflammatory marker C-Reactive protein employing acoustic biosensing
    Jeffrey D McBride
    Akubio Ltd, 181 Cambridge Science Park, Cambridge, CB4 0GJ, UK
    J Nanobiotechnology 6:5. 2008
    ....
  11. ncbi request reprint Kinetic analysis of antibody-antigen interactions at a supported lipid monolayer
    M A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Anal Biochem 276:36-47. 1999
    ..The affinities determined by Scatchard analysis of equilibrium binding levels were similar to those values obtained from an ELISA...
  12. pmc Profiling of molecular interactions in real time using acoustic detection
    Benjamin Godber
    Akubio Ltd, Unit 181 Cambridge Science Park, Cambridge CB4 0GJ, UK
    Biosens Bioelectron 22:2382-6. 2007
    ..Example applications are described for the quantification of myoglobin concentration and its interaction kinetics, and for the ranking of enzyme-cofactor specificities...
  13. ncbi request reprint Direct acoustic profiling of DNA hybridisation using HSV type 1 viral sequences
    Yildiz Uludag
    Akubio Ltd, 181 Cambridge Science Park, Cambridge, UK CB4 0GJ
    Analyst 133:52-7. 2008
    ..Using a three minute hybridisation with NeutrAvidin capture for signal enhancement, it was possible to detect HSV viral nucleic acids at 5.2 x 10(-11) M concentration...
  14. ncbi request reprint Quantification of small molecule-receptor affinities and kinetics by acoustic profiling
    Xin Li
    Akubio Ltd, Cambridge, UK
    Assay Drug Dev Technol 4:565-73. 2006
    ....
  15. ncbi request reprint Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms
    Jelena Trmcic-Cvitas
    Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
    Biomacromolecules 10:2885-94. 2009
    ..We found evidence that large macromolecules cannot infiltrate dense polymer brushes and that bulky antibody recognition occurs in the upper part of these coatings...
  16. ncbi request reprint A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions
    Matthew A Cooper
    Akubio Ltd, 181 Cambridge Science Park, Cambridge, United Kingdom, UK
    J Mol Recognit 20:154-84. 2007
    ..Key differentiators between optical and acoustic sensing modalities are also reviewed...
  17. pmc Single-step biocompatible coating for sulfhydryl coupling of receptors using 2-(pyridinyldithio)ethylcarbamoyl dextran
    Xin Li
    Akubio Ltd, 181 Cambridge Science Park, Cambridge, United Kingdom
    Colloids Surf B Biointerfaces 61:113-7. 2008
    ....
  18. ncbi request reprint Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis
    A Ciulli
    University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    Biochem Soc Trans 33:767-71. 2005
    ..Recent work on ketopantoate reductase, which catalyses an important step on the biosynthetic pathway to vitamin B5, is used to illustrate the potential of this approach...
  19. ncbi request reprint Structural insights into the evolution of the pantothenate-biosynthesis pathway
    C M C Lobley
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Biochem Soc Trans 31:563-71. 2003
    ..We conclude that it is likely to have evolved via a patchwork mechanism, whereby the individual enzymes were recruited separately...
  20. pmc The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice)
    U Genschel
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, U K
    Biochem J 341:669-78. 1999
    ..Antibodies raised against recombinant PS detected a band of 34 kDa in Western blots of Lotus proteins from both roots and leaves. The implications of these findings for pantothenate biosynthesis in plants are discussed...
  21. ncbi request reprint Piezoelectric sensors based on molecular imprinted polymers for detection of low molecular mass analytes
    Yildiz Uludag
    Cranfield Health, Cranfield University, Silsoe, UK, and Akubio Ltd, Cambridge, UK
    FEBS J 274:5471-80. 2007
    ..Analytes are classified by type and sample matrix presentation and various molecularly imprinted polymer synthetic fabrication strategies are also reviewed...
  22. doi request reprint Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy
    Matthew Batchelor
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW
    Org Biomol Chem 8:1142-8. 2010
    ..Clear adhesive contacts were observed between the vancomycin-sensitive peptide surfaces when vancomycin was present in solution, and the adhesion force demonstrated a clear dependence on antibiotic concentration...
  23. ncbi request reprint Direct quantification of analyte concentration by resonant acoustic profiling
    Benjamin Godber
    Akubio Ltd, Cambridge, United Kingdom
    Clin Chem 51:1962-72. 2005
    ..Applications include detection of bacteria, viruses, and oligonucleotides and measurement of myoglobin, interleukin 1beta (IL-1beta), and enzyme cofactors...
  24. ncbi request reprint Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism
    D Matak-Vinkovic
    Department of Biochemistry, University of Cambridge, UK
    Biochemistry 40:14493-500. 2001
    ..A model for the ternary enzyme-NADPH-ketopantoate ternary complex provides a rationale for kinetic data reported for specific site-directed mutants...
  25. ncbi request reprint A biophysical characterisation of factors controlling dimerisation and selectivity in the NF-kappaB and NFAT families
    Marie de Lumley
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    J Mol Biol 339:1059-75. 2004
    ....
  26. ncbi request reprint G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection
    James A Schouten
    University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Am Chem Soc 125:5594-5. 2003
    ..The heterocycle enhanced peptide binding affinity by approximately 1000-fold to give ligands with near micromolar affinity and >40-fold discrimination for quadruplex DNA over duplex...
  27. ncbi request reprint Real-time label-free acoustic technology for rapid detection of Escherichia coli O157:H7
    Ling Huang
    Akubio Limited, 181 Cambridge Science Park, Cambridge, CB4 0GJ, UK
    Clin Chem 52:2148-51. 2006
  28. pmc Chemical force microscopy with active enzymes
    M Fiorini
    Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom
    Biophys J 80:2471-6. 2001
    ..These experiments represent a step in the development of a screening methodology based upon chemical force microscopy...
  29. ncbi request reprint Profiling molecular interactions using label-free acoustic screening
    Matthew A Cooper
    Akubio Ltd, Unit 181 Cambridge Science Park, Cambridge, UK CB4 0GJ Electronic
    Drug Discov Today Technol 2:241-5. 2005
    ..We describe a recent advancement in label-free analysis from Akubio, Resonant Acoustic Profiling™ (RAP™) that has the potential to change the way assays are performed and to generate novel information on molecular interactions.: ..
  30. ncbi request reprint Measurement of Drug Lipophilicity and pK(a) Using Acoustics
    Xin Li
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Anal Chem 84:2609-13. 2012
    ..The lipophilicity/pH profile of a weakly basic drug (quinine; pK(a) = 7.95) was sigmoidal with respect to -dF/M(w) values, with a profile inverse to that of a weakly acidic drug (naproxen; pK(a) = 4.15)...
  31. pmc Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding
    M Lander
    University Chemical Laboratory, University of Cambridge, U K
    Biochem J 275:447-52. 1991
    ....
  32. ncbi request reprint Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing
    A Albert
    Department of Biochemistry, Cambridge, UK
    Nat Struct Biol 5:289-93. 1998
    ..The ester is an intermediate in the autocatalytic self-processing leading to formation of the pyruvoyl group. This unprecedented structure provides novel insights into the general phenomenon of protein processing...
  33. ncbi request reprint Novel chemical tagging method for combinatorial synthesis utilizing suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry
    M H Todd
    University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    J Comb Chem 3:319-27. 2001
    ..The method is exemplified for the coded assembly of a tripeptide...
  34. ncbi request reprint The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily
    F von Delft
    Department of Biochemistry, 80 Tennis Court Road, CB2 1GA, Cambridge, United Kingdom
    Structure 9:439-50. 2001
    ..Pantothenate synthetase (EC 6.3.2.1) is the last enzyme of the pathway of pantothenate (vitamin B(5)) synthesis. It catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction...
  35. pmc The sequence of hemC, hemD and two additional E. coli genes
    P R Alefounder
    University Chemical Laboratory, Cambridge, UK
    Nucleic Acids Res 16:9871. 1988
  36. pmc Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase)
    A D Miller
    University Chemical Laboratory, Cambridge, U K
    Biochem J 262:119-24. 1989
    ..Evidence is gained showing that (a) modification of one of two conserved lysine residues (Lys-55 or Lys-59) results in inactivation of hydroxymethylbilane synthase and (b) these lysine residues are present in or close to the active site...
  37. ncbi request reprint Direct and quantitative detection of bacteriophage by "hearing" surface detachment using a quartz crystal microbalance
    F N Dultsev
    Department of Chemistry, Cambridge University, UK
    Anal Chem 73:3935-9. 2001
    ..The detection is quantitative over at least 5 orders of magnitude and is sensitive enough to detect as few as 20 phage. The method has potential as a sensitive and low-cost method for virus detection...
  38. ncbi request reprint Mechanistic and inhibition studies of chorismate-utilizing enzymes
    O Kerbarh
    University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, UK
    Biochem Soc Trans 33:763-6. 2005
    ..A three-dimensional model for this enzyme was constructed that will guide the search for potent inhibitors of salicylate formation, and hence of bacterial iron uptake...