J D Cooper

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1730-7. 2008
  2. pmc Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    Rebecca Bailey
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 56:2616-21. 2007
  3. pmc Seven newly identified loci for autoimmune thyroid disease
    Jason D Cooper
    Department of Medical Genetics, Cambridge Institute for Medical Research, Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hum Mol Genet 21:5202-8. 2012
  4. pmc Confirmation of novel type 1 diabetes risk loci in families
    J D Cooper
    Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 55:996-1000. 2012
  5. pmc Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2XY, UK
    BMC Med Genet 7:20. 2006
  6. pmc Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes
    Gerard A J Morris
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    BMC Genet 7:12. 2006
  7. pmc Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes
    Lisa M Maier
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge, UK
    BMC Genet 6:9. 2005
  8. pmc Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1
    J D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S95-120. 2009
  9. pmc Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families
    J D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S85-94. 2009
  10. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008

Detail Information

Publications42

  1. doi request reprint PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1730-7. 2008
    ....
  2. pmc Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    Rebecca Bailey
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 56:2616-21. 2007
    ..Our aim was to study the association between the CYP27B1 and CYP24A1 gene polymorphisms and type 1 diabetes...
  3. pmc Seven newly identified loci for autoimmune thyroid disease
    Jason D Cooper
    Department of Medical Genetics, Cambridge Institute for Medical Research, Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hum Mol Genet 21:5202-8. 2012
    ..12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases...
  4. pmc Confirmation of novel type 1 diabetes risk loci in families
    J D Cooper
    Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 55:996-1000. 2012
    ....
  5. pmc Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2XY, UK
    BMC Med Genet 7:20. 2006
    ..Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with other immune-mediated diseases might perturb immune homeostasis, and hence also associate with predisposition to T1D...
  6. pmc Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes
    Gerard A J Morris
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    BMC Genet 7:12. 2006
    ....
  7. pmc Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes
    Lisa M Maier
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge, UK
    BMC Genet 6:9. 2005
    ..2), FRAP1 (orthologous to Frap1 in Idd9.2), 4-1BB/CD137/TNFRSF9 (orthologous to 4-1bb/Cd137/Tnrfrsf9 in Idd9.3), CD101/IGSF2 (orthologous to Cd101/Igsf2 in Idd10), B2M (orthologous to B2m in Idd13) and VAV3 (orthologous to Vav3 in Idd18)...
  8. pmc Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1
    J D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S95-120. 2009
    ..0 x 10(-4); odds ratio (OR)=0.92, 95% CI=0.88-0.96). This region, which contains many genes, has also been associated with rheumatoid arthritis...
  9. pmc Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families
    J D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S85-94. 2009
    ..Both TLR8 and TLR7 are functional candidate genes owing to their key roles as pathogen recognition receptors and, in the case of TLR7, overexpression has been associated directly with murine autoimmune disease...
  10. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
    ..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8))...
  11. pmc The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    BMC Med Genet 8:71. 2007
    ..In addition, we tested seven genes, TAF5L, PDCD1, TCF7, IL12B, IL6, ICAM1 and TBX21, with published marginal or inconsistent evidence of an association with type 1 diabetes...
  12. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  13. pmc No association of multiple type 2 diabetes loci with type 1 diabetes
    S M Raj
    Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetologia 52:2109-16. 2009
    ..11 at a false-positive rate of 0.003...
  14. doi request reprint Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  15. ncbi request reprint Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    Christopher E Lowe
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, UK
    Nat Genet 39:1074-82. 2007
    ..635). Furthermore, we have associated IL2RA T1D susceptibility genotypes with lower circulating levels of the biomarker, soluble IL-2RA (P = 6.28 x 10(-28)), suggesting that an inherited lower immune responsiveness predisposes to T1D...
  16. pmc CD226 Gly307Ser association with multiple autoimmune diseases
    J P Hafler
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Genes Immun 10:5-10. 2009
    ..20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017). The Ser(307) allele of rs763361 in exon 7 of CD226 predisposes to T1D, MS, and possibly AITD and RA, and based on the tag SNP analysis, could be the causal variant...
  17. pmc Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK
    Nature 450:887-92. 2007
    ..Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes...
  18. pmc Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes
    A Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetologia 51:811-5. 2008
    ..We therefore examined the association between common genetic variation in IGF1 and predisposition to type 1 diabetes, childhood growth and metabolism...
  19. doi request reprint Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes
    M L Marcovecchio
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:1173-81. 2009
    ..As microalbuminuria is preceded by a gradual rise in albumin excretion within the normal range, we hypothesised that ambulatory BP (ABP) may be closely related to albumin excretion and progression to microalbuminuria...
  20. pmc Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    Calliope A Dendrou
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Nat Genet 41:1011-5. 2009
    ....
  21. ncbi request reprint Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes
    Felicity Payne
    Juvenile Diabetes Research Foundation Wellcome Trust, Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge, UK
    J Leukoc Biol 81:581-3. 2007
    ....
  22. ncbi request reprint Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing
    Jeffrey S Szeszko
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetes 55:559-62. 2006
    ....
  23. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009
    ..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27...
  24. ncbi request reprint No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, U K
    Diabetes 55:1525-8. 2006
    ..99; P = 0.83). These results suggest that additional evidence of association of a low penetrance effect in common disease should be sought when the primary result comes from unaffected siblings in the absence of any effect in cases...
  25. ncbi request reprint A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 38:617-9. 2006
    ..In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A --> G (A946T) was 0.86 (95% confidence interval = 0.82-0.90) at P = 1.42 x 10(-10)...
  26. pmc Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
    ....
  27. ncbi request reprint Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Diabetes 53:2709-12. 2004
    ..K. and found no evidence of association. Overall, our results indicate that common sequence variation in the VDR gene has no major effect in type 1 diabetes in the populations tested...
  28. pmc Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    Adrian Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Hum Genet 76:773-9. 2005
    ..3x10(-3); combined P=1.3x10(-10)). These results illustrate the utility of tag SNPs in a chromosome-regional test of disease association and justify future fine mapping of the causal variant in the region...
  29. ncbi request reprint Population structure, differential bias and genomic control in a large-scale, case-control association study
    David G Clayton
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nat Genet 37:1243-6. 2005
    ..To avoid excluding SNPs and losing valuable information, we extended the genomic control method by applying a variable downweighting to each SNP...
  30. pmc A method to address differential bias in genotyping in large-scale association studies
    Vincent Plagnol
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 3:e74. 2007
    ..Therefore, we propose the use of "fuzzy" calls to deal with uncertain genotypes that would otherwise be labeled as missing...
  31. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
    ..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten...
  32. ncbi request reprint No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility
    Rebecca Pask
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY UK
    Diabetes Metab Res Rev 22:356-60. 2006
    ..Replication of association in independent, large-sample studies is essential to further identify the genes involved in T1D. Two single nucleotide polymorphisms (SNPs) in the catalase gene have been reported to be associated with T1D...
  33. ncbi request reprint Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb
    Felicity Payne
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, U K
    Diabetes 53:505-9. 2004
    ..484 for IAN4L1 and 0.692 for CBLB, suggesting that neither gene influences susceptibility to common alleles of human type 1 diabetes in these populations...
  34. ncbi request reprint Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes
    John S Hulme
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
    Diabetes 53:2479-82. 2004
    ..We conclude that a major role for the common LCK polymorphisms in type 1 diabetes is unlikely. However, we cannot rule out the possibility of there being a causal variant outside the exonic, intronic, and untranslated regions studied...
  35. ncbi request reprint Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    Deborah Smyth
    Juvenile Diabetes Research Foundation JDRF Wellcome Trust WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge, UK
    Diabetes 53:3020-3. 2004
    ..24 x 10(-4); OR 1.43 [95% CI 1.17-1.76]). Taken together, these results indicate a more general association of the PTPN22 locus with autoimmune disease...
  36. ncbi request reprint Cost-effective analysis of candidate genes using htSNPs: a staged approach
    C E Lowe
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, UK
    Genes Immun 5:301-5. 2004
    ..A saving of approximately 75% of potential genotyping reactions could be made with minimal loss of power. There was little evidence from our analysis for association between the TRANCE and RANK genes and T1D in the populations tested...
  37. ncbi request reprint No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes
    Felicity Payne
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge, UK
    Biochem Biophys Res Commun 331:435-41. 2005
    ..4, FLJ25454, FLJ13162, FLJ11152, PHF10 and CCR6. This study also provides an exon-based tag single nucleotide polymorphism map for these 10 genes that can be used for analysis of other diseases...
  38. ncbi request reprint Can we identify adolescents at high risk for nephropathy before the development of microalbuminuria?
    D B Dunger
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Diabet Med 24:131-6. 2007
    ..To determine whether higher than average albumin excretion during early puberty identifies subjects who will subsequently develop microalbuminuria (MA) and clinical proteinuria...
  39. pmc Prevalence of abnormal lipid profiles and the relationship with the development of microalbuminuria in adolescents with type 1 diabetes
    M Loredana Marcovecchio
    Department of Paediatrics and the Institute of Metabolic Science, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Care 32:658-63. 2009
    ..To explore the prevalence of lipid abnormalities and their relationship with albumin excretion and microalbuminuria in adolescents with type 1 diabetes...
  40. ncbi request reprint Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power
    Juliet M Chapman
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Hum Hered 56:18-31. 2003
    ..A new 'multi-locus TDT' is also proposed...
  41. ncbi request reprint Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    Oliver J Brand
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Clin Endocrinol (Oxf) 66:508-12. 2007
    ....
  42. pmc Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users
    Jonathan P Roiser
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke, s Hospital, Cambridge CB2 2QQ, UK
    Am J Psychiatry 162:609-12. 2005
    ..The authors' goal was to assess the contribution of a functional polymorphism in the gene encoding serotonin transporter to changes in emotional processing following chronic Ecstasy use...