Research Topics
| C E CooperSummaryAffiliation: University of Essex Country: UK Publications
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Publications
Nitrogen dioxide oxidizes mitochondrial cytochrome cRebecca S Silkstone
Department of Biological Sciences, University of Essex, Colchester, Essex, UK
Free Radic Biol Med 52:80-7. 2012..The present study does not support the previous hypothesis that NO and cytochrome c can generate appreciable amounts of nitroxyl ions (NO(-) or HNO) or of peroxynitrite...
Comparison of local adipose tissue content and SRS-derived NIRS muscle oxygenation measurements in 90 individualsChris E Cooper
Department of Biological Sciences, Centre for Sports and Exercise Science, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Adv Exp Med Biol 662:177-81. 2010..There was a strong positive correlation between adipose content and TOI in male subjects. However, no correlation was seen in the female group. The possible optical and physiological explanations for these results are discussed...- Radical producing and consuming reactions of hemoglobin: how can we limit toxicity?Chris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK
Artif Organs 33:110-4. 2009..Molecules have been designed with these modifications and this article will review their role in determining mechanism as well as their possible functionality as blood substitutes... 
Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiologyChris E Cooper
Dept of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom
Am J Physiol Cell Physiol 292:C1993-2003. 2007..However, a detailed mapping of NO and oxygen levels, combined with direct measures of cytochrome oxidase/NO binding, in physiology is still awaited...- Drugs and ergogenic aids to improve sport performanceChris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
Essays Biochem 44:1-10. 2008 - The biochemistry of drugs and doping methods used to enhance aerobic sport performanceChris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
Essays Biochem 44:63-83. 2008..However, given the proven success of blood doping and EPO, attempts to manipulate these pathways are likely to lead to an ongoing battle between the athlete and the drug testers... - A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidaseChris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
Biochim Biophys Acta 1777:867-76. 2008..Antioxid. Redox Signal. 9 (2007) 1569-1579)... - Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC)Chris E Cooper
Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ UK
Biochim Biophys Acta 1784:1415-20. 2008..The present finding confirms the primary and secondary roles of ascorbate and urate respectively in maintaining the oxidative stability of infused Hb... - The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significanceChris E Cooper
Department of Biological Sciences, University of Essex, Colchester, UK
J Bioenerg Biomembr 40:533-9. 2008..A reasonable case can be made for NO, and perhaps CO and H(2)S, inhibiting cytochrome oxidase in vivo, but endogenous levels of HCN seem unlikely to be high enough... - Steady state redox levels in cytochrome oxidase: relevance for in vivo near infrared spectroscopy (NIRS)Chris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester Essex, CO4 3SQ, UK
Adv Exp Med Biol 645:123-8. 2009..However, it titrated with an apparent redox potential of +230 mV, far from its equilibrium value (+400 mV). The implications of these results for the interpretation of non invasive measurements of mitochondrial function are discussed... - Bicuculline-induced seizures: a challenge for optical and biochemical modeling of the cytochrome oxidase CuA NIRS signalChris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester Essex, CO4 3SQ, UK
Adv Exp Med Biol 645:129-34. 2009.... - Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxideChris E Cooper
Department of Biological Sciences, University of Essex, Colchester C04 3SQ, UK
IUBMB Life 55:591-7. 2003..This review critically assesses the present state of knowledge as regards the hypothesis that nitric oxide is a competitive, reversible, physiological inhibitor of cytochrome oxidase... - Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studiesChris E Cooper
Department of Biological Sciences, University of Essex, Central Campus Wivenhoe Park, Essex CO4 3SQ, Colchester, UK
Biochim Biophys Acta 1607:27-34. 2003..Studies of cell respiration that fail to vary the oxygen concentration systematically are therefore likely to significantly underestimate the degree of irreversible damage to cytochrome oxidase... - Effects of nitric oxide and peroxynitrite on the cytochrome oxidase K(m) for oxygen: implications for mitochondrial pathologyC E Cooper
Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
Biochim Biophys Acta 1459:390-6. 2000.... - Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?Chris E Cooper
Dept of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
Trends Biochem Sci 27:33-9. 2002..Therefore, NO can be a substrate, inhibitor or effector of cytochrome oxidase, depending on cellular conditions... - The relationship of oxygen delivery to absolute haemoglobin oxygenation and mitochondrial cytochrome oxidase redox state in the adult brain: a near-infrared spectroscopy studyC E Cooper
Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
Biochem J 332:627-32. 1998..The results suggest that the brain maintains more than adequate oxygen delivery to mitochondria and that near-infrared spectroscopy may be a good measure of oxygen insufficiency in vivo... - Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins with nitric oxide?C E Cooper
Department of Biological Sciences, University of Essex, Central Campus, Colchester, UK
FEBS Lett 414:281-4. 1997..These reactions may have implications for the interactions of NO with other copper proteins... - Exercise, free radicals and oxidative stressC E Cooper
Centre for Sports and Exercise Science, Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, U K
Biochem Soc Trans 30:280-5. 2002..We suggest that the free-radical-mediated damage caused by the interaction of metmyoglobin and methaemoglobin with peroxides may be an important source of oxidative stress during exercise... - Nitric oxide and iron proteinsC E Cooper
Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
Biochim Biophys Acta 1411:290-309. 1999..The possible significance of iron reactions with reactive NO metabolites, in particular peroxynitrite and nitroxyl anion, is also discussed... - A new sensitive assay reveals that hemoglobin is oxidatively modified in vivoNiels B J Vollaard
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
Free Radic Biol Med 39:1216-28. 2005..The exercise-induced increase is short-lived, suggesting the existence of an active mechanism for repairing or removing the damaged heme proteins... - Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivoJacqueline Dunne
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
Biochem J 399:513-24. 2006..g. haemolytic anaemias, subarachnoid haemorrhage, rhabdomyolysis... - Fast reduction of a copper center in laccase by nitric oxide and formation of a peroxide intermediateJaume Torres
Department of Biological Sciences, University of Essex, Wivenhoe Park CO4 3SQ, Colchester, Essex, UK
J Am Chem Soc 124:963-7. 2002..This enables the O-O scission step in the catalytic cycle to be studied by electron addition to the peroxide derivative through the native electron entry site, type 1 copper... - A model of brain circulation and metabolism: NIRS signal changes during physiological challengesMurad Banaji
Department of Biological Sciences, University of Essex, Colchester, United Kingdom
PLoS Comput Biol 4:e1000212. 2008..The comparisons are encouraging, showing that the model is able to reproduce observed behaviour in response to various stimuli... - Tyrosine residues as redox cofactors in human hemoglobin: implications for engineering nontoxic blood substitutesBrandon J Reeder
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
J Biol Chem 283:30780-7. 2008..Engineering hemoglobin with enhanced rates of ferryl removal, as we show here, is therefore likely to result in molecules better suited for in vivo oxygen delivery... - Comparative study of tyrosine radicals in hemoglobin and myoglobins treated with hydrogen peroxideDimitri A Svistunenko
Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
Biophys J 83:2845-55. 2002..Tyr103 is the closest to the heme. We suggest that Tyr103 is the initial site of the radical, which then rapidly migrates to Tyr151... - Modelling of mitochondrial oxygen consumption and NIRS detection of cytochrome oxidase redox stateMurad Banaji
Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK
Adv Exp Med Biol 662:285-91. 2010..Our findings indicate strongly that the DeltaoxCCO signal contains useful information despite the noise, and has responses consistent with the known physiology... - Nitrosyl heme production compared in endotoxemic and hemorrhagic shockNathan A Davies
Department of Biological Sciences, University of Essex, Colchester, Essex, UK
Free Radic Biol Med 38:41-9. 2005.... - The steady-state mechanism of cytochrome c oxidase: redox interactions between metal centresMaria G Mason
Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
Biochem J 422:237-46. 2009..Turnover is instead dependent upon electron transfer from haem a to haem a3, but the haem a potential closely matches cytochrome c at all times... - Tryptophan or tyrosine? On the nature of the amino acid radical formed following hydrogen peroxide treatment of cytochrome c oxidaseDimitri A Svistunenko
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Biochim Biophys Acta 1655:372-80. 2004..This correspondence between the two enzymes at least allows the possibility that this radical may have functional importance... - A new method of identifying the site of tyrosyl radicals in proteinsDimitri A Svistunenko
Department of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom
Biophys J 87:582-95. 2004..The possibility of a similar relationship between rho(C) and g(x) in other radicals, e.g., tryptophanyl, is discussed... - Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain componentsDimitri A Svistunenko
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Biochim Biophys Acta 1757:262-72. 2006.... - A quantitative approach to nitric oxide inhibition of terminal oxidases of the respiratory chainMaria G Mason
Department of Biological Sciences, University of Essex, Colchester, United Kingdom
Methods Enzymol 437:135-59. 2008..Additionally, it describes a system designed to acquire polarographic and spectral data simultaneously to permit identification of spectral intermediates under defined conditions... - Ferryl haem protonation gates peroxidatic reactivity in globinsRadu Silaghi Dumitrescu
Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK
Biochem J 403:391-5. 2007..We also demonstrate for the first time a direct correlation between Hb/Mb ferryl reactivity and ferryl protonation status, simultaneously informing on chemical mechanism and toxicity and with broader biochemical implications... - Near infrared spectroscopy as a noninvasive assessment of cortical abnormality in migraine?Murray Griffin
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, England
Adv Exp Med Biol 578:203-8. 2006 - NIRS-detected changes in the motor cortex during mental rehearsal of physical activity (imaginary exercise)Chris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, England
Adv Exp Med Biol 578:185-90. 2006 - Inhibition of mitochondrial respiration during early stage sepsisNathan A Davies
Dept. Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
Adv Exp Med Biol 530:725-36. 2003..We conclude that nitric oxide produced in response to a septic insult can inhibit mitochondria causing an impairment of oxygen utilisation by aerobic respiration... - Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen speciesChris E Cooper
Dept of Biological Sciences, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
Trends Biochem Sci 27:489-92. 2002..The findings offer the enticing possibility that the cell can distinguish between different degrees of oxidant and nitrosative exposure by modification at a single site on a signaling molecule... - Cytochrome bd confers nitric oxide resistance to Escherichia coliMaria G Mason
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
Nat Chem Biol 5:94-6. 2009..coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate... - Blood volume changes are controlled centrally not locally--a near-infrared spectroscopy study of one legged aerobic exerciseChris E Cooper
University of Essex, Essex, United Kingdom
Adv Exp Med Biol 530:627-35. 2003..The large haemodynamic changes in the non-exercising leg observed here may be partially responsible for the cross-training effect... - Exercise-induced oxidative stress in overload training and taperingNiels B J Vollaard
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, United Kingdom
Med Sci Sports Exerc 38:1335-41. 2006..It was hypothesized that overload training will increase oxidative stress through an accumulative effect of repeated high-intensity exercise, whereas tapering will improve the antioxidant defense system and alleviate oxidative stress... - NIRS-detected changes in the arm during mental rehearsal of physical activity (imaginary exercise)Chris E Cooper
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, England
Adv Exp Med Biol 578:191-6. 2006 - Endogenous superoxide production and the nitrite/nitrate ratio control the concentration of bioavailable free nitric oxide in leavesAnatoly F Vanin
Institute of Chemical Physics, Russian Academy of Sciences, Moscow 117977, Russia
J Biol Chem 279:24100-7. 2004.... - Exercise-induced oxidative stress:myths, realities and physiological relevanceNiels B J Vollaard
School of Life Sciences, Heriot Watt University, Edinburgh, UK
Sports Med 35:1045-62. 2005..It is clear that ROS play important roles in numerous physiological processes at rest; however, the detailed physiological functions of ROS in exercise remain to be elucidated... - Exogenous ferrous iron is required for the nitric oxide-catalysed destruction of the iron-sulphur centre in adrenodoxinNina V Voevodskaya
Institute of Chemical Physics, Russian Academy of Sciences, Kosygin str. 4, Moscow, 119991, Russia
Biochem J 368:633-9. 2002..This attack leads to a release of endogenous iron from the centres, which is capable of forming both low-molecular-mass and protein-bound DNIC, thereby ensuring further ISC degradation... - Association between mitochondrial dysfunction and severity and outcome of septic shockDavid Brealey
Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute of Biomedical Research and Department of Medicine, University College London, London W1T 3AA, UK
Lancet 360:219-23. 2002..These data implicate bioenergetic failure as an important pathophysiological mechanism underlying multiorgan dysfunction... - A wide gap second derivative NIR spectroscopic method for measuring tissue hemoglobin oxygen saturationDean E Myers
Hutchinson Technology Inc, Hutchinson, Minnesota 55350, USA
Adv Exp Med Biol 578:217-22. 2006 - Protein-template-driven formation of polynuclear iron speciesSimon A Malone
School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK
J Am Chem Soc 126:496-504. 2004..From analyses of X-ray structures and amino acid sequence comparisons, possible nucleation sites are identified... - Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasisJonathan P McHugh
School of Animal and Microbial Sciences, University of Reading, Reading, RG6 6AJ, United Kingdom
J Biol Chem 278:29478-86. 2003..In combination, the results provide compelling evidence for the regulation of intracellular iron consumption by the Fe2+-Fur complex...