C E Cooper

Summary

Affiliation: University of Essex
Country: UK

Publications

  1. pmc Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145
    Chris E Cooper
    School of Biological Sciences, University of Essex, Essex, United Kingdom
    Antioxid Redox Signal 18:2264-73. 2013
  2. pmc Nitrogen dioxide oxidizes mitochondrial cytochrome c
    Rebecca S Silkstone
    Department of Biological Sciences, University of Essex, Colchester, Essex, UK
    Free Radic Biol Med 52:80-7. 2012
  3. doi request reprint Steady state redox levels in cytochrome oxidase: relevance for in vivo near infrared spectroscopy (NIRS)
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester Essex, CO4 3SQ, UK
    Adv Exp Med Biol 645:123-8. 2009
  4. ncbi request reprint Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiology
    Chris E Cooper
    Dept of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom
    Am J Physiol Cell Physiol 292:C1993-2003. 2007
  5. doi request reprint Drugs and ergogenic aids to improve sport performance
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Essays Biochem 44:1-10. 2008
  6. doi request reprint The biochemistry of drugs and doping methods used to enhance aerobic sport performance
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Essays Biochem 44:63-83. 2008
  7. doi request reprint A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidase
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
    Biochim Biophys Acta 1777:867-76. 2008
  8. doi request reprint Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC)
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ UK
    Biochim Biophys Acta 1784:1415-20. 2008
  9. doi request reprint The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Colchester, UK
    J Bioenerg Biomembr 40:533-9. 2008
  10. doi request reprint Radical producing and consuming reactions of hemoglobin: how can we limit toxicity?
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK
    Artif Organs 33:110-4. 2009

Collaborators

Detail Information

Publications49

  1. pmc Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145
    Chris E Cooper
    School of Biological Sciences, University of Essex, Essex, United Kingdom
    Antioxid Redox Signal 18:2264-73. 2013
    ....
  2. pmc Nitrogen dioxide oxidizes mitochondrial cytochrome c
    Rebecca S Silkstone
    Department of Biological Sciences, University of Essex, Colchester, Essex, UK
    Free Radic Biol Med 52:80-7. 2012
    ..The present study does not support the previous hypothesis that NO and cytochrome c can generate appreciable amounts of nitroxyl ions (NO(-) or HNO) or of peroxynitrite...
  3. doi request reprint Steady state redox levels in cytochrome oxidase: relevance for in vivo near infrared spectroscopy (NIRS)
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester Essex, CO4 3SQ, UK
    Adv Exp Med Biol 645:123-8. 2009
    ..However, it titrated with an apparent redox potential of +230 mV, far from its equilibrium value (+400 mV). The implications of these results for the interpretation of non invasive measurements of mitochondrial function are discussed...
  4. ncbi request reprint Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiology
    Chris E Cooper
    Dept of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom
    Am J Physiol Cell Physiol 292:C1993-2003. 2007
    ..However, a detailed mapping of NO and oxygen levels, combined with direct measures of cytochrome oxidase/NO binding, in physiology is still awaited...
  5. doi request reprint Drugs and ergogenic aids to improve sport performance
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Essays Biochem 44:1-10. 2008
  6. doi request reprint The biochemistry of drugs and doping methods used to enhance aerobic sport performance
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Essays Biochem 44:63-83. 2008
    ..However, given the proven success of blood doping and EPO, attempts to manipulate these pathways are likely to lead to an ongoing battle between the athlete and the drug testers...
  7. doi request reprint A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidase
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
    Biochim Biophys Acta 1777:867-76. 2008
    ..Antioxid. Redox Signal. 9 (2007) 1569-1579)...
  8. doi request reprint Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC)
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ UK
    Biochim Biophys Acta 1784:1415-20. 2008
    ..The present finding confirms the primary and secondary roles of ascorbate and urate respectively in maintaining the oxidative stability of infused Hb...
  9. doi request reprint The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Colchester, UK
    J Bioenerg Biomembr 40:533-9. 2008
    ..A reasonable case can be made for NO, and perhaps CO and H(2)S, inhibiting cytochrome oxidase in vivo, but endogenous levels of HCN seem unlikely to be high enough...
  10. doi request reprint Radical producing and consuming reactions of hemoglobin: how can we limit toxicity?
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK
    Artif Organs 33:110-4. 2009
    ..Molecules have been designed with these modifications and this article will review their role in determining mechanism as well as their possible functionality as blood substitutes...
  11. doi request reprint Bicuculline-induced seizures: a challenge for optical and biochemical modeling of the cytochrome oxidase CuA NIRS signal
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester Essex, CO4 3SQ, UK
    Adv Exp Med Biol 645:129-34. 2009
    ....
  12. doi request reprint Comparison of local adipose tissue content and SRS-derived NIRS muscle oxygenation measurements in 90 individuals
    Chris E Cooper
    Department of Biological Sciences, Centre for Sports and Exercise Science, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Adv Exp Med Biol 662:177-81. 2010
    ..There was a strong positive correlation between adipose content and TOI in male subjects. However, no correlation was seen in the female group. The possible optical and physiological explanations for these results are discussed...
  13. ncbi request reprint Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxide
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Colchester C04 3SQ, UK
    IUBMB Life 55:591-7. 2003
    ..This review critically assesses the present state of knowledge as regards the hypothesis that nitric oxide is a competitive, reversible, physiological inhibitor of cytochrome oxidase...
  14. ncbi request reprint Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins with nitric oxide?
    C E Cooper
    Department of Biological Sciences, University of Essex, Central Campus, Colchester, UK
    FEBS Lett 414:281-4. 1997
    ..These reactions may have implications for the interactions of NO with other copper proteins...
  15. ncbi request reprint Exercise, free radicals and oxidative stress
    C E Cooper
    Centre for Sports and Exercise Science, Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, U K
    Biochem Soc Trans 30:280-5. 2002
    ..We suggest that the free-radical-mediated damage caused by the interaction of metmyoglobin and methaemoglobin with peroxides may be an important source of oxidative stress during exercise...
  16. ncbi request reprint Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?
    Chris E Cooper
    Dept of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
    Trends Biochem Sci 27:33-9. 2002
    ..Therefore, NO can be a substrate, inhibitor or effector of cytochrome oxidase, depending on cellular conditions...
  17. ncbi request reprint Effects of nitric oxide and peroxynitrite on the cytochrome oxidase K(m) for oxygen: implications for mitochondrial pathology
    C E Cooper
    Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
    Biochim Biophys Acta 1459:390-6. 2000
    ....
  18. ncbi request reprint Nitric oxide and iron proteins
    C E Cooper
    Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Biochim Biophys Acta 1411:290-309. 1999
    ..The possible significance of iron reactions with reactive NO metabolites, in particular peroxynitrite and nitroxyl anion, is also discussed...
  19. pmc The relationship of oxygen delivery to absolute haemoglobin oxygenation and mitochondrial cytochrome oxidase redox state in the adult brain: a near-infrared spectroscopy study
    C E Cooper
    Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
    Biochem J 332:627-32. 1998
    ..The results suggest that the brain maintains more than adequate oxygen delivery to mitochondria and that near-infrared spectroscopy may be a good measure of oxygen insufficiency in vivo...
  20. ncbi request reprint Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Central Campus Wivenhoe Park, Essex CO4 3SQ, Colchester, UK
    Biochim Biophys Acta 1607:27-34. 2003
    ..Studies of cell respiration that fail to vary the oxygen concentration systematically are therefore likely to significantly underestimate the degree of irreversible damage to cytochrome oxidase...
  21. ncbi request reprint A new sensitive assay reveals that hemoglobin is oxidatively modified in vivo
    Niels B J Vollaard
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
    Free Radic Biol Med 39:1216-28. 2005
    ..The exercise-induced increase is short-lived, suggesting the existence of an active mechanism for repairing or removing the damaged heme proteins...
  22. pmc Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo
    Jacqueline Dunne
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Biochem J 399:513-24. 2006
    ..g. haemolytic anaemias, subarachnoid haemorrhage, rhabdomyolysis...
  23. ncbi request reprint Fast reduction of a copper center in laccase by nitric oxide and formation of a peroxide intermediate
    Jaume Torres
    Department of Biological Sciences, University of Essex, Wivenhoe Park CO4 3SQ, Colchester, Essex, UK
    J Am Chem Soc 124:963-7. 2002
    ..This enables the O-O scission step in the catalytic cycle to be studied by electron addition to the peroxide derivative through the native electron entry site, type 1 copper...
  24. pmc Tyrosine residues as redox cofactors in human hemoglobin: implications for engineering nontoxic blood substitutes
    Brandon J Reeder
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    J Biol Chem 283:30780-7. 2008
    ..Engineering hemoglobin with enhanced rates of ferryl removal, as we show here, is therefore likely to result in molecules better suited for in vivo oxygen delivery...
  25. doi request reprint The steady-state mechanism of cytochrome c oxidase: redox interactions between metal centres
    Maria G Mason
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    Biochem J 422:237-46. 2009
    ..Turnover is instead dependent upon electron transfer from haem a to haem a3, but the haem a potential closely matches cytochrome c at all times...
  26. pmc A model of brain circulation and metabolism: NIRS signal changes during physiological challenges
    Murad Banaji
    Department of Biological Sciences, University of Essex, Colchester, United Kingdom
    PLoS Comput Biol 4:e1000212. 2008
    ..The comparisons are encouraging, showing that the model is able to reproduce observed behaviour in response to various stimuli...
  27. doi request reprint Modelling of mitochondrial oxygen consumption and NIRS detection of cytochrome oxidase redox state
    Murad Banaji
    Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK
    Adv Exp Med Biol 662:285-91. 2010
    ..Our findings indicate strongly that the DeltaoxCCO signal contains useful information despite the noise, and has responses consistent with the known physiology...
  28. pmc Comparative study of tyrosine radicals in hemoglobin and myoglobins treated with hydrogen peroxide
    Dimitri A Svistunenko
    Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Biophys J 83:2845-55. 2002
    ..Tyr103 is the closest to the heme. We suggest that Tyr103 is the initial site of the radical, which then rapidly migrates to Tyr151...
  29. ncbi request reprint Tryptophan or tyrosine? On the nature of the amino acid radical formed following hydrogen peroxide treatment of cytochrome c oxidase
    Dimitri A Svistunenko
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Biochim Biophys Acta 1655:372-80. 2004
    ..This correspondence between the two enzymes at least allows the possibility that this radical may have functional importance...
  30. pmc A new method of identifying the site of tyrosyl radicals in proteins
    Dimitri A Svistunenko
    Department of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom
    Biophys J 87:582-95. 2004
    ..The possibility of a similar relationship between rho(C) and g(x) in other radicals, e.g., tryptophanyl, is discussed...
  31. ncbi request reprint Nitrosyl heme production compared in endotoxemic and hemorrhagic shock
    Nathan A Davies
    Department of Biological Sciences, University of Essex, Colchester, Essex, UK
    Free Radic Biol Med 38:41-9. 2005
    ....
  32. ncbi request reprint Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components
    Dimitri A Svistunenko
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Biochim Biophys Acta 1757:262-72. 2006
    ....
  33. pmc Ferryl haem protonation gates peroxidatic reactivity in globins
    Radu Silaghi-Dumitrescu
    Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK
    Biochem J 403:391-5. 2007
    ..We also demonstrate for the first time a direct correlation between Hb/Mb ferryl reactivity and ferryl protonation status, simultaneously informing on chemical mechanism and toxicity and with broader biochemical implications...
  34. doi request reprint A quantitative approach to nitric oxide inhibition of terminal oxidases of the respiratory chain
    Maria G Mason
    Department of Biological Sciences, University of Essex, Colchester, United Kingdom
    Methods Enzymol 437:135-59. 2008
    ..Additionally, it describes a system designed to acquire polarographic and spectral data simultaneously to permit identification of spectral intermediates under defined conditions...
  35. ncbi request reprint Inhibition of mitochondrial respiration during early stage sepsis
    Nathan A Davies
    Dept Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    Adv Exp Med Biol 530:725-36. 2003
    ..We conclude that nitric oxide produced in response to a septic insult can inhibit mitochondria causing an impairment of oxygen utilisation by aerobic respiration...
  36. ncbi request reprint Near infrared spectroscopy as a noninvasive assessment of cortical abnormality in migraine?
    Murray Griffin
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, England
    Adv Exp Med Biol 578:203-8. 2006
  37. ncbi request reprint NIRS-detected changes in the motor cortex during mental rehearsal of physical activity (imaginary exercise)
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, England
    Adv Exp Med Biol 578:185-90. 2006
  38. ncbi request reprint Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species
    Chris E Cooper
    Dept of Biological Sciences, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
    Trends Biochem Sci 27:489-92. 2002
    ..The findings offer the enticing possibility that the cell can distinguish between different degrees of oxidant and nitrosative exposure by modification at a single site on a signaling molecule...
  39. ncbi request reprint Blood volume changes are controlled centrally not locally--a near-infrared spectroscopy study of one legged aerobic exercise
    Chris E Cooper
    University of Essex, Essex, United Kingdom
    Adv Exp Med Biol 530:627-35. 2003
    ..The large haemodynamic changes in the non-exercising leg observed here may be partially responsible for the cross-training effect...
  40. ncbi request reprint Exercise-induced oxidative stress in overload training and tapering
    Niels B J Vollaard
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, United Kingdom
    Med Sci Sports Exerc 38:1335-41. 2006
    ..It was hypothesized that overload training will increase oxidative stress through an accumulative effect of repeated high-intensity exercise, whereas tapering will improve the antioxidant defense system and alleviate oxidative stress...
  41. ncbi request reprint NIRS-detected changes in the arm during mental rehearsal of physical activity (imaginary exercise)
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, England
    Adv Exp Med Biol 578:191-6. 2006
  42. doi request reprint Cytochrome bd confers nitric oxide resistance to Escherichia coli
    Maria G Mason
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Nat Chem Biol 5:94-6. 2009
    ..coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate...
  43. pmc Exogenous ferrous iron is required for the nitric oxide-catalysed destruction of the iron-sulphur centre in adrenodoxin
    Nina V Voevodskaya
    Institute of Chemical Physics, Russian Academy of Sciences, Kosygin Str 4, Moscow, 119991, Russia
    Biochem J 368:633-9. 2002
    ..This attack leads to a release of endogenous iron from the centres, which is capable of forming both low-molecular-mass and protein-bound DNIC, thereby ensuring further ISC degradation...
  44. ncbi request reprint Exercise-induced oxidative stress:myths, realities and physiological relevance
    Niels B J Vollaard
    School of Life Sciences, Heriot Watt University, Edinburgh, UK
    Sports Med 35:1045-62. 2005
    ..It is clear that ROS play important roles in numerous physiological processes at rest; however, the detailed physiological functions of ROS in exercise remain to be elucidated...
  45. ncbi request reprint Association between mitochondrial dysfunction and severity and outcome of septic shock
    David Brealey
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute of Biomedical Research and Department of Medicine, University College London, London W1T 3AA, UK
    Lancet 360:219-23. 2002
    ....
  46. ncbi request reprint Endogenous superoxide production and the nitrite/nitrate ratio control the concentration of bioavailable free nitric oxide in leaves
    Anatoly F Vanin
    Institute of Chemical Physics, Russian Academy of Sciences, Moscow 117977, Russia
    J Biol Chem 279:24100-7. 2004
    ....
  47. ncbi request reprint Protein-template-driven formation of polynuclear iron species
    Simon A Malone
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK
    J Am Chem Soc 126:496-504. 2004
    ..From analyses of X-ray structures and amino acid sequence comparisons, possible nucleation sites are identified...
  48. ncbi request reprint A wide gap second derivative NIR spectroscopic method for measuring tissue hemoglobin oxygen saturation
    Dean E Myers
    Hutchinson Technology Inc, Hutchinson, Minnesota 55350, USA
    Adv Exp Med Biol 578:217-22. 2006
  49. ncbi request reprint Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis
    Jonathan P McHugh
    School of Animal and Microbial Sciences, University of Reading, Reading, RG6 6AJ, United Kingdom
    J Biol Chem 278:29478-86. 2003
    ..In combination, the results provide compelling evidence for the regulation of intracellular iron consumption by the Fe2+-Fur complex...