C Cooper

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study
    Arief Lalmohamed
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands
    BMJ 345:e5085. 2012
  2. pmc Ischaemic cardiac events and use of strontium ranelate in postmenopausal osteoporosis: a nested case-control study in the CPRD
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, SO16 6YD, UK
    Osteoporos Int 25:737-45. 2014
  3. pmc Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle
    K Akesson
    Department of Orthopaedics Malmo, Skane University Hospital, Malmo, Sweden
    Osteoporos Int 24:2135-52. 2013
  4. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
  5. pmc The high bone mass phenotype is characterised by a combined cortical and trabecular bone phenotype: findings from a pQCT case-control study
    Celia L Gregson
    Musculoskeletal Research Unit, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK
    Bone 52:380-8. 2013
  6. pmc Tools in the assessment of sarcopenia
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Calcif Tissue Int 93:201-10. 2013
  7. pmc Epidemiology and burden of osteoarthritis
    Anna Litwic
    MRC Lifecourse Epidemiology Unit University of Southampton, Southampton General Hospital, Southampton, UK
    Br Med Bull 105:185-99. 2013
  8. pmc Southampton Mealtime Assistance Study: design and methods
    Helen C Roberts
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, Hampshire, UK
    BMC Geriatr 13:5. 2013
  9. doi request reprint Frailty and sarcopenia: definitions and outcome parameters
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, England, UK
    Osteoporos Int 23:1839-48. 2012
  10. pmc Using cohort studies in lifecourse epidemiology
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Public Health 126:190-2. 2012

Detail Information

Publications222 found, 100 shown here

  1. pmc Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study
    Arief Lalmohamed
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands
    BMJ 345:e5085. 2012
    ..To estimate fracture risk in patients receiving bariatric surgery versus matched controls...
  2. pmc Ischaemic cardiac events and use of strontium ranelate in postmenopausal osteoporosis: a nested case-control study in the CPRD
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, SO16 6YD, UK
    Osteoporos Int 25:737-45. 2014
    ..While known cardiovascular risk factors like obesity and smoking were associated with increased cardiac risk, use of strontium ranelate was not associated with any increase in myocardial infarction or cardiovascular death...
  3. pmc Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle
    K Akesson
    Department of Orthopaedics Malmo, Skane University Hospital, Malmo, Sweden
    Osteoporos Int 24:2135-52. 2013
    ..The International Osteoporosis Foundation (IOF) Capture the Fracture Campaign aims to support implementation of Fracture Liaison Services (FLS) throughout the world...
  4. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
    ..The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction...
  5. pmc The high bone mass phenotype is characterised by a combined cortical and trabecular bone phenotype: findings from a pQCT case-control study
    Celia L Gregson
    Musculoskeletal Research Unit, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK
    Bone 52:380-8. 2013
    ..In contrast to the radius, neither trabecular nor cortical BMD declined with age in the tibia of HBM cases, suggesting attenuation of age-related bone loss in weight-bearing limbs contributes to the observed bone phenotype...
  6. pmc Tools in the assessment of sarcopenia
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Calcif Tissue Int 93:201-10. 2013
    ..The choice of outcome measures for clinical trials in sarcopenia is more difficult; co-primary outcomes, tailored to the specific intervention in question, may be the best way forward in this difficult but clinically important area. ..
  7. pmc Epidemiology and burden of osteoarthritis
    Anna Litwic
    MRC Lifecourse Epidemiology Unit University of Southampton, Southampton General Hospital, Southampton, UK
    Br Med Bull 105:185-99. 2013
    ..OA of the hips and knees tends to cause the greatest burden to the population as pain and stiffness in these large weight-bearing joints often leads to significant disability requiring surgical intervention...
  8. pmc Southampton Mealtime Assistance Study: design and methods
    Helen C Roberts
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, Hampshire, UK
    BMC Geriatr 13:5. 2013
    ..This study aims to evaluate the effectiveness of using trained volunteer mealtime assistants to help patients on an acute medical ward for older people at mealtimes...
  9. doi request reprint Frailty and sarcopenia: definitions and outcome parameters
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, England, UK
    Osteoporos Int 23:1839-48. 2012
    ..Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients...
  10. pmc Using cohort studies in lifecourse epidemiology
    C Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Public Health 126:190-2. 2012
    ....
  11. ncbi request reprint Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial
    Cyrus Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, UK
    Curr Med Res Opin 28:231-9. 2012
    ..We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis...
  12. pmc MAVIDOS Maternal Vitamin D Osteoporosis Study: study protocol for a randomized controlled trial. The MAVIDOS Study Group
    Nicholas C Harvey
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Trials 13:13. 2012
    ..MAVIDOS is a randomised, double-blind, placebo-controlled trial (ISRCTN82927713, registered 2008 Apr 11), funded by Arthritis Research UK, MRC, Bupa Foundation and NIHR...
  13. pmc Validation of a maternal questionnaire on correlates of physical activity in preschool children
    Alison M McMinn
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Int J Behav Nutr Phys Act 6:81. 2009
    ..With minor revision, this could be a useful tool for future research in this area. This, in turn, will aid the development of interventions to promote physical activity in this age group...
  14. pmc Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system
    Olivier Bruyere
    WHO Collaborating Center for the Public Health Aspect of Musculoskeletal Disorders, University of Liege, Belgium
    BMC Musculoskelet Disord 9:165. 2008
    ..Symptomatic slow-acting drugs (SYSADOA) have been largely studied over the last decade. The objective of this study is to prepare a document providing recommendations for the use of SYSADOA in osteoarthritis (OA)...
  15. pmc Hertfordshire sarcopenia study: design and methods
    Harnish P Patel
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    BMC Geriatr 10:43. 2010
    ....
  16. pmc Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Endocr Disord 9:15. 2009
    ..TRIAL REGISTRATION: Current Controlled Trials: ISRCTN60986572...
  17. ncbi request reprint Review: developmental origins of osteoporotic fracture
    Cyrus Cooper
    MRC Epidemiology Resource Centre and Centre for Developmental Origins of Health and Adult Disease, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Osteoporos Int 17:337-47. 2006
    ..The optimisation of maternal nutrition and intrauterine growth should also be included within preventive strategies against osteoporotic fracture, albeit for future generations...
  18. ncbi request reprint Epidemiology of osteoporotic fracture: looking to the future
    C Cooper
    MRC Epidemiology Resource Center, University of Southhampton, Southhampton General Hospital, Southhampton SO16 6YD, UK
    Rheumatology (Oxford) 44:iv36-iv40. 2005
    ..This paper reviews the recent literature on candidate genes, anthropometric and environmental factors, and the evolving area of intrauterine fetal programming with regard to the development of osteoporosis...
  19. ncbi request reprint Developmental origins of osteoporosis: the role of maternal nutrition
    Cyrus Cooper
    MRC Epidemiology Resource Centre and Centre for Developmental Origins of Health and Adult Disease, University of Southampton, Southampton General Hospital, Southampton, UK
    Adv Exp Med Biol 646:31-9. 2009
    ..The optimisation of maternal nutrition and intrauterine growth should also be included within preventive strategies against osteoporotic fracture, albeit for future generations...
  20. ncbi request reprint Developmental origins of osteoporotic fracture: the role of maternal vitamin D insufficiency
    Cyrus Cooper
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    J Nutr 135:2728S-34S. 2005
    ..The optimization of maternal nutrition and intrauterine growth should also be included within preventive strategies against osteoporotic fracture, albeit for future generations...
  21. pmc Secular trends in the incidence of hip and other osteoporotic fractures
    C Cooper
    The MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Osteoporos Int 22:1277-88. 2011
    ..Understanding the reasons for the recent declines in rates of hip fracture may help understand ways to reduce rates of hip fracture worldwide...
  22. ncbi request reprint Osteoporosis research thrives: IOF WCO-ECCEO10
    Cyrus Cooper
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Expert Rev Pharmacoecon Outcomes Res 10:367-70. 2010
    ..A total of 12 satellite symposia enhanced the program by offering a wealth of information and practical new knowledge for clinicians...
  23. ncbi request reprint Beyond daily dosing: clinical experience
    C Cooper
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 38:S13-7. 2006
    ..Being the first study to demonstrate antifracture efficacy with an intermittent regimen, it provided "proof of concept" for beyond weekly dosing with ibandronate and prompted further development of a more convenient once-monthly regimen...
  24. ncbi request reprint Efficacy and safety of oral weekly ibandronate in the treatment of postmenopausal osteoporosis
    Cyrus Cooper
    Southampton General Hospital, Medical Research Council Environmental Epidemiology Unit, Southampton, SO16 6YD United Kingdom
    J Clin Endocrinol Metab 88:4609-15. 2003
    ..65% prespecified margin and a more stringent margin of -1.10%. These results demonstrate that oral weekly ibandronate provides the same efficacy and safety as oral daily ibandronate in women with postmenopausal osteoporosis...
  25. ncbi request reprint Fracture incidence and changes in quality of life in women with an inadequate clinical outcome from osteoporosis therapy: the Observational Study of Severe Osteoporosis (OSSO)
    C Cooper
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, UK
    Osteoporos Int 19:493-501. 2008
    ....
  26. ncbi request reprint Growth and bone development
    Cyrus Cooper
    MRC Epidemiology Resource Centre and Centre for Developmental Origins of Health and Adult Disease, University of Southampton, Southampton General Hospital, Southampton, UK
    Nestle Nutr Workshop Ser Pediatr Program 61:53-68. 2008
    ..The optimization of maternal nutrition and intrauterine growth should also be included within preventive strategies against osteoporotic fracture, albeit for future generations...
  27. ncbi request reprint Epidemiology of childhood fractures in Britain: a study using the general practice research database
    Cyrus Cooper
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Bone Miner Res 19:1976-81. 2004
    ..Fractures were more common among boys than girls, with peak incidences at 14 and 11 years of age, respectively. At childhood peak, incidence rates were only surpassed later in life at 85 years of age among women and never among men...
  28. ncbi request reprint Osteoporosis: disease severity and consequent fracture management
    C Cooper
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, SO16 6YD, UK
    Osteoporos Int 21:S425-9. 2010
    ..It has been demonstrated to be effective for a broad spectrum of patients, including women with osteopenia, osteoporosis, and severe disease...
  29. ncbi request reprint Update on the epidemiology of Paget's disease of bone
    Cyrus Cooper
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    J Bone Miner Res 21:P3-8. 2006
    ..2; 95% CI, 1.0-1.5). Using life table methodology, the estimated proportion of patients dying within 5 years of follow-up was 32.7% among the cohort with PDB compared with 28.0% among control patients (p < 0.05)...
  30. ncbi request reprint Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study
    C Cooper
    The MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Osteoporos Int 12:623-9. 2001
    ....
  31. ncbi request reprint The fetal origins of osteoporotic fracture
    C Cooper
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, England
    Calcif Tissue Int 70:391-4. 2002
  32. ncbi request reprint Prevalence and occupational associations of neck pain in the British population
    K T Palmer
    Environmental Epidemiology Unit, Medical Research Council MRC, University of Southampton, England
    Scand J Work Environ Health 27:49-56. 2001
    ..This study determined the prevalence of neck pain and its relation to occupation and occupational activities in the general population...
  33. pmc Parental determinants of neonatal body composition
    N C Harvey
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 92:523-6. 2007
    ..We used data from the Southampton Women's Survey to investigate parental influences on neonatal body composition ascertained by dual x-ray absorptiometry...
  34. ncbi request reprint Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Lancet 367:36-43. 2006
    ..We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth...
  35. doi request reprint Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Osteoporos Int 21:1817-24. 2010
    ..We found deterioration in the mental health domain over follow-up in osteoporotic men (but not women) compared with other groups (relative rate ratio=5.78, 95% confidence interval (CI) 1.78-19.2)...
  36. ncbi request reprint Paternal skeletal size predicts intrauterine bone mineral accrual
    N C Harvey
    Medical Research Council Epidemiology Resource Centre, University of Southampton, and Southampton General Hospital, Southampton, United Kingdom
    J Clin Endocrinol Metab 93:1676-81. 2008
    ..However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a father's bone mass and that of his offspring...
  37. ncbi request reprint Umbilical cord leptin predicts neonatal bone mass
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Soumampton General Hospital, Southampton, SO16 6YD, UK
    Calcif Tissue Int 76:341-7. 2005
    ..In addition, among previously documented maternal determinants of neonatal bone mass in healthy pregnancies, maternal fat stores may mediate their effect on fetal bone accrual through variation in fetal leptin concentrations...
  38. pmc Placental size at 19 weeks predicts offspring bone mass at birth: findings from the Southampton Women's Survey
    C R Holroyd
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Placenta 33:623-9. 2012
    ..In this study we investigate the relationships between placental size and neonatal bone mass and body composition, in a population-based cohort...
  39. ncbi request reprint Physical performance and physical activity in older people: are developmental influences important?
    H J Martin
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Gerontology 55:186-93. 2009
    ..Reduced physical performance and physical activity have serious health consequences, but adult determinants do not fully explain variation in older people...
  40. doi request reprint Growth in childhood predicts hip fracture risk in later life
    M K Javaid
    MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
    Osteoporos Int 22:69-73. 2011
    ..2-fold increase in hip fracture risk compared with those in the highest quarter (p < 0.001). These data point to a relationship between childhood growth and fracture risk during later life...
  41. ncbi request reprint Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual
    R Martin
    Centre for the Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Bone 40:1203-8. 2007
    ..This association may explain, in part, the mechanism whereby a mother's 25(OH)-vitamin D stores influence her offspring's bone mass...
  42. ncbi request reprint The prevalence of sensorineural symptoms attributable to hand-transmitted vibration in Great Britain: a national postal survey
    K T Palmer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Am J Ind Med 38:99-107. 2000
    ..Exposure to hand-transmitted vibration (HTV) can cause sensorineural symptoms in the upper limb, but its impact has not previously been assessed in the general population...
  43. ncbi request reprint Maternal and seasonal predictors of change in calcaneal quantitative ultrasound during pregnancy
    M K Javaid
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 90:5182-7. 2005
    ..However, the environmental determinants of maternal bone resorption during pregnancy in healthy adult mothers have not been previously described...
  44. ncbi request reprint A simple clinical score for estimating the long-term risk of fracture in post-menopausal women
    T P Van Staa
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands
    QJM 99:673-82. 2006
    ..Simple tools are needed to identify patients at high risk of fracture...
  45. doi request reprint Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the Hertfordshire cohort study
    M B R Patel
    Medical Research Council MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    Calcif Tissue Int 91:416-22. 2012
    ..This suggests that in men, although αCa is a contributing factor in FN bone density, it is not the main mechanism whereby the early environment modifies adult BMD...
  46. pmc Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood
    R J Moon
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 98:299-307. 2013
    ..Maternal diet during pregnancy has been linked to offspring adiposity, but it is unclear whether maternal polyunsaturated fatty acid (PUFA) status during pregnancy affects offspring body composition...
  47. ncbi request reprint The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort study
    K M Leyland
    Botnar Research Centre, Institute of Musculoskeletal Sciences, University of Oxford, Oxford, UK
    Arthritis Rheum 64:2243-51. 2012
    ..To establish the natural history of radiographic knee osteoarthritis (OA) over 14 years in a community-based cohort...
  48. pmc Physical activity, calcium intake and childhood bone mineral: a population-based cross-sectional study
    N C Harvey
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Osteoporos Int 23:121-30. 2012
    ..Relationships between physical activity and bone indices were stronger when calcium intake was above compared with below median (966 mg/day)...
  49. ncbi request reprint Risk of hand-arm vibration syndrome according to occupation and sources of exposure to hand-transmitted vibration: A national survey
    K T Palmer
    MRC Clinical Scientist and Consultant Occupational Physician, MRC Environmental Epidemiology Unit, Community Clinical Sciences, University of Southampton, Southampton, SO16 6YD, UK
    Am J Ind Med 39:389-96. 2001
    ..Although some occupational sources of hand-transmitted vibration (HTV) have been extensively investigated, the risks associated with others are poorly characterized...
  50. doi request reprint Is grip strength a good marker of physical performance among community-dwelling older people?
    P J Stevens
    Academic Geriatric Medicine, School of Medicine, University of Southampton, UK
    J Nutr Health Aging 16:769-74. 2012
    ..As muscle strength is central to physical performance, we explored whether grip strength could be used as a marker of the Short Physical Performance Battery...
  51. ncbi request reprint Cohort profile: the Hertfordshire cohort study
    H E Syddall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 34:1234-42. 2005
  52. pmc Increased fat mass is associated with increased bone size but reduced volumetric density in pre pubertal children
    Z A Cole
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 50:562-7. 2012
    ..003; β=-7.7 mg/mm(3) per sd, p=0.02 respectively). These results suggest that fat mass is negatively associated with volumetric bone density at 6 years old, independent of lean mass, despite positive associations with bone size...
  53. pmc Factors associated with symptoms of anxiety and depression in five cohorts of community-based older people: the HALCyon (Healthy Ageing across the Life Course) Programme
    C R Gale
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Psychol Med 41:2057-73. 2011
    ..Symptoms of anxiety and depression are common in older people, but the relative importance of factors operating in early and later life in influencing risk is unclear, particularly in the case of anxiety...
  54. pmc Size at birth and its relation to muscle strength in young adult women
    H M Inskip
    MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
    J Intern Med 262:368-74. 2007
    ..To assess the relationship between development in utero, assessed by birth weight, and muscle strength in young adult women as assessed by grip strength...
  55. pmc Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    QJM 100:297-303. 2007
    ..Body mass index (BMI) and bone mineral density (BMD) are positively correlated in several studies, but few data relate bone density, lipid profile and anthropometric measures...
  56. ncbi request reprint Intrauterine programming of bone. Part 2: alteration of skeletal structure
    S A Lanham
    Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 6YD, UK
    Osteoporos Int 19:157-67. 2008
    ..Rat dams were given a low protein diet during pregnancy, and offspring were studied at different ages. Old aged rats showed site-specific strength differences. In utero nutrition has consequences in later life...
  57. doi request reprint Relationship between customary physical activity, muscle strength and physical performance in older men and women: findings from the Hertfordshire Cohort Study
    H J Martin
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, Hampshire, UK
    Age Ageing 37:589-93. 2008
  58. ncbi request reprint Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy
    K Godfrey
    MRC Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Bone Miner Res 16:1694-703. 2001
    ....
  59. pmc Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men
    K M Jordan
    Bone and Joint, MRC Epidemiology Resource Centre, Southampton University, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Ann Rheum Dis 65:871-7. 2006
    ..To investigate the association between biochemical markers of bone, cartilage, and synovial turnover with the presence and severity of knee osteoarthritis (OA) in men...
  60. ncbi request reprint Relationships between SF-36 health profile and bone mineral density: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Osteoporos Int 17:1435-42. 2006
    ..05], but no other relationships were significant. Poorer functioning (assessed by SF-36 questionnaire) is associated with lower total femoral BMD in older men (but less so in women) after adjustment for lifestyle factors and comorbidity...
  61. pmc Maternal vitamin D status during pregnancy and child outcomes
    C R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur J Clin Nutr 62:68-77. 2008
    ..To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child...
  62. pmc Exposure to heavy physical occupational activities during working life and bone mineral density at the hip at retirement age
    K Walker-Bone
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    Occup Environ Med 71:329-31. 2014
    ..Physical activity is important in the development and maintenance of BMD, but the effects of occupational physical activity on bone health are unclear. We investigated the influence of lifetime physical activity on BMD at the hip...
  63. pmc Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people
    D Baylis
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK
    Age (Dordr) 35:963-71. 2013
    ..Progress towards the prevention of frailty would bring major health and socio-economic benefits at the individual and the population level...
  64. pmc Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire Cohort Study
    T A Ashfield
    Academic Geriatric Medicine, UK
    Age Ageing 39:185-91. 2010
    ..reduced grip strength is associated with adverse health consequences, and there is interest in identifying modifiable influences. Cardiovascular drugs are commonly used by older people, but their effect on muscle strength is unclear...
  65. ncbi request reprint Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition
    M K Javaid
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    J Bone Miner Res 19:56-63. 2004
    ..However IGF-1 did not explain the relationships of maternal smoking, fat mass, and physical activity with neonatal bone mass. The study supports a direct role for circulating IGF-1 in growth of the fetal skeleton...
  66. doi request reprint Pre-operative expectation predicts 12-month post-operative outcome among patients undergoing primary total hip replacement in European orthopaedic centres
    A Judge
    Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
    Osteoarthritis Cartilage 19:659-67. 2011
    ..Identify patient characteristics associated with pre-operative expectations of total hip replacement (THR); (2). Explore whether pre-operative expectations predict surgical outcomes 12-months post-THR...
  67. pmc The autoantibody rheumatoid factor may be an independent risk factor for ischaemic heart disease in men
    C J Edwards
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Heart 93:1263-7. 2007
    ..This is most likely in those people with the autoantibody rheumatoid factor (RF). RF is strongly associated with rheumatoid arthritis (RA) but is also present in up to 15% of all adults...
  68. ncbi request reprint Size at birth and plasma leptin concentrations in adult life
    D I Phillips
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Obes Relat Metab Disord 23:1025-9. 1999
    ..To determine whether low birthweight is associated with higher plasma leptin concentrations in adult life and whether leptin contributes to the metabolic alterations in adults that are associated with reduced foetal growth...
  69. pmc Prevalence of Raynaud's phenomenon in Great Britain and its relation to hand transmitted vibration: a national postal survey
    K T Palmer
    MRC Environmental Epidemiology Unit, Community Clinical Sciences, University of Southampton, SO16 6YD, UK
    Occup Environ Med 57:448-52. 2000
    ..To assess the prevalence of Raynaud's phenomenon in the general population of Great Britain and to estimate the proportion and number of cases attributable to hand transmitted vibration (HTV)...
  70. pmc Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study
    A A Sayer
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    QJM 100:707-13. 2007
    ..Sarcopenia, the loss of muscle mass and strength with age, is significantly associated with type 2 diabetes in older people...
  71. doi request reprint Does birthweight predict bone mass in adulthood? A systematic review and meta-analysis
    J Baird
    MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Osteoporos Int 22:1323-34. 2011
    ..Higher birthweight was associated with higher bone mineral content of the spine and hip in adult men and women at ages between 18 and 80 years across a range of settings...
  72. ncbi request reprint Exposure to hand-transmitted vibration and pain in the neck and upper limbs
    K T Palmer
    MRC Environmental Epidemiology Unit, Community Clinical Sciences, University of Southampton, Southampton, UK
    Occup Med (Lond) 51:464-7. 2001
    ..7 versus 1.8 for neck pain). This accords with the pattern of transmission of HTV to the upper limb, although a confounding effect from other ergonomic risk factors cannot be discounted...
  73. ncbi request reprint A simple score for estimating the long-term risk of fracture in patients using oral glucocorticoids
    T P Van Staa
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    QJM 98:191-8. 2005
    ..Previous analyses of risk factors for glucocorticoid (GC)-induced osteoporosis have focused on the estimation of relative rather than absolute fracture probability...
  74. doi request reprint Risk of fracture in patients with Parkinson's disease
    S Pouwels
    Utrecht Institute for Pharmaceutical Sciences, Universiteit Utrecht, Universiteitsweg, 99, 3584 CG Utrecht, Netherlands
    Osteoporos Int 24:2283-90. 2013
    ....
  75. doi request reprint Burden of pelvis fracture: a population-based study of incidence, hospitalisation and mortality
    D Prieto-Alhambra
    Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Osteoporos Int 23:2797-803. 2012
    ..There was a higher 3-year mortality in those admitted (17%) vs. those not admitted (6.3%). Given the substantial health burden, further work is required to identify the optimal post-fracture therapeutic strategy to improve outcomes...
  76. doi request reprint Reduced cortical bone density with normal trabecular bone density in girls with Turner syndrome
    C R Holroyd
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, UK
    Osteoporos Int 21:2093-9. 2010
    ..These findings may account for the increased fracture risk noted in this population...
  77. ncbi request reprint Prevalence of reported knee pain over twelve years in a community-based cohort
    A Soni
    University of Oxford, Oxford, UK
    Arthritis Rheum 64:1145-52. 2012
    ..To describe the temporal patterns of knee pain in a community-based cohort over 12 years...
  78. ncbi request reprint Patterns of dietary supplement use among older men and women in the UK: findings from the Hertfordshire Cohort Study
    H J Denison
    MRC Lifecourse Epidemiology Unit University of Southampton, Southampton, United Kingdom
    J Nutr Health Aging 16:307-11. 2012
    ..To determine patterns of supplement use in a UK community-dwelling older population, and to investigate the extent to which supplement user groups differ, in terms of their sociodemographic and lifestyle characteristics, diet and morbidity...
  79. ncbi request reprint Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD)
    M B R Patel
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 37:833-41. 2005
    ..Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to support these hypotheses...
  80. ncbi request reprint Epidemiology of osteoporosis
    K M Jordan
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Best Pract Res Clin Rheumatol 16:795-806. 2002
    ..and prevalence of osteoporosis and fracture? Is there geographical variation in the occurrence of osteoporosis? What are the risk factors for osteoporosis and do they explain the occurrence of osteoporosis and osteoporotic fracture?..
  81. ncbi request reprint Polymorphism in the growth hormone gene, weight in infancy, and adult bone mass
    E M Dennison
    Medical Research Council Epidemiology Resource Center, University of Southampton, Southampton General Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 89:4898-903. 2004
    ..The interaction with infant weight suggests that early environment may influence the effect of GH1 genotype on bone loss...
  82. ncbi request reprint Natural history of low back pain. A longitudinal study in nurses
    J Smedley
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    Spine (Phila Pa 1976) 23:2422-6. 1998
    ..In the absence of other information, the differentials in risk associated with a person's history of back pain appear to remain constant for a period of at least 2 years...
  83. ncbi request reprint Do all systems age together?
    A Aihie Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Gerontology 45:83-6. 1999
    ..Aging changes in different body system are well described, but few studies have considered the relationship between them...
  84. ncbi request reprint Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance?
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Diabetologia 47:1963-8. 2004
    ..Previous studies have suggested that the high bone density often observed in type 2 diabetic patients may be explained by insulin resistance. We explored this hypothesis in the Hertfordshire Cohort Study...
  85. ncbi request reprint Intrauterine programming of bone. Part 1: alteration of the osteogenic environment
    S A Lanham
    Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 6YD, UK
    Osteoporos Int 19:147-56. 2008
    ..Rat dams were given a low protein diet during pregnancy and 135 offspring studied at different ages. Bone biochemistry showed altered characteristics. Altered in utero diet has consequences for later life...
  86. ncbi request reprint Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, United Kingdom
    Calcif Tissue Int 74:401-6. 2004
    ....
  87. ncbi request reprint Intrauterine programming of adult body composition
    C R Gale
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom S016 6YD
    J Clin Endocrinol Metab 86:267-72. 2001
    ..The presence of these relationships at birth adds to the evidence that bone and muscle growth may be programmed by genetic and/or environmental influences during intrauterine life...
  88. ncbi request reprint Knee osteoarthritis and obesity
    D Coggon
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Obes Relat Metab Disord 25:622-7. 2001
    ..People undergoing meniscectomy or with a history of knee injury might be a focus for targeted advice...
  89. pmc Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study
    Holly Syddall
    MRC Epidemiology Resource Centre, University of Southampton, UK
    Age Ageing 39:197-203. 2010
    ..frailty, a multi-dimensional geriatric syndrome, confers a high risk for falls, disability, hospitalisation and mortality. The prevalence and correlates of frailty in the UK are unknown...
  90. ncbi request reprint Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes
    Santiago Rodriguez
    Human Genetics Division, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK
    Eur J Hum Genet 14:109-16. 2006
    ..Our results, taken together with other data on IGFII levels and TH activity, point to the importance of (*)5 as an integrated polygenic haplotype relevant to obesity and insulin response to glucose in men...
  91. ncbi request reprint The presence of anticardiolipin antibodies in adults may be influenced by infections in infancy
    C J Edwards
    Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton, UK
    QJM 101:41-7. 2008
    ..We measured anticardiolipin antibodies (aCL) in a general population with well-defined early lives to see whether fetal and infant growth and infections were associated with aCL positivity in adult life...
  92. pmc The epidemiology of osteonecrosis: findings from the GPRD and THIN databases in the UK
    C Cooper
    Rheumatology, University of Southampton, Southampton, UK
    Osteoporos Int 21:569-77. 2010
    ..Statistically significant risk factors for ON included systemic corticosteroid use, hospitalization, referral or specialist visit, bone fracture, any cancer, osteoporosis, connective tissue disease, and osteoarthritis...
  93. ncbi request reprint Long-term outcome following total knee arthroplasty: a controlled longitudinal study
    J Cushnaghan
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, UK
    Ann Rheum Dis 68:642-7. 2009
    ..To assess long-term outcome and predictors of prognosis following total knee arthroplasty (TKA) for osteoarthritis...
  94. ncbi request reprint Comparison of calcaneal ultrasound and DXA to assess the risk of corticosteroid-induced osteoporosis: a cross-sectional study
    M K Javaid
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Osteoporos Int 12:788-93. 2001
    ..However, the absolute T-score required to give similar discriminatory capacity to femoral neck T-score varied substantially (T= -0.81 to -1.5) between the different measurement techniques and sites...
  95. pmc What is osteoporosis?
    C Christodoulou
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton
    Postgrad Med J 79:133-8. 2003
    ..Pharmacological treatments include the bisphosphonates, hormone replacement therapy, selective oestrogen receptor modulators, calcitonin, the 1-34 fragment of parathyroid hormone, calcium and vitamin D supplements, and calcitriol...
  96. ncbi request reprint Are rates of ageing determined in utero?
    A A Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton S016 6YD, UK
    Age Ageing 27:579-83. 1998
    ..The long-term effects of poor early nutrition on ageing have been demonstrated in animals but not studied in man...
  97. pmc Smoking and musculoskeletal disorders: findings from a British national survey
    K T Palmer
    MRC Environmental Epidemiology Unit, Community Clinical Sciences, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Ann Rheum Dis 62:33-6. 2003
    ..To explore the relation between smoking habits and regional pain in the general population...
  98. ncbi request reprint Use of keyboards and symptoms in the neck and arm: evidence from a national survey
    K T Palmer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Occup Med (Lond) 51:392-5. 2001
    ..Previous estimates of risk in the occupational setting may have been biased by shared expectations, concerns, or other aspects of illness behaviour...
  99. ncbi request reprint Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis
    T P Van Staa
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Arthritis Rheum 54:3104-12. 2006
    ..To determine whether patients with rheumatoid arthritis (RA) have an increased risk of fracture, and to estimate their long-term absolute fracture risk...
  100. ncbi request reprint Does a fracture at one site predict later fractures at other sites? A British cohort study
    T P Van Staa
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Osteoporos Int 13:624-9. 2002
    ..7% and 13.3%, respectively. Our results indicate that fractures at any site are strong risk factors for subsequent fractures, among both elderly men and women...
  101. ncbi request reprint Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy
    T P Van Staa
    University of Southampton, Southampton, UK
    Arthritis Rheum 48:3224-9. 2003
    ..To evaluate predictors of vertebral fractures, including a threshold for bone mineral density (BMD), in patients receiving oral glucocorticoids (GCs)...