Roshan Cools

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Brain 125:584-94. 2002
  2. ncbi request reprint L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB3 9DF, UK
    Neuropsychologia 41:1431-41. 2003
  3. ncbi request reprint Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson's disease
    Angie A Kehagia
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Neuropsychologia 47:1117-27. 2009
  4. pmc Dissociable responses to punishment in distinct striatal regions during reversal learning
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Neuroimage 51:1459-67. 2010
  5. ncbi request reprint L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:180-9. 2007
  6. ncbi request reprint Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 24:1129-35. 2004
  7. pmc Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience
    Oliver J Robinson
    Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 219:599-605. 2012
  8. pmc Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion
    Jonathan P Roiser
    Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Neuropsychopharmacology 31:2264-72. 2006
  9. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
  10. ncbi request reprint Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:2291-9. 2008

Detail Information

Publications27

  1. ncbi request reprint Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Brain 125:584-94. 2002
    ..These data suggest that L-dopa ameliorates high-level cognitive deficits in Parkinson's disease by inducing relative blood flow changes in the right dorsolateral prefrontal cortex...
  2. ncbi request reprint L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB3 9DF, UK
    Neuropsychologia 41:1431-41. 2003
    ....
  3. ncbi request reprint Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson's disease
    Angie A Kehagia
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Neuropsychologia 47:1117-27. 2009
    ..These findings suggest that switching entire task sets may be a function of extrastriatal, possibly non-dopaminergic pathology which increases as the disease progresses...
  4. pmc Dissociable responses to punishment in distinct striatal regions during reversal learning
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Neuroimage 51:1459-67. 2010
    ..These data help to reconcile conflicting findings from previous studies by showing that distinct regions of the striatum exhibit dissociable responses to punishment during reversal learning...
  5. ncbi request reprint L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:180-9. 2007
    ..These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning...
  6. ncbi request reprint Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 24:1129-35. 2004
    ....
  7. pmc Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience
    Oliver J Robinson
    Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 219:599-605. 2012
    ..in J Neurosci 29:11993-11999, 2009) approaches have, however, further specified this role by showing that serotonin is critical for punishment-induced inhibition...
  8. pmc Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion
    Jonathan P Roiser
    Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Neuropsychopharmacology 31:2264-72. 2006
    ....
  9. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
    ..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue...
  10. ncbi request reprint Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:2291-9. 2008
    ..Furthermore, the finding highlights the importance of central 5-HT in resilience to adversity and may have implications for a variety of neuropsychiatric disorders including depression and anxiety...
  11. pmc Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 211:187-95. 2010
    ..Here, we extend these prior findings by examining the effects of artificially reducing DA synthesis in healthy individuals performing this previously employed task...
  12. ncbi request reprint Reversal learning in Parkinson's disease depends on medication status and outcome valence
    Roshan Cools
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, UK
    Neuropsychologia 44:1663-73. 2006
    ..These data indicate that dopaminergic medication in PD impairs reversal shifting depending on the motivational valence of unexpected outcomes...
  13. ncbi request reprint Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:1362-73. 2005
    ..By contrast, ATD left unaltered the ability to inhibit prepotent responses. Our findings may have implications for a variety of neuropsychiatric disorders including impulsive aggressive disorders and depression...
  14. doi request reprint Feedback-related negativity codes prediction error but not behavioral adjustment during probabilistic reversal learning
    Henry W Chase
    University of Cambridge, UK
    J Cogn Neurosci 23:936-46. 2011
    ..These data suggest that the FRN reflects prediction error and associated RL-based adjustment of decision values, whereas the P3 reflects adjustment of behavior on the basis of explicit rules...
  15. ncbi request reprint Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, University of Cambridge, CB2 2PY, UK
    Neuropsychologia 41:645-54. 2003
    ..The results also suggest that performance on the Tower of London task may prove to be a useful discriminant variable in defining the nature of cognitive heterogeneity in Parkinson's disease...
  16. ncbi request reprint Chemistry of the adaptive mind
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Philos Trans A Math Phys Eng Sci 362:2871-88. 2004
    ..The work has considerable implications for the understanding of and treatment development for abnormalities such as Parkinson's disease, attention deficit hyperactivity disorder and drug addiction...
  17. doi request reprint Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learning
    Chris M Dodds
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:5976-82. 2008
    ..The results show that the precise neural site of modulation by methylphenidate depends on the nature of the cognitive subprocess recruited...
  18. ncbi request reprint Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:4563-7. 2002
    ..Overall, these data concur with findings in rodents and nonhuman primates of reversal-learning deficits after damage to ventral frontostriatal circuitry, and also support recent clinical findings using this task...
  19. ncbi request reprint Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective
    Trevor W Robbins
    Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    Mov Disord 29:597-607. 2014
    ..The utility is proposed of a new, integrated cognitive neuroscience approach based on combining genetic and neuroimaging methodologies with neuropsychological and, ultimately, psychopharmacological approaches...
  20. doi request reprint Working memory capacity predicts dopamine synthesis capacity in the human striatum
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3190, USA
    J Neurosci 28:1208-12. 2008
    ....
  21. doi request reprint Role of dopamine in the motivational and cognitive control of behavior
    Roshan Cools
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
    Neuroscientist 14:381-95. 2008
    ....
  22. ncbi request reprint Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3190, USA
    J Neurosci 27:5506-14. 2007
    ..The present results provide a key link between dopamine D2 receptor function, impulsivity, and frontostriatal activity during component processes of working memory...
  23. ncbi request reprint Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
    Mov Disord 21:1656-62. 2006
    ..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions...
  24. ncbi request reprint Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, 132 Barker Hall, Berkeley, USA
    Neurosci Biobehav Rev 30:1-23. 2006
    ....
  25. ncbi request reprint Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning
    Elizabeth A T Evers
    Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
    Neuropsychopharmacology 30:1138-47. 2005
    ..These data suggest that ATD affects reversal learning and the processing of aversive signals by modulation of the dorsomedial PFC...
  26. ncbi request reprint Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
    Roshan Cools
    MRC Behavioural and Clinical Neuroscience Centre
    Psychopharmacology (Berl) 180:670-9. 2005
    ....
  27. ncbi request reprint Serotoninergic regulation of emotional and behavioural control processes
    Roshan Cools
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Trends Cogn Sci 12:31-40. 2008
    ..We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects...