W O Cookson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The immunogenetics of asthma and eczema: a new focus on the epithelium
    William Cookson
    Human Genetics, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Rev Immunol 4:978-88. 2004
  2. ncbi request reprint A new gene for asthma: would you ADAM and Eve it?
    William Cookson
    Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK
    Trends Genet 19:169-72. 2003
  3. ncbi request reprint Genetics of asthma and allergic disease
    W O Cookson
    Asthma Genetics Group, Wellcome Trust Centre for Human Genetic Disease, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 9:2359-64. 2000
  4. pmc Extent and distribution of linkage disequilibrium in three genomic regions
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England OX3 7BN
    Am J Hum Genet 68:191-197. 2001
  5. ncbi request reprint Pedigree tests of transmission disequilibrium
    G R Abecasis
    Wellcome Trust Center for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 8:545-51. 2000
  6. ncbi request reprint Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits
    A J Walley
    Asthma Genetics Group, Wellcome Centre for Human Genetics, Henry Wellcome Building for Genomic Medicine, Headington, OX3 7BN, United Kingdom
    Genomics 72:15-20. 2001
  7. ncbi request reprint Association analysis in a variance components framework
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Genet Epidemiol 21:S341-6. 2001
  8. ncbi request reprint A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma
    Y Zhang
    Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 8:601-5. 1999
  9. pmc The power to detect linkage disequilibrium with quantitative traits in selected samples
    G R Abecasis
    University of Oxford, Oxford, OX3 7BN, United Kingdom
    Am J Hum Genet 68:1463-74. 2001
  10. pmc A general test of association for quantitative traits in nuclear families
    G R Abecasis
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Am J Hum Genet 66:279-92. 2000

Collaborators

Detail Information

Publications29

  1. ncbi request reprint The immunogenetics of asthma and eczema: a new focus on the epithelium
    William Cookson
    Human Genetics, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Rev Immunol 4:978-88. 2004
    ..Understanding events at the epithelial-cell surface might provide new insights for the development of new treatments for inflammatory epithelial disease...
  2. ncbi request reprint A new gene for asthma: would you ADAM and Eve it?
    William Cookson
    Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK
    Trends Genet 19:169-72. 2003
    ..Although its function is at present unknown, these potential actions of ADAM33 provide many possibilities for further research...
  3. ncbi request reprint Genetics of asthma and allergic disease
    W O Cookson
    Asthma Genetics Group, Wellcome Trust Centre for Human Genetic Disease, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 9:2359-64. 2000
    ..Several single gene disorders are associated with allergic disease and on occasion are also linked to the same chromosomal regions. The positional cloning of asthma genes is now feasible...
  4. pmc Extent and distribution of linkage disequilibrium in three genomic regions
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England OX3 7BN
    Am J Hum Genet 68:191-197. 2001
    ..Although these findings are encouraging for the prospects of a genomewide LD map, they suggest caution in interpreting localization due to allelic association...
  5. ncbi request reprint Pedigree tests of transmission disequilibrium
    G R Abecasis
    Wellcome Trust Center for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 8:545-51. 2000
    ..As a practical application, the method is used to investigate the relationship between circulating angiotensin-1 converting enzyme (ACE) levels and polymorphisms in the ACE gene using previously published data...
  6. ncbi request reprint Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits
    A J Walley
    Asthma Genetics Group, Wellcome Centre for Human Genetics, Henry Wellcome Building for Genomic Medicine, Headington, OX3 7BN, United Kingdom
    Genomics 72:15-20. 2001
    ..Allelic association was observed between D5S463 and atopy (P = 0.002) and the skin prick test index (P = 0.04). The data support the possibility of three asthma/atopy loci in the 5q31-q33 region, each with a relatively small effect...
  7. ncbi request reprint Association analysis in a variance components framework
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Genet Epidemiol 21:S341-6. 2001
    ..We examine some of these models and their properties in a blind analysis of the simulated Genetic Analysis Workshop 12 data sets...
  8. ncbi request reprint A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma
    Y Zhang
    Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 8:601-5. 1999
    ..Five potentially linked loci were identified, four of which corresponded to human regions of syntenic homology that previously have shown linkage to asthma-associated traits...
  9. pmc The power to detect linkage disequilibrium with quantitative traits in selected samples
    G R Abecasis
    University of Oxford, Oxford, OX3 7BN, United Kingdom
    Am J Hum Genet 68:1463-74. 2001
    ..Overall, proband selection from either tail provides the best balance of power, robustness, and simplicity of ascertainment for family-based association analysis...
  10. pmc A general test of association for quantitative traits in nuclear families
    G R Abecasis
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Am J Hum Genet 66:279-92. 2000
    ..Finally, it is shown that, when siblings are available, the total number of genotypes required in order to achieve comparable power is smaller if parents are not genotyped...
  11. ncbi request reprint The effect of genotype and pedigree error on linkage analysis: analysis of three asthma genome scans
    S S Cherny
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Genet Epidemiol 21:S117-22. 2001
    ..The results provide empirical evidence for the predicted effects of genotype and relationship error and highlight the need for rigorous detection and elimination of data error in complex trait studies...
  12. ncbi request reprint A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness
    M R Hill
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, UK
    Hum Mol Genet 5:959-62. 1996
    ..04), RAST to grass (p = 0.002) and bronchial reactivity to methacholine (p = 0.0009). The relative risk of individuals with E237G having asthma compared to subjects without the variant was 2.3 (95% CI 1.26-4.19; p = 0.005)...
  13. ncbi request reprint Gene polymorphism in Netherton and common atopic disease
    A J Walley
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Nat Genet 29:175-8. 2001
    ..Our results implicate a previously unrecognized pathway for the development of common allergic illnesses...
  14. ncbi request reprint Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample
    M F Moffatt
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Eur J Hum Genet 9:341-6. 2001
    ..The results indicate that HLA-DRB1 alleles modulate the total serum IgE concentration and IgE responses to allergens, but do not account for the previous observations of linkage of asthma to the MHC...
  15. ncbi request reprint GRR: graphical representation of relationship errors
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7RZ, UK
    Bioinformatics 17:742-3. 2001
    ..A graphical tool for verifying assumed relationships between individuals in genetic studies is described. GRR can detect many common errors using genotypes from many markers...
  16. ncbi request reprint Oxford genome screen for asthma-associated traits
    W O Cookson
    Asthma Genetics Group, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    Genet Epidemiol 21:S1-3. 2001
    ..Genotypic data for at a total of 296 markers were available. This paper describes the ascertainment, phenotypic data, and genotypic data made available for Genetic Analysis Workshop 12...
  17. ncbi request reprint A genome-wide search for quantitative trait loci underlying asthma
    S E Daniels
    Wellcome Trust Centre for Human Genetic Disease, University of Oxford, UK
    Nature 383:247-50. 1996
    ..The results demonstrate the extent and the complexity of the genetic predisposition to asthma...
  18. ncbi request reprint Recent advances in the genetics of allergy and asthma
    G G Anderson
    Wellcome Trust Centre for Human Genetics, Windmill Road, Oxford, UK OX3 7BN
    Mol Med Today 5:264-73. 1999
    ..Here, we describe the recent advances in the understanding of the inherited susceptibility to asthma and atopy and discuss their potential implications...
  19. ncbi request reprint GOLD--graphical overview of linkage disequilibrium
    G R Abecasis
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Bioinformatics 16:182-3. 2000
    ..We describe a software package that provides a graphical summary of linkage disequilibrium in human genetic data. It allows for the analysis of family data and is well suited to the analysis of dense genetic maps...
  20. ncbi request reprint Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci
    W O Cookson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 27:372-3. 2001
    ..These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity...
  21. ncbi request reprint Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor
    T Shirakawa
    Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Genet 7:125-9. 1994
    ..Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q...
  22. ncbi request reprint Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q
    A J Sandford
    Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK
    Lancet 341:332-4. 1993
    ..The known roles of Fc epsilon RI in antigen-induced mast-cell degranulation and in the release of cytokines that enhance IgE production make the gene for its beta subunit a candidate for the chromosome 11 atopy locus...
  23. ncbi request reprint A case study of QTL analysis in a mouse model of asthma
    Youming Zhang
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Methods Mol Biol 195:253-79. 2002
  24. ncbi request reprint Genetics and genomics of asthma and allergic diseases
    William Cookson
    University of Oxford, The Wellcome Trust Centre for Human Genetics, Oxford, England
    Immunol Rev 190:195-206. 2002
    ..Genetic and genomic studies both provide evidence that epithelial surfaces are active in the induction of allergic disease...
  25. ncbi request reprint Making sense of asthma genes
    William Cookson
    N Engl J Med 351:1794-6. 2004
  26. ncbi request reprint Haplotypes and asthma
    Miriam Moffatt
    Am J Respir Crit Care Med 171:1066-7. 2005
  27. ncbi request reprint Genetic variation in the beta subunit of the high affinity IgE receptor and atopy and asthma
    Julian Hopkin
    Clin Exp Allergy 36:855-7. 2006
  28. ncbi request reprint Is eczema really on the increase worldwide?
    Hywel Williams
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, United Kingdom
    J Allergy Clin Immunol 121:947-54.e15. 2008
    ..It is unclear whether eczema prevalence is truly increasing worldwide...
  29. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
    ..Our data furthermore confirm association of STAT6 variation with serum IgE levels...