Alan Connelly

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Neural bases of childhood speech disorders: lateralization and plasticity for speech functions during development
    Frédérique J Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Neurosci Biobehav Rev 36:439-58. 2012
  2. ncbi request reprint Role of fMRI in the decision-making process: epilepsy surgery for children
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom
    J Magn Reson Imaging 23:933-40. 2006
  3. ncbi request reprint Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhood
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Brain Lang 106:195-203. 2008
  4. ncbi request reprint Language after hemispherectomy in childhood: contributions from memory and intelligence
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH UK
    Neuropsychologia 46:3101-7. 2008
  5. ncbi request reprint Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
    F Liegeois
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, UCL, 4th Floor, 30 Guilford Street, London WC1N 1EH, UK
    Brain 127:1229-36. 2004
  6. ncbi request reprint Language fMRI abnormalities associated with FOXP2 gene mutation
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK
    Nat Neurosci 6:1230-7. 2003
  7. ncbi request reprint Speech and oral motor profile after childhood hemispherectomy
    Frédérique Liégeois
    UCL Institute of Child Health, London, UK
    Brain Lang 114:126-34. 2010
  8. doi request reprint Endophenotypes of FOXP2: dysfunction within the human articulatory network
    F Liegeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Eur J Paediatr Neurol 15:283-8. 2011
  9. doi request reprint Influence of motor functional magnetic resonance imaging on the surgical management of children and adolescents with symptomatic focal epilepsy
    Xavier De Tiège
    Neurosciences Unit, University College London Institute of Child Health, London, United Kingdom
    Neurosurgery 64:856-64; discussion 864. 2009
  10. ncbi request reprint Extra-hippocampal grey matter density abnormalities in paediatric mesial temporal sclerosis
    Francesca Cormack
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Neuroimage 27:635-43. 2005

Collaborators

Detail Information

Publications30

  1. doi request reprint Neural bases of childhood speech disorders: lateralization and plasticity for speech functions during development
    Frédérique J Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Neurosci Biobehav Rev 36:439-58. 2012
    ..In conclusion, for the first time we provide evidence that longterm and severe childhood speech disorders result predominantly from bilateral disruption of the neural networks involved in speech production...
  2. ncbi request reprint Role of fMRI in the decision-making process: epilepsy surgery for children
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom
    J Magn Reson Imaging 23:933-40. 2006
    ..In our experience, fMRI has significantly contributed to the decision-making process, and improved the counseling and management of young people with intractable epilepsy...
  3. ncbi request reprint Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhood
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Brain Lang 106:195-203. 2008
    ..The results suggest that distinct subregions of Broca's area and their right homologs can subserve speech and language, and that this variability may determine functional outcome...
  4. ncbi request reprint Language after hemispherectomy in childhood: contributions from memory and intelligence
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH UK
    Neuropsychologia 46:3101-7. 2008
    ....
  5. ncbi request reprint Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
    F Liegeois
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, UCL, 4th Floor, 30 Guilford Street, London WC1N 1EH, UK
    Brain 127:1229-36. 2004
    ..In conclusion, it is difficult to infer intra- versus inter-hemispheric language reorganization on the basis of clinical observations in the presence of early pathology to the left hemisphere...
  6. ncbi request reprint Language fMRI abnormalities associated with FOXP2 gene mutation
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK
    Nat Neurosci 6:1230-7. 2003
    ..Our findings suggest that the FOXP2 gene is critically involved in the development of the neural systems that mediate speech and language...
  7. ncbi request reprint Speech and oral motor profile after childhood hemispherectomy
    Frédérique Liégeois
    UCL Institute of Child Health, London, UK
    Brain Lang 114:126-34. 2010
    ..These results indicate incomplete functional re-organization for the control of fine speech motor movements throughout childhood, and provide no evidence of hemispheric differences...
  8. doi request reprint Endophenotypes of FOXP2: dysfunction within the human articulatory network
    F Liegeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Eur J Paediatr Neurol 15:283-8. 2011
    ..We suggest that nonword repetition is the optimal endophenotype for FOXP2 disruption in humans because this task recruits brain regions involved in the imitation and vocal learning of novel sequences of speech sounds...
  9. doi request reprint Influence of motor functional magnetic resonance imaging on the surgical management of children and adolescents with symptomatic focal epilepsy
    Xavier De Tiège
    Neurosciences Unit, University College London Institute of Child Health, London, United Kingdom
    Neurosurgery 64:856-64; discussion 864. 2009
    ..To determine the clinical value of motor functional magnetic resonance imaging (fMRI) in the presurgical evaluation of a large group of children and adolescents with epilepsy caused by lesions close to the central sulcus...
  10. ncbi request reprint Extra-hippocampal grey matter density abnormalities in paediatric mesial temporal sclerosis
    Francesca Cormack
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Neuroimage 27:635-43. 2005
    ....
  11. ncbi request reprint Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changes
    Rod C Scott
    Neurosciences Unit, Institute of Child Health, University College London, London, UK
    Epilepsia 47:1493-8. 2006
    ....
  12. ncbi request reprint Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution
    J Donald Tournier
    Radiology and Physics Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, London, WC1N 1EH, UK
    Neuroimage 23:1176-85. 2004
    ..5-T clinical scanner. The technique can recover the fiber ODF in regions of multiple fiber crossing and holds promise for applications such as tractography...
  13. ncbi request reprint Cortical abnormalities and language function in young patients with basal ganglia stroke
    Alison Rowan
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London WClN 1EH, UK
    Neuroimage 36:431-40. 2007
    ..We suggest that language impairments following basal ganglia damage may be attributable primarily to abnormalities in cortical language areas that are too subtle to detect on conventional structural MRI...
  14. pmc Pediatric traumatic brain injury: language outcomes and their relationship to the arcuate fasciculus
    Frédérique J Liégeois
    Developmental Cognitive Neuroscience Unit, University College London, Institute of Child Health, London, United Kingdom Electronic address
    Brain Lang 127:388-98. 2013
    ..Word comprehension was predicted by fractional anisotropy in the right arcuate. The co-morbidity between dysarthria and language deficits therefore seems to be the consequence of multiple tract damage. ..
  15. ncbi request reprint Reduction of errors in ASL cerebral perfusion and arterial transit time maps using image de-noising
    Jack A Wells
    Wellcome Trust Advanced MR Imaging Group, Department of Medical Physics and Bioengineering, University College London, London, UK
    Magn Reson Med 64:715-24. 2010
    ..A number of these methods (and particularly independent component analysis) were shown to achieve this aim without compromising image contrast...
  16. ncbi request reprint Cortical lateralization during verb generation: a combined ERP and fMRI study
    Alison Rowan
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, WC1N 1EH, UK
    Neuroimage 22:665-75. 2004
    ..Thus, ERPs and fMRI provided convergent evidence regarding language lateralization, with ERPs revealing the temporal sequence of posterior to anterior cortical activation during semantic retrieval...
  17. doi request reprint Corticobulbar tract changes as predictors of dysarthria in childhood brain injury
    Frédérique Liégeois
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK
    Neurology 80:926-32. 2013
    ..To identify corticobulbar tract changes that may predict chronic dysarthria in young people who have sustained a traumatic brain injury (TBI) in childhood using diffusion MRI tractography...
  18. ncbi request reprint Bolus delay and dispersion in perfusion MRI: implications for tissue predictor models in stroke
    Fernando Calamante
    Radiology and Physics Unit, UCL Institute of Child Health, University College London, London, UK
    Magn Reson Med 55:1180-5. 2006
    ..The results are compared with previous numerical simulations, and their implications for the assessment and management of acute stroke are discussed...
  19. ncbi request reprint EEG-fMRI in children with pharmacoresistant focal epilepsy
    Xavier De Tiège
    Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom
    Epilepsia 48:385-9. 2007
    ..To evaluate the usefulness of EEG-combined functional magnetic resonance imaging (EEG-fMRI) to localize epileptogenic sources...
  20. ncbi request reprint Improved deconvolution of perfusion MRI data in the presence of bolus delay and dispersion
    Lisa Willats
    Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
    Magn Reson Med 56:146-56. 2006
    ..Such maps would be a useful adjunct for interpreting bolus-tracking data...
  21. ncbi request reprint Hippocampal abnormalities after prolonged febrile convulsion: a longitudinal MRI study
    Rod C Scott
    Neurosciences Unit, Institute of Child Health, University College London, UK
    Brain 126:2551-7. 2003
    ..Alternatively, the asymmetry could represent return (post-acute oedema) to a pre-existing hippocampal abnormality similar to that identified in family members of patients with MTS and a history of PFC...
  22. ncbi request reprint Is quantification of bolus tracking MRI reliable without deconvolution?
    Joanna E Perthen
    Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
    Magn Reson Med 47:61-7. 2002
    ..The results presented here show that the use of summary parameters requires considerable caution, since tissue or patient types can easily be incorrectly classified due to the effect of variations in patient AIF and R(t)...
  23. ncbi request reprint Diffusion-weighted magnetic resonance imaging fibre tracking using a front evolution algorithm
    J Donald Tournier
    Radiology and Physics Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Neuroimage 20:276-88. 2003
    ..Example tracks are shown to illustrate some of the properties of the algorithm, such as robustness to noise and branching capability. Finally, the dependence of the algorithm on the model used to derive the fibre ODF is discussed...
  24. ncbi request reprint Modified constraint-induced movement therapy after childhood stroke
    Anne Gordon
    Neurosciences Unit, Institute of Child Health, University College London, London, UK
    Dev Med Child Neurol 49:23-7. 2007
    ..The use of mCIT is a promising intervention for children with chronic acquired hemiparesis. In this severely impaired group functional improvements were seen after therapy despite unchanged sensorimotor measures...
  25. ncbi request reprint Sickle cell disease: ischemia and seizures
    Mara Prengler
    Neurosciences Unit, Institute of Child Health, University College London, London, United Kingdom
    Ann Neurol 58:290-302. 2005
    ..These findings suggest that vasculopathy and focal hypoperfusion may be factors in the development of sickle cell disease-associated seizures...
  26. doi request reprint Ophthalmological, cognitive, electrophysiological and MRI assessment of visual processing in preterm children without major neuromotor impairment
    Michelle O'Reilly
    Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK
    Dev Sci 13:692-705. 2010
    ..Whilst this P100 finding suggests that subtle abnormalities may exist at the neurophysiological level, we conclude that visual dysfunction is not systematically associated with preterm birth in the context of normal neurological status...
  27. ncbi request reprint Abnormalities in hippocampi remote from the seizure focus: a T2 relaxometry study
    Rod C Scott
    Neurosciences Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, UK
    Brain 126:1968-74. 2003
    ....
  28. ncbi request reprint Quantification of bolus-tracking MRI: Improved characterization of the tissue residue function using Tikhonov regularization
    Fernando Calamante
    Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
    Magn Reson Med 50:1237-47. 2003
    ..On the other hand, the use of the proposed regularization method improves the characterization of the tissue residue function...
  29. ncbi request reprint Sickle cell disease and electroencephalogram hyperventilation
    Mara Prengler
    Ann Neurol 59:214-5. 2006
  30. ncbi request reprint Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution
    J Donald Tournier
    Brain Research Institute, Melbourne, Australia
    Neuroimage 35:1459-72. 2007
    ..This should allow tractography algorithms to be designed that are able to track reliably through crossing fibre regions...