Philip Conaghan

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi Methotrexate for pain relief in knee osteoarthritis: an open-label study
    Claire Y J Wenham
    Section of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 52:888-92. 2013
  2. ncbi Proceedings from the 5th Annual International Society for Musculoskeletal Imaging in Rheumatology Annual Conference
    Philip G Conaghan
    University of Leeds, Leeds, United Kingdom
    Semin Arthritis Rheum 42:433-46. 2013
  3. ncbi Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies
    Philip G Conaghan
    Division of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds LS7 4SA, UK
    Nat Rev Rheumatol 9:68-70. 2013
  4. ncbi Imaging tools in rheumatoid arthritis: ultrasound vs magnetic resonance imaging
    York Kiat Tan
    Division of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Rheumatology (Oxford) 51:vii36-42. 2012
  5. ncbi A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis
    Claire Y J Wenham
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK
    Rheumatology (Oxford) 51:2286-94. 2012
  6. ncbi Depression and anxiety in patients with rheumatoid arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale (HADS)
    Tanya Covic
    School of Psychology, University of Western Sydney, Australia
    BMC Psychiatry 12:6. 2012
  7. ncbi Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis
    Amanda E Nelson
    Thurston Arthritis Research Center, University of North Carolina, 3300 Thurston Building CB 7280, Chapel Hill, NC, 27599, USA
    Arthritis Res Ther 13:R176. 2011
  8. ncbi A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity
    Philip G Conaghan
    Section of Musculoskeletal Disease, Department of Musculoskeletal Medicine, Leeds Institute of Molecular Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK
    Rheumatol Int 32:1491-502. 2012
  9. ncbi A longitudinal evaluation of the Center for Epidemiologic Studies-Depression scale (CES-D) in a rheumatoid arthritis population using Rasch analysis
    Tanya Covic
    School of Psychology, University of Western Sydney, Penrith South DC, NSW, Australia
    Health Qual Life Outcomes 5:41. 2007
  10. ncbi Measuring the impact and distress of osteoarthritis from the patients' perspective
    Julie F Pallant
    School of Rural Health, University of Melbourne, 49 Graham St, Shepparton, Victoria, 3630, Australia
    Health Qual Life Outcomes 7:37. 2009

Detail Information

Publications105 found, 100 shown here

  1. ncbi Methotrexate for pain relief in knee osteoarthritis: an open-label study
    Claire Y J Wenham
    Section of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Rheumatology (Oxford) 52:888-92. 2013
    ..This open-label trial suggests analgesic efficacy for MTX in OA knee and suggests that a randomized controlled trial is warranted. Trial Registration. Current controlled trials, http://www.controlled-trials.com/, ISRCTN66676866...
  2. ncbi Proceedings from the 5th Annual International Society for Musculoskeletal Imaging in Rheumatology Annual Conference
    Philip G Conaghan
    University of Leeds, Leeds, United Kingdom
    Semin Arthritis Rheum 42:433-46. 2013
    ..This publication is based upon the proceedings from the 2012 ISEMIR educational meeting that took place on April 26th in Chicago, Illinois. Presentations from the live proceedings can be viewed at www.isemir.org...
  3. ncbi Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies
    Philip G Conaghan
    Division of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds LS7 4SA, UK
    Nat Rev Rheumatol 9:68-70. 2013
    ..Together, these advances could go some way to addressing the urgent need for disease-modifying treatments for this common disease...
  4. ncbi Imaging tools in rheumatoid arthritis: ultrasound vs magnetic resonance imaging
    York Kiat Tan
    Division of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Rheumatology (Oxford) 51:vii36-42. 2012
    ....
  5. ncbi A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis
    Claire Y J Wenham
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK
    Rheumatology (Oxford) 51:2286-94. 2012
    ..Anti-inflammatory therapies are effective analgesics for OA. This study determined whether low-dose oral prednisolone (PNL) was an effective analgesic for hand OA...
  6. ncbi Depression and anxiety in patients with rheumatoid arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale (HADS)
    Tanya Covic
    School of Psychology, University of Western Sydney, Australia
    BMC Psychiatry 12:6. 2012
    ....
  7. ncbi Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis
    Amanda E Nelson
    Thurston Arthritis Research Center, University of North Carolina, 3300 Thurston Building CB 7280, Chapel Hill, NC, 27599, USA
    Arthritis Res Ther 13:R176. 2011
    ..Therefore, our aim was to apply factor analytic methods to radiographic OA (rOA) grades across multiple joint sites, representing both presence and severity, to quantify the burden of rOA...
  8. ncbi A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity
    Philip G Conaghan
    Section of Musculoskeletal Disease, Department of Musculoskeletal Medicine, Leeds Institute of Molecular Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK
    Rheumatol Int 32:1491-502. 2012
    ....
  9. ncbi A longitudinal evaluation of the Center for Epidemiologic Studies-Depression scale (CES-D) in a rheumatoid arthritis population using Rasch analysis
    Tanya Covic
    School of Psychology, University of Western Sydney, Penrith South DC, NSW, Australia
    Health Qual Life Outcomes 5:41. 2007
    ..The aim of this study was to test the internal validity of the total Center for Epidemiologic Studies-Depression (CES-D) scale using Rasch analysis in a rheumatoid arthritis (RA) population...
  10. ncbi Measuring the impact and distress of osteoarthritis from the patients' perspective
    Julie F Pallant
    School of Rural Health, University of Melbourne, 49 Graham St, Shepparton, Victoria, 3630, Australia
    Health Qual Life Outcomes 7:37. 2009
    ....
  11. ncbi Assessment and management of neurogenic claudication associated with lumbar spinal stenosis in a UK primary care musculoskeletal service: a survey of current practice among physiotherapists
    Christine M Comer
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, LS7 4SA, UK
    BMC Musculoskelet Disord 10:121. 2009
    ..Non-surgical management is recommended as initial treatment, but little is known about current practice in relation to the assessment and management of these patients in the non-surgical setting...
  12. ncbi Variability in depression prevalence in early rheumatoid arthritis: a comparison of the CES-D and HAD-D Scales
    Tanya Covic
    School of Psychology, University of Western Sydney, Penrith South DC 1797, NSW, Australia
    BMC Musculoskelet Disord 10:18. 2009
    ..e. depression); and (c) identify similar levels of depression...
  13. ncbi Predicting outcomes in rheumatoid arthritis
    Philip G Conaghan
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Clin Rheumatol 30:S41-7. 2011
    ..Further work is needed, however, to identify the efficacy of current therapies in preventing disease onset and the long-term cost-effectiveness of appropriately targeted treatment with biologics...
  14. ncbi Examining a whole-organ magnetic resonance imaging scoring system for osteoarthritis of the knee using Rasch analysis
    P G Conaghan
    Academic Unit of Musculoskeletal Disease and Rehabilitation, University of Leeds, Leeds, UK
    Osteoarthritis Cartilage 14:A116-21. 2006
    ..The fit of data to the Rasch model offers a measure of the validity of summing different items into a subscale score and the degree to which this score behaves as a unidimensional, interval level measurement tool...
  15. ncbi MRI and non-cartilaginous structures in knee osteoarthritis
    P G Conaghan
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Osteoarthritis Cartilage 14:A87-94. 2006
    ..Improvements in quantitative and semi-quantitative assessments of non-cartilage features will greatly assist understanding of the OA process and its response to therapy...
  16. ncbi Internal construct validity of the Oxford Knee Scale: evidence from Rasch measurement
    Philip G Conaghan
    University of Leeds, Leeds, UK
    Arthritis Rheum 57:1363-7. 2007
    ..Several tools have been devised to assess knee problems. The goal of this study was to evaluate the Oxford Knee Scale (OKS) against strict modern psychometric standards through application of the Rasch measurement model...
  17. ncbi A multicenter reliability study of extremity-magnetic resonance imaging in the longitudinal evaluation of rheumatoid arthritis
    Philip G Conaghan
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 34:857-8. 2007
    ..Overall, E-MRI demonstrated ability to detect change comparable to that reported for high-field MRI for erosion and synovitis...
  18. ncbi Update on research and future directions of the OMERACT MRI inflammatory arthritis group
    Philip G Conaghan
    Department of Rheumatology, Pitie Salpetriere Hospital, APHP, Universite Paris 6 UPMC, Paris, France
    J Rheumatol 38:2031-3. 2011
    ..Subsequent longitudinal evaluation of this unique resource will be a major continuing focus for the group...
  19. ncbi Care and management of osteoarthritis in adults: summary of NICE guidance
    Philip G Conaghan
    Section of Musculoskeletal Disease, University of Leeds, Leeds LS7 4SA
    BMJ 336:502-3. 2008
  20. ncbi How to manage musculoskeletal conditions
    Philip G Conaghan
    Academic Unit of Musculoskeletal Disease, 2nd Floor, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Best Pract Res Clin Rheumatol 22:387-94. 2008
    ....
  21. ncbi An ultrasonographic study of metatarsophalangeal joint pain: synovitis, structural pathology and their relationship to symptoms and function
    Helen I Keen
    University Department of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Ann Rheum Dis 70:2140-3. 2011
    ..Pain in the first metatarsophalangeal joint (MTPJ) is common, though the link between pathology and symptoms is poorly understood...
  22. ncbi Assessment by MRI of inflammation and damage in rheumatoid arthritis patients with methotrexate inadequate response receiving golimumab: results of the GO-FORWARD trial
    Philip G Conaghan
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 70:1968-74. 2011
    ..To evaluate golimumab's effect on MRI-detected inflammation and structural damage in patients with active rheumatoid arthritis (RA) despite methotrexate (MTX)...
  23. ncbi The OMERACT MRI inflammatory arthritis group: advances and future research priorities
    Philip G Conaghan
    Section of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds, UK
    J Rheumatol 36:1803-5. 2009
    ....
  24. ncbi Transdermal buprenorphine plus oral paracetamol vs an oral codeine-paracetamol combination for osteoarthritis of hip and/or knee: a randomised trial
    P G Conaghan
    Section of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK
    Osteoarthritis Cartilage 19:930-8. 2011
    ..This study compared symptom relief obtained with buprenorphine patches plus oral paracetamol with that obtained with an oral codeine-paracetamol combination tablet (co-codamol) in older adults with OA...
  25. ncbi Persistently moderate DAS-28 is not benign: loss of function occurs in early RA despite step-up DMARD therapy
    Philip G Conaghan
    Section of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds, UK
    Rheumatology (Oxford) 49:1894-9. 2010
    ..The aim of this study was to examine the effect on patient-reported function of persistently moderate DAS-28 despite modern step-up DMARD therapy in an early arthritis cohort...
  26. ncbi Is MRI useful in osteoarthritis?
    Philip Conaghan
    Academic Unit of Musculoskeletal Disease, 2nd Floor, Chapel Allerton Hospital, Chapel Town Road, Leeds LS7 4SA, UK
    Best Pract Res Clin Rheumatol 20:57-68. 2006
    ..The evidence reviewed here will relate to knee OA, reflecting the vast preponderance of MRI studies in the knee...
  27. ncbi Is progressive osteoarthritis an atheromatous vascular disease?
    P G Conaghan
    Academic Unit of Musculoskeletal Disease, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 64:1539-41. 2005
    ..Further epidemiological studies, imaging investigations of relevant blood vessels, and trials of the effects of statins on the prevention and treatment of OA are needed to examine this hypothesis...
  28. ncbi Summary and recommendations of the OARSI FDA osteoarthritis Assessment of Structural Change Working Group
    P G Conaghan
    Section of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Osteoarthritis Cartilage 19:606-10. 2011
    ..The development of disease-modifying osteoarthritis drugs (DMOADs) remains challenging. The Assessment of Structural Change (ASC) Working Group aimed to provide a state-of-the-art critical update on imaging tools for OA clinical trials...
  29. ncbi Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort
    Ann W Morgan
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Arthritis Res Ther 12:R57. 2010
    ..This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort...
  30. ncbi Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease
    James I Robinson
    NIHR Leeds Musculoskeletal Biomedical Research Unit, St James s University Hospital, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Ann Rheum Dis 69:1054-7. 2010
    ..This study aimed to replicate previous candidate gene studies that had identified a significant association between the FCGR3A-158V allele and RA and then sought to estimate specific subgroup effects...
  31. ncbi OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Exercise 4: an international multicenter longitudinal study using the RA-MRI Score
    Philip Conaghan
    Academic Unit of Musculoskeletal and Rehabilitation Medicine, University of Leeds, UK
    J Rheumatol 30:1376-9. 2003
    ..Bone defects had the poorest agreement and have been omitted from new scoring recommendations. Despite limited training, multicenter readers demonstrated acceptable levels of agreement...
  32. ncbi Can flare be predicted in DMARD treated RA patients in remission, and is it important? A cohort study
    Benazir Saleem
    Divsion of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Ann Rheum Dis 71:1316-21. 2012
    ..This study aimed to determine the clinical, functional and imaging associations of disease flare in patients with RA in remission and any effect on long-term outcomes...
  33. ncbi Discrepancies in categorizing rheumatoid arthritis patients by DAS-28(ESR) and DAS-28(CRP): can they be reduced?
    Elizabeth M A Hensor
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, UK
    Rheumatology (Oxford) 49:1521-9. 2010
    ..The 28-joint disease activity score (DAS-28) guides the use of biologics in RA. The aims of this study were to investigate agreement between the ESR- and CRP-based DAS-28 definitions, and to examine how this agreement may be improved...
  34. ncbi Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis
    L A Rhodes
    Academic Unit of Medical Physics, University of Leeds, Wellcome Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Ann Rheum Dis 64:1347-9. 2005
    ..IRE and ME measures were greater at the CPJ than the SPP. CONCLUSIONS: The magnitude of synovitis at the CPJ is not disease-specific and applies across the spectrum of degenerative disease as well as inflammatory diseases...
  35. ncbi Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression
    A K Brown
    Chapel Allerton Hospital, University of Leeds, Leeds, UK
    Arthritis Rheum 54:3761-73. 2006
    ..Imaging assessment may be necessary for the accurate evaluation of disease status and, in particular, for the definition of true remission...
  36. ncbi FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study
    A W Morgan
    Rheumatology and Rehabilitation Research Unit, University of Leeds, UK
    Rheumatology (Oxford) 42:528-33. 2003
    ..To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA)...
  37. ncbi The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis
    H I Keen
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, University of Leeds, Leeds, UK
    Ann Rheum Dis 67:651-5. 2008
    ..We aimed to develop a preliminary US hand OA scoring system, initially focusing on relevant pathological features with potentially high reliability...
  38. ncbi The validation of simple scoring methods for evaluating compartment-specific synovitis detected by MRI in knee osteoarthritis
    L A Rhodes
    Academic Unit of Medical Physics, University of Leeds, Wellcome Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Rheumatology (Oxford) 44:1569-73. 2005
    ..The aim of this study was to compare simple, semiquantitative synovitis scores with detailed volume assessments in subjects with knee OA using magnetic resonance imaging (MRI) as the investigative tool...
  39. ncbi The relationship between limited MRI section analyses and volumetric assessment of synovitis in knee osteoarthritis
    L A Rhodes
    Academic Unit of Medical Physics, University of Leeds and Leeds General Infirmary, UK
    Clin Radiol 60:1295-9. 2005
    ..To assess whether simple, limited section analysis can replace detailed volumetric assessment of synovitis in patients with osteoarthritis (OA) of the knee using contrast-enhanced magnetic resonance imaging (MRI)...
  40. ncbi Can ultrasonography improve on radiographic assessment in osteoarthritis of the hands? A comparison between radiographic and ultrasonographic detected pathology
    H I Keen
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 67:1116-20. 2008
    ..This study aimed to compare the detection of osteophytosis and joint space narrowing (JSN) by US and conventional radiography (CR) in OA of the hand...
  41. ncbi Prevalence and impact of joint symptoms in people with stroke aged 55 years and over
    Chamila Hettiarachchi
    Academic Department of Rehabilitation Medicine, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine University of Leeds, Level D, Martin Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, United Kingdom
    J Rehabil Med 43:197-203. 2011
    ..To establish the prevalence and patterns of self-reported musculoskeletal symptoms in community-dwelling stroke survivors and their impact on common activities of daily living...
  42. ncbi Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: a comparison with arthroscopy and clinical examination
    Z Karim
    University of Leeds and Leeds General Infirmary, Leeds, UK
    Arthritis Rheum 50:387-94. 2004
    ..It may be valuable as a tool in studies investigating pain, diagnosis, and treatment response in knee arthritis...
  43. ncbi Magnetic resonance imaging in the assessment of metacarpophalangeal joint disease in early psoriatic and rheumatoid arthritis
    H Marzo-Ortega
    Academic Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Chapel Allerton Hospital, Leeds LS74SA, UK
    Scand J Rheumatol 38:79-83. 2009
    ....
  44. ncbi An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis
    A K Brown
    Leeds Institute of Molecular Medicine, University of Leeds, and Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 58:2958-67. 2008
    ..The purpose of this study was to evaluate the long-term significance of subclinical synovitis and its relationship to structural outcome...
  45. ncbi Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population
    Ann W Morgan
    Leeds Musculoskeletal Biomedical Research Unit, Institute of Molecular Medicine, University of Leeds, St James University Hospital, Leeds, UK
    Arthritis Rheum 60:2565-76. 2009
    ..To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA)...
  46. ncbi A diagnostic algorithm for persistence of very early inflammatory arthritis: the utility of power Doppler ultrasound when added to conventional assessment tools
    J E Freeston
    University of Leeds, Chapel Allerton Hospital, UK
    Ann Rheum Dis 69:417-9. 2010
    ..The aim of this study was to assess the value of power Doppler ultrasound (PDUS) in combination with routine management in a cohort of patients with very early inflammatory arthritis (IA)...
  47. ncbi New approaches to imaging early inflammatory arthritis
    A K Brown
    Academic Unit of Musculoskeletal Disease, Department of Rheumatology, University of Leeds, Leeds General Infirmary, UK
    Clin Exp Rheumatol 22:S18-25. 2004
    ..This article reviews the current evidence supporting the role of MUS and MRI in the assessment of patients with inflammatory arthritis...
  48. ncbi Predictors of outcome in patients with oligoarthritis: results of a protocol of intraarticular corticosteroids to all clinically active joints
    M Green
    University of Leeds, UK
    Arthritis Rheum 44:1177-83. 2001
    ..Failure to respond by 2 weeks indicates a high likelihood of persistent disease, and this is relevant when producing management guidelines and selecting patients for studies focusing on early intervention...
  49. ncbi Imaging the joints in early rheumatoid arthritis
    D McGonagle
    Rheumatology and Rehabilitation Research Unit, University of Leeds, 36 Clarendon Road, Leeds, LS2 9NZ, UK
    Best Pract Res Clin Rheumatol 15:91-104. 2001
    ..The relationship between synovitis and bone damage is also addressed in the light of recent magnetic resonance imaging observations...
  50. ncbi Does the use of tumour necrosis factor antagonist therapy in poor prognosis, undifferentiated arthritis prevent progression to rheumatoid arthritis?
    B Saleem
    Academic Section of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Ann Rheum Dis 67:1178-80. 2008
    ..To evaluate the ability of tumour necrosis factor (TNF) antagonist therapy to produce remission and prevent progression to rheumatoid arthritis (RA) in patients with poor prognosis undifferentiated inflammatory arthritis (UA)...
  51. ncbi Systematic review of MRI, ultrasound, and scintigraphy as outcome measures for structural pathology in interventional therapeutic studies of knee arthritis: focus on responsiveness
    Helen I Keen
    School of Medicine and Pharmacology, University of Western Australia Perth, Australia
    J Rheumatol 38:142-54. 2011
    ..Our aim was to review the published literature to ascertain the responsiveness of novel imaging techniques as outcome measures in interventional therapeutic studies of knee arthritis...
  52. ncbi Effect of intra-articular corticosteroid injections and inflammation on periarticular and generalised bone loss in early rheumatoid arthritis
    Glenn Haugeberg
    Department of Rheumatology, Sørlandet Hospital, Kristiansand, Norway
    Ann Rheum Dis 70:184-7. 2011
    ..To explore the effect of intra-articular corticosteroid (IAST) injections on bone mineral density (BMD) in the hand and at the metacarpophalangeal (MCP) joints in early rheumatoid arthritis (RA)...
  53. ncbi Does extremity-MRI improve erosion detection in severely damaged joints? A study of long-standing rheumatoid arthritis using three imaging modalities
    J E Freeston
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 66:1538-40. 2007
    ..The use of extremity magnetic resonance imaging (eMRI) offers the possibility of improved disease assessment because of greater patient tolerability...
  54. ncbi MRI and clinical findings in patients with ankylosing spondylitis eligible for anti-tumour necrosis factor therapy after a short course of etoricoxib
    S J Jarrett
    University of Leeds, Leeds, UK
    Ann Rheum Dis 68:1466-9. 2009
    ..To describe and assess the response to short-term etoricoxib as shown by MRI and clinical variables in patients with ankylosing spondylitis (AS) selected for eligibility for anti-tumour necrosis factor therapy...
  55. ncbi The therapeutic approach of early intervention for rheumatoid arthritis: what is the evidence?
    M A Quinn
    Rheumatology and Rehabilitation Research Unit, University of Leeds, Leeds, UK
    Rheumatology (Oxford) 40:1211-20. 2001
    ..The evidence for these is diverse and the best therapeutic approach remains vehemently debated. This review addresses these issues...
  56. ncbi Finger tendon disease in untreated early rheumatoid arthritis: a comparison of ultrasound and magnetic resonance imaging
    R J Wakefield
    Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 57:1158-64. 2007
    ..To investigate the frequency and distribution of finger tenosynovitis in patients with early, untreated rheumatoid arthritis (RA) using gray-scale ultrasound (US) and magnetic resonance imaging (MRI)...
  57. ncbi Debridement of plantar callosities in rheumatoid arthritis: a randomized controlled trial
    H J Davys
    Health Department, The Leeds General Infirmary, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK
    Rheumatology (Oxford) 44:207-10. 2005
    ..To compare forefoot pain, pressure and function before and after normal and sham callus treatment in rheumatoid arthritis (RA). Patients and..
  58. ncbi Hand bone loss in early undifferentiated arthritis: evaluating bone mineral density loss before the development of rheumatoid arthritis
    G Haugeberg
    Academic Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, UK
    Ann Rheum Dis 65:736-40. 2006
    ..Further studies are needed to evaluate the role of hand bone loss as a prognostic factor and outcome measure in rheumatoid arthritis...
  59. ncbi Infliximab in combination with methotrexate in active ankylosing spondylitis: a clinical and imaging study
    H Marzo-Ortega
    Academic Unit of Musculoskeletal Disease, Department of Rheumatology, 1st Floor, Old Nurses Home, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Ann Rheum Dis 64:1568-75. 2005
    ..However, disease flares were reported 8 weeks after the last infusion, indicating that addition of methotrexate failed to extend the infliximab dosing interval...
  60. ncbi True infliximab resistance in rheumatoid arthritis: a role for lymphotoxin alpha?
    M H Buch
    Academic Unit of Musculoskeletal Disease, 1st Floor, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Ann Rheum Dis 63:1344-6. 2004
    ..However, a proportion of patients are not responsive to this treatment. Inefficacy may represent a TNFalpha independent disease or insufficient drug at the site of action...
  61. ncbi Clinical effectiveness and dose response of image-guided intra-articular corticosteroid injection for hip osteoarthritis
    P Robinson
    Leeds Teaching Hospitals, Leeds, UK
    Rheumatology (Oxford) 46:285-91. 2007
    ..To assess symptomatic change after intra-articular corticosteroid (IAST) injection at 2 doses in hip osteoarthritis (OA), and to examine dose response and predictors of response...
  62. ncbi Effect of the early use of the anti-tumor necrosis factor adalimumab on the prevention of job loss in patients with early rheumatoid arthritis
    Victoria Bejarano
    University of Leeds, Leeds, UK
    Arthritis Rheum 59:1467-74. 2008
    ..To compare work disability and job loss in early rheumatoid arthritis (RA) patients receiving adalimumab plus methotrexate (adalimumab + MTX) versus MTX alone...
  63. ncbi OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis
    Laure Gossec
    Medicine Faculty, Paris 5 René Descartes University AP HP, Cochin Hospital, Department of Rheumatology B, Paris, France
    J Rheumatol 34:1432-5. 2007
    ..quot;..
  64. ncbi Can very high-dose anti-tumor necrosis factor blockade at onset of rheumatoid arthritis produce long-term remission?
    Philip G Conaghan
    Arthritis Rheum 46:1971-2; author reply 1973. 2002
  65. ncbi Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis
    Philip G Conaghan
    University of Leeds and Leeds General Infirmary, Leeds, UK
    Arthritis Rheum 48:64-71. 2003
    ..In the treatment of patients with RA, outcome measures and therapies should focus on synovitis...
  66. ncbi Role of metacarpophalangeal joint anatomic factors in the distribution of synovitis and bone erosion in early rheumatoid arthritis
    Ai Lyn Tan
    Leeds General Infirmary, Leeds, UK
    Arthritis Rheum 48:1214-22. 2003
    ..These findings have implications regarding the pathogenesis of joint damage in RA...
  67. ncbi Imaging of the musculoskeletal system: magnetic resonance imaging, ultrasonography and computed tomography
    Ai Lyn Tan
    Academic Unit of Musculoskeletal Disease, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Best Pract Res Clin Rheumatol 17:513-28. 2003
    ..This chapter reviews recent imaging studies relevant to rheumatic diseases...
  68. ncbi Prognostic factors in a large cohort of patients with early undifferentiated inflammatory arthritis after application of a structured management protocol
    Mark A Quinn
    Royal Adelaide Hospital, Adelaide, Australia
    Arthritis Rheum 48:3039-45. 2003
    ..Results of the clinical assessment at 12 weeks is the single best predictor of future therapy. This study provides background data for use in determining future therapeutic interventions...
  69. ncbi Structural associations of osteoarthritis pain: lessons from magnetic resonance imaging
    Philip G Conaghan
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Novartis Found Symp 260:191-201; discussion 201-5, 277-9. 2004
    ..Meniscal tears in OA knees, although common, have not been linked with pain. Improved, reliable quantification of the structural features and the rapid advances in MRI technology can only improve structure-pain understanding...
  70. ncbi A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee
    Richard Day
    Department of Clinical Pharmacology and Toxicology, University of New South Wales, St Vincent s Hospital, Darllinghurst, Sydney, Australia
    J Rheumatol 31:775-82. 2004
    ..To investigate the efficacy and tolerability of a course of 5 injections of hyaluronan (HA) given at intervals of one week in patients with symptomatic, mild to moderate osteoarthritis (OA) of the knee...
  71. ncbi Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case series
    Stephen J Jarrett
    Academic Unit of Musculoskeletal Medicine, University of Leeds, Great George Street, Leeds LS1 3EX, United Kingdom
    J Rheumatol 30:2287-91. 2003
    ..We discuss the literature and potential causal mechanisms, including disease activity, the role of autoantibodies, and shifts in T cell responses...
  72. ncbi Assessing single joints in arthritis clinical trials
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Rheumatol 34:641-7. 2007
    ..At OMERACT 8, the group developed a research agenda to perform additional validation studies of clinical and functional indices, imaging, synovial histopathology, and soluble biomarkers...
  73. ncbi The OMERACT Magnetic Resonance Imaging Inflammatory Arthritis Group - advances and priorities
    Mikkel Østergaard
    Department of Rheumatology, Copenhagen University Hospitals at Herlev, Denmark
    J Rheumatol 34:852-3. 2007
    ..This work focused on testing the reliability of dedicated extremity MRI in rheumatoid arthritis and on the initial steps in the development of an MRI score for peripheral psoriatic arthritis...
  74. ncbi The OMERACT Ultrasound Group: status of current activities and research directions
    Richard J Wakefield
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 34:848-51. 2007
    ..The reliability of acquiring images was also enhanced using standardized positions. Future studies will assess the value of US in clinical trials...
  75. ncbi Summary findings of a systematic review of the ultrasound assessment of synovitis
    Fredrick Joshua
    Department of Rheumatology, St George Hospital, University of NSW, Sydney, Australia
    J Rheumatol 34:839-47. 2007
    ..The review highlights the current gaps in the literature, including a lack of reliability data with respect to intra-occasion and intra- and inter-reader reliability. Current work by our group is addressing these issues...
  76. ncbi Musculoskeletal ultrasound including definitions for ultrasonographic pathology
    Richard J Wakefield
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 32:2485-7. 2005
    ..Also proposed for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis...
  77. ncbi Imaging outcomes and their role in determining outcomes in osteoarthritis and rheumatoid arthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, and the Department of Medicine at Boston Medical Center, Boston, Massachussetts 02118, USA
    Curr Opin Rheumatol 18:157-62. 2006
    ..This review describes the advances in knowledge of outcomes that have occurred recently as a result of imaging research in both osteoarthritis and rheumatoid arthritis...
  78. ncbi The Foot Posture Index: Rasch analysis of a novel, foot-specific outcome measure
    Anne Maree Keenan
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Arch Phys Med Rehabil 88:88-93. 2007
    ..To investigate the internal construct validity of a clinician-assessed measure of foot position, the Foot Posture Index (FPI), versions FPI-8 and FPI-6...
  79. ncbi Efficacy of infliximab on MRI-determined bone oedema in psoriatic arthritis
    Helena Marzo-Ortega
    Consultant Rheumatologist, Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 66:778-81. 2007
    ..On MRI, areas of active clinical involvement are represented by bone oedema and synovitis. Aim: To assess the impact of infliximab on bone oedema in PsA as shown by MRI...
  80. ncbi Response to intramuscular methyl prednisolone in inflammatory hand pain: evidence for a targeted clinical, ultrasonographic and therapeutic approach
    Zunaid Karim
    Academic Unit of Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK
    Ann Rheum Dis 66:690-2. 2007
    ..Hand pain with stiffness is a common clinical presentation to early arthritis clinics, with outcome varying from resolution to the development of rheumatoid arthritis...
  81. ncbi Impact of multiple joint problems on daily living tasks in people in the community over age fifty-five
    Anne Maree Keenan
    Academic Unit of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 55:757-64. 2006
    ..To establish the prevalence of multiple joint problems and their impact on everyday tasks...
  82. ncbi Developing a magnetic resonance imaging scoring system for peripheral psoriatic arthritis
    Fiona McQueen
    Department of Rheumatology, Auckland University, Auckland, New Zealand
    J Rheumatol 34:859-61. 2007
    ..Measures to improve reliability for future exercises will include reviewing definitions of pathological features and prior reader calibration...
  83. ncbi Quantifying peri-meniscal synovitis and its relationship to meniscal pathology in osteoarthritis of the knee
    Andrew J Grainger
    Department of Radiology, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK
    Eur Radiol 17:119-24. 2007
    ..524, P<0..000). The results suggest the semiquantitative scoring system is valid for assessing perimeniscal synovitis. The relationship between meniscal pathology and adjacent synovitis requires further study...
  84. ncbi Development and validation of a needs-based quality of life instrument for osteoarthritis
    Anne Maree Keenan
    University of Leeds, Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 59:841-8. 2008
    ..To develop and validate a disease-specific quality of life (QOL) measure for osteoarthritis (OA), the OAQoL, using the needs-based conceptual model...
  85. ncbi Using extremity magnetic resonance imaging to assess and monitor early rheumatoid arthritis: the optimal joint combination to be scanned in clinical practice
    Ewa Olech
    University of Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Rheumatol 35:580-3. 2008
    ..To identify the optimal combination for detecting erosions in early rheumatoid arthritis using extremity magnetic resonance imaging (eMRI)...
  86. ncbi Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-m
    Mark A Quinn
    Academic Unit of Musculoskeletal Disease, First Floor, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Arthritis Rheum 52:27-35. 2005
    ..At 2 years, functional and quality of life benefits were sustained, despite withdrawal of infliximab therapy. These data may have significant implications for the optimal use of expensive biologic therapies...
  87. ncbi Early diagnosis crucial in polyarthralgia
    Robert Ley
    Yorkshire Deanery, University of Leeds
    Practitioner 251:17-8, 21-2. 2007
    ....
  88. ncbi A multireader reliability study comparing conventional high-field magnetic resonance imaging with extremity low-field MRI in rheumatoid arthritis
    Paul Bird
    Department of Rheumatology, St George Hospital, University of New South Wales, Sydney, Australia
    J Rheumatol 34:854-6. 2007
    ..However, for synovitis and bone edema, considerable intermachine and interreader variability was found. Further studies are needed before recommendations on multireader E-MRI assessment of these pathologies can be given...
  89. ncbi The Rasch measurement model in rheumatology: what is it and why use it? When should it be applied, and what should one look for in a Rasch paper?
    Alan Tennant
    University of Leeds, Leeds, UK
    Arthritis Rheum 57:1358-62. 2007
  90. ncbi Evidence for a different anatomic basis for joint disease localization in polymyalgia rheumatica in comparison with rheumatoid arthritis
    Helena Marzo Ortega
    University of Leeds, and Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 56:3496-501. 2007
    ..This study used contrast-enhanced and fat suppression magnetic resonance imaging (MRI) to evaluate the relationship between synovial and extracapsular inflammation in PMR and early rheumatoid arthritis (RA)...
  91. ncbi Study of individual joint pathology in rheumatoid arthritis suggests a single pathology: comment on the editorial by Kirwan
    Philip G Conaghan
    Arthritis Rheum 52:672-3; author reply 673. 2005
  92. ncbi A modification of the Omeract RA MRI score for erosions for use with an extremity MRI system with reduced field of view
    Jane E Freeston
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 66:1669-71. 2007
    ..To develop and test the reliability of a modified version of the OMERACT rheumatoid arthritis magnetic resonance imaging score (RAMRIS) for erosions using extremity MRI (eMRI) with reduced field of view (RAMRIS-RV)...
  93. ncbi MRI and musculoskeletal ultrasonography as diagnostic tools in early arthritis
    Helen I Keen
    Academic Unit of Musculoskeletal Disease, Department of Rheumatology, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Rheum Dis Clin North Am 31:699-714. 2005
    ..These imaging modalities are likely to be increasingly used in the management of early rheumatoid arthritis to ensure the best patient outcomes, although more work is required to determine their optimal roles...
  94. ncbi Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis
    Stephen J Jarrett
    University of Leeds, Leeds, UK
    Arthritis Rheum 54:1410-4. 2006
    ....
  95. ncbi The evidence for magnetic resonance imaging as an outcome measure in proof-of-concept rheumatoid arthritis studies
    Philip G Conaghan
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 32:2465-9. 2005
    ..We review the extent to which MRI assessments of joint erosion, bone edema, and synovitis fulfil these criteria, particularly as they relate to proof-of-concept RA clinical trials...
  96. ncbi Magnetic resonance imaging in rheumatoid arthritis advances and research priorities
    Mikkel Ostergaard
    Copenhagen University Hospitals, Herlev, Copenhagen, Denmark
    J Rheumatol 32:2462-4. 2005
    ....
  97. ncbi MR imaging findings in the hands
    Philip G Conaghan
    Radiology 241:320-1; author reply 321. 2006
  98. ncbi Response: office-based low-field extremity magnetic resonance imaging: is the glass half empty or half full?
    David E Yocum
    Genentech, South San Francisco, California 94080 4990, USA
    Arthritis Rheum 54:1048-50. 2006
  99. ncbi Musculoskeletal ultrasonography: improving our senses
    Philip G Conaghan
    Arthritis Rheum 53:639-42. 2005
  100. ncbi Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema
    Marissa N Lassere
    Department of Rheumatology, St George Hospital, University of New South Wales, Sydney, Australia
    J Rheumatol 34:607-15. 2007
    ..Our objective was to review the literature on biomarkers and surrogates to develop a hierarchical schema that systematically evaluates and ranks the surrogacy status of biomarkers and surrogates; and to obtain feedback from stakeholders...
  101. ncbi Principles of managing musculoskeletal conditions. Preface
    Peter Brooks
    Best Pract Res Clin Rheumatol 22:385-6. 2008