Juliet Compston

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Bone remodeling rate and remodeling balance are not co-regulated in adulthood: implications for the use of activation frequency as an index of remodeling rate
    Juliet E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    J Bone Miner Res 22:1031-6. 2007
  2. doi request reprint Obesity and bone
    Juliet Compston
    Department of Medicine, Addenbrooke s Hospital, Box 157, Level 5, Hills Road, Cambridge CB2 0QQ, UK
    Curr Osteoporos Rep 11:30-5. 2013
  3. doi request reprint The use of combination therapy in the treatment of postmenopausal osteoporosis
    Juliet Compston
    Bone Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
    Endocrine 41:11-8. 2012
  4. ncbi request reprint Compliance with osteoporosis therapy is the weakest link
    Juliet E Compston
    Department of Medicine, University of Cambridge Clinical School, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Lancet 368:973-4. 2006
  5. ncbi request reprint How to manage osteoporosis after the menopause
    Juliet Compston
    University of Cambridge School of Clinical Medicine, Box 157, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Rheumatol 19:1007-19. 2005
  6. ncbi request reprint Recombinant parathyroid hormone in the management of osteoporosis
    J Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital Hills Road, Box 157, CB2 2QQ, Cambridge, UK
    Calcif Tissue Int 77:65-71. 2005
  7. ncbi request reprint Changes in bone mineral density, body composition and biochemical markers of bone turnover during weight gain in adolescents with severe anorexia nervosa: a 1-year prospective study
    J E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Osteoporos Int 17:77-84. 2006
  8. ncbi request reprint The risks and benefits of HRT
    J E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    J Musculoskelet Neuronal Interact 4:187-90. 2004
  9. ncbi request reprint Prevention of vertebral fractures by strontium ranelate in postmenopausal women with osteoporosis
    Juliet Compston
    Department of Medicine, Box 157, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Osteoporos Int 16:S4-6. 2005
  10. ncbi request reprint Guidelines for the management of osteoporosis: the present and the future
    Juliet Compston
    Department of Medicine, University of Cambridge School of Medicine, Addenbrooke s Hospital, PO Box 157, Cambridge CB2 2QQ, UK
    Osteoporos Int 16:1173-6. 2005

Detail Information

Publications78

  1. ncbi request reprint Bone remodeling rate and remodeling balance are not co-regulated in adulthood: implications for the use of activation frequency as an index of remodeling rate
    Juliet E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    J Bone Miner Res 22:1031-6. 2007
    ..In iliac crest biopsy specimens from 57 healthy subjects 19-80 yr of age, no correlations were shown between these variables, an observation that challenges the use of activation frequency as an estimate of remodeling rate...
  2. doi request reprint Obesity and bone
    Juliet Compston
    Department of Medicine, Addenbrooke s Hospital, Box 157, Level 5, Hills Road, Cambridge CB2 0QQ, UK
    Curr Osteoporos Rep 11:30-5. 2013
    ..The evidence base for strategies to prevent fractures in obese individuals is weak and is an important area for future research...
  3. doi request reprint The use of combination therapy in the treatment of postmenopausal osteoporosis
    Juliet Compston
    Bone Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
    Endocrine 41:11-8. 2012
    ..Anti-resorptive therapy after PTH therapy maintains or increases the gains in BMD. Further research is required to establish the cost-effectiveness and safety of combined and sequential regimens...
  4. ncbi request reprint Compliance with osteoporosis therapy is the weakest link
    Juliet E Compston
    Department of Medicine, University of Cambridge Clinical School, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Lancet 368:973-4. 2006
  5. ncbi request reprint How to manage osteoporosis after the menopause
    Juliet Compston
    University of Cambridge School of Clinical Medicine, Box 157, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Rheumatol 19:1007-19. 2005
    ....
  6. ncbi request reprint Recombinant parathyroid hormone in the management of osteoporosis
    J Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital Hills Road, Box 157, CB2 2QQ, Cambridge, UK
    Calcif Tissue Int 77:65-71. 2005
  7. ncbi request reprint Changes in bone mineral density, body composition and biochemical markers of bone turnover during weight gain in adolescents with severe anorexia nervosa: a 1-year prospective study
    J E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Osteoporos Int 17:77-84. 2006
    ..These results indicate that although weight gain in young anorexics is associated with linear growth, bone mineral density does not increase. Whether this deficit can be corrected subsequently requires longer-term prospective studies...
  8. ncbi request reprint The risks and benefits of HRT
    J E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    J Musculoskelet Neuronal Interact 4:187-90. 2004
    ..Nevertheless, the mechanisms by which estrogen exerts its beneficial skeletal effects remain a major area of research that has important implications for the development of novel therapies...
  9. ncbi request reprint Prevention of vertebral fractures by strontium ranelate in postmenopausal women with osteoporosis
    Juliet Compston
    Department of Medicine, Box 157, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Osteoporos Int 16:S4-6. 2005
    ..These results demonstrate that strontium ranelate is a new therapeutic option in the prevention of osteoporotic vertebral fractures in postmenopausal women...
  10. ncbi request reprint Guidelines for the management of osteoporosis: the present and the future
    Juliet Compston
    Department of Medicine, University of Cambridge School of Medicine, Addenbrooke s Hospital, PO Box 157, Cambridge CB2 2QQ, UK
    Osteoporos Int 16:1173-6. 2005
    ..This review considers the challenges involved in the development and implementation of guidelines and proposes a paradigm for the unification of guidelines in the future...
  11. ncbi request reprint US and UK guidelines for glucocorticoid-induced osteoporosis: similarities and differences
    Juliet Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 157, Cambridge, CB2 2QQ, UK
    Curr Rheumatol Rep 6:66-9. 2004
    ....
  12. ncbi request reprint Glucocorticoid-induced osteoporosis
    Juliet Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Horm Res 60:77-9. 2003
    ..In other glucocorticoid-treated individuals, the decision to treat should be based on bone densitometry...
  13. ncbi request reprint Osteoporosis associated with gastrointestinal diseases
    Juliet Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Eur J Gastroenterol Hepatol 15:841-3. 2003
  14. ncbi request reprint Skeletal actions of intermittent parathyroid hormone: effects on bone remodelling and structure
    Juliet E Compston
    School of Clinical Medicine, University of Cambridge, Cambridge CB2 2QQ, UK
    Bone 40:1447-52. 2007
    ..Better definition of the effects of intermittent PTH administration on cancellous and cortical bone remodelling and structure at different skeletal sites may inform these speculations and is an important area for future research...
  15. ncbi request reprint Bone quality: what is it and how is it measured?
    Juliet Compston
    School of Clinical Medicine, University of Cambridge, Cambridge, UK
    Arq Bras Endocrinol Metabol 50:579-85. 2006
    ..New techniques to assess these components of bone quality are being developed and should produce important insights into determinants of fracture risk in untreated and treated disease...
  16. doi request reprint Obesity is not protective against fracture in postmenopausal women: GLOW
    Juliet E Compston
    Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Am J Med 124:1043-50. 2011
    ..To investigate the prevalence and incidence of clinical fractures in obese, postmenopausal women enrolled in the Global Longitudinal study of Osteoporosis in Women (GLOW)...
  17. doi request reprint Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw
    J Compston
    Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
    Osteoporos Int 22:2951-61. 2011
    ..Other possible pathogenetic factors include suppression of bone turnover, altered immune status and adverse effects of bisphosphonates on the oral mucosa...
  18. doi request reprint Clinical question: What is the best approach to managing glucocorticoid-induced osteoporosis?
    Juliet Compston
    Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Clin Endocrinol (Oxf) 74:547-50. 2011
    ..Calcium and vitamin D supplements should be co-prescribed unless there is evidence of an adequate dietary calcium intake and vitamin D status...
  19. doi request reprint Osteoporosis: social and economic impact
    Juliet Compston
    Department of Medicine, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Radiol Clin North Am 48:477-82. 2010
    ..Finally, there is a discussion of the recent advances in fracture risk prediction and the use of independent clinical risk factors to improve bone mineral density-based prediction...
  20. doi request reprint Management of glucocorticoid-induced osteoporosis
    Juliet Compston
    University of Cambridge School of Clinical Medicine, Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Nat Rev Rheumatol 6:82-8. 2010
    ....
  21. doi request reprint Monitoring osteoporosis treatment
    Juliet Compston
    University of Cambridge School of Clinical Medicine, Cambridge, UK
    Best Pract Res Clin Rheumatol 23:781-8. 2009
    ....
  22. doi request reprint Clinical and therapeutic aspects of osteoporosis
    Juliet Compston
    University of Cambridge School of Clinical Medicine, Box 157, Department of Medicine, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Eur J Radiol 71:388-91. 2009
    ..Compliance and persistence with long-term treatment is poor but may be improved by less frequent dosing regimens...
  23. doi request reprint Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK
    J Compston
    University of Cambridge School of Clinical Medicine, Department of Medicine, Cambridge, United Kingdom
    Maturitas 62:105-8. 2009
    ..University of Sheffield Press; 2008], a practical summary of which is detailed below. The management algorithms are underpinned by a health economic analysis applied to the epidemiology of fracture in the UK...
  24. ncbi request reprint Over-suppression of bone turnover: does it exist?
    Juliet Compston
    Department of Medicine, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Curr Osteoporos Rep 5:179-85. 2007
    ..Nevertheless, further research is required to establish the optimal duration of treatment with antiresorptive agents...
  25. ncbi request reprint Emerging consensus on prevention and treatment of glucocorticoid-induced osteoporosis
    Juliet E Compston
    University of Cambridge School of Clinical Medicine, and Addenbrooke s Hospital, Box 157, Cambridge CB2 2QQ, UK
    Curr Rheumatol Rep 9:78-84. 2007
    ..Organized care programs together with the use of evidence-based guidelines have the potential to improve significantly the management of this serious complication of glucocorticoid therapy...
  26. ncbi request reprint Osteoporosis after liver transplantation
    Juliet E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, United Kingdom
    Liver Transpl 9:321-30. 2003
    ....
  27. ncbi request reprint Can biochemical markers be used to screen patients with inflammatory bowel disease for osteoporosis?
    Juliet E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Eur J Gastroenterol Hepatol 14:587-9. 2002
    ....
  28. pmc Is fracture risk increased in patients with coeliac disease?
    J Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Gut 52:459-60. 2003
  29. ncbi request reprint Sex steroids and bone
    J E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    Physiol Rev 81:419-447. 2001
    ....
  30. ncbi request reprint Bone marrow and bone: a functional unit
    J E Compston
    Department of Medicine, Box 157, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Endocrinol 173:387-94. 2002
    ....
  31. pmc Reduced bone formation in UK Gulf War veterans: a bone histomorphometric study
    J E Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 2QQ, UK
    J Clin Pathol 55:897-9. 2002
    ..The aim of this study was to establish whether there were abnormalities in bone turnover and remodelling in a group of symptomatic subjects who had served in the Gulf War...
  32. ncbi request reprint The localization of the functional glucocorticoid receptor alpha in human bone
    E O Abu
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, United Kingdom
    J Clin Endocrinol Metab 85:883-9. 2000
    ..The absence of receptor expression in osteoclasts also suggests that the effects of glucocorticoids on bone resorption may be mediated indirectly...
  33. pmc Bone structure and remodelling in stroke patients: early effects of zoledronate
    Kenneth E S Poole
    Division of Bone Research, Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Cambridge, England, CB2 2QQ, UK
    Bone 44:629-33. 2009
    ..Participants from the trial also volunteered for trans-iliac bone biopsy, to assess the early effects of stroke and zoledronate on iliac bone remodelling...
  34. ncbi request reprint Mechanisms of bone loss and gain in untreated and treated osteoporosis
    Juliet Compston
    Department of Medicine, University of Cambridge School of Clinical Medicine, UK
    Endocrine 17:21-7. 2002
  35. doi request reprint Obesity and fractures in postmenopausal women
    Melissa Orlandin Premaor
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Bone Miner Res 25:292-7. 2010
    ....
  36. ncbi request reprint The localization of thyroid hormone receptor mRNAs in human bone
    E O Abu
    Department of Medicine, University of Cambridge School of Clinical Medicine, England
    Thyroid 10:287-93. 2000
    ..This is also the first demonstration of the presence of TRbeta2 mRNA in bone. The role of TRbeta2 in mediating the actions of thyroid hormones in bone is not known and requires further investigation...
  37. pmc Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha, interleukin 1, and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts
    D O' Gradaigh
    Bone Research Group, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Ann Rheum Dis 63:354-9. 2004
    ..RANKL-independent osteoclastogenesis also occurs, though IL1 is required for resorptive function in most studies. These inflammatory cytokines have a pivotal role in rheumatoid arthritis,..
  38. ncbi request reprint The effects of hormone replacement therapy on cortical bone in postmenopausal women. A histomorphometric study
    S Vedi
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Bone 33:330-4. 2003
    ..There was also a trend toward higher wall width with increasing dose of oestrogen, consistent with the previously reported anabolic effect in cancellous bone...
  39. ncbi request reprint Effects of estrogen on collagen synthesis by cultured human osteoblasts depend on the rate of cellular differentiation
    Deborah C Ireland
    University of Cambridge School of Clinical Medicine, Box 157, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ
    J Cell Biochem 86:251-7. 2002
    ..Since the young and old-donor hOBs were cultured under identical conditions, our results indicate that the response of hOBs to estrogen is largely dependent on intracellular mechanisms that control the timing of cellular differentiation...
  40. ncbi request reprint The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 157, Cambridge CB2 2QQ, UK
    Bone 32:136-41. 2003
    ..ERalpha mRNA but not ERbeta expression was up-regulated by estrogen. Our results suggest that estrogen may exert its anti-resorptive effects on bone, at least in part, by stimulating ER and OPG expression in osteoblasts...
  41. ncbi request reprint Megakaryocytes modulate osteoblast synthesis of type-l collagen, osteoprotegerin, and RANKL
    S Bord
    Cambridge University School of Clinical Medicine, Addenbrooke s Hospital, Box 157, Cambridge CB2 2QQ, UK
    Bone 36:812-9. 2005
    ..These data provide further evidence that megakaryocytes may play an important role in bone remodeling...
  42. ncbi request reprint Osteoclast formation and bone resorption are inhibited by megakaryocytes
    C A Beeton
    Department of Medicine, School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Box 157, Hills Road, Cambridge CB2 2QQ, UK
    Bone 39:985-90. 2006
    ..These results show that MKs inhibit osteoclast formation and activity. The most pronounced effects were seen when MKs and osteoclasts were co-cultured from day 0, suggesting that MKs act primarily on osteoclast precursors...
  43. ncbi request reprint Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone
    A Horner
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
    Bone 19:353-62. 1996
    ..These data demonstrate the widespread expression of PDGF-A and its receptor in forming human bone and indicate that this growth factor may exert autocrine and paracrine effects to regulate osteogenesis during skeletal development...
  44. ncbi request reprint Stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) expression in developing human bone: potential roles in skeletal development
    S Bord
    Department of Medicine University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
    Bone 23:7-12. 1998
    ..In situ zymography demonstrates that SL-2 is produced in an active form with associated degradation, whereas SL-1, in a matrix-bound proenzyme form, may act as a reservoir for later activation...
  45. ncbi request reprint Mechanisms by which high-dose estrogen therapy produces anabolic skeletal effects in postmenopausal women: role of locally produced growth factors
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Bone 29:216-22. 2001
    ....
  46. ncbi request reprint Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone
    A Horner
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
    Bone 23:95-102. 1998
    ....
  47. ncbi request reprint Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) distribution in normal and pathological human bone
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
    Bone 24:229-35. 1999
    ..Furthermore, TIMP-1 may play a role in the regulation of bone modeling and remodeling in normal developing human bone...
  48. pmc Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage
    A Horner
    University of Cambridge School of Clinical Medicine, Department of Medicine, Addenbrooke s Hospital, UK
    J Anat 194:519-24. 1999
    ....
  49. ncbi request reprint Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling?
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Bone 27:397-401. 2000
    ..The ability of MKs to express ERs and synthesise TGFbeta, a potent mitogen in osteoblast differentiation, suggests that these cells may play a role in mediating estrogen-induced effects on bone...
  50. ncbi request reprint Tie2 ligands angiopoietin-1 and angiopoietin-2 are coexpressed with vascular endothelial cell growth factor in growing human bone
    A Horner
    Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Bone 28:65-71. 2001
    ..The distribution of Ang-1, Ang-2, and VEGF indicate these factors may play key roles in the regulation of angiogenesis at sites of endochondral ossification, intramembranous ossification, and bone turnover in the growing human skeleton...
  51. ncbi request reprint A histomorphometric study of cortical bone of the iliac crest in patients treated with glucocorticoids
    S Vedi
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Calcif Tissue Int 77:79-83. 2005
    ..Effects of the underlying disease on bone remodeling may also contributed to these changes and could not be excluded in the present study; since control subjects were not matched in terms of disease status...
  52. ncbi request reprint Synthesis of osteoprotegerin and RANKL by megakaryocytes is modulated by oestrogen
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 126:244-51. 2004
    ..001). Thus, E stimulates megakaryocytopoiesis and modulates OPG and RANKL expression, providing evidence that MKs may play a role in bone remodelling and, in particular, in E-induced changes in osteoclastogenesis and bone resorption...
  53. ncbi request reprint Hydrocortisone increases the rate of differentiation of cultured human osteoblasts
    Deborah C Ireland
    University of Cambridge School of Clinical Medicine, Cambridge CB2 2QQ, United Kingdom
    J Cell Biochem 91:594-601. 2004
    ..The data suggest that increasing concentrations of glucocorticoid, including concentrations similar to plasma levels in patients receiving oral glucocorticoid therapy, increase the rate of cellular differentiation...
  54. ncbi request reprint Estrogen stimulates differentiation of megakaryocytes and modulates their expression of estrogen receptors alpha and beta
    Sharyn Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Cell Biochem 92:249-57. 2004
    ..This finding together with the stimulation of ER protein and mRNA expression adds to the increasing evidence for a role for MKs in estrogen-induced bone formation...
  55. ncbi request reprint Lack of effect of intravenous pamidronate on fracture incidence and bone mineral density after orthotopic liver transplantation
    Mary Ninkovic
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Hepatol 37:93-100. 2002
    ..The aim of this study was to investigate the effects of a pre-transplant infusion of pamidronate on fracture incidence and bone loss during the first year after transplantation...
  56. ncbi request reprint Combination therapy for postmenopausal osteoporosis
    Juliet E Compston
    Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Clin Endocrinol (Oxf) 56:565-9. 2002
    ..Thus, the use of combination therapy for treatment of osteoporosis cannot be recommended on the basis of currently available evidence...
  57. doi request reprint Bone health in HIV infection
    Emily Pollock
    Clinical School of Medicine, University of Cambridge, Cambridge, UK
    Br Med Bull 92:123-33. 2009
    ..Osteoporosis is among the chronic problems emerging as the human immunodeficiency virus (HIV)-positive population ages...
  58. ncbi request reprint Bone histomorphometry
    Shobna Vedi
    Bone Research Group, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Methods Mol Med 80:283-98. 2003
  59. ncbi request reprint A prospective study of discordance in diagnosis of osteoporosis using spine and proximal femur bone densitometry
    D O'Gradaigh
    Bone Research Group, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Osteoporos Int 14:13-8. 2003
    ..We conclude that, as the most usual indication for bone densitometry is to aid the determination of an individual's fracture risk, both proximal femur and lumbar spine should continue to be assessed...
  60. ncbi request reprint Effects of a single infusion of pamidronate prior to liver transplantation: a bone histomorphometric study
    Shobna Vedi
    Department of Medicine, Box 157, Addenbrooke s Hospital, University of Cambridge School of Clinical Medicine, Cambridge CB2 2QQ, UK
    Transpl Int 15:290-5. 2002
    ..These results indicate that pre-operative administration of pamidronate in patients with chronic liver disease prevents, at least in part, the increase in bone turnover which occurs in untreated patients after transplantation...
  61. ncbi request reprint Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry
    G Holt
    Department of Medicine Box 157, Clinical Gerontology and the Institute of Public Health, Clinical School, Hills Road, University of Cambridge, UK
    Br J Radiol 75:736-42. 2002
    ..Providing that the relationship between fracture rates and BMD is the same in Britain and the US, it would still be appropriate to apply the reference data in fracture risk assessment in the UK...
  62. ncbi request reprint High prevalence of osteoporosis in patients with chronic liver disease prior to liver transplantation
    M Ninkovic
    Department of Medicine, University of Cambridge School of Clinical Medicine, UK
    Calcif Tissue Int 69:321-6. 2001
    ..With the exception of increasing age and lower body weight in women, no independent risk factors were found, emphasizing the importance of BMD measurements in these patients and the need for prophylactic measures to optimize bone health...
  63. doi request reprint Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis
    Elizabeth F Shead
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    J Cyst Fibros 9:93-8. 2010
    ..We assessed osteoclast number and activity during infective exacerbations and examined their relationship to serum inflammatory cytokines and bone turnover markers...
  64. ncbi request reprint Characterization of osteocrin expression in human bone
    Sharyn Bord
    Cambridge University School of Clinical Medicine, Addenbrooke s Hospital, UK
    J Histochem Cytochem 53:1181-7. 2005
    ..Thus, Ostn provides a marker of osteoblast lineage cells and appears to correlate with osteoblast activity...
  65. ncbi request reprint Treatments for Crohn's disease that minimise steroid doses are associated with a reduced risk of osteoporosis
    K L Dear
    Department of Gastroenterology, Addenbrooke's Hospital NHS Trust, Cambridge, UK
    Clin Nutr 20:541-6. 2001
    ..We conclude that corticosteroid therapy is an independent risk factor for osteoporosis in patients with Crohn's disease and should be used as little as possible...
  66. ncbi request reprint T-cell involvement in osteoclast biology: implications for rheumatoid bone erosion
    D O'Gradaigh
    Bone Research Group, University of Cambridge School of Clinical Medicine, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Rheumatology (Oxford) 43:122-30. 2004
  67. ncbi request reprint The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial
    Charlotte Atkinson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, United Kingdom
    Am J Clin Nutr 79:326-33. 2004
    ..Isoflavone phytoestrogen therapy has been proposed as a natural alternative to hormone replacement therapy (HRT). HRT has a beneficial effect on bone, but few trials in humans have investigated the effects of isoflavones on bone...
  68. ncbi request reprint Significant and persistent loss of bone mineral density in the femoral neck after haematopoietic stem cell transplantation: long-term follow-up of a prospective study
    Maher K Gandhi
    Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Br J Haematol 121:462-8. 2003
    ..In conclusion, significant and persistent bone loss at the femoral neck was demonstrated in this group of patients following stem cell transplantation. The implications of these findings for future fracture risk require further study...
  69. pmc Osteoporosis and its management
    Kenneth E S Poole
    Addenbrooke s Hospital, Cambridge CB2 2QQ
    BMJ 333:1251-6. 2006
  70. ncbi request reprint Osteoclastogenesis during infective exacerbations in patients with cystic fibrosis
    Elizabeth F Shead
    Department of Haematology, NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Respir Crit Care Med 174:306-11. 2006
    ..Adults with cystic fibrosis (CF) are at increased risk of developing osteoporosis. During infective exacerbations, increased production of proinflammatory cytokines and markers of bone resorption have been reported...
  71. pmc Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial
    Eleanor M Gurnell
    Department of Public Health and Primary Care, Centre for Applied Medical Statistics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 93:400-9. 2008
    ..In Addison's disease, glucocorticoid and mineralocorticoid deficiencies require lifelong replacement, but the associated near-total failure of DHEA synthesis is not typically corrected...
  72. ncbi request reprint Evidence supporting a role of glucocorticoids in short-term bone loss in burned children
    Gordon L Klein
    Department of Pediatrics, Children s Hospital, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0352, USA
    Osteoporos Int 15:468-74. 2004
    ..05). The eightfold elevation of urinary free cortisol excretion, low osteoblast number, decreased resorptive surface, and reduced markers of osteoblast differentiation are all consistent with an acute glucocorticoid effect on bone...
  73. ncbi request reprint Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis
    Sarah L Elkin
    Department of Cystic Fibrosis, Royal Brompton Hospital, Imperial College, London
    Am J Respir Crit Care Med 166:1470-4. 2002
    ..Osteomalacia was diagnosed in one patient. This condition should be excluded as a cause of low bone mineral density in patients with CF and vitamin D insufficiency corrected...
  74. ncbi request reprint Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women
    Georges Boivin
    Inserm Unite 403, Faculté de Médecine R Laennec, Université C Bernard Lyon 1, 69372 Lyon Cedex 08, France
    Bone 36:562-7. 2005
    ..However, this increase was about two-fold lower than that observed after alendronate therapy (10 mg/day/3 years) in postmenopausal osteoporotic women...
  75. ncbi request reprint Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study
    Stuart H Ralston
    Rheumatic Diseases Unit, University of Edinburgh Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    Hum Mol Genet 14:943-51. 2005
    ..This study provides evidence for gender-specific, site-specific and age-specific QTL, which regulate BMD in humans, and illustrates the importance of conducting subgroup analysis to detect these loci...
  76. pmc Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human bone
    Elizabeth F Shead
    Thorax 62:650-1. 2007
  77. ncbi request reprint Influence of LRP5 polymorphisms on normal variation in BMD
    M Audrey Koay
    Institute of Musculoskeletal Sciences, University of Oxford, The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford, UK
    J Bone Miner Res 19:1619-27. 2004
    ....
  78. ncbi request reprint PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton
    Carles Vilariño-Güell
    Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington, Oxford, UK
    Calcif Tissue Int 81:270-8. 2007
    ..006) and total body less head BMD (P = 0.02), corrected for age and gender, confirming the family findings. These findings suggest a role for PTHR1 variation in determining peak BMD...