Sean J Colloby

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias
    Sean J Colloby
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Brain 135:2798-808. 2012
  2. doi Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study
    Sean J Colloby
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Br J Psychiatry 200:150-5. 2012
  3. doi White matter changes in late-life depression: a diffusion tensor imaging study
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Affect Disord 135:216-20. 2011
  4. ncbi Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 18:86-90. 2010
  5. doi Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    J Geriatr Psychiatry Neurol 23:54-62. 2010
  6. doi Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow
    S J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Neurobiol Aging 32:293-301. 2011
  7. ncbi A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 20:1124-40. 2008
  8. ncbi In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006
  9. ncbi Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT
    Sean J Colloby
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle University, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 32:1176-85. 2005
  10. ncbi The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 23:956-66. 2004

Detail Information

Publications23

  1. ncbi Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias
    Sean J Colloby
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Brain 135:2798-808. 2012
    ..However, dysfunctional nigral neurons may have an additional effect on striatal uptake in vivo but their respective role remains to be elucidated...
  2. doi Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study
    Sean J Colloby
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Br J Psychiatry 200:150-5. 2012
    ..A limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies...
  3. doi White matter changes in late-life depression: a diffusion tensor imaging study
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Affect Disord 135:216-20. 2011
    ..The objective was to investigate the integrity of white matter tracts in subjects with LLD compared to similar aged healthy individuals using diffusion tensor imaging (DTI)...
  4. ncbi Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 18:86-90. 2010
    ....
  5. doi Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    J Geriatr Psychiatry Neurol 23:54-62. 2010
    ..Principal component analysis captures additional sources of variance and if perfusion SPECT is the only scan available, this procedure may offer extra information...
  6. doi Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow
    S J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Neurobiol Aging 32:293-301. 2011
    ..I-5IA-85380 binding was compared to corresponding regional cerebral blood flow (rCBF) changes in the same subjects...
  7. ncbi A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 20:1124-40. 2008
    ....
  8. ncbi In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006
    ..123I-QNB binding was also compared to the corresponding cerebral perfusion changes in the same subjects...
  9. ncbi Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT
    Sean J Colloby
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle University, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 32:1176-85. 2005
    ....
  10. ncbi The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 23:956-66. 2004
    ....
  11. ncbi Cortical thickness and VBM-DARTEL in late-life depression
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Affect Disord 133:158-64. 2011
    ..The objective was to investigate GM changes in older depressed and similar aged healthy subjects using two different methods, cortical thickness in frontal lobe structures and voxel-based morphometry (VBM)...
  12. ncbi Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 40:1056-63. 2008
    ....
  13. doi Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?
    James O'Donovan
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Int Psychogeriatr 25:111-9. 2013
    ..Therefore, we assessed whether visual rating scales for assessing posterior atrophy (PA), medial temporal lobe atrophy (MTA), and ventricular enlargement (VEn) aid in the discrimination between AD, DLB, and normal aging...
  14. ncbi Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT
    Sanjeet Pakrasi
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol 254:907-13. 2007
    ..One of the most characteristic changes in Alzheimer's disease (AD) is a deficit in cortical cholinergic neurotransmission and associated receptor changes...
  15. ncbi A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping
    Sean J Colloby
    Wolfson Research Centre, The Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 29:615-22. 2002
    ..In conclusion, we found evidence of frontal and parietal hypoperfusion in both AD and DLB, while temporal perfusion deficits were observed exclusively in AD and parieto-occipital deficits in DLB...
  16. doi Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 199:404-10. 2011
    ..There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes...
  17. pmc Covariant perfusion patterns provide clues to the origin of cognitive fluctuations and attentional dysfunction in dementia with Lewy bodies
    John Paul Taylor
    Institute for Ageing and Health, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 25:1917-28. 2013
    ..The aim of our study was therefore to characterize perfusion patterns in DLB patients that are associated with the severity and frequency of FC as measured both clinically and using objective neuropsychological assessments...
  18. pmc Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer's disease: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    J Cereb Blood Flow Metab 33:612-8. 2013
    ..86, sensitivity 80%, specificity 80%). Multivariate analysis of blood flow SPECT data appears to be robust and shows good diagnostic accuracy in two independent cohorts for distinguishing DLB from AD...
  19. pmc Characterizing dementia with Lewy bodies by means of diffusion tensor imaging
    Rosie Watson
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Neurology 79:906-14. 2012
    ..To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging...
  20. pmc Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies
    John Paul Taylor
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 78:1069-71. 2007
    ..As ChEi are frequently used in people with dementia, it is important to determine whether their use affects 123I-FP-CIT uptake in the striatum...
  21. doi Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression
    Akshya Vasudev
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 20:691-9. 2012
    ..To explore the relationship between specific aspects of cognition, white matter hyperintensities (WMHs), and cardiovascular autonomic parameters in late-life depression (LLD)...
  22. doi PET imaging of brain amyloid in dementia: a review
    Harriet Quigley
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 26:991-9. 2011
    ....
  23. ncbi Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer's disease
    James O'Donovan
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 26:627-35. 2014
    ..Diffusion tensor imaging (DTI) is an MR technique used to assess neuronal microstructural integrity that may help develop a better understanding of the differences between the conditions...