J Martin Collinson

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo
    J Martin Collinson
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Dev Biol 255:303-12. 2003
  2. pmc Effects of elevated Pax6 expression and genetic background on mouse eye development
    Simon A Chanas
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 50:4045-59. 2009
  3. ncbi request reprint Analysis of mouse eye development with chimeras and mosaics
    J Martin Collinson
    School of Medical Sciences, University of Aberdeen, Scotland, UK
    Int J Dev Biol 48:793-804. 2004
  4. pmc Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis
    Richard L Mort
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e28895. 2011
  5. pmc Stem cells and corneal epithelial maintenance: insights from the mouse and other animal models
    Richard L Mort
    University of Edinburgh, Edinburgh, EH4 2XU, UK
    Results Probl Cell Differ 55:357-94. 2012
  6. ncbi request reprint Corneal abnormalities in Pax6+/- small eye mice mimic human aniridia-related keratopathy
    Thaya Ramaesh
    Department of Reproductive and Developmental Sciences, Genes and Development Group, Princess Alexandra Eye Pavilion, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 44:1871-8. 2003
  7. pmc Penetrance of eye defects in mice heterozygous for mutation of Gli3 is enhanced by heterozygous mutation of Pax6
    Paulette A Zaki
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Dev Biol 6:46. 2006
  8. ncbi request reprint Corneal development, limbal stem cell function, and corneal epithelial cell migration in the Pax6(+/-) mouse
    J Martin Collinson
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 45:1101-8. 2004
  9. pmc The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6+/- mouse model of epithelial wound-healing delay
    Lucy J Leiper
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    BMC Biol 4:27. 2006
  10. pmc The molecular basis of defective lens development in the Iberian mole
    F David Carmona
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    BMC Biol 6:44. 2008

Detail Information

Publications20

  1. ncbi request reprint The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo
    J Martin Collinson
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Dev Biol 255:303-12. 2003
    ....
  2. pmc Effects of elevated Pax6 expression and genetic background on mouse eye development
    Simon A Chanas
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 50:4045-59. 2009
    ..To analyze the effects of Pax6 overexpression and its interaction with genetic background on eye development...
  3. ncbi request reprint Analysis of mouse eye development with chimeras and mosaics
    J Martin Collinson
    School of Medical Sciences, University of Aberdeen, Scotland, UK
    Int J Dev Biol 48:793-804. 2004
    ..The uses of chimeras, Cre-loxP mosaics and in vitro tissue recombination for study of ocular organogenesis are compared. Wider use of mosaics and chimeras should provide further insights into eye development...
  4. pmc Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis
    Richard L Mort
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e28895. 2011
    ..Corneal pathologies also occur in other mouse Pax6 mutants and in PAX77(Tg/-) transgenics, which over-express Pax6 and model human PAX6 duplication...
  5. pmc Stem cells and corneal epithelial maintenance: insights from the mouse and other animal models
    Richard L Mort
    University of Edinburgh, Edinburgh, EH4 2XU, UK
    Results Probl Cell Differ 55:357-94. 2012
    ..Finally, we highlight some recent research on other stem cell systems and consider how this could influence future research directions for identifying the stem cells that maintain the corneal epithelium...
  6. ncbi request reprint Corneal abnormalities in Pax6+/- small eye mice mimic human aniridia-related keratopathy
    Thaya Ramaesh
    Department of Reproductive and Developmental Sciences, Genes and Development Group, Princess Alexandra Eye Pavilion, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 44:1871-8. 2003
    ..To investigate corneal abnormalities in heterozygous Pax6(+/Sey-Neu) (Pax6(+/-), small eye) mice and compare them with aniridia-related keratopathy in PAX6(+/-) patients...
  7. pmc Penetrance of eye defects in mice heterozygous for mutation of Gli3 is enhanced by heterozygous mutation of Pax6
    Paulette A Zaki
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Dev Biol 6:46. 2006
    ..Here we examined whether eye development, which is abnormal in mice lacking functional Gli3, is defective in Gli3+/- mice...
  8. ncbi request reprint Corneal development, limbal stem cell function, and corneal epithelial cell migration in the Pax6(+/-) mouse
    J Martin Collinson
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 45:1101-8. 2004
    ..To investigate the etiology of corneal dysfunction in the Pax6(+/-) mouse model of aniridia-related keratopathy...
  9. pmc The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6+/- mouse model of epithelial wound-healing delay
    Lucy J Leiper
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    BMC Biol 4:27. 2006
    ..We investigated the hypothesis that reducing Pax6 gene dosage leads to corneal wound-healing defects. and assayed the immediate molecular responses to wounding in wild-type and mutant corneal epithelial cells...
  10. pmc The molecular basis of defective lens development in the Iberian mole
    F David Carmona
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    BMC Biol 6:44. 2008
    ..This is the first embryological developmental study of the eyes of any fossorial mammal at the molecular level...
  11. pmc Video analysis of the escape flight of Pileated Woodpecker Dryocopus pileatus: does the Ivory-billed Woodpecker Campephilus principalis persist in continental North America?
    J Martin Collinson
    University of Aberdeen, School of Medical Sciences, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    BMC Biol 5:8. 2007
    ..Plumage patterns and wingbeat frequency of the putative Ivory-billed Woodpecker were said to be incompatible with the only possible confusion species native to the area, the Pileated Woodpecker Dryocopus pileatus...
  12. ncbi request reprint Maternal smoking during pregnancy specifically reduces human fetal desert hedgehog gene expression during testis development
    Paul A Fowler
    Department of Obstetrics and Gynaecology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Endocrinol Metab 93:619-26. 2008
    ..Maternal cigarette smoking during gestation increases cryptorchidism and hypospadias and reduces testis size and fertility in sons by unknown mechanisms...
  13. ncbi request reprint Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium
    J Martin Collinson
    Department of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Dev Dyn 224:432-40. 2002
    ..There are approximately 100 clones of limbal stem cells initially, and clones are lost during postnatal life. Our studies provide a new assay for limbal and corneal defects in mutant mice...
  14. pmc PAX6 dosage effects on corneal development, growth, and wound healing
    Natalie DorĂ 
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
    Dev Dyn 237:1295-306. 2008
    ..Although there are similarities between the eye phenotype of Pax6 heterozygotes and overexpressing mice, there are also striking differences. Developmental..
  15. pmc Cell surface glycoconjugate abnormalities and corneal epithelial wound healing in the pax6+/- mouse model of aniridia-related keratopathy
    Romana Kucerova
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom
    Invest Ophthalmol Vis Sci 47:5276-82. 2006
    ..This study investigated how defects in glycoconjugate component of the cell surface of Pax6+/- could cause the abnormal cellular migration phenotypes associated with the disease...
  16. ncbi request reprint Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice
    Tina Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    Cells Tissues Organs 170:83-98. 2002
    ..Finally, our observations of abnormal SMGs in BMP7(-/-) and Pax6(-/-) indicate that both BMP7 and Pax6 play important roles during embryonic SMG branching morphogenesis...
  17. ncbi request reprint De novo deletions in the paired domain of PAX6 in south Indian aniridic patients
    Guruswamy Neethirajan
    Department of Genetics, Aravind Medical Research Foundation, Madurai, 625 020, India
    J Hum Genet 49:647-9. 2004
    ..537delA (codon 59) and c.728del14 (codon 122), in the paired domain of PAX6. These deletions probably represent null or hypomorphic alleles consistent with PAX6 haploinsufficiency as the underlying genetic factor of aniridia...
  18. ncbi request reprint Pax6 regulates regional development and neuronal migration in the cerebral cortex
    Ana Talamillo
    Comparative and Developmental Genetics Section, MRC Human Genetic Unit, Western General Hospital, Edinburgh, UK
    Dev Biol 255:151-63. 2003
    ....
  19. ncbi request reprint A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells
    Kerry Ann Miller
    School of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Dev Biol 311:665-78. 2007
    ..The results of these studies provide evidence of a mechanistic link between the Wnt/TCF and the Msx1/Pax3/MyoD pathways within limb bud muscle precursor cells...
  20. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    ....