Rory Collins

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Current misconception 3: that subgroup-specific trial mortality results often provide a good basis for individualising patient care
    R Peto
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK
    Br J Cancer 104:1057-8. 2011
  2. pmc Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches
    Steffen E Petersen
    Centre Lead for Advanced Cardiovascular Imaging, William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts, The London Chest Hospital, Bonner Road, London E2 9JX, UK
    J Cardiovasc Magn Reson 15:46. 2013
  3. pmc Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths
    David Zaridze
    Department of Epidemiology and Prevention, N N Blokhin Russian Cancer Research Centre, Moscow, Russia
    Lancet 373:2201-14. 2009
  4. pmc Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India
    Vendhan Gajalakshmi
    Epidemiological Research Center, Chennai, India
    BMC Public Health 4:47. 2004
  5. pmc The prevalence of chronic diseases and major disease risk factors at different ages among 150,000 men and women living in Mexico City: cross-sectional analyses of a prospective study
    Pablo Kuri-Morales
    Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    BMC Public Health 9:9. 2009
  6. pmc Recent trends in cancer mortality in the UK
    R Doll
    Epidemiological Studies Unit, University of Oxford, Radcliffe Infirmary, Unit Harkness Building, OX2 6HE Oxford, UK
    Br J Cancer 92:1329-35. 2005
  7. ncbi request reprint Commentary: The age distribution of cancer and a multistage theory of carcinogenesis
    Richard Doll
    CTSU, Harkness Building, Radcliffe Infirmary, Oxford
    Int J Epidemiol 33:1183-4. 2004
  8. ncbi request reprint High-risk elderly patients PROSPER from cholesterol-lowering therapy
    Rory Collins
    Clinical Trial Service Unit and Epidemiological Studies Unit, Harkness Building, Radcliffe Infirmary, OX2 6HE, Oxford, UK
    Lancet 360:1618-9. 2002
  9. ncbi request reprint Mortality in relation to alcohol consumption: a prospective study among male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Int J Epidemiol 34:199-204. 2005
  10. pmc Mortality from cancer in relation to smoking: 50 years observations on British doctors
    R Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit, Harkness Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Br J Cancer 92:426-9. 2005

Detail Information

Publications98

  1. pmc Current misconception 3: that subgroup-specific trial mortality results often provide a good basis for individualising patient care
    R Peto
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK
    Br J Cancer 104:1057-8. 2011
    ..We hope that this series will prove instructive to cancer researchers in other disciplines as well as to students of epidemiology. Adrian L Harris and Leo Kinlen...
  2. pmc Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches
    Steffen E Petersen
    Centre Lead for Advanced Cardiovascular Imaging, William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts, The London Chest Hospital, Bonner Road, London E2 9JX, UK
    J Cardiovasc Magn Reson 15:46. 2013
    ....
  3. pmc Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths
    David Zaridze
    Department of Epidemiology and Prevention, N N Blokhin Russian Cancer Research Centre, Moscow, Russia
    Lancet 373:2201-14. 2009
    ..Our case-control study investigated the effects of alcohol consumption on male and female cause-specific mortality...
  4. pmc Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India
    Vendhan Gajalakshmi
    Epidemiological Research Center, Chennai, India
    BMC Public Health 4:47. 2004
    ....
  5. pmc The prevalence of chronic diseases and major disease risk factors at different ages among 150,000 men and women living in Mexico City: cross-sectional analyses of a prospective study
    Pablo Kuri-Morales
    Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    BMC Public Health 9:9. 2009
    ..While most of the global burden from chronic diseases, and especially vascular diseases, is now borne by low and middle-income countries, few large-scale epidemiological studies of chronic diseases in such countries have been performed...
  6. pmc Recent trends in cancer mortality in the UK
    R Doll
    Epidemiological Studies Unit, University of Oxford, Radcliffe Infirmary, Unit Harkness Building, OX2 6HE Oxford, UK
    Br J Cancer 92:1329-35. 2005
    ..The UK rates are not generally worse than those in the other countries and are sometimes better. Exceptions were cancer of the lung, large bowel, and breast, the first of which is explained by differences in the prevalence of smoking...
  7. ncbi request reprint Commentary: The age distribution of cancer and a multistage theory of carcinogenesis
    Richard Doll
    CTSU, Harkness Building, Radcliffe Infirmary, Oxford
    Int J Epidemiol 33:1183-4. 2004
  8. ncbi request reprint High-risk elderly patients PROSPER from cholesterol-lowering therapy
    Rory Collins
    Clinical Trial Service Unit and Epidemiological Studies Unit, Harkness Building, Radcliffe Infirmary, OX2 6HE, Oxford, UK
    Lancet 360:1618-9. 2002
  9. ncbi request reprint Mortality in relation to alcohol consumption: a prospective study among male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Int J Epidemiol 34:199-204. 2005
    ..To relate alcohol consumption patterns to mortality in an elderly population...
  10. pmc Mortality from cancer in relation to smoking: 50 years observations on British doctors
    R Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit, Harkness Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Br J Cancer 92:426-9. 2005
    ....
  11. pmc Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study
    Ruth C Travis
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK
    Lancet 375:2143-51. 2010
    ..To test for evidence of gene-environment interactions, we compared genotypic relative risks for breast cancer across the other risk factors in a large UK prospective study...
  12. pmc Alcohol consumption in 0.5 million people from 10 diverse regions of China: prevalence, patterns and socio-demographic and health-related correlates
    Iona Y Millwood
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Nuffield Department of Population Health, University of Oxford, UK
    Int J Epidemiol 42:816-27. 2013
    ..Drinking alcohol has a long tradition in Chinese culture. However, data on the prevalence and patterns of alcohol consumption in China, and its main correlates, are limited...
  13. pmc Breast cancer risk in relation to the interval between menopause and starting hormone therapy
    Valerie Beral
    University of Oxford, Oxford, OX3 7LF, UK
    J Natl Cancer Inst 103:296-305. 2011
    ..We investigated whether the timing of these therapies affected breast cancer incidence...
  14. doi request reprint The exon 1-8C/G SNP in the PSMA6 gene contributes only a small amount to the burden of myocardial infarction in 6946 cases and 2720 controls from a United Kingdom population
    Derrick A Bennett
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Eur J Hum Genet 16:480-6. 2008
    ..However, given the rarity of this variant in Caucasians, the attributable risk of rs1048990 for MI is unlikely to be great in western populations...
  15. pmc China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up
    Zhengming Chen
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Int J Epidemiol 40:1652-66. 2011
    ..Large blood-based prospective studies can provide reliable assessment of the complex interplay of lifestyle, environmental and genetic factors as determinants of chronic disease...
  16. doi request reprint Plasma phospholipid fatty acids and CHD in older men: Whitehall study of London civil servants
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX37LF, UK
    Br J Nutr 102:279-84. 2009
    ....
  17. ncbi request reprint Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, England
    Arch Intern Med 167:1373-8. 2007
    ..The relevance of blood lipid levels as risk factors for ischemic heart disease (IHD) in older people is uncertain; hence, cholesterol-lowering therapy is not routinely prescribed in older populations...
  18. pmc Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study
    Jemma C Hopewell
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    Eur Heart J 34:982-92. 2013
    ..This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess their impact on vascular risk response...
  19. pmc The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls
    Sarah Parish
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK
    Eur Heart J 30:2137-46. 2009
    ..The interdependence of these four risk factors is unclear...
  20. doi request reprint Body mass index and chronic obstructive pulmonary disease-related mortality: a nationally representative prospective study of 220,000 men in China
    Ling Yang
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    Int J Epidemiol 39:1027-36. 2010
    ..Substantial uncertainty remains about the relationship in populations with lower mean BMI levels, and about the relevance to it of the effects of smoking or of reverse causality...
  21. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
    ..Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention...
  22. ncbi request reprint Physical activity and sedentary leisure time and their associations with BMI, waist circumference, and percentage body fat in 0.5 million adults: the China Kadoorie Biobank study
    Huaidong Du
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Am J Clin Nutr 97:487-96. 2013
    ..Few large studies in China have investigated total physical activity and sedentary leisure time and their associations with adiposity...
  23. doi request reprint Analyses of cancer data from three ezetimibe trials
    Richard Peto
    Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford University, Oxford, United Kingdom
    N Engl J Med 359:1357-66. 2008
    ..gov number, NCT00092677) has raised the hypothesis that adding ezetimibe to statin therapy for larger LDL cholesterol reductions might increase the incidence of cancer...
  24. doi request reprint Hormone replacement therapy and incidence of central nervous system tumours in the Million Women Study
    Victoria S Benson
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 127:1692-8. 2010
    ..97, 95% CI: 0.82-1.16) (heterogeneity p < 0.001). Among current users of oestrogen-only and oestrogen-progestagen HRT, there was no significant heterogeneity by duration of use, hormonal constituent or mode of administration of HRT...
  25. pmc Fluid intake and incidence of renal cell carcinoma in UK women
    N E Allen
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK
    Br J Cancer 104:1487-92. 2011
    ..We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women...
  26. pmc Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk
    Jane Green
    Cancer Epidemiology Unit, University of Oxford, UK
    Lancet Oncol 12:785-94. 2011
    ....
  27. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
    ..To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages...
  28. doi request reprint Factors associated with incident and fatal pancreatic cancer in a cohort of middle-aged women
    Richard J Stevens
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, United Kingdom
    Int J Cancer 124:2400-5. 2009
    ..22-2.03, with vs. without such a history). These factors were also associated with increased mortality from pancreatic cancer. Height, alcohol consumption and physical activity showed little or no association with pancreatic cancer risk...
  29. ncbi request reprint Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
    Sarah Lewington
    CTSU, University of Oxford, Oxford OX3 7LF, UK
    Lancet 370:1829-39. 2007
    ..This meta-analysis combined prospective studies of vascular mortality that recorded both blood pressure and total cholesterol at baseline, to determine the joint relevance of these two risk factors...
  30. pmc The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
    Colin Baigent
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    Lancet 377:2181-92. 2011
    ..The SHARP trial aimed to assess the efficacy and safety of the combination of simvastatin plus ezetimibe in such patients...
  31. ncbi request reprint The second United Kingdom Heart and Renal Protection (UK-HARP-II) Study: a randomized controlled study of the biochemical safety and efficacy of adding ezetimibe to simvastatin as initial therapy among patients with CKD
    Martin Landray
    Clinical Trial Service Unit, University of Oxford, Churchill Hospital, Oxford, UK
    Am J Kidney Dis 47:385-95. 2006
    ..In preparation for such a trial, we assessed the biochemical efficacy, safety, and tolerability of adding ezetimibe, 10 mg/d, to simvastatin, 20 mg/d, as initial therapy for such patients...
  32. doi request reprint Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study
    Jemma C Hopewell
    Clinical Trial Service Unit, University of Oxford, Oxford, England
    Circ Cardiovasc Genet 4:68-73. 2011
    ....
  33. doi request reprint Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women
    Miranda E G Armstrong
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    J Bone Miner Res 26:1330-8. 2011
    ..68 (95% CI 0.62-0.75), with similar results for strenuous exercise. In this large cohort of postmenopausal women, BMI and physical activity had independent effects on hip fracture risk...
  34. doi request reprint Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study
    Sarah Parish
    Heart Protection Study, Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Bldg, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Circulation 125:2469-78. 2012
    ..Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein particle concentrations may be stronger determinants of risk...
  35. doi request reprint No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study
    Jemma C Hopewell
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    J Am Coll Cardiol 57:2000-7. 2011
    ..The aim of this study was to test the effects of the KIF6 Trp719Arg polymorphism (rs20455) on vascular risk and response to statin therapy in 18,348 participants from the Heart Protection Study...
  36. pmc Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial
    Jane Armitage
    SEARCH Study, Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Lancet 376:1658-69. 2010
    ..We aimed to establish efficacy and safety of more intensive statin treatment in patients at high cardiovascular risk...
  37. doi request reprint Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:2518-28. 2009
    ..The genetic determinants of the Lp(a) lipoprotein level and their relevance for the risk of coronary disease are incompletely understood...
  38. ncbi request reprint Body mass index and mortality from lung cancer in smokers and nonsmokers: a nationally representative prospective study of 220,000 men in China
    Ling Yang
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, United Kingdom
    Int J Cancer 125:2136-43. 2009
    ..In this relatively lean Chinese male population, low BMI was strongly associated with increased risk of lung cancer only among current smokers...
  39. ncbi request reprint Moderate alcohol intake and cancer incidence in women
    Naomi E Allen
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Oxford OX3 7LF, UK
    J Natl Cancer Inst 101:296-305. 2009
    ..With the exception of breast cancer, little is known about the effect of moderate intakes of alcohol, or of particular types of alcohol, on cancer risk in women...
  40. doi request reprint Biomarkers of inflammation predict both vascular and non-vascular mortality in older men
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Eur Heart J 29:800-9. 2008
    ..To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men...
  41. pmc Reproductive factors and specific histological types of breast cancer: prospective study and meta-analysis
    G K Reeves
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Br J Cancer 100:538-44. 2009
    ..The effect of menopause did not vary significantly by tumour histology. Meta-analysis of published results on the effects of age at menarche and age at first birth on ductal and lobular cancers were in keeping with our findings...
  42. ncbi request reprint Temporal trends of main reproductive characteristics in ten urban and rural regions of China: the China Kadoorie Biobank study of 300 000 women
    Sarah Lewington
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK, School of Public Health, Peking University Health Science Center, Beijing, China, Chinese Academy of Medical Sciences, Dong Cheng District, Beijing, China, Chinese National Center for Food Safety Risk Assessment, Beijing, China, Nangang Center for Disease Control, Haerbin, Heilongjiang, China, Jiangsu Centre for Disease Control, Nanjing, Jiangsu, China, Huixian Centre for Disease Control, Huixian, Hennan, China, Gansu Centre for Disease Control, Lanzhou, Gansu, China and Liuzhou Centre for Disease Control, Liuzhou, Guangxi, China
    Int J Epidemiol 43:1252-62. 2014
    ..Chinese women's reproductive patterns have changed significantly over the past several decades. However, relatively little is known about the pace and characteristics of these changes either overall or by region and socioeconomic status...
  43. doi request reprint Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12,000 deaths
    Joseph Tomson
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Eur Heart J 34:1365-74. 2013
    ..To examine the independent relevance of plasma concentrations of 25-hydroxyvitamin D [25(OH)D] for vascular and non-vascular mortality...
  44. doi request reprint Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank
    Sarah Lewington
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, UK
    J Hypertens 30:1383-91. 2012
    ..Substantial uncertainty exists, however, about the strength of the relationship in other populations and its relevance to age, adiposity, medical treatment, climate and housing conditions...
  45. pmc Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    PLoS Med 9:e1001177. 2012
    ....
  46. ncbi request reprint Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci
    Gillian K Reeves
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    JAMA 304:426-34. 2010
    ..There is limited evidence on how the risk of breast cancer and its subtypes depend on low-penetrance susceptibility loci, individually or in combination...
  47. doi request reprint Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden
    Paul McGale
    Clinical Trial Service Unit, University of Oxford, UK
    Radiother Oncol 100:167-75. 2011
    ..To study incidence of radiation-related heart disease in a large population of breast cancer patients followed for up to 30 years...
  48. pmc Use of drug treatment for secondary prevention of cardiovascular disease in urban and rural communities of China: China Kadoorie Biobank Study of 0.5 million people
    YiPing Chen
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Nuffield Department of Population Health, University of Oxford, Oxford, UK Electronic address
    Int J Cardiol 172:88-95. 2014
    ..Relatively little is known about the use of medication for the secondary prevention of cardiovascular disease (CVD) events in China, and the relevance to it of socioeconomic, lifestyle and health-related factors...
  49. ncbi request reprint Body mass index and mortality from ischaemic heart disease in a lean population: 10 year prospective study of 220,000 adult men
    Zhengming Chen
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, University of Oxford, UK
    Int J Epidemiol 35:141-50. 2006
    ..Substantial uncertainty remains, however, about the relationship between BMI and IHD in populations with lower BMI levels...
  50. ncbi request reprint N-terminal Pro-B-type natriuretic peptide, vascular disease risk, and cholesterol reduction among 20,536 patients in the MRC/BHF heart protection study
    Jonathan R Emberson
    Clinical Trial Service Unit, University of Oxford, UK
    J Am Coll Cardiol 49:311-9. 2007
    ..We sought to assess the ability of N-terminal pro-B-type natriuretic peptide (N-BNP) to predict vascular events in high-risk people and to test whether statins benefit people with high levels of N-BNP...
  51. pmc Exhaled carbon monoxide and its associations with smoking, indoor household air pollution and chronic respiratory diseases among 512,000 Chinese adults
    Qiuli Zhang
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK, School of Public Health, Peking University Health Science Center, Beijing, China, Chinese Academy of Medical Sciences, Dong Cheng District, Beijing, China, China National Center for Food Safety Risk Assessment, Chaoyang District, Beijing, China, Licang Center for Disease Control and Prevention, Qingdao, Shandong, China, Heilongjiang Center for Disease Control and Prevention, Harbin, Heilongjiang, China, Meilan Center for Disease Control and Prevention, Haikou, Hainan, China, Guangxi Center for Disease Control and Prevention, Nanning, Guangxi, China and Liuyang Center for Disease Control and Prevention, Changsha, Hunan, China
    Int J Epidemiol 42:1464-75. 2013
    ..Relatively little is known about its determinants in China despite the population having a high prevalence of smoking and use of biomass/coal...
  52. ncbi request reprint First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease
    Colin Baigent
    Clinical Trial Service Unit, Oxford University, Oxford, UK
    Am J Kidney Dis 45:473-84. 2005
    ..Patients with chronic kidney disease are at increased risk for cardiovascular disease, but the efficacy and safety of simvastatin and aspirin are unknown in this patient group...
  53. pmc Prevalence and correlates of airflow obstruction in ∼317,000 never-smokers in China
    Margaret Smith
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    Eur Respir J 44:66-77. 2014
    ..Associations were similar for males. AFO is prevalent in Chinese never-smokers, particularly among those with low socioeconomic status or prior tuberculosis, and in rural males. ..
  54. ncbi request reprint Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    Eur J Cardiovasc Prev Rehabil 14:280-6. 2007
    ....
  55. ncbi request reprint Cohort profile: the Kadoorie Study of Chronic Disease in China (KSCDC)
    Zhengming Chen
    Clinical Trial Service Unit CTSU, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Int J Epidemiol 34:1243-9. 2005
  56. ncbi request reprint Effect of temperature and light on the stability of fat-soluble vitamins in whole blood over several days: implications for epidemiological studies
    Sarah Clark
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Int J Epidemiol 33:518-25. 2004
    ..Using a high performance liquid chromatography assay developed in-house, we have investigated the separate effects of temperature and light on the stability of vitamins in whole blood over several days...
  57. pmc Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort
    V S Benson
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Br J Cancer 99:185-90. 2008
    ..In conclusion, for women in the United Kingdom, the incidence of glioma or meningioma tumours increases with increasing height and increasing BMI...
  58. pmc 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial
    Alison Halliday
    Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, UK
    Lancet 376:1074-84. 2010
    ..We assessed the long-term effects of successful CEA...
  59. ncbi request reprint Smoking and liver cancer in China: case-control comparison of 36,000 liver cancer deaths vs. 17,000 cirrhosis deaths
    Zheng Ming Chen
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, University of Oxford, United Kingdom
    Int J Cancer 107:106-12. 2003
    ..09, 95% CI 0.94-1.25). These associations indicate that tobacco is currently responsible for about 50,000 liver cancer deaths each year in China, chiefly among men with chronic HBV infection...
  60. doi request reprint Passive smoking and breast cancer in never smokers: prospective study and meta-analysis
    Kirstin Pirie
    Cancer Epidemiology Unit, University of Oxford, England
    Int J Epidemiol 37:1069-79. 2008
    ..Active smoking has little or no effect on women's risk of developing breast cancer, but it has been suggested that passive exposure to tobacco smoke may increase this risk among women who have never smoked...
  61. ncbi request reprint Extending the age range for breast screening in England: pilot study to assess the feasibility and acceptability of randomization
    Kath Moser
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF
    J Med Screen 18:96-102. 2011
    ..To assess the feasibility and acceptability of randomizing the phased introduction of the extension of the invited age range in the National Health Service (NHS) Breast Screening Programme in England from 50-70 to 47-73 years...
  62. pmc Body mass index and risk of liver cirrhosis in middle aged UK women: prospective study
    Bette Liu
    Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF
    BMJ 340:c912. 2010
    ..To determine the relation between body mass index (BMI) and liver cirrhosis and the contribution that BMI and alcohol consumption make to the incidence of liver cirrhosis in middle aged women in the UK...
  63. doi request reprint Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
    Robert Clarke
    University of Oxford, England
    Arch Intern Med 170:1622-31. 2010
    ..Dietary supplementation with folic acid to lower homocysteine levels had no significant effects within 5 years on cardiovascular events or on overall cancer or mortality in the populations studied...
  64. pmc Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study
    Robert Clarke
    Clinical Trial Service Unit, Old Road Campus, Oxford, United Kingdom
    PLoS Genet 2:e107. 2006
    ..Overall, these studies provide reliable evidence that these common polymorphisms for the LTA gene are not strongly associated with susceptibility to coronary disease...
  65. ncbi request reprint Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p
    Helen M Broadbent
    Department of Cardiovascular Medicine, University of Oxford, UK
    Hum Mol Genet 17:806-14. 2008
    ..A large antisense non-coding RNA gene (ANRIL) collocates with the high-risk haplotype, is expressed in tissues and cell types that are affected by atherosclerosis and is a prime candidate gene for the chromosome 9p CAD locus...
  66. ncbi request reprint Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries
    Sarah C Darby
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Lancet Oncol 6:557-65. 2005
    ..This study aimed to assess the hazards in the general US population from routine cancer-registry and death-certificate data...
  67. pmc Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial
    Christina Davies
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, UK
    Lancet 381:805-16. 2013
    ..We aimed to assess the further effects of continuing tamoxifen to 10 years instead of stopping at 5 years...
  68. doi request reprint The MRC spine stabilization trial: surgical methods, outcomes, costs, and complications of surgical stabilization
    James Wilson-MacDonald
    Nuffield Orthopaedic Centre, Headington, Oxford, UK
    Spine (Phila Pa 1976) 33:2334-40. 2008
    ..A review of the surgical costs and results in a group of patients randomly allocated to surgery as part of a large prospective randomized trial of patients with chronic back pain...
  69. ncbi request reprint Stability of plasma analytes after delayed separation of whole blood: implications for epidemiological studies
    Sarah Clark
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Int J Epidemiol 32:125-30. 2003
    ..To assess the feasibility and reliability of transporting blood samples over several days at ambient temperature (e.g. by mail), we evaluated the stability of various plasma analytes in samples stored at room temperature or chilled...
  70. pmc Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90 000 Swedish women
    Sarah Darby
    Clinical Trial Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 326:256-7. 2003
  71. ncbi request reprint Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
    John R Geddes
    Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Lancet 375:385-95. 2010
    ..We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder...
  72. ncbi request reprint Stabilization of homocysteine in unseparated blood over several days: a solution for epidemiological studies
    Sarah Clark
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Clin Chem 49:518-20. 2003
  73. pmc An epidemiologist at work: the personal papers of Sir Richard Doll
    Chris Beckett
    Wellcome Library for the History and Understanding of Medicine, Wellcome Trust, 183 Euston Road, London NW1 2BE
    Med Hist 46:403-21. 2002
  74. ncbi request reprint Mortality of british radiologists: a lecture note
    Richard Doll
    University of Oxford, CTSU, Radcliffe Infirmary Oxford, UK
    J Radiat Res 46:123-9. 2005
    ..In assessing the risk of occupational exposure to radiation, life-style has to be taken into consideration, as well as dose of radiation...
  75. pmc The mortality of doctors in relation to their smoking habits: a preliminary report. 1954
    Richard Doll
    BMJ 328:1529-33; discussion 1533. 2004
  76. ncbi request reprint A conversation with Sir Richard Doll
    Richard Doll
    Epidemiology 14:375-9. 2003
  77. ncbi request reprint Sir Richard Doll
    Ivan Oransky
    Lancet 366:448. 2005
  78. ncbi request reprint Sir Richard Doll
    Douglas Holdstock
    Lancet 366:1434. 2005
  79. pmc Sir Richard Doll, epidemiologist - a personal reminiscence with a selected bibliography
    Leo Kinlen
    Br J Cancer 93:963-6. 2005
  80. ncbi request reprint Obituary: Richard Doll (1912-2005)
    Leo Kinlen
    Leo Kinlen is in the Cancer Epidemiology Unit, Richard Doll Building, Roosevelt Drive, Headington, Oxford OX3 7LF
    Nature 438:41. 2005
  81. ncbi request reprint Sir Richard Doll, 1912 to 2005: a tribute and personal remembrance
    Charles H Hennekens
    Ann Epidemiol 16:533. 2006
  82. ncbi request reprint Proof of causality: deduction from epidemiological observation
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Oxford, United Kingdom
    Perspect Biol Med 45:499-515. 2002
  83. ncbi request reprint Oral history - Sir Richard Doll
    Christopher Cook
    J Public Health (Oxf) 26:327-36. 2004
  84. ncbi request reprint Sir Richard Doll on chance and genetic susceptibility in carcinogenesis, or, why not all smokers get lung cancer
    Arthur Schatzkin
    Cancer Epidemiol Biomarkers Prev 15:1420. 2006
  85. ncbi request reprint Residential radon and lung cancer--detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe
    Sarah Darby
    Clinical Trial Service Unit, Richard Doll Building, University of Oxford, Oxford, United Kingdom
    Scand J Work Environ Health 32:1-83. 2006
    ..Therefore data from all 13 European studies of residential radon and lung cancer satisfying certain prespecified criteria have been brought together and analyzed...
  86. pmc Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial
    Daksha P Trivedi
    Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ
    BMJ 326:469. 2003
    ..To determine the effect of four monthly vitamin D supplementation on the rate of fractures in men and women aged 65 years and over living in the community...
  87. pmc Spanish toxic oil syndrome
    Richard Doll
    Med Hist 47:99. 2003
  88. pmc Cancer risks attributable to low doses of ionizing radiation: assessing what we really know
    David J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:13761-6. 2003
    ..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others...
  89. ncbi request reprint Patient navigation in cancer care: program delivery and research in British Columbia
    Richard Doll
    University of British Columbia
    Can Oncol Nurs J 13:193. 2003
  90. pmc Saudi Arabia: Doll and Peto honoured
    David Simpson
    Tob Control 14:150-1. 2005
  91. pmc Development and validation of a psychosocial screening instrument for cancer
    Wolfgang Linden
    Psychology Department, The University of British Columbia, 2136 West Mall, Psychology UBC, Vancouver BC, V6T 1Z4, Canada
    Health Qual Life Outcomes 3:54. 2005
    ....
  92. ncbi request reprint Fisher and Bradford Hill: their personal impact
    Richard Doll
    Sir Richard Doll, CTSU, Harkness Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Int J Epidemiol 32:929-31; discussion 945-8. 2003
  93. ncbi request reprint [A tribute to Sir Richard Doll]
    Eduardo Faerstein
    Cad Saude Publica 21:1610-1. 2005
  94. pmc Controlled trials testing two or more treatments simultaneously
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit, Harkness Building, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J R Soc Med 98:479-80. 2005
  95. ncbi request reprint The impact of acculturation on the use of traditional Chinese medicine in newly diagnosed Chinese cancer patients
    Mark Anthony Ferro
    Department of Epidemiology and Biostatistics, University of Western Ontario, Kresge Building, Room K201, London, Ontario N6A 5C1, Canada
    Support Care Cancer 15:985-92. 2007
    ..The individual determinants of TCM/CAM use among patients were also investigated...
  96. ncbi request reprint [Sir Richard Doll]
    Silvia Franceschi
    Agencia Internacional para la Investigación sobre Cáncer, Lyon, Francia
    Salud Publica Mex 48:S217-8. 2006
  97. pmc A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling
    Gregory E Miller
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Biol Psychiatry 64:266-72. 2008
    ..Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood...

Research Grants3

  1. Monitoring tobacco mortality in 2M adults in 4 countries
    Richard Peto; Fiscal Year: 2002
    ..We already have evidence that this has taken place in China, where the earliest study was established. ..
  2. Monitoring tobacco mortality in 2M adults in 4 countries
    Richard Peto; Fiscal Year: 2003
    ..We already have evidence that this has taken place in China, where the earliest study was established. ..
  3. Monitoring tobacco mortality in 2M adults in 4 countries
    Richard Peto; Fiscal Year: 2004
    ..We already have evidence that this has taken place in China, where the earliest study was established. ..