Anne T Collins

Summary

Affiliation: University of York
Country: UK

Publications

  1. ncbi request reprint Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
  2. ncbi request reprint Prostate cancer stem cells
    Anne T Collins
    University of York, YCR Cancer Research Unit, Department of Biology, Heslington, York YO10 5DD, UK
    Eur J Cancer 42:1213-8. 2006
  3. doi request reprint Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells
    Fiona M Frame
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, North Yorkshire, YO10 5DD, UK
    Exp Cell Res 316:3161-71. 2010
  4. pmc Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer
    Davide Pellacani
    YCR Cancer Research Unit, Department of Biology, University of York, UK
    Mol Cancer 10:94. 2011
  5. pmc Modeling the prostate stem cell niche: an evaluation of stem cell survival and expansion in vitro
    Shona H Lang
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York, United Kingdom
    Stem Cells Dev 19:537-46. 2010
  6. doi request reprint Prostate cancer stem cells: do they have a basal or luminal phenotype?
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology Area 13, University of York, Heslington, York YO10 5DD, UK
    Horm Cancer 2:47-61. 2011
  7. doi request reprint The calcium sensor STIM1 is regulated by androgens in prostate stromal cells
    Paul A Berry
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York, UK
    Prostate 71:1646-55. 2011
  8. doi request reprint Prostate cancer stem cells: are they androgen-responsive?
    Emma E Oldridge
    YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK
    Mol Cell Endocrinol 360:14-24. 2012
  9. doi request reprint Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells
    Euan S Polson
    YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire, UK
    Nat Commun 4:1623. 2013
  10. doi request reprint Prostate cancer stem cells: a new target for therapy
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, Heslinton, York, YO10 5YW, United Kingdom
    J Clin Oncol 26:2862-70. 2008

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
    ..The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic process and to develop therapies targeted to the stem cell...
  2. ncbi request reprint Prostate cancer stem cells
    Anne T Collins
    University of York, YCR Cancer Research Unit, Department of Biology, Heslington, York YO10 5DD, UK
    Eur J Cancer 42:1213-8. 2006
    ....
  3. doi request reprint Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells
    Fiona M Frame
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, North Yorkshire, YO10 5DD, UK
    Exp Cell Res 316:3161-71. 2010
    ....
  4. pmc Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer
    Davide Pellacani
    YCR Cancer Research Unit, Department of Biology, University of York, UK
    Mol Cancer 10:94. 2011
    ..In this study we investigated the role of epigenetic regulation of CD133 in epithelial differentiation and cancer...
  5. pmc Modeling the prostate stem cell niche: an evaluation of stem cell survival and expansion in vitro
    Shona H Lang
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York, United Kingdom
    Stem Cells Dev 19:537-46. 2010
    ..It is likely that the physical arrangement of cells in monolayer provides an injury-type response, which can activate stem cells into cycle...
  6. doi request reprint Prostate cancer stem cells: do they have a basal or luminal phenotype?
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology Area 13, University of York, Heslington, York YO10 5DD, UK
    Horm Cancer 2:47-61. 2011
    ..In vitro differentiation experiments, employing lentivirally transduced SCs with a luminal (PSA-probasin) promoter regulating a fluorescent indicator gene, confirm that the basal SCs are the source of luminal progeny...
  7. doi request reprint The calcium sensor STIM1 is regulated by androgens in prostate stromal cells
    Paul A Berry
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York, UK
    Prostate 71:1646-55. 2011
    ..Androgens can drive this process by direct action on the stroma. We investigated whether there was a direct link between androgens and another key regulator of stromal cells, intracellular Ca2+ ([Ca2+ ]i )...
  8. doi request reprint Prostate cancer stem cells: are they androgen-responsive?
    Emma E Oldridge
    YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK
    Mol Cell Endocrinol 360:14-24. 2012
    ..The development of CSC-targeted therapies is now of crucial importance and identifying the phenotypic differences between CSCs and both their progeny will be key in this process...
  9. doi request reprint Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells
    Euan S Polson
    YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire, UK
    Nat Commun 4:1623. 2013
    ..The presence and expression of TMPRSS2/ERG in prostate stem cells would provide ERG-driven survival advantages, allowing maintenance of this mutated genotype...
  10. doi request reprint Prostate cancer stem cells: a new target for therapy
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, Heslinton, York, YO10 5YW, United Kingdom
    J Clin Oncol 26:2862-70. 2008
    ..9% of tumor mass, but paradoxically have a poor tumor-initiating capacity...
  11. pmc Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions
    Richard Birnie
    Pro Cure Therapeutics Ltd, The Biocentre, Innovation Way, York Science Park, Heslington, York, UK
    Genome Biol 9:R83. 2008
    ..We have compared gene expression in these cells relative to their normal and differentiated (CD133-/alpha2beta1low) counterparts, resulting in an informative cancer stem cell gene-expression signature...
  12. doi request reprint Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells
    Davide Pellacani
    YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, YO10 5DD, York, UK
    Adv Exp Med Biol 777:167-84. 2013
    ....
  13. doi request reprint Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells
    Paul A Berry
    YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK
    Mol Cell Endocrinol 288:30-7. 2008
    ..Some of these genes have direct androgen receptor binding ability...
  14. doi request reprint Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?
    Norman J Maitland
    YCR Cancer Research Unit, Deparment of Biology, University of York, York YO10 5YW, United Kingdom
    J Cell Biochem 105:931-9. 2008
    ..The establishment of one or more autocrine signalling loops results in an expansion of these cells in the absence of inflammation, as a potential first stage in the development of the tumour...
  15. ncbi request reprint Cancer stem cells - A therapeutic target?
    Norman J Maitland
    University of York, YCR Cancer Research Unit, Department of Biology, York YO1 5YW, UK
    Curr Opin Mol Ther 12:662-73. 2010
    ..Instead, the ideal therapies targeting CSCs will be directed against functions that contribute to the oncogenic nature of CSCs relative to healthy stem cells, an altogether more challenging task...
  16. doi request reprint An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner
    Stefanie Hager
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom
    Hum Gene Ther 19:840-50. 2008
    ..We therefore conclude that an internal polyadenylation signal in lentiviral vectors has a highly beneficial effect on transgene expression, but reduces viral titer in a promoter-dependent manner...