Graham L Collingridge

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. doi request reprint Tyrosine dephosphorylation regulates AMPAR internalisation in mGluR-LTD
    Clare M Gladding
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS81TD, UK
    Mol Cell Neurosci 40:267-79. 2009
  2. pmc A pivotal role of GSK-3 in synaptic plasticity
    Clarrisa A Bradley
    MRC Centre for Synaptic Plasticity, University of Bristol Bristol, UK
    Front Mol Neurosci 5:13. 2012
  3. pmc Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP
    Robert Nistico
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Sci Rep 1:103. 2011
  4. ncbi request reprint Functional roles of protein interactions with AMPA and kainate receptors
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neurosci Res 47:3-15. 2003
  5. ncbi request reprint Receptor trafficking and synaptic plasticity
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Nat Rev Neurosci 5:952-62. 2004
  6. ncbi request reprint Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
  7. doi request reprint Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95
    Jihoon Jo
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Nat Neurosci 13:1216-24. 2010
  8. pmc ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function
    Sheila L Dargan
    MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 56:121-30. 2009
  9. pmc Metabotropic glutamate receptor-mediated LTD involves two interacting Ca(2+) sensors, NCS-1 and PICK1
    Jihoon Jo
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Neuron 60:1095-111. 2008
  10. ncbi request reprint Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression
    Peter R Moult
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:2544-54. 2006

Detail Information

Publications86

  1. doi request reprint Tyrosine dephosphorylation regulates AMPAR internalisation in mGluR-LTD
    Clare M Gladding
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS81TD, UK
    Mol Cell Neurosci 40:267-79. 2009
    ..Together, these results indicate that the subunit selective tyrosine dephosphorylation of surface GluR2 regulates AMPAR internalisation in DHPG-LTD but not in NMDA-LTD in the hippocampus...
  2. pmc A pivotal role of GSK-3 in synaptic plasticity
    Clarrisa A Bradley
    MRC Centre for Synaptic Plasticity, University of Bristol Bristol, UK
    Front Mol Neurosci 5:13. 2012
    ..We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders...
  3. pmc Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP
    Robert Nistico
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Sci Rep 1:103. 2011
    ..Thus three distinct glutamate receptors interact, in both an AND and OR gate fashion, to regulate both immediate and long-term presynaptic function in the brain...
  4. ncbi request reprint Functional roles of protein interactions with AMPA and kainate receptors
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neurosci Res 47:3-15. 2003
    ..In this article we reflect upon this work, which has led to some new ideas about how AMPA and kainate receptors are regulated at synapses...
  5. ncbi request reprint Receptor trafficking and synaptic plasticity
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Nat Rev Neurosci 5:952-62. 2004
    ..Recent insights into how these receptors are rapidly moved into and out of synaptic membranes has profound implications for our understanding of the mechanisms of long-term potentiation and long-term depression...
  6. ncbi request reprint Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    Thomas E Bartlett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Neuropharmacology 52:60-70. 2007
    ..4 microM. The lack of effect of 0.1 microM NVP on LTD contrasts with its marked effect on LTP and raises the possibility that different NVP-sensitive NR2 subunit-containing NMDA receptors are required for LTP and LTD in this preparation...
  7. doi request reprint Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95
    Jihoon Jo
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Nat Neurosci 13:1216-24. 2010
    ....
  8. pmc ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function
    Sheila L Dargan
    MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 56:121-30. 2009
    ..Taken together our data provide further evidence for a physiological role of GluK1-containing KARs in synaptic facilitation and LTP induction at mossy fibre-CA3 synapses...
  9. pmc Metabotropic glutamate receptor-mediated LTD involves two interacting Ca(2+) sensors, NCS-1 and PICK1
    Jihoon Jo
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Neuron 60:1095-111. 2008
    ..Furthermore, the NCS-1-PICK1 association is stimulated by activation of mGluRs, but not NMDARs, and introduction of a PICK1 BAR domain fusion protein specifically blocks mGluR-LTD. Thus, NCS-1 plays a distinct role in mGluR-LTD...
  10. ncbi request reprint Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression
    Peter R Moult
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:2544-54. 2006
    ..Together, these data suggest that activation of postsynaptic PTP results in tyrosine dephosphorylation of AMPARs and their removal from the synapse...
  11. ncbi request reprint Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists
    Nigel P Dolman
    Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Med Chem 50:1558-70. 2007
    ....
  12. doi request reprint The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs
    Sonia Piccinin
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 55:459-63. 2008
    ..This unusual form of plasticity, which presumably also occurs when synaptic transmission is intact, could contribute to long-term alterations in synchronised activity in hippocampal neuronal networks...
  13. doi request reprint Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses
    Joanne E Nash
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK
    J Neurochem 112:677-90. 2010
    ..e. 'silent' synapses). Together, these results indicate that myosin VI/SAP97 plays an important role in trafficking and activity-dependent recruitment of AMPARs to synapses...
  14. ncbi request reprint Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists
    Nigel P Dolman
    Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    J Med Chem 49:2579-92. 2006
    ..However, 43 displayed no activity on homomeric GLU(K6) or GLU(K7) kainate receptors or homomeric GLU(A1-4) AMPA receptors (IC(50) values > 100 microM). Thus, 43 is a potent and selective GLU(K5) receptor antagonist...
  15. doi request reprint An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuropharmacology 55:454-8. 2008
    ..Indeed, metaplasticity was induced by stimuli that were subthreshold for the induction of LTP per se. Thus, metaplasticity has a lower threshold than the synaptic plasticity that it regulates...
  16. ncbi request reprint A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus
    Sari E Lauri
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuron 39:327-41. 2003
    ..These findings suggest that presynaptic kainate receptors at mossy fiber synapses can initiate a cascade involving Ca2+ release from intracellular stores that is important in both short-term and long-term plasticity...
  17. ncbi request reprint Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors
    Nigel P Dolman
    Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
    J Med Chem 48:7867-81. 2005
    ..5-Iodo substitution of the uracil ring of 44a gave 45, which was found to have enhanced potency and selectivity for GLUK5...
  18. doi request reprint Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors
    David Lodge
    Centre for Synaptic Plasticity, School of Physiology and Pharmacology, Dorothy Hodgkin Building, University of Bristol, Bristol BS1 3NY, UK
    Neuropharmacology 74:135-46. 2013
    ..This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'. ..
  19. ncbi request reprint Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
    Peter V Massey
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:7821-8. 2004
    ..Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex...
  20. pmc Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells
    Valerie J Collett
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD
    Br J Pharmacol 142:991-1001. 2004
    ..Inhibition of these processes reveals a tonic, mGlu5 receptor and PTK-dependent potentiation of NMDA receptors that can be augmented by either stimulating mGlu5 receptors or by inhibiting PTPs...
  21. ncbi request reprint Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
    Karen Plant
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK
    Nat Neurosci 9:602-4. 2006
    ..Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation...
  22. doi request reprint GLUK1 receptor antagonists and hippocampal mossy fiber function
    Robert Nistico
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Int Rev Neurobiol 85:13-27. 2009
    ..In particular, we show that the GluK1-containing KARs are important for regulating synaptic facilitation and LTP induction at hippocampal mossy fiber synapses...
  23. pmc A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha
    Bryony A Dickinson
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Mol Brain 2:18. 2009
    ..However, we find a distinct mechanism of LTD involving GRIP and liprin-alpha...
  24. ncbi request reprint Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression
    Michael I Daw
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Nat Neurosci 5:835-6. 2002
    ..These findings suggest that the synapse specificity of hippocampal LTD may not be an intrinsic property of this form of homosynaptic plasticity, but rather that it can be regulated by PI3 kinase...
  25. pmc Regulation of synaptic strength and AMPA receptor subunit composition by PICK1
    Akira Terashima
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:5381-90. 2004
    ..These findings suggest that PICK1 acts to downregulate the GluR2 content of AMPARs at hippocampal CA1 synapses, thereby increasing synaptic strength at resting membrane potentials...
  26. ncbi request reprint The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 49:13-25. 2005
    ..In addition, the mGlu5 selective agonist CHPG ((RS)-2-chloro-5-hydroxyphenylglycine) sets the molecular switch. These data demonstrate that the operation of the molecular switch requires activation of mGlu5 receptors...
  27. pmc Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus
    Garry Whitehead
    1 Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Brain 136:3753-65. 2013
    ..These then trigger the additional NMDA receptor-independent form of LTP during high frequency stimulation...
  28. doi request reprint The NMDA receptor as a target for cognitive enhancement
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol BS1 3NY, UK
    Neuropharmacology 64:13-26. 2013
    ..This article is part of a Special Issue entitled 'Cognitive Enhancers'...
  29. doi request reprint Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus
    Marion S Mercier
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Dorothy Hodgkin Building, Bristol BS1 3NY, UK
    Neuropharmacology 67:294-303. 2013
    ..MDCPG may be a useful tool in determining whether observable DCPG effects are attributable to mGlu8, versus mGlu2, receptor activation...
  30. pmc Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro
    Arturas Volianskis
    MRC Centre for Synaptic Plasticity, Departments of Anatomy, University of Bristol, Bristol, UK
    J Physiol 591:955-72. 2013
    ..These data demonstrate that synaptic potentiation at CA1 synapses is more complex than is commonly thought, an observation that has major implications for understanding the role of NMDARs in cognition...
  31. pmc Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity
    Andreas Lüthi
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK
    BMC Neurosci 5:44. 2004
    ..In the present study we have used whole-cell dendritic recording, failures analysis and non-stationary fluctuation analysis to investigate the mechanism of depotentiation of LTP...
  32. pmc Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
    Hélène Hirbec
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuron 37:625-38. 2003
    ....
  33. doi request reprint The use of the hippocampal slice preparation in the study of Alzheimer's disease
    Stephen M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Eur J Pharmacol 585:50-9. 2008
    ..iv) The identification of a mechanism that can account for the cognitive enhancing effects of the NMDA receptor antagonist memantine. (v) The discovery of a role of glycogen synthase kinase-3beta (tau kinase) in synaptic plasticity...
  34. ncbi request reprint Altered short-term synaptic plasticity in mice lacking the metabotropic glutamate receptor mGlu7
    Trevor J Bushell
    MRC Centre for Synaptic Plasticity, Department of Anatomy, The School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    ScientificWorldJournal 2:730-7. 2002
    ..These results show that the absence of mGlu7 receptors results in alterations in short-term synaptic plasticity in the hippocampus...
  35. ncbi request reprint LTP inhibits LTD in the hippocampus via regulation of GSK3beta
    Stephane Peineau
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
    Neuron 53:703-17. 2007
    ..We conclude that the regulation of GSK3beta activity provides a powerful mechanism to preserve information encoded during LTP from erasure by subsequent LTD, perhaps thereby permitting the initial consolidation of learnt information...
  36. ncbi request reprint Kainate receptors and mossy fiber LTP
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, University of Bristol, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Neurotoxicology 26:769-77. 2005
    ..This form of LTP is triggered by the synaptic activation of kainate receptors. We also address the importance of Ca2+ availability in the extracellular environment and the release of Ca2+ from intracellular stores for this form of LTP...
  37. pmc A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1
    Stephen M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, UK
    Mol Brain 3:21. 2010
    ..These data show that a prolonged, substantially elevated level of Abeta are not sufficient to cause deficits in the induction or expression of LTP in the CA1 hippocampal region...
  38. ncbi request reprint Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations
    John R Huxter
    Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 27:2212-23. 2007
    ..In addition, the effects on cellular responses provide both insight into the mechanisms of theta pacing, and useful information for models of temporal coding...
  39. doi request reprint LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression
    Vanessa J Appleby
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, UK
    J Neurochem 116:530-43. 2011
    ..CaMKII activation is therefore an important factor in the activity-dependent recruitment of native GluA1 subunit-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors to the cell surface of hippocampal neurons...
  40. doi request reprint Synaptic plasticity in the hippocampal slice preparation
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Curr Protoc Neurosci . 2011
    ..Most of these principles also apply to the study of synaptic plasticity in other brain slice preparations...
  41. pmc Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs
    Thomas M Sanderson
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, UK
    Mol Brain 4:30. 2011
    ..The implications of these findings for the initial mechanisms of expression of both NMDA receptor- and mGluR-induced LTD are discussed...
  42. pmc Hippocalcin functions as a calcium sensor in hippocampal LTD
    Claire L Palmer
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Neuron 47:487-94. 2005
    ..These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD...
  43. pmc The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity
    Daniel L Rocca
    School of Biochemistry, Centre for Synaptic Plasticity, Medical Sciences Building and Dorothy Hodgkin Building, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuron 79:293-307. 2013
    ..Furthermore, NMDAR stimulation downregulates Arf1 activation and binding to PICK1 via the Arf-GAP GIT1. This study defines Arf1 as a critical regulator of actin dynamics and synaptic function via modulation of PICK1. ..
  44. doi request reprint Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation
    John L Sherwood
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, BS8 1TD, UK
    Neurochem Int 61:482-9. 2012
    ..Transverse slices have denser fibre tracts but a smaller proportion of giant mossy fibre boutons. These results further demonstrate a considerable heterogeneity in the functional properties of the mossy fibre projection...
  45. pmc The Jak/STAT pathway is involved in synaptic plasticity
    Céline S Nicolas
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK
    Neuron 73:374-90. 2012
    ..Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain...
  46. ncbi request reprint Promiscuous interactions between AMPA-Rs and MAGUKs
    Stephen M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuron 52:222-4. 2006
    ..In this issue of Neuron, Elias et al. have elucidated the roles of three MAGUKs, PSD-95, PSD-93, and SAP-102, in the targeting of AMPA receptors to synapses in hippocampal neurons...
  47. pmc Kainate receptors and the induction of mossy fibre long-term potentiation
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Philos Trans R Soc Lond B Biol Sci 358:657-66. 2003
    ..We conclude that activation of presynaptic GLU(K5)-containing kainate receptors is an important trigger for the induction of mossy fibre LTP in the hippocampus...
  48. ncbi request reprint A presynaptic kainate receptor is involved in regulating the dynamic properties of thalamocortical synapses during development
    Fleur L Kidd
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, BS8 1TD, United Kingdom
    Neuron 34:635-46. 2002
    ..This receptor may, therefore, limit the transfer of high-frequency activity to the developing cortex, the loss of which mechanism may be important for the maturation of sensory processing...
  49. pmc Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression
    Peter R Moult
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 586:2499-510. 2008
    ..These data therefore demonstrate that a novel combination of signalling cascades, requiring both activation of p38 MAPK and tyrosine de-phosphorylation, underlies the induction of synaptically induced mGluR-LTD...
  50. ncbi request reprint Multiple, developmentally regulated expression mechanisms of long-term potentiation at CA1 synapses
    Mary J Palmer
    The Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom
    J Neurosci 24:4903-11. 2004
    ..These findings suggest that a single class of synapse uses a number of different molecular mechanisms to produce long-term changes in synaptic strength...
  51. pmc Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors
    Mark W Irvine
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK
    Neurochem Int 61:593-600. 2012
    ..UBP714 is therefore a novel template for the development of potent and subunit selective NMDAR potentiators that may have therapeutic applicability in the treatment of patients with cognitive deficits or schizophrenia...
  52. doi request reprint Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala
    Sarah J Lucas
    MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 66:196-201. 2013
    ..LY541850 induced a substantial LTD showing that either receptor alone is capable of inducing LTD in this pathway. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  53. pmc A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases
    Stephane Peineau
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Mol Brain 2:22. 2009
    ..Here we provide the first systematic investigation of the involvement of serine/threonine (ser/thr) protein kinases in NMDAR-LTD, using whole-cell recordings from CA1 pyramidal neurons...
  54. doi request reprint Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype
    Laura Ceolin
    Medical Research Council Centre for Synaptic Plasticity, University of Bristol, Bristol, BS8 1TD, United Kingdom
    J Neurosci 31:6721-31. 2011
    ..These findings have implications for rat models of psychiatric disease and are especially pertinent given that mGlu2 receptors are targets for compounds under development for anxiety...
  55. pmc Wavelet transform-based de-noising for two-photon imaging of synaptic Ca2+ transients
    Cezar M Tigaret
    Medical Research Council Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Biophys J 104:1006-17. 2013
    ..In conclusion, the de-noising of fluorescent Ca(2+) transients using PURE-LET enhances detection and characterization of Ca(2+) responses at central excitatory synapses...
  56. ncbi request reprint Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist
    Julia C A More
    Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 47:46-64. 2004
    ..These data provide further evidence for a role for GLUK5-containing kainate receptors in mossy fibre LTP. In conclusion, UBP296 is the most potent and selective antagonist of GLUK5-containing kainate receptors so far described...
  57. doi request reprint A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus
    Laura Ceolin
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neurochem Int 61:517-22. 2012
    ..The concentrations of perampanel required to reduce AMPA receptor-mediated responses are not dissimilar to those in plasma following anti-convulsant doses and are consistent with AMPA receptor antagonism being its primary mode of action...
  58. pmc Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors
    Mark W Irvine
    MRC Centre for Synaptic Plasticity, University of Bristol, Medical Sciences Building, University Walk, Bristol, BS8 1TD, U K
    J Med Chem 55:327-41. 2012
    ..Consistent with this idea, antagonist 18i (30 mg/kg ip) showed antinociceptive effects in an animal model of mild nerve injury...
  59. pmc Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs
    Michael C Ashby
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:5172-6. 2004
    ..We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs...
  60. ncbi request reprint Parallel kinase cascades are involved in the induction of LTP at hippocampal CA1 synapses
    Martin A Wikström
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 45:828-36. 2003
    ..These experiments reveal, unexpectedly, the existence of two parallel kinase pathways, one involving CaMKII and the other PKA and PKC, either of which can fully support the induction of LTP, at this stage of development...
  61. pmc Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons
    Sonia A L Corrêa
    Department of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Sci 122:4186-94. 2009
    ..The role of this novel motif is therefore not to directly target trafficking of the channel to subcellular compartments, but to regulate channel location by subjecting it to rapid clathrin-mediated endocytosis...
  62. pmc Automated multi-slice extracellular and patch-clamp experiments using the WinLTP data acquisition system with automated perfusion control
    William W Anderson
    MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Neurosci Methods 207:148-60. 2012
    ....
  63. ncbi request reprint Endocannabinoids: losing inhibition to increase learning capacity?
    Stephen M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Neuron 43:762-4. 2004
    ....
  64. doi request reprint Long-term depression in the CNS
    Graham L Collingridge
    Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Nat Rev Neurosci 11:459-73. 2010
    ..In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases...
  65. doi request reprint Kainate receptors: pharmacology, function and therapeutic potential
    David E Jane
    Department of Physiology and Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 56:90-113. 2009
    ..This potential has now been confirmed in dental pain and migraine in initial studies in man...
  66. ncbi request reprint Tyrosine dephosphorylation underlies DHPG-induced LTD
    Peter R Moult
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 43:175-80. 2002
    ..These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase...
  67. ncbi request reprint Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1
    Robin A Morton
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University of Walk, Bristol BS8 1TD, UK
    Neurosci Lett 319:37-40. 2002
    ..These results demonstrate that chronic reduction of PS1 activity leads to impaired synaptic plasticity, thus suggesting a role for PS1 in normal cognitive function...
  68. pmc The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Philos Trans R Soc Lond B Biol Sci 358:635-41. 2003
    ..In this article I present a personal reflection upon the role that my colleagues and I played in the discovery of the mechanism of induction of NMDA receptor-dependent LTP...
  69. ncbi request reprint Group I mGluRs modulate the pattern of non-synaptic epileptiform activity in the hippocampus
    Sébastien J Thuault
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 43:141-6. 2002
    ..These effects are likely to contribute to the group I mGluR-induced changes in synaptic epileptic activity that are already well documented...
  70. ncbi request reprint Capabilities of the WinLTP data acquisition program extending beyond basic LTP experimental functions
    William W Anderson
    MRC Centre for Synaptic Plasticity and Department of Anatomy, University of Bristol, University Walk, Bristol, UK
    J Neurosci Methods 162:346-56. 2007
    ..Protocol flow can be changed while the experiment is running. WinLTP runs on National Instruments M-Series and Molecular Devices Digidata 132x boards, and is available at www.winltp.com...
  71. ncbi request reprint Neuroscience. ZAP and ZIP, a story to forget
    Tim V P Bliss
    Division of Neurophysiology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Science 313:1058-9. 2006
  72. pmc An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity
    Akira Terashima
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 57:872-82. 2008
    ..In addition, deletion of PICK1 or blockade of PICK1 PDZ binding prevented NMDAR-dependent LTD. Thus, PICK1 plays a critical role in bidirectional NMDAR-dependent long-term synaptic plasticity in the hippocampus...
  73. ncbi request reprint Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus
    Sari E Lauri
    Neuroscience Center and Department of Biological and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 25:4473-84. 2005
    ..By virtue of this, KARs are likely to play a central role in the development of hippocampal synaptic circuits...
  74. ncbi request reprint Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice
    Jon T Brown
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, United Kingdom
    Hippocampus 15:110-7. 2005
    ....
  75. ncbi request reprint Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate release
    Sari E Lauri
    Neuroscience Center and Department of Bio and Environmental Sciences, P O Box 65 Viikinkaari 1, 00014 University of Helsinki, Finland
    Neuron 50:415-29. 2006
    ..Early development of the glutamatergic connectivity thus involves an activity-dependent loss of presynaptic KAR function producing maturation in the mode of excitatory transmission from CA3 to CA1...
  76. ncbi request reprint Presynaptic mechanisms involved in the expression of STP and LTP at CA1 synapses in the hippocampus
    Sari E Lauri
    Neuroscience Center and Department of Biological and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland
    Neuropharmacology 52:1-11. 2007
    ..We describe how this is caused by the rapid down-regulation of a high affinity kainate receptor, which otherwise responds to ambient levels of l-glutamate by depressing Pr...
  77. ncbi request reprint Hippocampal synaptic plasticity in mice carrying the rd mutation in the gene encoding cGMP phosphodiesterase type 6 (PDE6)
    Frederick Kuenzi
    The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Brain Res 967:144-51. 2003
    ..Thus in the CA1 region synaptic plasticity is likely to be regulated by the PDE5 rather than the PDE6 isoform...
  78. pmc The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation
    Yang Zhang
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:10561-6. 2008
    ..Moreover, DHPG-triggered AMPAR internalization was abolished in STEP knock-out mice and restored after replacement of wild-type STEP. These results suggest a role for STEP in the regulation of AMPAR trafficking...
  79. pmc Introduction. Long-term potentiation and structure of the issue
    Tim V P Bliss
    Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Philos Trans R Soc Lond B Biol Sci 358:607-11. 2003
  80. pmc Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    J Physiol 546:455-60. 2003
    ..These data do not support the notion that DHPG-induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression...
  81. ncbi request reprint The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors
    Seb J Thuault
    Neurology and GI CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Biochem Pharmacol 68:1655-66. 2004
    ..Taken together with previous gene deletion studies for the GABA(B1) subunit, this suggests that classical GABA(B) function in the brain is exclusively mediated by GABA(B1/2) heteromers...
  82. ncbi request reprint Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit
    Sébastien J Thuault
    Neurology and GI CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Epilepsy Res 65:41-51. 2005
    ....
  83. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  84. ncbi request reprint Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice
    Jon T Brown
    Neurology CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Epilepsy Res 57:121-36. 2003
    ....
  85. ncbi request reprint Calcium stores and synaptic plasticity
    Stephen M Fitzjohn
    School of Biological Sciences, University of Manchester, Manchester, UK
    Cell Calcium 32:405-11. 2002
    ....
  86. ncbi request reprint Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures
    Ilse Smolders
    Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Nat Neurosci 5:796-804. 2002
    ..Therefore, we propose that subtype-selective GLU(K5) kainate receptor antagonists offer a potential new therapy for epilepsy...