H M Colhoun

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Design of the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with type 2 diabetes
    H M Colhoun
    EURODIAB, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Diabet Med 19:201-11. 2002
  2. ncbi Lipoprotein subclasses and particle sizes and their relationship with coronary artery calcification in men and women with and without type 1 diabetes
    Helen M Colhoun
    Royal Free and University College London Medical School, London, UK
    Diabetes 51:1949-56. 2002
  3. ncbi Problems of reporting genetic associations with complex outcomes
    Helen M Colhoun
    Department of Epidemiology and Public Health, University College London, WC1E 6BT, London, UK
    Lancet 361:865-72. 2003
  4. ncbi The effect of atorvastatin on serum lipids, lipoproteins and NMR spectroscopy defined lipoprotein subclasses in type 2 diabetic patients with ischaemic heart disease
    S S Soedamah-Muthu
    Royal Free and University College London Medical School, London, UK
    Atherosclerosis 167:243-55. 2003
  5. ncbi Baseline characteristics in the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with Type 2 diabetes
    M J Thomason
    EURODIAB, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Diabet Med 21:901-5. 2004
  6. ncbi Lipid transfer protein activities in type 1 diabetic patients without renal failure and nondiabetic control subjects and their association with coronary artery calcification
    H M Colhoun
    Royal Free and University College London Medical School, UK
    Diabetes 50:652-9. 2001
  7. ncbi Cost-effectiveness of primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes: results from the Collaborative Atorvastatin Diabetes Study (CARDS)
    M Raikou
    LSE Health and Social Care, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, UK
    Diabetologia 50:733-40. 2007
  8. ncbi The effect of type 1 diabetes mellitus on the gender difference in coronary artery calcification
    H M Colhoun
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, United Kingdom
    J Am Coll Cardiol 36:2160-7. 2000
  9. ncbi Blood pressure screening, management and control in England: results from the health survey for England 1994
    H M Colhoun
    Department of Epidemiology and Public Health, University College London Medical School, UK
    J Hypertens 16:747-52. 1998
  10. ncbi The scope for cardiovascular disease risk factor intervention among people with diabetes mellitus in England: a population-based analysis from the Health Surveys for England 1991-94
    H M Colhoun
    Department of Epidemiology and Public Health, University College London Medical School, UK
    Diabet Med 16:35-40. 1999

Detail Information

Publications31

  1. ncbi Design of the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with type 2 diabetes
    H M Colhoun
    EURODIAB, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Diabet Med 19:201-11. 2002
    ..This paper describes the design of a collaborative clinical trial between Diabetes UK, the NHS Research and Development Directorate and Pfizer UK, that addresses this question...
  2. ncbi Lipoprotein subclasses and particle sizes and their relationship with coronary artery calcification in men and women with and without type 1 diabetes
    Helen M Colhoun
    Royal Free and University College London Medical School, London, UK
    Diabetes 51:1949-56. 2002
    ..Type 1 diabetes is associated with differences in NMR-derived particle size, but their pathogenic significance is unclear...
  3. ncbi Problems of reporting genetic associations with complex outcomes
    Helen M Colhoun
    Department of Epidemiology and Public Health, University College London, WC1E 6BT, London, UK
    Lancet 361:865-72. 2003
    ..Without changes to present practice, we risk wastage of scientific effort and rejection of a potentially useful research strategy...
  4. ncbi The effect of atorvastatin on serum lipids, lipoproteins and NMR spectroscopy defined lipoprotein subclasses in type 2 diabetic patients with ischaemic heart disease
    S S Soedamah-Muthu
    Royal Free and University College London Medical School, London, UK
    Atherosclerosis 167:243-55. 2003
    ....
  5. ncbi Baseline characteristics in the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with Type 2 diabetes
    M J Thomason
    EURODIAB, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Diabet Med 21:901-5. 2004
    ....
  6. ncbi Lipid transfer protein activities in type 1 diabetic patients without renal failure and nondiabetic control subjects and their association with coronary artery calcification
    H M Colhoun
    Royal Free and University College London Medical School, UK
    Diabetes 50:652-9. 2001
    ..However, abnormalities in cholesteryl ester transfer or lipid transfer protein activities do not underlie the increased CAC risk in diabetic women compared with nondiabetic women or the loss of the sex difference in CAC in diabetes...
  7. ncbi Cost-effectiveness of primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes: results from the Collaborative Atorvastatin Diabetes Study (CARDS)
    M Raikou
    LSE Health and Social Care, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, UK
    Diabetologia 50:733-40. 2007
    ..We estimated the cost-effectiveness of atorvastatin treatment in the primary prevention of cardiovascular disease in patients with type 2 diabetes using data from the Collaborative Atorvastatin Diabetes Study (CARDS)...
  8. ncbi The effect of type 1 diabetes mellitus on the gender difference in coronary artery calcification
    H M Colhoun
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, United Kingdom
    J Am Coll Cardiol 36:2160-7. 2000
    ....
  9. ncbi Blood pressure screening, management and control in England: results from the health survey for England 1994
    H M Colhoun
    Department of Epidemiology and Public Health, University College London Medical School, UK
    J Hypertens 16:747-52. 1998
    ..To assess the current levels of awareness, treatment and control of hypertension in England and to determine the number and type of drugs prescribed...
  10. ncbi The scope for cardiovascular disease risk factor intervention among people with diabetes mellitus in England: a population-based analysis from the Health Surveys for England 1991-94
    H M Colhoun
    Department of Epidemiology and Public Health, University College London Medical School, UK
    Diabet Med 16:35-40. 1999
    ..This evaluation included calculating the proportion who require lipid lowering therapy according to the Standing Medical Advisory Committee (SMAC) guidelines...
  11. ncbi Study of agreement between LDL size as measured by nuclear magnetic resonance and gradient gel electrophoresis
    D R Witte
    EURODIAB, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom
    J Lipid Res 45:1069-76. 2004
    ..In particular, the two methods should not be assumed to be interchangeable in women and diabetic subjects. Whether NMR or GGE predicts cardiovascular disease risk better has not yet been evaluated...
  12. ncbi Risk factors for renal failure: the WHO Mulinational Study of Vascular Disease in Diabetes
    H M Colhoun
    EURODIAB, Department of Epidemiology and Public Health, University College London, UK
    Diabetologia 44:S46-53. 2001
    ..Plasma triglycerides seem to be an important predictor of renal failure in Type II diabetes. In Type I diabetes systolic blood pressure is an important predictor of renal failure...
  13. ncbi Changes in endothelium-dependent vasodilatation and alpha-adrenergic responses in resistance vessels during the menstrual cycle in healthy women
    N N Chan
    Center for Clinical Pharmacology Department of Epidemiology and Public Health, University College London, London, United Kingdom WC1E 6BT
    J Clin Endocrinol Metab 86:2499-504. 2001
    ..If exogenous estrogens have similar effects, the balance of these two opposing actions may determine whether estrogen replacement in postmenopausal women has beneficial or harmful effects on the vasculature...
  14. ncbi All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992-1999
    S S Soedamah-Muthu
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
    Diabetologia 49:660-6. 2006
    ..We compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK...
  15. ncbi Trends in hypertension management in Type I diabetes across Europe, 1989/1990 - 1997/1999
    S S Soedamah-Muthu
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, 1 19 Torrington Place, London WC1E 6BT, UK
    Diabetologia 45:1362-71. 2002
    ..Our aim was to examine the change in the management of hypertension in patients with Type I (insulin-dependent) diabetes mellitus in Europe, between 1989-1990 and 1997-1999...
  16. ncbi The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification: a study in type 1 diabetic patients and the general population
    H M Colhoun
    Deparetment of Epidemiology and Public Health, Royal Free and University College London Medical School, 1 19 Torrington Place, London WC1E 6BT, U K
    Diabetes Care 24:1108-14. 2001
    ..Reduced heart-rate variability is associated with increased risk of coronary events. Whether it is associated with coronary atherosclerosis is unknown...
  17. ncbi Cardiovascular risk factors as determinants of endothelium-dependent and endothelium-independent vascular reactivity in the general population
    N N Chan
    EURODIAB, Department of Epidemiology and Public HealthUniversity College London, London, United Kingdom
    J Am Coll Cardiol 38:1814-20. 2001
    ..The FRS is predictive of agonist-stimulated, endothelium-dependent vasodilation and basal NO release. However, much of the variation in the vascular responses to these drugs, at this age, remains unexplained...
  18. ncbi Differences in HDL-cholesterol:apoA-I + apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients
    S S Soedamah-Muthu
    EURODIAB, Royal Free and UCL Medical School, London, UK
    Diabetologia 43:1353-9. 2000
    ....
  19. ncbi Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS)
    H Andrew W Neil
    Division of Public Health and Primary Health Care, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK
    Diabetes Care 29:2378-84. 2006
    ..We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1,129 patients aged 65-75 years at randomization with 1,709 younger patients in the Collaborative Atorvastatin Diabetes Study (CARDS)...
  20. ncbi C-reactive protein in type 1 diabetes and its relationship to coronary artery calcification
    Helen M Colhoun
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
    Diabetes Care 25:1813-7. 2002
    ..In 196 type 1 diabetic subjects and 195 nondiabetic subjects aged 30-55 years, we examined whether C-reactive protein (CRP) is elevated in diabetes and whether CRP is associated with coronary artery calcification (CAC)...
  21. ncbi Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial
    Helen M Colhoun
    EURODIAB, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Lancet 364:685-96. 2004
    ..We aimed to assess the effectiveness of atorvastatin 10 mg daily for primary prevention of major cardiovascular events in patients with type 2 diabetes without high concentrations of LDL-cholesterol...
  22. ncbi The safety and tolerability of atorvastatin 10 mg in the Collaborative Atorvastatin Diabetes Study (CARDS)
    Connie B Newman
    Department of Medicine, New York University School of Medicine, VA Hospital, 423 East 23rd Street, Dept of Medicine 11093 South, New York, NY 10010, USA
    Diab Vasc Dis Res 5:177-83. 2008
    ..Overall, these data demonstrate that atorvastatin 10 mg was well tolerated in patients with type 2 diabetes during long-term treatment...
  23. ncbi Activated factor XII levels and factor XII 46C>T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects
    Helen M Colhoun
    Department of Epidemiology and Public Health, EURODIAB, Royal Free and University College London Medical School, 1 19 Torrington Place, UK
    Atherosclerosis 163:363-9. 2002
    ..Type 1 diabetes is associated with lower levels of FXIIa despite a greater prevalence of atherosclerosis...
  24. ncbi Relationship of phospholipid transfer protein activity to HDL and apolipoprotein B-containing lipoproteins in subjects with and without type 1 diabetes
    Helen M Colhoun
    Royal Free and University College London Medical School, London, U K
    Diabetes 51:3300-5. 2002
    ..They also support a role for PLTP in the metabolism of apoB-containing lipoproteins...
  25. ncbi Lipid goals in metabolic syndrome and diabetes
    Helen M Colhoun
    The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Curr Atheroscler Rep 9:286-95. 2007
    ....
  26. ncbi Eicosapentaenoic acid for prevention of major coronary events
    Helen M Colhoun
    Lancet 370:215; author reply 215-6. 2007
  27. ncbi The big picture on obesity and insulin resistance
    Helen M Colhoun
    J Am Coll Cardiol 40:944-5. 2002
  28. ncbi High risk of cardiovascular disease in patients with type 1 diabetes in the U.K.: a cohort study using the general practice research database
    Sabita S Soedamah-Muthu
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, UK
    Diabetes Care 29:798-804. 2006
    ..To estimate the absolute and relative risk of cardiovascular disease (CVD) in patients with type 1 diabetes in the U.K...
  29. ncbi Insight into the nature of the CRP-coronary event association using Mendelian randomization
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, UCL, London, UK
    Int J Epidemiol 35:922-31. 2006
    ..Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded...
  30. ncbi Human cytomegalovirus seropositivity is associated with impaired vascular function
    Cairistine Grahame-Clarke
    Department of Epidemiology and Public Health, University College London, 5 University St, London, WC1E 6JJ, UK
    Circulation 108:678-83. 2003
    ..This association was independent of conventional risk factors and may be associated with increased atherosclerosis burden...
  31. ncbi The effects of hormone replacement therapy on endothelial function in women with Turner's syndrome
    N Norman Chan
    Centre for Clinical Pharmacology, EURODIAB, Department of Epidemiology and Public Health, University College London, London, UK
    Clin Endocrinol (Oxf) 56:615-20. 2002
    ..To examine the effect of hormone replacement therapy (HRT) on endothelial function of forearm resistance vessels in women with Turner's syndrome...