J P Coles

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Imaging of cerebral blood flow and metabolism
    Jonathan P Coles
    University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Anaesthesiol 19:473-80. 2006
  2. ncbi request reprint Imaging after brain injury
    J P Coles
    University Department of Anaesthesia, Addenbrooke s Hospital, Box 93, Hills Road, Cambridge CB2 2QQ, UK
    Br J Anaesth 99:49-60. 2007
  3. pmc Inter subject variability and reproducibility of diffusion tensor imaging within and between different imaging sessions
    Tonny V Veenith
    Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 8:e65941. 2013
  4. doi request reprint Imaging in the diagnosis and prognosis of traumatic brain injury
    Eleanor Carter
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0AA, UK 01223 217889 01223 217887
    Expert Opin Med Diagn 6:541-54. 2012
  5. pmc Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure
    Thomas Geeraerts
    University Division of Anaesthesia and Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Crit Care 12:R114. 2008
  6. ncbi request reprint Regional ischemia after head injury
    Jonathan P Coles
    University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Crit Care 10:120-5. 2004
  7. ncbi request reprint Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 30:1950-9. 2002
  8. ncbi request reprint Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 35:568-78. 2007
  9. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
  10. ncbi request reprint Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury
    A S Cunningham
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK
    Brain 128:1931-42. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Imaging of cerebral blood flow and metabolism
    Jonathan P Coles
    University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Anaesthesiol 19:473-80. 2006
    ..To review the techniques for imaging cerebral blood flow and metabolism following injury to the brain...
  2. ncbi request reprint Imaging after brain injury
    J P Coles
    University Department of Anaesthesia, Addenbrooke s Hospital, Box 93, Hills Road, Cambridge CB2 2QQ, UK
    Br J Anaesth 99:49-60. 2007
    ..Future developments with such imaging techniques should improve understanding of the pathophysiology of brain injury and provide data that should improve management and prediction of functional outcome...
  3. pmc Inter subject variability and reproducibility of diffusion tensor imaging within and between different imaging sessions
    Tonny V Veenith
    Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 8:e65941. 2013
    ..These data can be utilised in interventional studies to quantify change within a single imaging session, or to assess the significance of change in longitudinal studies of brain injury and disease. ..
  4. doi request reprint Imaging in the diagnosis and prognosis of traumatic brain injury
    Eleanor Carter
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0AA, UK 01223 217889 01223 217887
    Expert Opin Med Diagn 6:541-54. 2012
    ..Developments in imaging techniques promise to improve understanding of the structural and functional derangements, improve management and guide the development and implementation of novel neuroprotective strategies following head injury...
  5. pmc Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure
    Thomas Geeraerts
    University Division of Anaesthesia and Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Crit Care 12:R114. 2008
    ..The objective of this study was to assess the relationship between optic nerve sheath diameter (ONSD), as measured using MRI, and ICP...
  6. ncbi request reprint Regional ischemia after head injury
    Jonathan P Coles
    University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Crit Care 10:120-5. 2004
    ..To examine the evidence of regional cerebral ischemia after traumatic brain injury...
  7. ncbi request reprint Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 30:1950-9. 2002
    ..To investigate the effect of hyperventilation on cerebral blood flow in traumatic brain injury...
  8. ncbi request reprint Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 35:568-78. 2007
    ..To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury...
  9. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  10. ncbi request reprint Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury
    A S Cunningham
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK
    Brain 128:1931-42. 2005
    ..At a voxel-based level, however (and in common with ischaemic stroke), the extent of irreversible tissue damage cannot be accurately predicted by early abnormalities of any single physiological variable...
  11. ncbi request reprint Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:17-20. 2005
    ..Our data suggest that the response of pressure reactivity to hyperventilation is heterogeneous. This could be due to hyperventilation-induced changes in cerebral metabolism, or the change in CPP...
  12. ncbi request reprint Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study
    M T O'Connell
    Department of Anaesthesia, University of Cambridge, Cambridge CB2 2QQ, UK
    Acta Neurochir Suppl 95:165-8. 2005
    ..Further observations are required with regions of interest (microdialysis catheters positioned) adjacent to mass lesions notably contusions...
  13. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
    ..To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury...
  14. ncbi request reprint Effects of propofol on cerebral oxygenation and metabolism after head injury
    A J Johnston
    University of Cambridge Department of Anaesthesia, Box 93, Cambridge CB2 2QQ, UK
    Br J Anaesth 91:781-6. 2003
    ..We have used a step increase in target plasma propofol concentration in head injured patients to explore flow-metabolism coupling in these patients...
  15. ncbi request reprint Predicting the response of intracranial pressure to moderate hyperventilation
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Acta Neurochir (Wien) 147:477-83; discussion 483. 2005
    ..We investigated the ability of pre-hyperventilation ICP and cerebrospinal compensatory reserve to predict the reduction in ICP achievable with moderate hyperventilation in head injured patients...
  16. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  17. ncbi request reprint Analysis of acute traumatic axonal injury using diffusion tensor imaging
    V F J Newcombe
    University Division of Anaesthesia, Cambridge University, Cambridge, UK
    Br J Neurosurg 21:340-8. 2007
    ..This technique holds promise for examining disease progression, and may help define therapeutic windows for the treatment of diffuse brain injury...
  18. ncbi request reprint Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study
    Peter J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 22:735-45. 2002
    ..9 kPa resulted in a significant elevation of the OEF, in association with a reduction in glucose, but no significant elevation in the L/P ratio or glutamate...
  19. ncbi request reprint Assessment of cerebrovascular autoregulation in head-injured patients: a validation study
    Luzius A Steiner
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2404-9. 2003
    ..Cerebrovascular autoregulation is frequently measured in head-injured patients. We attempted to validate 4 bedside methods used for assessment of autoregulation...
  20. ncbi request reprint Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?
    Jonathan P Coles
    Division of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Brain 127:2479-90. 2004
    ..It also remains unclear whether CPP values below 65 mmHg can be safely used in this population. Clarification of the significance of a reduction in CMRO2 and neuronal electrical function will require further study...
  21. ncbi request reprint Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity
    M Giulia Abate
    The Division of Anaesthesia, Addenbrooke s Hospital, University of Cambridge, Box 93, Cambridge, CB2 2QQ, UK
    Neurocrit Care 9:319-25. 2008
    ..Conclusive evidence of cerebral ischemia following head injury has been elusive. We aimed to use (15)O and (18)Fluorodeoxyglucose positron emission tomography (PET) to investigate pathophysiological derangements following head injury...
  22. ncbi request reprint Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure
    Luzius A Steiner
    Wolfson Brain Imaging Centre, University Department of Anesthesia, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 23:1371-7. 2003
    ..Pericontusional oedema on computed tomography was associated with lower absolute values of CBF and CBV but did not differ from nonoedematous tissue in the relative response to CPP elevation...
  23. ncbi request reprint Early metabolic characteristics of lesion and nonlesion tissue after head injury
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 29:965-75. 2009
    ..Such pathophysiological derangements may result in selective neuronal loss and impact on functional outcome...
  24. ncbi request reprint Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology
    Jonathan P Coles
    The Division of Anesthesia, and The Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:191-201. 2004
    ..We conclude that this technique is a valid and useful tool for quantifying ischemic burden after traumatic brain injury...
  25. ncbi request reprint Incidence and mechanisms of cerebral ischemia in early clinical head injury
    Jonathan P Coles
    The Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:202-11. 2004
    ..The ischemic burden represented by this "traumatic penumbra" is poorly detected by bedside clinical monitors and has significant associations with outcome...
  26. ncbi request reprint Assessment of the Caradyne WhisperFlow for administration of continuous positive airway pressure in a 3 Tesla magnetic resonance scanner
    L A Steiner
    University Department of Anaesthesia and Academic Neurosurgery, Box 167, Addenbrooke s Hospital, Cambridge CB 2QQ, UK
    Anaesthesia 57:470-4. 2002
    ..In addition, the airway pressure generated by the valves was not affected by the magnetic field. We conclude that the tested system can be safely used in a 3 Tesla magnetic resonance environment...
  27. ncbi request reprint Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma
    Virginia F J Newcombe
    University Division of Anaesthesia, Cambridge University, Box 93, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Acta Neurochir Suppl 102:247-51. 2008
    ..Cerebral edema is a common sequelum post traumatic brain injury (TBI). Quantification of the apparent diffusion coefficient (ADC) using diffusion tensor imaging (DTI) may help to characterize the pathophysiology of brain swelling...
  28. pmc Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury
    Virginia F J Newcombe
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 2QQ, UK
    Brain 134:759-68. 2011
    ..The ability to detect such damage in vivo may have important implications for patient management, patient selection for trials, and to help understand complex neurocognitive pathways...
  29. ncbi request reprint A combined microdialysis and FDG-PET study of glucose metabolism in head injury
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Acta Neurochir (Wien) 151:51-61; discussion 61. 2009
    ..In particular, we aimed to determine the fate of glucose in terms of differential metabolism to pyruvate and lactate...
  30. ncbi request reprint Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings
    Jurgens Nortje
    University Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 36:273-81. 2008
    ..To determine the effect of normobaric hyperoxia on cerebral metabolism in patients with severe traumatic brain injury...
  31. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
    ..To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury...
  32. ncbi request reprint Intersubject variability and reproducibility of 15O PET studies
    Jonathan P Coles
    The Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 26:48-57. 2006
    ..While ideally each centre should develop its own bank of such data, the figures provided will allow initial generic approximations of sample size for such studies...
  33. ncbi request reprint Blood pressure management in acute head injury
    Monica Trivedi
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Intensive Care Med 24:96-107. 2009
    ..Such functional improvements may be of immense importance to patients and require formal neurocognitive assessments to discriminate improvements...
  34. ncbi request reprint The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesth Analg 97:572-6, table of contents. 2003
    ..We propose that large doses of propofol should be used cautiously in head-injured patients, because there is the potential to increase the injured brain's vulnerability to secondary insults...
  35. ncbi request reprint Integrated image analysis solutions for PET datasets in damaged brain
    Peter Smielewski
    Wolfson Brain Imaging Centre, Department of Neurosurgery, University of Cambridge, UK
    J Clin Monit Comput 17:427-40. 2002
    ..To present an integrated imaging solution for analysis of such datasets and report on its use in practice...
  36. ncbi request reprint Diffusion limited oxygen delivery following head injury
    David K Menon
    Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1384-90. 2004
    ..To use a range of techniques to explore diffusion limitation as a mechanism of cellular hypoxia in the setting of head injury...
  37. pmc Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent
    P J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Clin Pharmacol 53:275-83. 2002
    ....
  38. ncbi request reprint A comparison of remifentanil and fentanyl in patients undergoing carotid endarterectomy
    P W Doyle
    Department of Anaesthesia, Box 93, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Eur J Anaesthesiol 18:13-9. 2001
    ..62 +/- 3.89 vs. 18.0 +/- 15.18 min, P = 0.015). CONCLUSION: Remifentanil appears to be a comparable opioid to fentanyl when supplementing isoflurane/nitrous oxide anaesthesia for carotid endarterectomy...
  39. pmc Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury
    L A Steiner
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 74:765-70. 2003
    ..Investigation of these relations requires quantitative measures of cerebral blood flow and CMRO(2), to allow assessment of oxygen supply and demand relations...
  40. ncbi request reprint Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner
    J P Coles
    Department of Anaesthesia and Wolfson Brain Imaging Centre, Box 93, Addenbrookes Hospital, University of Cambridge, CB2 2QQ, UK
    Anaesthesia 58:143-8. 2003
    ..Although the system is MR compatible and produces generally acceptable imaging even at 3 Tesla, there is significant degradation of image quality during gradient echo sequences...
  41. ncbi request reprint Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome
    Richard J Mannion
    Wolfson Brain Injury Unit, Addenbrooke s Hospital NHS Foundation Trust, Hills Road, Cambridge, United Kingdom
    J Neurotrauma 24:128-35. 2007
    ..Understanding the anatomy and extent of brainstem injury, as well as its relationship to supratentorial abnormalities, will facilitate a more accurate use of early MRI as a prognostic tool and assist in the counseling of families...
  42. ncbi request reprint Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer
    Virginia F J Newcombe
    University Division of Anaesthesia, Cambridge University, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 109:159-64. 2008
    ..That is, in the authors' system, it can be safely used with the transmit-and-receive head coil, but when using the transmit body coil the transducer wire must be coiled into concentric loops outside of the receive-only head coil...
  43. ncbi request reprint Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure
    Luzius A Steiner
    Department of Anaesthesia, University Hospital Basel, 4031 Basel, Switzerland
    Intensive Care Med 30:2180-7. 2004
    ..We investigated the time-course of changes in middle cerebral artery mean flow velocity (FVm) and intracranial pressure (ICP) in head-injured patients during sustained moderate reductions in arterial partial pressure of CO(2) (PaCO(2))...