Research Topics
Genomes and Genes
| Patricia T W CohenSummaryAffiliation: University of Dundee Country: UK Publications
| Collaborators
|
Detail Information
Publications
Protein phosphatase 1--targeted in many directionsPatricia T W Cohen
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, UK
J Cell Sci 115:241-56. 2002..Understanding of the mode of action of PP1c complexes may facilitate development of drugs that target particular PP1c complexes and thereby modulate the phosphorylation state of a very limited subset of proteins...- Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivoIan R Kelsall
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, UK
Cell Signal 21:1123-34. 2009.... - Protein phosphatase 4--from obscurity to vital functionsPatricia T W Cohen
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
FEBS Lett 579:3278-86. 2005..Antitumour agents, cantharidin and fostriecin, potently inhibit the activity of Ppp4. Orthologues of mammalian Ppp4 subunits in Saccharomyces cerevisiae confer resistance to the anticancer, DNA-binding drugs, cisplatin and oxaliplatin... - Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damageCristina Vázquez-Martin
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK
FEBS J 275:4211-21. 2008.... - The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatinC James Hastie
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, UK
FEBS J 273:3322-34. 2006..By comparison with the yeast system, this complex may confer resistance to cisplatin in higher eukaryotes... - R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signalsIan R Kelsall
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
J Neurochem 118:596-610. 2011..Adenosine stimulation also modulates phosphorylation of R3F at Ser14/Ser18... - Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic backgroundJames Paterson
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
J Mol Endocrinol 40:47-59. 2008..The pH 6.8/pH 8.6 activity ratio of phosphorylase kinase was increased in lean C57BL/6 G(M)-/- mice compared with controls indicating that phosphorylase kinase is an in vivo substrate of PP1-G(M)... - Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazoleTamás Zeke
Medical Research Council Protein Phosphorylation Unit, Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
Biochem J 385:45-56. 2005.... - Ppm1E is an in cellulo AMP-activated protein kinase phosphataseMartin Voss
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
Cell Signal 23:114-24. 2011..The data indicate that Ppm1E and probably PpM1F are in cellulo AMPK phosphatases and that Ppm1E is a potential anti-diabetic drug target... - Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPasesCristina Martin-Granados
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Int J Biochem Cell Biol 40:2315-32. 2008..The results suggest that Ppp4c-R2-R3 complexes may co-ordinate centrosome maturation and cell migration via regulation of RhoGTPases and that Ppp4 may be a useful anticancer target... - SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting proteinGareth J Browne
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 402:187-96. 2007..The presence of a leucine zipper near the C-terminus of SARP1 and SARP2, and the binding of mammalian DNA to SARP2, suggests that SARP1 and SARP2 may be transcription factors or DNA-associated proteins that modulate gene expression... - The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivoBarry J Toole
Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Cell Signal 19:1044-55. 2007.... - A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodentsShonagh Munro
Medical Research Council Protein Phosphorylation Unit, University of Dundee, UK
FEBS J 272:1478-89. 2005..The observations imply that the mechanisms by which insulin regulates glycogen synthesis in liver and skeletal muscle are different in rodents and humans... - Inhibition of several protein phosphatases by a non-covalently interacting microcystin and a novel cyanobacterial peptide, nostocyclinC James Hastie
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee, DD1 5EH Scotland, UK
Biochim Biophys Acta 1726:187-93. 2005.... - The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drugIan R Kelsall
Medical Research Council, Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
FEBS Lett 581:4749-53. 2007..We show that a phosphorylase inhibitor blocks the interaction of phosphorylase a with the G(L) C-terminus, suggesting that the latter interaction could be targeted to develop an anti-diabetic drug... - Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPsGraeme K Carnegie
Medical Research Council Protein Phosphorylation Unit, Division of Cell Signalling, University of Dundee, Dundee DD1 5EH, Scotland, UK
J Cell Sci 116:1905-13. 2003..Expression of GFP-R2-PPP4c in HeLa cells enhances the temporal localisation of newly formed snRNPs, which is consistent with an association of R2-PPP4c with the SMN protein complex... - Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locusAlex S F Doney
Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
BMC Genet 4:11. 2003..We have investigated its role in age of diagnosis, body weight and glycaemic control in 1,950 individuals with type 2 diabetes in Tayside, Scotland, and compared the ARE2 allele frequencies with 1,014 local schoolchildren... - Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistanceMirela Delibegovic
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
Diabetes 52:596-604. 2003..Our results suggest that dysfunction of PP1-G(M) may contribute to the pathophysiology of human type 2 diabetes... - Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liverShonagh Munro
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, U K
Diabetes 51:591-8. 2002.... - Molecular basis for TPR domain-mediated regulation of protein phosphatase 5Jing Yang
Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK
EMBO J 24:1-10. 2005....