Patricia T W Cohen

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint Protein phosphatase 1--targeted in many directions
    Patricia T W Cohen
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, UK
    J Cell Sci 115:241-56. 2002
  2. doi request reprint Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo
    Ian R Kelsall
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, UK
    Cell Signal 21:1123-34. 2009
  3. ncbi request reprint Protein phosphatase 4--from obscurity to vital functions
    Patricia T W Cohen
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 579:3278-86. 2005
  4. doi request reprint Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage
    Cristina Vázquez-Martin
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK
    FEBS J 275:4211-21. 2008
  5. doi request reprint R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals
    Ian R Kelsall
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    J Neurochem 118:596-610. 2011
  6. ncbi request reprint The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin
    C James Hastie
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, UK
    FEBS J 273:3322-34. 2006
  7. doi request reprint Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background
    James Paterson
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    J Mol Endocrinol 40:47-59. 2008
  8. pmc Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis
    Alexander Von Wilamowitz-Moellendorff
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, U K
    Diabetes 62:4070-82. 2013
  9. pmc Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole
    Tamás Zeke
    Medical Research Council Protein Phosphorylation Unit, Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 385:45-56. 2005
  10. doi request reprint Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases
    Cristina Martin-Granados
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Int J Biochem Cell Biol 40:2315-32. 2008

Collaborators

  • Mathieu Bollen
  • Kei Sakamoto
  • Roger W Hunter
  • Li Kang
  • Angus I Lamond
  • Andrew D Morris
  • John Rouse
  • Hugo Ceulemans
  • Cristina Martin-Granados
  • Judith Sleeman
  • J E Ladbury
  • Ian R Kelsall
  • Martin Voss
  • C James Hastie
  • Shonagh Munro
  • Mark W Peggie
  • Cristina Vázquez-Martin
  • James Paterson
  • Alexander Von Wilamowitz-Moellendorff
  • Barry J Toole
  • Gareth J Browne
  • Daniel J R Cuthbertson
  • Jing Yang
  • Tamás Zeke
  • Amanda Philp
  • Nick Morrice
  • Mirela Delibegovic
  • Alex S F Doney
  • Graeme K Carnegie
  • Carlos Martínez-Pons
  • Kathryn Campbell
  • Joaquim Calbo
  • Joan J Guinovart
  • Alan R Prescott
  • Nastja Saranzewa
  • David H Wasserman
  • Iliana López-Soldado
  • Mar Garcia-Rocha
  • Kashyap Patel
  • Louise Lantier
  • David G Campbell
  • Doron Rosenzweig
  • Irene Hallyburton
  • Margarida Fardilha
  • Odete A B da Cruz e Silva
  • Senga K Oxenham
  • Wenjuan Wu
  • Nicholas R Helps
  • Judith L Treadway
  • Edgar F da Cruz e Silva
  • Michael J R Stark
  • Emma B Borthwick
  • S Mark Roe
  • Julie Diplexcito
  • Geoffrey A Codd
  • David Barford
  • Matthew J Cliff
  • Mark A Williams
  • Louise F Morrison
  • Joanne E Cecil
  • Christopher G Armstrong
  • Douglas I Boyle
  • Graham Leese
  • Lorraine Dobbie
  • Colin N A Palmer
  • Bettina Fischer
  • Andrew J H Smith
  • Peter W Watt
  • Joan Cunningham
  • Mark Sales

Detail Information

Publications22

  1. ncbi request reprint Protein phosphatase 1--targeted in many directions
    Patricia T W Cohen
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, UK
    J Cell Sci 115:241-56. 2002
    ..Understanding of the mode of action of PP1c complexes may facilitate development of drugs that target particular PP1c complexes and thereby modulate the phosphorylation state of a very limited subset of proteins...
  2. doi request reprint Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo
    Ian R Kelsall
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, UK
    Cell Signal 21:1123-34. 2009
    ....
  3. ncbi request reprint Protein phosphatase 4--from obscurity to vital functions
    Patricia T W Cohen
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 579:3278-86. 2005
    ..Antitumour agents, cantharidin and fostriecin, potently inhibit the activity of Ppp4. Orthologues of mammalian Ppp4 subunits in Saccharomyces cerevisiae confer resistance to the anticancer, DNA-binding drugs, cisplatin and oxaliplatin...
  4. doi request reprint Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage
    Cristina Vázquez-Martin
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK
    FEBS J 275:4211-21. 2008
    ....
  5. doi request reprint R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals
    Ian R Kelsall
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    J Neurochem 118:596-610. 2011
    ..Adenosine stimulation also modulates phosphorylation of R3F at Ser14/Ser18...
  6. ncbi request reprint The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin
    C James Hastie
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, UK
    FEBS J 273:3322-34. 2006
    ..By comparison with the yeast system, this complex may confer resistance to cisplatin in higher eukaryotes...
  7. doi request reprint Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background
    James Paterson
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    J Mol Endocrinol 40:47-59. 2008
    ..The pH 6.8/pH 8.6 activity ratio of phosphorylase kinase was increased in lean C57BL/6 G(M)-/- mice compared with controls indicating that phosphorylase kinase is an in vivo substrate of PP1-G(M)...
  8. pmc Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis
    Alexander Von Wilamowitz-Moellendorff
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, U K
    Diabetes 62:4070-82. 2013
    ..These data show that G6P-mediated activation of GYS2 plays a key role in controlling glycogen synthesis and hepatic glucose-G6P flux control and thus whole-body glucose homeostasis. ..
  9. pmc Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole
    Tamás Zeke
    Medical Research Council Protein Phosphorylation Unit, Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 385:45-56. 2005
    ....
  10. doi request reprint Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases
    Cristina Martin-Granados
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Int J Biochem Cell Biol 40:2315-32. 2008
    ..The results suggest that Ppp4c-R2-R3 complexes may co-ordinate centrosome maturation and cell migration via regulation of RhoGTPases and that Ppp4 may be a useful anticancer target...
  11. doi request reprint Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
    Martin Voss
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Cell Signal 23:114-24. 2011
    ..The data indicate that Ppm1E and probably PpM1F are in cellulo AMPK phosphatases and that Ppm1E is a potential anti-diabetic drug target...
  12. pmc SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein
    Gareth J Browne
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 402:187-96. 2007
    ..The presence of a leucine zipper near the C-terminus of SARP1 and SARP2, and the binding of mammalian DNA to SARP2, suggests that SARP1 and SARP2 may be transcription factors or DNA-associated proteins that modulate gene expression...
  13. doi request reprint Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin
    Martin Voss
    Medical Research Council Protein Phosphorylation and Ubiquitylation Unit College of Life Sciences University of Dundee Dundee, Scotland, UK
    Cell Cycle 12:2876-87. 2013
    ....
  14. ncbi request reprint The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo
    Barry J Toole
    Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Cell Signal 19:1044-55. 2007
    ....
  15. ncbi request reprint A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents
    Shonagh Munro
    Medical Research Council Protein Phosphorylation Unit, University of Dundee, UK
    FEBS J 272:1478-89. 2005
    ..The observations imply that the mechanisms by which insulin regulates glycogen synthesis in liver and skeletal muscle are different in rodents and humans...
  16. ncbi request reprint Inhibition of several protein phosphatases by a non-covalently interacting microcystin and a novel cyanobacterial peptide, nostocyclin
    C James Hastie
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee, DD1 5EH Scotland, UK
    Biochim Biophys Acta 1726:187-93. 2005
    ....
  17. ncbi request reprint The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug
    Ian R Kelsall
    Medical Research Council, Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    FEBS Lett 581:4749-53. 2007
    ..We show that a phosphorylase inhibitor blocks the interaction of phosphorylase a with the G(L) C-terminus, suggesting that the latter interaction could be targeted to develop an anti-diabetic drug...
  18. ncbi request reprint Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs
    Graeme K Carnegie
    Medical Research Council Protein Phosphorylation Unit, Division of Cell Signalling, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Sci 116:1905-13. 2003
    ..Expression of GFP-R2-PPP4c in HeLa cells enhances the temporal localisation of newly formed snRNPs, which is consistent with an association of R2-PPP4c with the SMN protein complex...
  19. pmc Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus
    Alex S F Doney
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
    BMC Genet 4:11. 2003
    ..We have investigated its role in age of diagnosis, body weight and glycaemic control in 1,950 individuals with type 2 diabetes in Tayside, Scotland, and compared the ARE2 allele frequencies with 1,014 local schoolchildren...
  20. ncbi request reprint Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver
    Shonagh Munro
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, U K
    Diabetes 51:591-8. 2002
    ....
  21. ncbi request reprint Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance
    Mirela Delibegovic
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Diabetes 52:596-604. 2003
    ..Our results suggest that dysfunction of PP1-G(M) may contribute to the pathophysiology of human type 2 diabetes...
  22. pmc Molecular basis for TPR domain-mediated regulation of protein phosphatase 5
    Jing Yang
    Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    EMBO J 24:1-10. 2005
    ....