Jonathan M Cohen
Affiliation: University College London
- Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgGJonathan M Cohen
Centre for Respiratory Research, Department of Medicine, UCL, London, United Kingdom Infectious Diseases and Microbiology Unit, UCL Institute of Child Health, London, United Kingdom Electronic address
Vaccine 31:2328-32. 2013..Thus, flow cytometric binding to whole bacteria maybe a more reliable correlate of cross-protection for novel species-wide vaccines than whole cell ELISA...
- Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisationJonathan M Cohen
Centre for Respiratory Research, Department of Medicine, UCL, London, United Kingdom
Vaccine 30:4453-9. 2012..The data presented here aid our understanding of why only certain live attenuated strains are able to function as effective vaccines, and may be valuable in informing the constituents of future live attenuated vaccines...
- Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisationJonathan M Cohen
Centre for Respiratory Research, Department of Medicine, University College London, London, United Kingdom
PLoS ONE 6:e25558. 2011..These data suggest that whilst nasopharyngeal colonisation induces a range of immune responses, the effective protective responses depend upon the site of subsequent infection...
- Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivoSuneeta Chimalapati
Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
PLoS ONE 7:e41393. 2012..These data suggest that for S. pneumoniae loss of surface localisation of lipoproteins has widespread effects on ABC transporter functions that collectively prevent the Δlgt mutant from establishing invasive infection...
- Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiencyJose Yuste
Centre for Respiratory Research, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
Microbes Infect 12:626-34. 2010..pyogenes. Impaired opsonisation with C3b/iC3b and phagocytosis was not related to reduced recognition of the bacteria by antibody. These data suggest that patients with C2 deficiency are at increased risk of S. pyogenes infections...
- The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanismsCatherine Hyams
Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Building, 5 University Street, London WC1E 6JF, United Kingdom
Infect Immun 78:704-15. 2010..Overall, these data show that the S. pneumoniae capsule affects multiple aspects of complement- and neutrophil-mediated immunity, resulting in a profound inhibition of opsonophagocytosis...