Jonathan M Cohen

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgG
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, UCL, London
    Vaccine 31:2328-32. 2013
  2. pmc Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, UCL, London, United Kingdom
    Vaccine 30:4453-9. 2012
  3. pmc Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, University College London, London, United Kingdom
    PLoS ONE 6:e25558. 2011
  4. pmc Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo
    Suneeta Chimalapati
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    PLoS ONE 7:e41393. 2012
  5. doi request reprint Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency
    Jose Yuste
    Centre for Respiratory Research, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    Microbes Infect 12:626-34. 2010
  6. pmc The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms
    Catherine Hyams
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Building, 5 University Street, London WC1E 6JF, United Kingdom
    Infect Immun 78:704-15. 2010
  7. pmc Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis
    Shilpa Basavanna
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom
    Infect Immun 77:3412-23. 2009

Collaborators

Detail Information

Publications7

  1. doi request reprint Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgG
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, UCL, London
    Vaccine 31:2328-32. 2013
    ..Thus, flow cytometric binding to whole bacteria maybe a more reliable correlate of cross-protection for novel species-wide vaccines than whole cell ELISA...
  2. pmc Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, UCL, London, United Kingdom
    Vaccine 30:4453-9. 2012
    ..The data presented here aid our understanding of why only certain live attenuated strains are able to function as effective vaccines, and may be valuable in informing the constituents of future live attenuated vaccines...
  3. pmc Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, University College London, London, United Kingdom
    PLoS ONE 6:e25558. 2011
    ..These data suggest that whilst nasopharyngeal colonisation induces a range of immune responses, the effective protective responses depend upon the site of subsequent infection...
  4. pmc Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo
    Suneeta Chimalapati
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    PLoS ONE 7:e41393. 2012
    ..These data suggest that for S. pneumoniae loss of surface localisation of lipoproteins has widespread effects on ABC transporter functions that collectively prevent the Δlgt mutant from establishing invasive infection...
  5. doi request reprint Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency
    Jose Yuste
    Centre for Respiratory Research, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    Microbes Infect 12:626-34. 2010
    ..pyogenes. Impaired opsonisation with C3b/iC3b and phagocytosis was not related to reduced recognition of the bacteria by antibody. These data suggest that patients with C2 deficiency are at increased risk of S. pyogenes infections...
  6. pmc The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms
    Catherine Hyams
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Building, 5 University Street, London WC1E 6JF, United Kingdom
    Infect Immun 78:704-15. 2010
    ..Overall, these data show that the S. pneumoniae capsule affects multiple aspects of complement- and neutrophil-mediated immunity, resulting in a profound inhibition of opsonophagocytosis...
  7. pmc Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis
    Shilpa Basavanna
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom
    Infect Immun 77:3412-23. 2009
    ..These data demonstrate a previously unsuspected role for BCAA transport during infection for S. pneumoniae and provide more evidence that functioning ABC transporters are required for the full virulence of bacterial pathogens...