Martin Cohen-Gonsaud

Summary

Affiliation: University of London
Country: UK

Publications

  1. ncbi request reprint Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change
    Martin Cohen-Gonsaud
    Centre de Biochimie Structurale INSERM U554, CNRS UMR5048, UM1, Montpellier Cedex, France
    Proteins 60:392-400. 2005
  2. ncbi request reprint Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies
    Guillaume Poncet-Montange
    CNRS UMR5048, Centre de Biochimie Structurale, F 34090 Montpellier, France
    Acta Crystallogr D Biol Crystallogr 63:923-5. 2007
  3. ncbi request reprint Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
    Martin Cohen-Gonsaud
    Centre de Biochimie Structurale INSERM U554 CNRS UMR5048 UM1, 29 rue de Navacelles, 34090 Montpellier Cedex, France
    J Mol Biol 320:249-61. 2002
  4. pmc In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid
    Stephanie Ducasse-Cabanot
    Institut de Pharmacologie et de Biologie Structurale, Département des Mécanismes Moléculaires des Infections Mycobactériennes, CNRS, Toulouse, France
    Antimicrob Agents Chemother 48:242-9. 2004
  5. ncbi request reprint The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes
    Martin Cohen-Gonsaud
    School of Crystallography and Institute for Structural Molecular Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
    Nat Struct Mol Biol 12:270-3. 2005
  6. pmc Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors
    Cyril Goudet
    Department of Molecular Pharmacology, Centre National de la Recherche Scientifique, Unite Propre de Recherche 2580, CCIPE, 34094 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 101:378-83. 2004
  7. ncbi request reprint Resuscitation-promoting factors possess a lysozyme-like domain
    Martin Cohen-Gonsaud
    School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
    Trends Biochem Sci 29:7-10. 2004
  8. ncbi request reprint (1)H, (15)N, and (13)C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis
    Martin Cohen-Gonsaud
    J Biomol NMR 30:373-4. 2004
  9. doi request reprint The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c
    Marc J Canova
    Institut de Biologie et Chimie des Proteines, CNRS UMR 5086, Universite Lyon 1, IFR128 BioSciences, Lyon Gerland, Lyon, France
    Proteomics 8:521-33. 2008

Collaborators

  • Gilles Labesse
  • Virginie Molle
  • B Henderson
  • Stephanie Ducasse-Cabanot
  • Marc J Canova
  • Guillaume Poncet-Montange
  • Cyril Goudet
  • Michel Becchi
  • Romain Veyron-Churlet
  • Isabelle Zanella-Cleon
  • Alain J Cozzone
  • Laurent Kremer
  • Annaick Quemard
  • Hedia Marrakchi
  • Florence Gaven
  • Jean Philippe Pin
  • Michel Nguyen
  • Laurent Prezeau
  • Jean Bernadou
  • Julie Kniazeff
  • Annaik Quémard
  • Claire Vol
  • Mamadou Daffe
  • Francine Acher
  • Jiangfeng Liu
  • Didier Zerbib

Detail Information

Publications9

  1. ncbi request reprint Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change
    Martin Cohen-Gonsaud
    Centre de Biochimie Structurale INSERM U554, CNRS UMR5048, UM1, Montpellier Cedex, France
    Proteins 60:392-400. 2005
    ..This new structure of MabA is analyzed in view of its distinctive enzymatic and structural properties and those of related enzymes...
  2. ncbi request reprint Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies
    Guillaume Poncet-Montange
    CNRS UMR5048, Centre de Biochimie Structurale, F 34090 Montpellier, France
    Acta Crystallogr D Biol Crystallogr 63:923-5. 2007
    ..This observation suggests a new way to develop anti-MabA drugs via protein stabilization of the 'inactive' form...
  3. ncbi request reprint Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
    Martin Cohen-Gonsaud
    Centre de Biochimie Structurale INSERM U554 CNRS UMR5048 UM1, 29 rue de Navacelles, 34090 Montpellier Cedex, France
    J Mol Biol 320:249-61. 2002
    ..The distinctive enzymatic and structural properties of MabA are discussed in view of its crystal structure and that of related enzymes...
  4. pmc In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid
    Stephanie Ducasse-Cabanot
    Institut de Pharmacologie et de Biologie Structurale, Département des Mécanismes Moléculaires des Infections Mycobactériennes, CNRS, Toulouse, France
    Antimicrob Agents Chemother 48:242-9. 2004
    ..The description of the first inhibitor of the beta-ketoacyl reduction step of fatty acid biosynthesis should help in the design of new antituberculous drugs efficient against multidrug-resistant tubercle bacilli...
  5. ncbi request reprint The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes
    Martin Cohen-Gonsaud
    School of Crystallography and Institute for Structural Molecular Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
    Nat Struct Mol Biol 12:270-3. 2005
    ..These data, as well as the presence of a clear binding pocket for a large molecule, indicate that oligosaccharide cleavage is probably the signal for revival from dormancy...
  6. pmc Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors
    Cyril Goudet
    Department of Molecular Pharmacology, Centre National de la Recherche Scientifique, Unite Propre de Recherche 2580, CCIPE, 34094 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 101:378-83. 2004
    ..These data show that the HD of mGluRs behave like any other class-I GPCRs in terms of G protein coupling and regulation by various types of ligands...
  7. ncbi request reprint Resuscitation-promoting factors possess a lysozyme-like domain
    Martin Cohen-Gonsaud
    School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
    Trends Biochem Sci 29:7-10. 2004
    ..The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs...
  8. ncbi request reprint (1)H, (15)N, and (13)C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis
    Martin Cohen-Gonsaud
    J Biomol NMR 30:373-4. 2004
  9. doi request reprint The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c
    Marc J Canova
    Institut de Biologie et Chimie des Proteines, CNRS UMR 5086, Universite Lyon 1, IFR128 BioSciences, Lyon Gerland, Lyon, France
    Proteomics 8:521-33. 2008
    ....