P J Coates

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:262-73. 2001
  2. ncbi Regulating p73 isoforms in human tumours
    P J Coates
    Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    J Pathol 210:385-9. 2006
  3. ncbi Ongoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities
    P J Coates
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Pathol 214:610-6. 2008
  4. ncbi p53 and Mdm2: not all cells are equal
    P J Coates
    Cancer Biology and Clinical Pathology, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Pathol 213:357-9. 2007
  5. ncbi Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?
    Philip J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Pathol 201:377-88. 2003
  6. ncbi Indirect macrophage responses to ionizing radiation: implications for genotype-dependent bystander signaling
    Philip J Coates
    Cancer Biology and Clinical Pathology, Division of Pathology and Neurosciences, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Cancer Res 68:450-6. 2008
  7. ncbi Differential contextual responses of normal human breast epithelium to ionizing radiation in a mouse xenograft model
    Philip J Coates
    Centre for Oncology and Molecular Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Cancer Res 70:9808-15. 2010
  8. ncbi The yeast two-hybrid system for identifying protein-protein interactions
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Pathol 199:4-7. 2003
  9. ncbi Cell and tissue responses to genotoxic stress
    Philip J Coates
    Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Pathol 205:221-35. 2005
  10. ncbi Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?
    S A Lorimore
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Oncogene 20:7085-95. 2001

Collaborators

Detail Information

Publications42

  1. ncbi Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:262-73. 2001
    ..The data support conserved roles for the prohibitins in regulating mitochondrial respiratory activity and in aging...
  2. ncbi Regulating p73 isoforms in human tumours
    P J Coates
    Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    J Pathol 210:385-9. 2006
    ..Because p73 is also associated with tumour chemosensitivity, these new findings should provide prognostic information and have the potential to guide future therapeutic decisions...
  3. ncbi Ongoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities
    P J Coates
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Pathol 214:610-6. 2008
    ..The data implicate persistent activation of inflammatory-type responses in irradiated tissues as a contributory bystander mechanism for causing delayed DNA damage...
  4. ncbi p53 and Mdm2: not all cells are equal
    P J Coates
    Cancer Biology and Clinical Pathology, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Pathol 213:357-9. 2007
    ..These data challenge the view that p53 acts equally in all cell types and have important implications for the applicability of p53 therapeutics in the treatment of human cancers...
  5. ncbi Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?
    Philip J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Pathol 201:377-88. 2003
    ....
  6. ncbi Indirect macrophage responses to ionizing radiation: implications for genotype-dependent bystander signaling
    Philip J Coates
    Cancer Biology and Clinical Pathology, Division of Pathology and Neurosciences, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Cancer Res 68:450-6. 2008
    ....
  7. ncbi Differential contextual responses of normal human breast epithelium to ionizing radiation in a mouse xenograft model
    Philip J Coates
    Centre for Oncology and Molecular Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Cancer Res 70:9808-15. 2010
    ..These findings demonstrate highly complex responses of normal human breast epithelium following ionizing radiation exposure and emphasize the importance of studying whole-tissue effects rather than single-cell systems...
  8. ncbi The yeast two-hybrid system for identifying protein-protein interactions
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Pathol 199:4-7. 2003
    ..The information gained from these approaches is uncovering many aspects of the complex networks that underlie normal cellular processes and how they are perturbed in disease states...
  9. ncbi Cell and tissue responses to genotoxic stress
    Philip J Coates
    Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Pathol 205:221-35. 2005
    ..A fuller understanding of cell- and tissue-specific responses, alterations to the microenvironment, and genetic modifiers of these responses could lead to novel prevention and therapeutic strategies for common forms of human malignancy...
  10. ncbi Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?
    S A Lorimore
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Oncogene 20:7085-95. 2001
    ....
  11. ncbi Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Oncogene 20:7096-7. 2001
    ..The induction of endogenous enzyme activity therefore complicates the analysis of p53-lacZ transgenes and may also influence the analysis of radiation responses in other lacZ-reporter mice...
  12. ncbi In vivo interactions between ionizing radiation, inflammation and chemical carcinogens identified by increased DNA damage responses
    K A McAllister
    Centre for Oncology and Molecular Medicine, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Radiat Res 177:584-93. 2012
    ..These data indicate that short-term measurements of DNA damage and response to damage are useful for the identification of interactions between ionizing radiation and other agents...
  13. ncbi Fen1 expression: a novel marker for cell proliferation
    E Warbrick
    Department of Biochemistry, University of Dundee, Scotland, U K
    J Pathol 186:319-24. 1998
    ....
  14. ncbi Differential post-translational modification of the tumour suppressor proteins Rb and p53 modulate the rates of radiation-induced apoptosis in vivo
    M Wallace
    CRC Laboratories, Department of Surgery and Molecular Oncology, University of Dundee Medical School, Dundee DD1 9SY, UK
    Oncogene 20:3597-608. 2001
    ..This study highlights the possibility that genetic factors can be identified that affect differential sensitivity of cells to ionizing radiation in vivo...
  15. ncbi Characterisation of the interaction between PCNA and Gadd45
    P A Hall
    Department of Pathology, University of Dundee, Scotland
    Oncogene 10:2427-33. 1995
    ..These data provide support for the notion that PCNA-Gadd45 interactions co-ordinate cell cycle and DNA repair...
  16. ncbi The prohibitin family of mitochondrial proteins regulate replicative lifespan
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, UK
    Curr Biol 7:607-10. 1997
    ..Our observations highlight the relationship between the metabolic efficiency of cells and the ageing process, and provide evidence for its evolutionary conservation...
  17. ncbi The genetic basis of tissue responses to ionizing radiation
    K J Lindsay
    Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Br J Radiol 80:S2-6. 2007
    ..The data discussed here will aid our understanding of the genes and mechanisms involved in radiation responses...
  18. ncbi Proliferating cell nuclear antigen expression in non-cycling cells may be induced by growth factors in vivo
    P A Hall
    Department of Pathology, University of Dundee, UK
    Br J Cancer 70:244-7. 1994
    ..PCNA induction the normal cells surrounding tumours is a direct example of the effect of tumour cells on normal surrounding tissues. This effect may prove to be a useful parameter in the analysis of tumour-host interactions...
  19. ncbi Phenformin as prophylaxis and therapy in breast cancer xenografts
    M V C L Appleyard
    Centre for Oncology and Molecular Medicine, University of Dundee, Dundee DD1 9SY, UK
    Br J Cancer 106:1117-22. 2012
    ..We also compared the efficacy of phenformin and metformin in the treatment of MDAMB231...
  20. ncbi Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1
    J M Kearsey
    Department of Pathology, University of Dundee, Scotland
    Oncogene 11:1675-83. 1995
    ..It is postulated that the interactions of Gadd45 with both p21Cip1 and PCNA are important for the modulation of cell cycles, and for the inhibition of DNA replication...
  21. ncbi Chromosomal instability in unirradiated hemaopoietic cells induced by macrophages exposed in vivo to ionizing radiation
    Sally A Lorimore
    Division of Pathology and Neuroscience, Cancer Biology and Clinical Pathology Unit, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Cancer Res 68:8122-6. 2008
    ..As the majority of accidental, occupational, and therapeutic exposures to ionizing radiation are partial body exposures, the findings have implications for understanding the consequences of such exposure...
  22. ncbi Untargeted effects of ionizing radiation: implications for radiation pathology
    Eric G Wright
    University of Dundee, Division of Pathology and Neuroscience, Molecular and Cellular Pathology Laboratories, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Mutat Res 597:119-32. 2006
    ..Untargeted mechanisms may also contribute to other pathological consequences...
  23. ncbi Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation
    Sally A Lorimore
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Oncogene 22:7058-69. 2003
    ....
  24. ncbi Radiation-induced genomic instability in immortalized haemopoietic stem cells
    J McIlrath
    University of Dundee, Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Int J Radiat Biol 79:27-34. 2003
    ..The absence of significant instability in the descendants of 0.5 Gy gamma-irradiated cells implies a threshold for these endpoints in this haemopoietic stem cell line...
  25. ncbi Damaging and protective cell signalling in the untargeted effects of ionizing radiation
    Philip J Coates
    Division of Pathology and Neuroscience, Molecular and Cellular Pathology Laboratories, University of Dundee, Ninewells Hospital and Medical School, Dundee DD19SY, Scotland, UK
    Mutat Res 568:5-20. 2004
    ....
  26. ncbi Chromosomal instability in unirradiated hemopoietic cells resulting from a delayed in vivo bystander effect of gamma radiation
    Sally A Lorimore
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Cancer Res 65:5668-73. 2005
    ....
  27. ncbi Radiation-induced delayed bystander-type effects mediated by hemopoietic cells
    Karen L Burr
    Centre for Oncology and Molecular Medicine, University of Dundee Medical School, Scotland, United Kingdom
    Radiat Res 173:760-8. 2010
    ....
  28. ncbi Expression of p53 isoforms in squamous cell carcinoma of the head and neck
    Linda Boldrup
    Department of Medical Biosciences Pathology, Building 6M, 2nd Floor, Umea University, SE 901 85 Umea, Sweden, and Ninewells Hospital, Dundee, UK
    Eur J Cancer 43:617-23. 2007
    ..Improvements in methodologies and reagents to detect and quantify p53 isoform expression in clinical material will be required to correlate p53 status with clinical outcomes...
  29. ncbi p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck
    Xiaolian Gu
    Department of Medical Biosciences Pathology, Building 6M, 2nd Floor, Umea University, SE 901 85 Umea, Sweden
    Cancer Lett 263:26-34. 2008
    ..Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN...
  30. ncbi Expression of p63, COX-2, EGFR and beta-catenin in smokers and patients with squamous cell carcinoma of the head and neck reveal variations in non-neoplastic tissue and no obvious changes in smokers
    Linda Boldrup
    Department of Medical Biosciences Pathology, Umea University, SE 901 85 Umea, Sweden
    Int J Oncol 27:1661-7. 2005
    ..The data support the notion that pre-existing alterations in clinically normal epithelium exist in patients with SCCHN and could be important for the pathogenesis of the disease and for local recurrences...
  31. ncbi Differential expression of p63 isoforms in normal tissues and neoplastic cells
    Karin Nylander
    Department of Medical Biosciences Pathology, Umea University, SE 901 87 Umea, Sweden
    J Pathol 198:417-27. 2002
    ..The data indicate roles for specific p63 isoforms not only in maintaining epithelial stem cell populations, but also in cellular differentiation and neoplasia...
  32. ncbi TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN
    Xiaolian Gu
    Department of Medical Biosciences Pathology, Umea University, Umea, Sweden
    Cancer Biol Ther 6:1986-90. 2007
    ..These results indicate that TRAF4 is a common target of p53 family members and that localization of TRAF4 is associated with differentiation of SCCHN cells...
  33. ncbi Dysregulation of TAp63 mRNA and protein levels in psoriasis
    Xiaolian Gu
    Department of Medical Biosciences Pathology, Umea University, Umea, Sweden
    J Invest Dermatol 126:137-41. 2006
    ..The present data show a different regulation of TAp63 in psoriasis, where the discrepancy between mRNA levels and protein expression indicates a post-transcriptional regulation analogous to that seen in p53...
  34. ncbi Complex p63 mRNA isoform expression patterns in squamous cell carcinoma of the head and neck
    Niklas Thurfjell
    Department of Medical Biosciences Pathology, Umea University, SE 901 85 Umea, Sweden
    Int J Oncol 25:27-35. 2004
    ..The complexity of these p63 expression patterns seen in primary SCCHN indicates that p63 has multifaceted roles in tumour biology...
  35. ncbi Expression of novel p53 isoforms in oral lichen planus
    Majid Ebrahimi
    Department of Odontology, Umea University, SE 901 85 Umea, Sweden
    Oral Oncol 44:156-61. 2008
    ..Levels of p63 isoforms were lower in OLP lesions compared with normal tissue, however, changes were not statistically significant...
  36. ncbi Detection of antibodies against p63 and p73 isoforms in sera from patients diagnosed with oral lichen planus
    Majid Ebrahimi
    Department of Odontology, Umea University, Umea, Sweden
    J Oral Pathol Med 36:93-8. 2007
    ..Oral lichen planus (OLP) is a chronic inflammatory disease of oral mucosa. Despite numerous publications and intense research, the etiology of OLP is still unknown, however, autoimmunity as a possible causative factor has been discussed...
  37. ncbi Downregulation of TAp63 and unaffected levels of p63beta distinguishes oral wounds from SCCHN
    Niklas Thurfjell
    Cell Cycle 5:555-7. 2006
  38. ncbi Decreased expression of p63 in oral lichen planus and graft-vs.-host disease associated with oral inflammation
    Majid Ebrahimi
    Department of Odontology, , Ume, Sweden
    J Oral Pathol Med 35:46-50. 2006
    ..In SCCHN disruption of the TP53 gene and overrepresentation of certain p63 isoforms has been seen, indicating that this could lead to neoplastic transformation...
  39. ncbi Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin
    Niklas Thurfjell
    Department of Medical Biosciences Pathology, Umea University, SE 901 85 Umea, Sweden
    Int J Mol Med 16:1065-70. 2005
    ..Moreover, targeted inhibition of p63 expression in SCCHN could be a useful adjunct for conventional treatments of this disease...
  40. ncbi Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck
    Niklas Thurfjell
    Department of Medical Biosciences/Pathology, , Sweden
    Adv Otorhinolaryngol 62:49-57. 2005
    ..Data suggest that p63 expression in HNSCC influences tumour cell differentiation...
  41. ncbi Detecting and quantifying apoptosis in tissue sections
    Vicki Save
    Department of Pathology, Addenbrookes Hospital, Cambridge University, UK
    Methods Mol Biol 282:67-84. 2004
    ..The analysis of apoptotic cells and methods for their quantification are also discussed...
  42. ncbi Markers of senescence?
    Philip J Coates
    J Pathol 196:371-3. 2002
    ....