Research Topics
Species | Gavin ClowrySummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Expression of nitric oxide synthase by motor neurones in the spinal cord of the mutant mouse wobblerG J Clowry
University of Newcastle upon Tyne, Department of Child Health, Sir James Spence Institute, Newcastie upon Tyne, UK
Neurosci Lett 215:177-80. 1996....
Renewed focus on the developing human neocortexGavin Clowry
Institute of Neuroscience, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
J Anat 217:276-88. 2010..This review gives a flavour of the recent studies stemming from this renewed focus on the developing human brain...- The dependence of spinal cord development on corticospinal input and its significance in understanding and treating spastic cerebral palsyGavin J Clowry
Neural Development, Plasticity and Repair, School of Clinical Medical Sciences and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
Neurosci Biobehav Rev 31:1114-24. 2007.... - The effects of botulinum neurotoxin A induced muscle paresis during a critical period upon muscle and spinal cord development in the ratGavin J Clowry
Neural Development, Plasticity and Repair, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Exp Neurol 202:456-69. 2006..Temporary reduction in activity did not significantly alter muscle afferent development, but temporary blockade of neuromuscular junctions did affect both muscle and motor axon, in the longer term... - An immunohistochemical study of the development of sensorimotor components of the early fetal human spinal cordGavin J Clowry
Neural Development, Plasticity and Repair Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
J Anat 207:313-24. 2005..This investigation contributes towards a timetable for the functional development of human motor control and makes comparisons with well-studied rodent models... - Spinal cord plasticity in response to unilateral inhibition of the rat motor cortex during development: changes to gene expression, muscle afferents and the ipsilateral corticospinal projectionG J Clowry
Neural Development, Plasticity and Repair Group, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
Eur J Neurosci 20:2555-66. 2004..Unexpectedly, unilateral inhibition of the motor cortical input did not lead to an expanded muscle afferent input. Instead, this was reduced coincident with development of a bilateral corticospinal innervation... - Brainstem motor nuclei respond differentially to degenerative disease in the mutant mouse wobblerG J Clowry
Neural Development, Plasticity and Repair Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Neuropathol Appl Neurobiol 30:148-60. 2004..Induced CB expression may be neuroprotective but that constitutive expression of PV may not... - Changing pattern of expression of parvalbumin immunoreactivity during human fetal spinal cord developmentG J Clowry
Developmental Neuroscience Group, Department of Child Health, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
J Comp Neurol 423:727-35. 2000..The extent to which expression of PV immunoreactivity can be taken to indicate landmarks in human development will be discussed... - Developmental expression of parvalbumin by rat lower cervical spinal cord neurones and the effect of early lesions to the motor cortexG J Clowry
Department of Child Health, University of Newcastle upon Tyne, Sir James Spence Institute, UK
Brain Res Dev Brain Res 102:197-208. 1997..Early cortical lesions disrupt this transient phase of expression but also alter mature patterns of PV localisation. This suggests a critical role for corticospinal pathways in guiding maturation of segmental spinal cord circuitry... - N-methyl-D-aspartate receptor blockade during development induces short-term but not long-term changes in c-Jun and parvalbumin expression in the rat cervical spinal cordC L Gibson
Developmental Neuroscience Group, Department of Child Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
Exp Neurol 170:380-4. 2001.... 
Elimination of muscle afferent boutons from the cuneate nucleus of the rat medulla during developmentT Fisher
Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, UK
Neuroscience 161:787-93. 2009..Corticocuneate fibers invade the nucleus during the same period and may influence reorganization of its muscle afferent input, making it another potential site for aberrant reflex development in cerebral palsy...- Functional corticospinal projections are established prenatally in the human foetus permitting involvement in the development of spinal motor centresJ A Eyre
Developmental Neuroscience Group, Department of Child Health, University of Newcastle upon Tyne, UK
Brain 123:51-64. 2000..The possibility therefore exists to promote regeneration of disrupted corticospinal projections during the perinatal period with the double benefit of restoring corticospinal connectivity and normal development of spinal motor centres... - Abnormal corticospinal function but normal axonal guidance in human L1CAM mutationsC B Dobson
Developmental Neuroscience, Department of Child Health, University of Newcastle upon Tyne, UK
Brain 124:2393-406. 2001..These data support a role for L1CAM in corticospinal tract development in hemizygous males and 'carrier' females, but do not support a critical role for L1CAM in corticospinal axonal guidance... - A comparison of behavioural and histological outcomes of periventricular injection of ibotenic acid in neonatal rats at postnatal days 5 and 7Aiqing Chen
Institute of Neuroscience and School of Clinical Medical Sciences Child Health, Newcastle University, Newcastle upon Tyne, UK
Brain Res 1201:187-95. 2008..We conclude that IBA induced lesions provide a satisfactory model of PVWMI, particularly when made at P5... - Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system?Janet A Eyre
Department of Developmental Neuroscience, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
Ann Neurol 62:493-503. 2007.... - The effect on motor cortical neuronal development of focal lesions to the sub-cortical white matter in the neonatal rat: a model for periventricular leukomalaciaClaire L Gibson
Brain Development, Plasticity and Repair Group, School of Clinical Medical Sciences (Child Health, University of Newcastle upon Tyne, UK
Int J Dev Neurosci 21:171-82. 2003..Changes in expression of Bax, cJun and non-phosphorylated neurofilaments during normal development are also described... - A molecular neuroanatomical study of the developing human neocortex from 8 to 17 postconceptional weeks revealing the early differentiation of the subplate and subventricular zoneNadhim Bayatti
School of Clinical Medical Sciences, Department of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
Cereb Cortex 18:1536-48. 2008..PAX6 was extensively expressed in the proliferative zones such that the human outer SVZ contained a large reservoir of PAX6-positive potential progenitor cells...