Affiliation: University of Southampton
- Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skinGeraldine F Clough
Division of Infection, Inflammation and Repair, School of Medicine, Mail Point 825, General Hospital, University of Southampton, Southampton SO16 6YD, UK
J Pharmacol Exp Ther 302:681-6. 2002..They suggest that clearance of solute by the blood will have a significant impact on microdialysis probe recovery and that, in the skin, the magnitude of this clearance is directly related to blood flow...
- Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatmentGeraldine F Clough
Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital MP 887, Southampton, UK
Microcirculation 18:74-84. 2011....
- Evaluation of a new high power, wide separation laser Doppler probe: potential measurement of deeper tissue blood flowGeraldine Clough
Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
Microvasc Res 78:155-61. 2009..5 mm, with DRT4) (Moor UK) and to explore its potential for use in the noninvasive measurement of blood flow in deeper tissues in humans...
- Bend those knees!Geraldine Clough
Institute of Developmental Sciences, University of Southampton, School of Medicine, Southampton SO16 6YD, UK
J Physiol 586:1462. 2008
- The microcirculation: a target for developmental primingGeraldine F Clough
Vascular Research Group, Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
Microcirculation 18:286-97. 2011....
- Microdialysis of large moleculesGeraldine F Clough
Infection, Inflammation and Repair Research Division, School of Medicine, University of Southampton, UK
AAPS J 7:E686-92. 2005..From this may develop a better understanding of the disease process and its diagnosis and more targeted approaches to therapy...
- Vascular disease in the metabolic syndrome: do we need to target the microcirculation to treat large vessel disease?Andrew J Krentz
Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
J Vasc Res 46:515-26. 2009..The hypothesis that vascular events can be prevented, or at least deferred, through earlier therapeutic intervention in pre-diabetic subjects with glucose intolerance is amenable to testing in clinical trials...
- A microdialysis method for the recovery of IL-1beta, IL-6 and nerve growth factor from human brain in vivoCraig D Winter
Neurosurgical Department, Wessex Neurological Centre, Southampton General Hospital, Southampton SO16 6YD, UK
J Neurosci Methods 119:45-50. 2002..The technique provides a timely addition to the armamentarium of the clinical scientist and will potentially lead to a greater understanding of neuroinflammation following acute traumatic brain injury...
- Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expressionKimberley D Bruce
Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
Hepatology 50:1796-808. 2009..CONCLUSION: Maternal fat intake contributes toward the NAFLD progression in adult offspring, which is mediated through impaired hepatic mitochondrial metabolism and up-regulated hepatic lipogenesis...
- Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injuryCraig D Winter
Neurosurgical Department, Wessex Neurological Centre, Southampton, University Hospitals NHS Trust, School of Medicine, University of Southampton, SO16 7PX, UK
Brain 127:315-20. 2004..34, P = 0.03, n = 14). The levels of IL-1beta and NGF were similar in both groups of patients. From these data, we suggest that IL-6 is an endogenous neuroprotective cytokine produced in response to severe head trauma...
- What can microdialysis tell us about the temporal and spatial generation of cytokines in allergen-induced responses in human skin in vivo?Geraldine F Clough
Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK
J Invest Dermatol 127:2799-806. 2007..Furthermore, when used in conjunction with skin biopsies, it provides novel information about the mechanisms of dermal inflammation...
- A comparison of cutaneous vascular responses to transient pressure loading in smokers and nonsmokersMiriam Noble
School of Nursing and Midwifery and School of Medicine, University of Southampton, Southampton, United Kingdom
J Rehabil Res Dev 40:283-8. 2003..We have also shown that vascular responsiveness is altered in light smokers compared to control subjects. These preliminary data open the way for further investigation into the risk factors associated with pressure ulcer development...
- Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implicationsAndrew J Krentz
Department of Diabetes and Endocrinology, Southampton General Hospital, Southampton SO16 6YD, UK
Diabetes Obes Metab 9:781-91. 2007..Preferential use should be made of drug regimens that (i) maximize vascular protection, (ii) reduce the risk of iatrogenic vascular damage and (iii) minimize the increasing problem of polypharmacy...
- Age and cigarette smoking are independently associated with the cutaneous vascular response to local warmingMiriam R Avery
School of Medicine, University of Southampton, Southampton, UK
Microcirculation 16:725-34. 2009..To investigate the relative impacts of age and cigarette smoking on cutaneous blood flow and flow motion...
- Vascular responses in the skin: an accessible model of inflammationGeraldine F Clough
Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
News Physiol Sci 17:170-4. 2002..Until recently, changes in vascular perfusion and permeability could only be superficially visualized. A novel combination of techniques has now provided the appropriate tools with which to study this more extensively in humans...
- Recovery of nitric oxide from acetylcholine-mediated vasodilatation in human skin in vivoParaskevi Boutsiouki
Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
Microcirculation 11:249-59. 2004..Further they suggest that ACh at higher concentrations can induce an axon-reflex-mediated response that is independent of NO release at the site of dermal provocation or of local histamine release...
- Modulation of microvascular function following low-dose exposure to the organophosphorous compound malathion in human skin in vivoParaskevi Boutsiouki
Infection Inflammation and Repair, School of Medicine, Mail Point 825, Southampton General Hospital, Southampton SO16 6YD, UK
J Appl Physiol 97:1091-7. 2004....
- Cutaneous microdialysis as a novel means of continuously stimulating eccrine sweat glands in vivoCaroline J Morgan
IIR Research Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
J Invest Dermatol 126:1220-5. 2006..This method has made it possible to show that sweat glands are capable of sustaining near maximal activity for at least 5 hours. The method has future application in investigation of conditions with disordered sweat gland activity...
- Maximum skin hyperaemia induced by local heating: possible mechanismsKim M Gooding
Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, UK
J Vasc Res 43:270-7. 2006..CONCLUSION: NO, but not prostaglandins, histamine or an axon reflex, contributes to the increase in blood flow on heating and NO is also a component of the resolution of MH after heating...
- Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory responseRebecca C C Brooke
Photobiology Unit, Dermatological Sciences, University of Manchester, Salford Royal Hospital, Manchester, UK
J Invest Dermatol 126:2296-301. 2006..Thus, two discrete acute inflammatory responses to topical ALA-PDT occur in human skin; histamine mediates the immediate response, but does not appear involved in the delayed phototoxicity...
- Dermal microdialysis in the dog: in vivo assessment of the effect of cyclosporin A on cutaneous histamine and prostaglandin D2 releasePilar Brazis
UNIVET Servicio de Diagnostico Veterinario SL, Universitat Autonoma de Barcelona, Barcelona, Spain
Vet Dermatol 17:169-74. 2006..Dermal microdialysis provides a useful tool for investigating canine allergic reactions and their modulation by drugs...