Research Topics
Species | P G CliftonSummaryAffiliation: University of Sussex Country: UK Publications
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Publications
5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor functionPeter G Clifton
Experimental Psychology, University of Sussex, Brighton BN1 9QG, UK
Eur J Neurosci 17:185-90. 2003..These results demonstrate that compensatory adaptations to the constitutive loss of 5-HT1B receptors may be an important determinant of the altered response of 5-HT1B KO mice to a variety of pharmacological challenges...- Little and often: ingestive behavior patterns following hippocampal lesions in ratsP G Clifton
School of Biological Sciences, University of Sussex, Brighton, England
Behav Neurosci 112:502-11. 1998..The data are discussed in terms of changes in behavioral switching or a possible interoceptive agnosia following hippocampal damage... - Meal patterning in rodents: psychopharmacological and neuroanatomical studiesP G Clifton
Laboratory of Experimental Psychology, University of Sussex, Brighton, UK
Neurosci Biobehav Rev 24:213-22. 2000..These structures may play a role in the organisation of meal patterning... - Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist and d-fenfluramine on feeding patterns in the ratP G Clifton
Laboratory of Experimental Psychology, University of Sussex, Brighton, UK
Psychopharmacology (Berl) 152:256-67. 2000..Activation of 5-HT2C receptors is thought to enhance satiety and to mediate the action of the prototypical anorectic drug d-fenfluramine... - Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouseG L Dalton
Department of Psychology, Sussex University, Brighton, BN1 9QG, UK
Psychopharmacology (Berl) 185:45-57. 2006..These results also confirm that 5-HT1B-R activation alone cannot account for the hyperactive response of 5-HT2C KO mice to mCPP... - mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypesG L Dalton
Department of Psychology, Sussex University, Brighton BN1 9QG, UK
Neuropharmacology 46:663-71. 2004..By contrast, mCPP-induced hyperactivity depends on the inactivation of a separate 5-HT2C receptor population and is mediated by 5-HT2A and 5-HT1B receptor activation... - Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtypeS P Vickers
Laboratory of Experimental Psychology, University of Sussex, Brighton, UK
Psychopharmacology (Berl) 125:168-75. 1996..The implications of these results to the utility of the behavioural satiety sequence as a measure of postprandial satiety are discussed... - Partial reversal of fluoxetine anorexia by the 5-HT antagonist metergolineM D Lee
Laboratory of Experimental Psychology, University of Sussex, Brighton, UK
Psychopharmacology (Berl) 107:359-64. 1992..We conclude that fluoxetine reduces food intake by enhancing satiety through a serotonergic dependent mechanism but reduces feeding rate through a separate mechanism, whose neurochemical basis remains to be established... - Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant miceS P Vickers
Laboratory of Experimental Psychology, University of Sussex, Brighton, East Sussex, UK
Psychopharmacology (Berl) 143:309-14. 1999..d-Fenfluramine stimulates the release of serotonin (5-HT) and is a potent inhibitor of the re-uptake of 5-HT into nerve terminals. Administration of d-fenfluramine suppresses food intake in both animals and humans... 
Reduced activity at the 5-HT(2C) receptor enhances reversal learning by decreasing the influence of previously non-rewarded associationsS R O Nilsson
School of Psychology, University of Sussex, Brighton, BN1 9QH, UK
Psychopharmacology (Berl) 224:241-54. 2012..Successful reversal learning can be reduced to two dissociable cognitive mechanisms, to dissipate associations of previous positive (opposed by perseverance) and negative (opposed by learned non-reward) valence...- Monoamine receptors in the regulation of feeding behaviour and energy balanceP G Clifton
Department of Psychology, Sussex University, Brighton, BN1 9QG, UK
CNS Neurol Disord Drug Targets 5:293-312. 2006..We conclude that compounds interacting with 5-HT(2C), 5-HT(6) and histamine H(3) receptors may be of particular interest as specific drug development targets for the treatment of appetite disturbance in obesity... - Intra-accumbens baclofen, but not muscimol, mimics the effects of food withdrawal on feeding behaviourK G T Pulman
Schools of Psychology, University of Sussex, Brighton, UK
Pharmacol Biochem Behav 97:156-62. 2010.... - Effects of dopamine D1 and dopamine D2 antagonists on the free feeding and drinking patterns of ratsP G Clifton
Laboratory of Experimental Psychology, University of Sussex, Brighton, United Kingdom
Behav Neurosci 105:272-81. 1991..D1 receptors, in contrast, are of greater importance in controlling water intake... - Alpha1- and alpha2-containing GABAA receptor modulation is not necessary for benzodiazepine-induced hyperphagiaH V Morris
Department of Psychology, University of Sussex, Falmer, Brighton, UK
Appetite 52:675-83. 2009..These observations, together with evidence against the involvement of alpha5-containing GABA(A) receptors, suggest that alpha3-containing receptors mediate BZ-induced hyperphagia in the mouse...