Steven C Clifford

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas
    Charles S McManamy
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    J Neuropathol Exp Neurol 62:627-32. 2003
  2. ncbi request reprint Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis
    Steven C Clifford
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2666-70. 2006
  3. pmc Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2
    Jennifer A Anderton
    Northern Institute for Cancer Research, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
    Neuro Oncol 10:981-94. 2008
  4. doi request reprint MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma
    Sarra L Ryan
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Acta Neuropathol 123:501-13. 2012
  5. pmc Rapid diagnosis of medulloblastoma molecular subgroups
    Ed C Schwalbe
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Clin Cancer Res 17:1883-94. 2011
  6. doi request reprint DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
    Edward C Schwalbe
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Acta Neuropathol 125:359-71. 2013
  7. ncbi request reprint Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Int J Cancer 118:346-52. 2006
  8. ncbi request reprint The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma
    Adrian J Frank
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Brain Res Mol Brain Res 121:137-40. 2004
  9. ncbi request reprint Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior
    Charles S McManamy
    Northern Institute for Cancer Research, University of Newcastle, and Department of Neuropathology, Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK
    Brain Pathol 17:151-64. 2007
  10. ncbi request reprint Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma
    Deborah K Scott
    Northern Institute for Cancer Research, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2381-9. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas
    Charles S McManamy
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    J Neuropathol Exp Neurol 62:627-32. 2003
    ..Our study supports the concept of an anaplastic variant among MBs, demonstrating that it has clinical utility...
  2. ncbi request reprint Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis
    Steven C Clifford
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2666-70. 2006
    ....
  3. pmc Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2
    Jennifer A Anderton
    Northern Institute for Cancer Research, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
    Neuro Oncol 10:981-94. 2008
    ....
  4. doi request reprint MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma
    Sarra L Ryan
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Acta Neuropathol 123:501-13. 2012
    ....
  5. pmc Rapid diagnosis of medulloblastoma molecular subgroups
    Ed C Schwalbe
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Clin Cancer Res 17:1883-94. 2011
    ..Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management...
  6. doi request reprint DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
    Edward C Schwalbe
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Acta Neuropathol 125:359-71. 2013
    ..These findings have important implications for future risk-adapted clinical disease management...
  7. ncbi request reprint Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Int J Cancer 118:346-52. 2006
    ....
  8. ncbi request reprint The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma
    Adrian J Frank
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Brain Res Mol Brain Res 121:137-40. 2004
    ..Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma...
  9. ncbi request reprint Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior
    Charles S McManamy
    Northern Institute for Cancer Research, University of Newcastle, and Department of Neuropathology, Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK
    Brain Pathol 17:151-64. 2007
    ..In conclusion, the nodular/desmoplastic medulloblastoma appears to have clinical, genetic and biological characteristics that set it apart from other variants of this tumor...
  10. ncbi request reprint Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma
    Deborah K Scott
    Northern Institute for Cancer Research, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2381-9. 2006
    ..MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma...
  11. ncbi request reprint Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma
    David W Hamilton
    Northern Institute for Cancer Research, Paul O Gorman Building, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cancer Lett 227:75-81. 2005
    ..The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease...
  12. ncbi request reprint APC and CTNNB1 mutations are rare in sporadic ependymomas
    Olabisi E Onilude
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cancer Genet Cytogenet 168:158-61. 2006
    ....
  13. ncbi request reprint beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee
    David W Ellison
    Northern Institute for Cancer Research, University of Newcastle, UK
    J Clin Oncol 23:7951-7. 2005
    ..We tested the hypothesis that nuclear immunoreactivity for beta-catenin is a prognostic marker in medulloblastoma, and assessed the relationship between nuclear beta-catenin immunoreactivity and mutations of CTNNB1 and APC...
  14. ncbi request reprint Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma
    Richard J Gilbertson
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK, and Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Eur J Cancer 42:646-9. 2006
    ....
  15. pmc Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma
    Yuan Lu
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 4:e6159. 2009
    ..The identification of critical genes involved in its pathogenesis will be central to advances in our understanding of its molecular basis, and the development of improved therapeutic approaches...
  16. ncbi request reprint Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Carcinogenesis 25:661-8. 2004
    ..Furthermore, methylation observed in the normal cerebellum emphasises the requirement for appropriate control tissues when assessing the tumour-specificity of TSG hypermethylation...
  17. ncbi request reprint Epigenetic events in medulloblastoma development
    Janet C Lindsey
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Neurosurg Focus 19:E10. 2005
    ..Their nature, origins, and functional role(s) in tumorigenesis are considered, and the authors assess the potential utility of these events as a basis for novel diagnostic and therapeutic approaches...
  18. ncbi request reprint Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma
    Jacqueline A Langdon
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer 45:47-60. 2006
    ....
  19. doi request reprint The importance of biopsy following radiological diagnosis of relapsed medulloblastoma
    Jonathan Fisher
    Paediatric Oncology Department, Great North Children s Hospital, Queen Victoria Road, Newcastle upon Tyne, UK
    Br J Neurosurg 26:542-4. 2012
    ..The lesions were retrospectively assumed to be a radiation effect, highlighting the potential benefits of biopsy to confirm presumed radiological recurrence...
  20. ncbi request reprint What's new in neuro-oncology? Recent advances in medulloblastoma
    David W Ellison
    The Northern Institute for Cancer Research, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    Eur J Paediatr Neurol 7:53-66. 2003
  21. pmc The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
    Tamar Uziel
    Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA
    Genes Dev 19:2656-67. 2005
    ..Methylation of INK4C (CDKN2C) was observed in four of 23 human MBs, and p18(INK4C) protein expression was extinguished in 14 of 73 cases. Hence, p18(INK4C) loss may contribute to MB formation in children...
  22. ncbi request reprint A 7-year-old boy with midline cerebellar mass
    Azzam Ismail
    Brain Pathol 15:261-2, 267. 2005
    ..On the basis of the histologic and genetic abnormalities, we propose a diagnosis of PNET with multilineal differentiation...
  23. ncbi request reprint Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients
    Jayne M Lamont
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Clin Cancer Res 10:5482-93. 2004
    ....
  24. ncbi request reprint PDGFRB is overexpressed in metastatic medulloblastoma
    Richard J Gilbertson
    Nat Genet 35:197-8. 2003
  25. ncbi request reprint Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development
    Meryl E Lusher
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Cancer Res 62:5906-11. 2002
    ..Importantly, these data demonstrate that comprehensive analysis of the genome and epigenome will be required for identification of the key tumor suppressor genes involved in medulloblastoma development...