Research Topics
Genomes and GenesSpecies | Steven C CliffordSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomasCharles S McManamy
Northern Institute for Cancer Research, University of Newcastle, Newcastle-upon-Tyne, UK
J Neuropathol Exp Neurol 62:627-32. 2003..Our study supports the concept of an anaplastic variant among MBs, demonstrating that it has clinical utility...- Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosisSteven C Clifford
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
Cell Cycle 5:2666-70. 2006.... 
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2Jennifer A Anderton
Northern Institute for Cancer Research, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
Neuro Oncol 10:981-94. 2008....
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastomaSarra L Ryan
Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Acta Neuropathol 123:501-13. 2012....- Rapid diagnosis of medulloblastoma molecular subgroupsEd C Schwalbe
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
Clin Cancer Res 17:1883-94. 2011..Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management... - Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumoursJanet C Lindsey
Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
Int J Cancer 118:346-52. 2006.... - The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastomaAdrian J Frank
Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Brain Res Mol Brain Res 121:137-40. 2004..Our data provide the first evidence that alterations within the TP53-ARF tumor suppressor pathway contribute to development of aggressive forms of medulloblastoma... - Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behaviorCharles S McManamy
Northern Institute for Cancer Research, University of Newcastle, and Department of Neuropathology, Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK
Brain Pathol 17:151-64. 2007..In conclusion, the nodular/desmoplastic medulloblastoma appears to have clinical, genetic and biological characteristics that set it apart from other variants of this tumor... - Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastomaDeborah K Scott
Northern Institute for Cancer Research, The Medical School, Newcastle University, Newcastle upon Tyne, UK
Cell Cycle 5:2381-9. 2006..MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma... - Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymomaDavid W Hamilton
Northern Institute for Cancer Research, Paul O'Gorman Building, The Medical School, University of Newcastle, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK
Cancer Lett 227:75-81. 2005..The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease... - APC and CTNNB1 mutations are rare in sporadic ependymomasOlabisi E Onilude
Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Cancer Genet Cytogenet 168:158-61. 2006.... - beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour CommitteeDavid W Ellison
Northern Institute for Cancer Research, University of Newcastle, UK
J Clin Oncol 23:7951-7. 2005..We tested the hypothesis that nuclear immunoreactivity for beta-catenin is a prognostic marker in medulloblastoma, and assessed the relationship between nuclear beta-catenin immunoreactivity and mutations of CTNNB1 and APC... - Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profilingJanet C Lindsey
Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
Carcinogenesis 25:661-8. 2004..Furthermore, methylation observed in the normal cerebellum emphasises the requirement for appropriate control tissues when assessing the tumour-specificity of TSG hypermethylation... - Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastomaRichard J Gilbertson
Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK, and Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
Eur J Cancer 42:646-9. 2006.... - Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastomaYuan Lu
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
PLoS ONE 4:e6159. 2009..The identification of critical genes involved in its pathogenesis will be central to advances in our understanding of its molecular basis, and the development of improved therapeutic approaches... - Epigenetic events in medulloblastoma developmentJanet C Lindsey
Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, United Kingdom
Neurosurg Focus 19:E10. 2005..Their nature, origins, and functional role(s) in tumorigenesis are considered, and the authors assess the potential utility of these events as a basis for novel diagnostic and therapeutic approaches... - Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastomaJacqueline A Langdon
Northern Institute for Cancer Research, University of Newcastle, Newcastle-upon-Tyne, UK
Genes Chromosomes Cancer 45:47-60. 2006.... - DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsiesEdward C Schwalbe
Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
Acta Neuropathol 125:359-71. 2013..These findings have important implications for future risk-adapted clinical disease management... - The importance of biopsy following radiological diagnosis of relapsed medulloblastomaJonathan Fisher
Paediatric Oncology Department, Great North Children s Hospital, Queen Victoria Road, Newcastle upon Tyne, UK
Br J Neurosurg 26:542-4. 2012..The lesions were retrospectively assumed to be a radiation effect, highlighting the potential benefits of biopsy to confirm presumed radiological recurrence... - What's new in neuro-oncology? Recent advances in medulloblastomaDavid W Ellison
The Northern Institute for Cancer Research, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
Eur J Paediatr Neurol 7:53-66. 2003 - The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formationTamar Uziel
Department of Tumor Cell Biology and Genetics, Memphis, Tennessee 38105, USA
Genes Dev 19:2656-67. 2005..Methylation of INK4C (CDKN2C) was observed in four of 23 human MBs, and p18(INK4C) protein expression was extinguished in 14 of 73 cases. Hence, p18(INK4C) loss may contribute to MB formation in children... - A 7-year-old boy with midline cerebellar massAzzam Ismail
Brain Pathol 15:261-2, 267. 2005..On the basis of the histologic and genetic abnormalities, we propose a diagnosis of PNET with multilineal differentiation... - Combined histopathological and molecular cytogenetic stratification of medulloblastoma patientsJayne M Lamont
Northern Institute for Cancer Research, University of Newcastle, Newcastle-upon-Tyne, United Kingdom
Clin Cancer Res 10:5482-93. 2004.... - PDGFRB is overexpressed in metastatic medulloblastomaRichard J Gilbertson
Nat Genet 35:197-8. 2003 - Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma developmentMeryl E Lusher
Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle-upon-Tyne, NE2 4HH, United Kingdom
Cancer Res 62:5906-11. 2002..Importantly, these data demonstrate that comprehensive analysis of the genome and epigenome will be required for identification of the key tumor suppressor genes involved in medulloblastoma development...